NADPH oxidases and ROS signaling in the gastrointestinal tract

Autophagy regulates DUOX1 localization and superoxide production in airway epithelial cells during chronic IL-13 stimulation

(2018) John D. Dickinson et al.   Redox Biology

Oxygen as a driver of gut dysbiosis

(2017) Fabian Rivera-Chávez et al.   FREE RADICAL BIOLOGY AND MEDICINE

Serotonin disturbs colon epithelial tolerance of commensal E. coli by increasing NOX2-derived superoxide

(2017) Suhrid Banskota et al.   FREE RADICAL BIOLOGY AND MEDICINE

First Identification of Biallelic Inherited DUOX2 Inactivating Mutations as a Cause of Very Early Onset Inflammatory Bowel Disease

(2017) Marianna Parlato et al.   GASTROENTEROLOGY

Nlrp6- and ASC-Dependent Inflammasomes Do Not Shape the Commensal Gut Microbiota Composition

(2017) Michail Mamantopoulos et al.   IMMUNITY

Antioxidant activity of various oral Lactobacillus strains

(2017) A. Chooruk et al.   JOURNAL OF APPLIED MICROBIOLOGY

NADPH oxidase 1 supports proliferation of colon cancer cells by modulating reactive oxygen species-dependent signal transduction

(2017) Agnes Juhasz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Quality Items Required for Running a Paediatric Inflammatory Bowel Disease Centre: An ECCO Paper

(2017) Dan Turner et al.   Journal of Crohns & Colitis

Aquaporin-3 mediates hydrogen peroxide-dependent responses to environmental stress in colonic epithelia

(2017) Jay R. Thiagarajah et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CRISPR-Cas9 gene repair of hematopoietic stem cells from patients with X-linked chronic granulomatous disease

(2017) Suk See De Ravin et al.   Science Translational Medicine

Clinical Genomics in Inflammatory Bowel Disease

(2017) Holm H. Uhlig et al.   TRENDS IN GENETICS

p40phox-Deficient Mice Exhibit Impaired Bacterial Clearance and Enhanced Pro-inflammatory Responses during Salmonella enterica serovar Typhimurium Infection

(2017) Yali Li et al.   Frontiers in Immunology

Deficiency in Duox2 activity alleviates ileitis in GPx1- and GPx2 -knockout mice without affecting apoptosis incidence in the crypt epithelium

(2017) Fong-Fong Chu et al.   Redox Biology

European contribution to the study of ROS: A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS)

(2017) Javier Egea et al.   Redox Biology

Lactobacillus reuteriincreases mucus thickness and ameliorates dextran sulphate sodium-induced colitis in mice

(2016) D. Ahl et al.   Acta Physiologica

Neutrophil-Epithelial Interactions

(2016) Charles A. Parkos   AMERICAN JOURNAL OF PATHOLOGY

Annexin A1: shifting the balance towards resolution and repair

(2016) Giovanna Leoni et al.   BIOLOGICAL CHEMISTRY

ROS in gastrointestinal inflammation: Rescue Or Sabotage?

(2016) G Aviello et al.   BRITISH JOURNAL OF PHARMACOLOGY

Defensive Mutualism Rescues NADPH Oxidase Inactivation in Gut Infection

(2016) Gratiela Pircalabioru et al.   Cell Host & Microbe

The ROS-generating oxidase Nox1 is required for epithelial restitution following colitis

(2016) Masayoshi Kato et al.   EXPERIMENTAL ANIMALS

Genetic Complexity of Crohn’s Disease in Two Large Ashkenazi Jewish Families

(2016) Adam P. Levine et al.   GASTROENTEROLOGY

CYBA encoding p22phox, the cytochrome b558 alpha polypeptide: gene structure, expression, role and physiopathology

(2016) Marie José Stasia   GENE

Priming of the neutrophil respiratory burst: role in host defense and inflammation

(2016) Jamel El-Benna et al.   IMMUNOLOGICAL REVIEWS

Neutrophil interactions with epithelial-expressed ICAM-1 enhances intestinal mucosal wound healing

(2016) R Sumagin et al.   Mucosal Immunology

Mechanisms of inflammation-driven bacterial dysbiosis in the gut

(2016) M Y Zeng et al.   Mucosal Immunology

NADPH oxidase-derived H2O2subverts pathogen signaling by oxidative phosphotyrosine conversion to PB-DOPA

(2016) Luis A. Alvarez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A sentinel goblet cell guards the colonic crypt by triggering Nlrp6-dependent Muc2 secretion

(2016) G. M. H. Birchenough et al.   SCIENCE

NADPH oxidase-1 deficiency offers little protection in Salmonella typhimurium-induced typhlitis in mice

(2016) Fong-Fong Chu et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Mitochondrial function controls intestinal epithelial stemness and proliferation

(2016) Emanuel Berger et al.   Nature Communications

Host-Microbiota Interactions in the Pathogenesis of Antibiotic-Associated Diseases

(2016) Joshua S. Lichtman et al.   Cell Reports

Colitis susceptibility in p47 phox−/− mice is mediated by the microbiome

(2016) E. Liana Falcone et al.   Microbiome

The Dual Role of Neutrophils in Inflammatory Bowel Diseases

(2016) Odile Wéra et al.   Journal of Clinical Medicine

How informative is the mouse for human gut microbiota research?

(2015) T. L. A. Nguyen et al.   Disease Models & Mechanisms

Increased Expression of DUOX2 Is an Epithelial Response to Mucosal Dysbiosis Required for Immune Homeostasis in Mouse Intestine

(2015) Helmut Grasberger et al.   GASTROENTEROLOGY

Dual oxidase 2 generated reactive oxygen species selectively mediate the induction of mucins by epidermal growth factor in enterocytes

(2015) Simona Damiano et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

New developments in goblet cell mucus secretion and function

(2015) G M H Birchenough et al.   Mucosal Immunology

Molecular characterization of LC3-associated phagocytosis reveals distinct roles for Rubicon, NOX2 and autophagy proteins

(2015) Jennifer Martinez et al.   NATURE CELL BIOLOGY

Antibiotic-Induced Alterations of the Murine Gut Microbiota and Subsequent Effects on Colonization Resistance against Clostridium difficile

(2015) Alyxandria M. Schubert et al.   mBio

Transcriptomic landscape of lncRNAs in inflammatory bowel disease

(2015) Aashiq H Mirza et al.   Genome Medicine

Genetic disorders coupled to ROS deficiency

(2015) Sharon O’Neill et al.   Redox Biology

Nitrate Reduction to Nitrite, Nitric Oxide and Ammonia by Gut Bacteria under Physiological Conditions

(2015) Mauro Tiso et al.   PLoS One

Endoplasmic Reticulum Stress and Oxidative Stress in Cell Fate Decision and Human Disease

(2014) Stewart Siyan Cao et al.   ANTIOXIDANTS & REDOX SIGNALING

H2O2Production in Species of the Lactobacillus acidophilus Group: a Central Role for a Novel NADH-Dependent Flavin Reductase

(2014) Rosanne Hertzberger et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

NLRP6 Inflammasome Orchestrates the Colonic Host-Microbial Interface by Regulating Goblet Cell Mucus Secretion

(2014) Marta Wlodarska et al.   CELL

IBD: Microbiota Manipulation through Diet and Modified Bacteria

(2014) Hannah L. Simpson et al.   DIGESTIVE DISEASES

The composition of the gut microbiota shapes the colon mucus barrier

(2014) H. E. Jakobsson et al.   EMBO REPORTS

Protein chlorination in neutrophil phagosomes and correlation with bacterial killing

(2014) Jessie N. Green et al.   FREE RADICAL BIOLOGY AND MEDICINE

Serotonin regulates innate immune responses of colon epithelial cells through Nox2-derived reactive oxygen species

(2014) Sushil Chandra Regmi et al.   FREE RADICAL BIOLOGY AND MEDICINE

Variants in Nicotinamide Adenine Dinucleotide Phosphate Oxidase Complex Components Determine Susceptibility to Very Early Onset Inflammatory Bowel Disease

(2014) Sandeep S. Dhillon et al.   GASTROENTEROLOGY

Correlation Between Intraluminal Oxygen Gradient and Radial Partitioning of Intestinal Microbiota

(2014) Lindsey Albenberg et al.   GASTROENTEROLOGY

The Diagnostic Approach to Monogenic Very Early Onset Inflammatory Bowel Disease

(2014) Holm H. Uhlig et al.   GASTROENTEROLOGY

Transmigrating Neutrophils Shape the Mucosal Microenvironment through Localized Oxygen Depletion to Influence Resolution of Inflammation

(2014) Eric L. Campbell et al.   IMMUNITY

DUOX2 and DUOXA2 Form the Predominant Enzyme System Capable of Producing the Reactive Oxygen Species H2O2 in Active Ulcerative Colitis and are Modulated by 5-Aminosalicylic Acid

(2014) Tammie S. MacFie et al.   INFLAMMATORY BOWEL DISEASES

Pediatric Crohn disease patients exhibit specific ileal transcriptome and microbiome signature

(2014) Yael Haberman et al.   JOURNAL OF CLINICAL INVESTIGATION

The gut microbiota engages different signaling pathways to induce Duox2 expression in the ileum and colon epithelium

(2014) F Sommer et al.   Mucosal Immunology

The role of glycosylation in IBD

(2014) Evropi Theodoratou et al.   Nature Reviews Gastroenterology & Hepatology

Deficient Production of Reactive Oxygen Species Leads to Severe Chronic DSS-Induced Colitis in Ncf1/p47phox-Mutant Mice

(2014) Tiago Rodrigues-Sousa et al.   PLoS One

Combined NADPH Oxidase 1 and Interleukin 10 Deficiency Induces Chronic Endoplasmic Reticulum Stress and Causes Ulcerative Colitis-Like Disease in Mice

(2014) Xavier Tréton et al.   PLoS One

Nox Enzymes and New Thinking on Reactive Oxygen: A Double-Edged Sword Revisited

(2013) J. David Lambeth et al.   Annual Review of Pathology-Mechanisms of Disease

Mucosal Reactive Oxygen Species Are Required for Antiviral Response: Role of Duox in Influenza A Virus Infection

(2013) Monika Strengert et al.   ANTIOXIDANTS & REDOX SIGNALING

Aquaporin-facilitated transmembrane diffusion of hydrogen peroxide

(2013) Gerd P. Bienert et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Indicaxanthin inhibits NADPH oxidase (NOX)-1 activation and NF-κB-dependent release of inflammatory mediators and prevents the increase of epithelial permeability in IL-1β-exposed Caco-2 cells

(2013) L. Tesoriere et al.   BRITISH JOURNAL OF NUTRITION

Interaction of NADPH oxidase 1 with Toll-like receptor 2 induces migration of smooth muscle cells

(2013) Jee Hyun Lee et al.   CARDIOVASCULAR RESEARCH

Intestinal Epithelial Autophagy Is Essential for Host Defense against Invasive Bacteria

(2013) Jamaal L. Benjamin et al.   Cell Host & Microbe

IFNβ/TNFα synergism induces a non-canonical STAT2/IRF9-dependent pathway triggering a novel DUOX2 NADPH Oxidase-mediated airway antiviral response

(2013) Karin Fink et al.   CELL RESEARCH

Autophagy proteins control goblet cell function by potentiating reactive oxygen species production

(2013) Khushbu K Patel et al.   EMBO JOURNAL

Symbiotic lactobacilli stimulate gut epithelial proliferationviaNox-mediated generation of reactive oxygen species

(2013) Rheinallt M Jones et al.   EMBO JOURNAL

Nox1 causes ileocolitis in mice deficient in glutathione peroxidase-1 and -2

(2013) Robert S. Esworthy et al.   FREE RADICAL BIOLOGY AND MEDICINE

Dual Oxidases Control Release of Hydrogen Peroxide by the Gastric Epithelium to Prevent Helicobacter felis Infection and Inflammation in Mice

(2013) Helmut Grasberger et al.   GASTROENTEROLOGY

Bacteria penetrate the normally impenetrable inner colon mucus layer in both murine colitis models and patients with ulcerative colitis

(2013) Malin E V Johansson et al.   GUT

Dysbiosis in inflammatory bowel diseases: the oxygen hypothesis

(2013) Lionel Rigottier-Gois   ISME Journal

Redox signaling regulates commensal-mediated mucosal homeostasis and restitution and requires formyl peptide receptor 1

(2013) A Alam et al.   Mucosal Immunology

The gastrointestinal mucus system in health and disease

(2013) Malin E. V. Johansson et al.   Nature Reviews Gastroenterology & Hepatology

Rac2-Deficiency Leads to Exacerbated and Protracted Colitis in Response to Citrobacter rodentium Infection

(2013) Ramzi Fattouh et al.   PLoS One

Bacterial Community Mapping of the Mouse Gastrointestinal Tract

(2013) Shenghua Gu et al.   PLoS One

NADPH Oxidase Deficient Mice Develop Colitis and Bacteremia upon Infection with Normally Avirulent, TTSS-1- and TTSS-2-Deficient Salmonella Typhimurium

(2013) Boas Felmy et al.   PLoS One

Neutrophils enlist IL-22 to restore order in the gut

(2013) T. L. Denning et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Microbiotas from UC patients display altered metabolism and reduced ability of LAB to colonize mucus

(2013) Louise Kristine Vigsnaes et al.   Scientific Reports

Reactive Oxygen Species Production in the Phagosome: Impact on Antigen Presentation in Dendritic Cells

(2012) Fiorella Kotsias et al.   ANTIOXIDANTS & REDOX SIGNALING

Redox Reactions and Microbial Killing in the Neutrophil Phagosome

(2012) Christine C. Winterbourn et al.   ANTIOXIDANTS & REDOX SIGNALING

Aquaporin 1, Nox1, and Ask1 mediate oxidant-induced smooth muscle cell hypertrophy

(2012) Imad Al Ghouleh et al.   CARDIOVASCULAR RESEARCH

Mucosal Reactive Oxygen Species Decrease Virulence by Disrupting Campylobacter jejuni Phosphotyrosine Signaling

(2012) Nicolae Corcionivoschi et al.   Cell Host & Microbe

Neutrophil-Delivered Myeloperoxidase Dampens the Hydrogen Peroxide Burst after Tissue Wounding in Zebrafish

(2012) Luke Pase et al.   CURRENT BIOLOGY

Expression of lactoperoxidase in differentiated mouse colon epithelial cells

(2012) Byung-Wook Kim et al.   FREE RADICAL BIOLOGY AND MEDICINE

Butyricicoccus pullicaecorumin inflammatory bowel disease

(2012) Venessa Eeckhaut et al.   GUT

Chronic Granulomatous Disease

(2012) Steven M. Holland   HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA

Annexin A1, formyl peptide receptor, and NOX1 orchestrate epithelial repair

(2012) Giovanna Leoni et al.   JOURNAL OF CLINICAL INVESTIGATION

p40phox Expression Regulates Neutrophil Recruitment and Function during the Resolution Phase of Intestinal Inflammation

(2012) K. L. Conway et al.   JOURNAL OF IMMUNOLOGY

Hyperinflammation of chronic granulomatous disease is abolished by NOX2 reconstitution in macrophages and dendritic cells

(2012) Christine Deffert et al.   JOURNAL OF PATHOLOGY

Bacterial tyrosine kinases: evolution, biological function and structural insights

(2012) C. Grangeasse et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

TLR-4 Signalling Accelerates Colon Cancer Cell Adhesion via NF-κB Mediated Transcriptional Up-Regulation of Nox-1

(2012) D. Peter O'Leary et al.   PLoS One

Effects of Hydrogen Peroxide on Wound Healing in Mice in Relation to Oxidative Damage

(2012) Alvin Eng Kiat Loo et al.   PLoS One

RGS2 is a negative regulator of STAT3-mediated Nox1 expression

(2011) Hyung-Kyoung Lee et al.   CELLULAR SIGNALLING

Analysis of gut microbial regulation of host gene expression along the length of the gut and regulation of gut microbial ecology through MyD88

(2011) Erik Larsson et al.   GUT

Gp91phox contributes to the development of experimental inflammatory bowel disease

(2011) Shisan Bao et al.   IMMUNOLOGY AND CELL BIOLOGY

Altered O-glycosylation profile of MUC2 mucin occurs in active ulcerative colitis and is associated with increased inflammation

(2011) Jessica M. Holmn Larsson et al.   INFLAMMATORY BOWEL DISEASES

Up-regulation and Sustained Activation of Stat1 Are Essential for Interferon-γ (IFN-γ)-induced Dual Oxidase 2 (Duox2) and Dual Oxidase A2 (DuoxA2) Expression in Human Pancreatic Cancer Cell Lines

(2011) Yongzhong Wu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mouse and human intestinal immunity: same ballpark, different players; different rules, same score

(2011) D L Gibbons et al.   Mucosal Immunology

Lyn is a redox sensor that mediates leukocyte wound attraction in vivo

(2011) Sa Kan Yoo et al.   NATURE

Enteric commensal bacteria potentiate epithelial restitution via reactive oxygen species-mediated inactivation of focal adhesion kinase phosphatases

(2011) P. A. Swanson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Effect of Lactobacilli on Paracellular Permeability in the Gut

(2011) Siv Ahrne et al.   Nutrients

Polychlorinated Biphenyls Disrupt Intestinal Integrity via NADPH Oxidase-Induced Alterations of Tight Junction Protein Expression

(2010) Yean Jung Choi et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Dextran sulfate sodium and 2,4,6-trinitrobenzene sulfonic acid induce lipid peroxidation by the proliferation of intestinal gram-negative bacteria in mice

(2010) In-Ah Lee et al.   Journal of Inflammation-London

Residual NADPH Oxidase and Survival in Chronic Granulomatous Disease

(2010) Douglas B. Kuhns et al.   NEW ENGLAND JOURNAL OF MEDICINE

A Peroxidase/Dual Oxidase System Modulates Midgut Epithelial Immunity in Anopheles gambiae

(2010) S. Kumar et al.   SCIENCE

Dual oxidase in mucosal immunity and host–microbe homeostasis

(2010) Yun Soo Bae et al.   TRENDS IN IMMUNOLOGY

Mechanisms of Vascular Smooth Muscle NADPH Oxidase 1 (Nox1) Contribution to Injury-Induced Neointimal Formation

(2009) Moo Yeol Lee et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Mitochondrial dysfunction, persistent oxidative damage, and catalase inhibition in immune cells of naïve and treated Crohnʼs disease

(2009) Belén Beltrán et al.   INFLAMMATORY BOWEL DISEASES

DUOX2-derived reactive oxygen species are effectors of NOD2-mediated antibacterial responses

(2009) S. Lipinski et al.   JOURNAL OF CELL SCIENCE

Potential role of Noxes in the protection of mucosae: H2O2 as abacterial repellent

(2009) A. Botteaux et al.   MICROBES AND INFECTION

NADPH Oxidase 1 Controls the Persistence of Directed Cell Migration by a Rho-Dependent Switch of  2/ 3 Integrins

(2009) A. Sadok et al.   MOLECULAR AND CELLULAR BIOLOGY

A tissue-scale gradient of hydrogen peroxide mediates rapid wound detection in zebrafish

(2009) Philipp Niethammer et al.   NATURE

Coordination of multiple dual oxidase–regulatory pathways in responses to commensal and infectious microbes in drosophila gut

(2009) Eun-Mi Ha et al.   NATURE IMMUNOLOGY

Regulation of cell proliferation by NADPH oxidase-mediated signaling: Potential roles in tissue repair, regenerative medicine and tissue engineering

(2009) Elsa C. Chan et al.   PHARMACOLOGY & THERAPEUTICS

Chronic Granulomatous Disease: The European Experience

(2009) J. Merlijn van den Berg et al.   PLoS One

Activation of antibacterial autophagy by NADPH oxidases

(2009) J. Huang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cellular Defenses against Superoxide and Hydrogen Peroxide

(2008) James A. Imlay   Annual Review of Biochemistry

Signaling Components of Redox Active Endosomes: The Redoxosomes

(2008) Fredrick D. Oakley et al.   ANTIOXIDANTS & REDOX SIGNALING

Alterations in Mucosal Immunity Identified in the Colon of Patients With Irritable Bowel Syndrome

(2008) Jeroen Aerssens et al.   Clinical Gastroenterology and Hepatology

Tumor necrosis factor α activates transcription of the NADPH oxidase organizer 1 (NOXO1) gene and upregulates superoxide production in colon epithelial cells

(2008) Yuki Kuwano et al.   FREE RADICAL BIOLOGY AND MEDICINE

Unique Role of Junctional Adhesion Molecule-A in Maintaining Mucosal Homeostasis in Inflammatory Bowel Disease

(2008) Stefania Vetrano et al.   GASTROENTEROLOGY

Nox1 is over-expressed in human colon cancers and correlates with activating mutations in K-Ras

(2008) Eunice Laurent et al.   INTERNATIONAL JOURNAL OF CANCER

A Model of Salmonella Colitis with Features of Diarrhea in SLC11A1 Wild-Type Mice

(2008) Heungjeong Woo et al.   PLoS One

Nox1-dependent superoxide production controls colon adenocarcinoma cell migration

(2007) Amine Sadok et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH