Protein Carriers for Glycoconjugate Vaccines: History, Selection Criteria, Characterization and New Trends

Malaria Derived Glycosylphosphatidylinositol Anchor Enhances Anti-Pfs25 Functional Antibodies That Block Malaria Transmission

(2018) Neeraj Kapoor et al.   BIOCHEMISTRY

Investigation on Sugar–Protein Connectivity in Salmonella O-Antigen Glycoconjugate Vaccines

(2018) Gianluigi De Benedetto et al.   BIOCONJUGATE CHEMISTRY

Analytical Comparability Assessments of 5 Recombinant CRM 197 Proteins From Different Manufacturers and Expression Systems

(2018) John M. Hickey et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Immunization with outer membrane vesicles displaying conserved surface polysaccharide antigen elicits broadly antimicrobial antibodies

(2018) Taylor C. Stevenson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

T cells control the generation of nanomolar-affinity anti-glycan antibodies

(2017) Zinaida Polonskaya et al.   JOURNAL OF CLINICAL INVESTIGATION

Safety, immunogenicity, and preliminary clinical efficacy of a vaccine against extraintestinal pathogenic Escherichia coli in women with a history of recurrent urinary tract infection: a randomised, single-blind, placebo-controlled phase 1b trial

(2017) Angela Huttner et al.   LANCET INFECTIOUS DISEASES

Preparation and immunogenicity of gold glyco-nanoparticles as antipneumococcal vaccine model

(2017) Maria Vetro et al.   Nanomedicine

Polysaccharide conjugate vaccine protein carriers as a “neglected valency” – Potential and limitations

(2017) Michael Bröker et al.   VACCINE

Comprehensive vaccine design for commensal disease progression

(2017) Charles H. Jones et al.   Science Advances

Towards the next generation of biomedicines by site-selective conjugation

(2016) Qi-Ying Hu et al.   CHEMICAL SOCIETY REVIEWS

Safety and Immunogenicity of a Candidate Bioconjugate Vaccine against Shigella flexneri 2a Administered to Healthy Adults: a Single-Blind, Randomized Phase I Study

(2016) Mark S. Riddle et al.   Clinical and Vaccine Immunology

Outer membrane vesicles displaying engineered glycotopes elicit protective antibodies

(2016) Linxiao Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Preclinical studies on new proteins as carrier for glycoconjugate vaccines

(2016) M. Tontini et al.   VACCINE

Fully Synthetic Self-Adjuvanting α-2,9-Oligosialic Acid Based Conjugate Vaccines against Group C Meningitis

(2016) Guochao Liao et al.   ACS Central Science

Glycoengineered Outer Membrane Vesicles: A Novel Platform for Bacterial Vaccines

(2016) Nancy L. Price et al.   Scientific Reports

Anti-Group B Streptococcus Glycan-Conjugate Vaccines Using Pilus Protein GBS80 As Carrier and Antigen: Comparing Lysine and Tyrosine-directed Conjugation

(2015) Alberto Nilo et al.   ACS Chemical Biology

Sugar-Protein Connectivity Impacts on the Immunogenicity of Site-SelectiveSalmonellaO-Antigen Glycoconjugate Vaccines

(2015) Giuseppe Stefanetti et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Exploring the Effect of Conjugation Site and Chemistry on the Immunogenicity of an anti-Group B Streptococcus Glycoconjugate Vaccine Based on GBS67 Pilus Protein and Type V Polysaccharide

(2015) Alberto Nilo et al.   BIOCONJUGATE CHEMISTRY

The role of structural proteomics in vaccine development: recent advances and future prospects

(2015) Danilo Donnarumma et al.   Expert Review of Proteomics

Protein Crystallography in Vaccine Research and Development

(2015) Enrico Malito et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Conjugate-like immunogens produced as protein capsular matrix vaccines

(2015) Ann Thanawastien et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Safety and immunogenicity of a candidate bioconjugate vaccine against Shigella dysenteriae type 1 administered to healthy adults: A single blind, partially randomized Phase I study

(2015) Christoph F.R Hatz et al.   VACCINE

Defined Conjugation of Glycans to the Lysines of CRM197Guided by their Reactivity Mapping

(2014) Stefano Crotti et al.   CHEMBIOCHEM

Identification of glycosylated regions in pneumococcal PspA conjugated to serotype 6B capsular polysaccharide

(2014) Giovana Cappio Barazzone et al.   GLYCOCONJUGATE JOURNAL

A semisynthetic carbohydrate-lipid vaccine that protects against S. pneumoniae in mice

(2014) Marco Cavallari et al.   Nature Chemical Biology

Deciphering the structure–immunogenicity relationship of anti-Candida glycoconjugate vaccines

(2014) Roberto Adamo et al.   Chemical Science

Recombinant Clostridium difficile Toxin Fragments as Carrier Protein for PSII Surface Polysaccharide Preserve Their Neutralizing Activity

(2014) Maria Romano et al.   Toxins

Synthetic carbohydrate antigens for HIV vaccine design

(2013) Lai-Xi Wang   CURRENT OPINION IN CHEMICAL BIOLOGY

Prevention of Staphylococcus aureus Infections by Glycoprotein Vaccines Synthesized in Escherichia coli

(2013) Michael Wacker et al.   JOURNAL OF INFECTIOUS DISEASES

The Development of an Experimental Multiple Serogroups Vaccine for Neisseria meningitidis

(2013) Valerian B. Pinto et al.   PLoS One

Defining a protective epitope on factor H binding protein, a key meningococcal virulence factor and vaccine antigen

(2013) Enrico Malito et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Multiple antigen-presenting system (MAPS) to induce comprehensive B- and T-cell immunity

(2013) F. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Gold nanoparticles as carriers for a syntheticStreptococcus pneumoniaetype 14 conjugate vaccine

(2012) Dodi Safari et al.   Nanomedicine

Opsonic and Protective Properties of Antibodies Raised to Conjugate Vaccines Targeting Six Staphylococcus aureus Antigens

(2012) Clarissa Pozzi et al.   PLoS One

Structural basis for lack of toxicity of the diphtheria toxin mutant CRM197

(2012) E. Malito et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Coordinated Synthesis and Conjugation Strategy for the Preparation of Homogeneous Glycoconjugate Vaccine Candidates

(2011) Elizabeth J. Grayson et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Biochemical and biological characteristics of cross-reacting material 197 (CRM197), a non-toxic mutant of diphtheria toxin: Use as a conjugation protein in vaccines and other potential clinical applications

(2011) Michael Bröker et al.   BIOLOGICALS

The design of semi-synthetic and synthetic glycoconjugate vaccines

(2011) Paolo Costantino et al.   Expert Opinion on Drug Discovery

A structurally diversified linker enhances the immune response to a small carbohydrate hapten

(2011) Tomasz Lipinski et al.   GLYCOCONJUGATE JOURNAL

Salmonella enterica Serovar Enteritidis Core O Polysaccharide Conjugated to H:g,m Flagellin as a Candidate Vaccine for Protection against Invasive Infection withS.Enteritidis

(2011) Raphael Simon et al.   INFECTION AND IMMUNITY

A mechanism for glycoconjugate vaccine activation of the adaptive immune system and its implications for vaccine design

(2011) Fikri Y Avci et al.   NATURE MEDICINE

Production of glycoprotein vaccines in Escherichia coli

(2010) Julian Ihssen et al.   Microbial Cell Factories

Overview of the development and current use of CRM197 conjugate vaccines for pediatric use

(2010) Henry R. Shinefield   VACCINE

Glycoconjugate vaccines and immune interference: A review

(2010) Ron Dagan et al.   VACCINE

Vi-CRM197 as a new conjugate vaccine against Salmonella Typhi

(2010) F. Micoli et al.   VACCINE

Multimeric bivalent immunogens from recombinant tetanus toxin HC fragment, synthetic hexasaccharides, and a glycopeptide adjuvant

(2009) Aileen F. G. Bongat et al.   GLYCOCONJUGATE JOURNAL

Rational design and immunogenicity of liposome-based diepitope constructs: Application to synthetic oligosaccharides mimicking the Shigella flexneri 2a O-antigen

(2009) Fatouma Said Hassane et al.   VACCINE

Protein D of Haemophilus influenzae: A Protective Nontypeable H. influenzae Antigen and a Carrier for Pneumococcal Conjugate Vaccines

(2008) A. Forsgren et al.   CLINICAL INFECTIOUS DISEASES

Synthetic glycopeptide vaccines combining  -mannan and peptide epitopes induce protection against candidiasis

(2008) H. Xin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Physicochemical characterisation of glycoconjugate vaccines for prevention of meningococcal diseases

(2008) Angela Bardotti et al.   VACCINE