Towards the next generation of biomedicines by site-selective conjugation

Anti-Group B Streptococcus Glycan-Conjugate Vaccines Using Pilus Protein GBS80 As Carrier and Antigen: Comparing Lysine and Tyrosine-directed Conjugation

(2015) Alberto Nilo et al.   ACS Chemical Biology

Multiformat T-Cell-Engaging Bispecific Antibodies Targeting Human Breast Cancers

(2015) Yu Cao et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Sugar-Protein Connectivity Impacts on the Immunogenicity of Site-SelectiveSalmonellaO-Antigen Glycoconjugate Vaccines

(2015) Giuseppe Stefanetti et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Chemoenzymatic Conjugation of Toxic Payloads to the Globally Conserved N-Glycan of Native mAbs Provides Homogeneous and Highly Efficacious Antibody–Drug Conjugates

(2015) Remon van Geel et al.   BIOCONJUGATE CHEMISTRY

Site-Specific Glycoconjugation of Protein via Bioorthogonal Tetrazine Cycloaddition with a Genetically Encoded trans-Cyclooctene or Bicyclononyne

(2015) Takuya Machida et al.   BIOCONJUGATE CHEMISTRY

Exploring the Effect of Conjugation Site and Chemistry on the Immunogenicity of an anti-Group B Streptococcus Glycoconjugate Vaccine Based on GBS67 Pilus Protein and Type V Polysaccharide

(2015) Alberto Nilo et al.   BIOCONJUGATE CHEMISTRY

Site-Specific Antibody–Drug Conjugates: The Nexus of Bioorthogonal Chemistry, Protein Engineering, and Drug Development

(2015) Paresh Agarwal et al.   BIOCONJUGATE CHEMISTRY

Functional native disulfide bridging enables delivery of a potent, stable and targeted antibody–drug conjugate (ADC)

(2015) João P. M. Nunes et al.   CHEMICAL COMMUNICATIONS

Advances in Chemical Protein Modification

(2015) Omar Boutureira et al.   CHEMICAL REVIEWS

Antibody-drug conjugates: a mini-review. The synopsis of two approved medicines

(2015) Apostolos Papachristos et al.   DRUG DELIVERY

Antibody Conjugates with Unnatural Amino Acids

(2015) Trevor J. Hallam et al.   MOLECULAR PHARMACEUTICS

Rational Design of Adjuvant for Skin Delivery: Conjugation of Synthetic β-Glucan Dectin-1 Agonist to Protein Antigen

(2015) Agnese Donadei et al.   MOLECULAR PHARMACEUTICS

Phase III placebo-controlled, double-blind, randomized trial of pegfilgrastim to reduce the risk of febrile neutropenia in breast cancer patients receiving docetaxel/cyclophosphamide chemotherapy

(2015) Yoshimasa Kosaka et al.   SUPPORTIVE CARE IN CANCER

A plug-and-play approach to antibody-based therapeutics via a chemoselective dual click strategy

(2015) Antoine Maruani et al.   Nature Communications

Targeting host-derived glycans on enveloped viruses for antibody-based vaccine design

(2015) Max Crispin et al.   Current Opinion in Virology

One-Step Enzymatic Modification of the Cell Surface Redirects Cellular Cytotoxicity and Parasite Tropism

(2014) Lee Kim Swee et al.   ACS Chemical Biology

Antibody-Drug Conjugates: An Emerging Concept in Cancer Therapy

(2014) Ravi V. J. Chari et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A CXCR4-Targeted Site-Specific Antibody-Drug Conjugate

(2014) Sumith A. Kularatne et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Improving the Serum Stability of Site-Specific Antibody Conjugates with Sulfone Linkers

(2014) James T. Patterson et al.   BIOCONJUGATE CHEMISTRY

Bridging Disulfides for Stable and Defined Antibody Drug Conjugates

(2014) George Badescu et al.   BIOCONJUGATE CHEMISTRY

Homogeneous Bispecifics by Disulfide Bridging

(2014) Elizabeth A. Hull et al.   BIOCONJUGATE CHEMISTRY

Regioselective and Stoichiometrically Controlled Conjugation of Photodynamic Sensitizers to a HER2 Targeting Antibody Fragment

(2014) Francesca Bryden et al.   BIOCONJUGATE CHEMISTRY

Site-Specific Incorporation of Three Toll-Like Receptor 2 Targeting Adjuvants into Semisynthetic, Molecularly Defined Nanoparticles: Application to Group A Streptococcal Vaccines

(2014) Peter M. Moyle et al.   BIOCONJUGATE CHEMISTRY

Transglutaminase-Based Chemo-Enzymatic Conjugation Approach Yields Homogeneous Antibody–Drug Conjugates

(2014) Patrick Dennler et al.   BIOCONJUGATE CHEMISTRY

Production of Site-Specific Antibody–Drug Conjugates Using Optimized Non-Natural Amino Acids in a Cell-Free Expression System

(2014) Erik S. Zimmerman et al.   BIOCONJUGATE CHEMISTRY

Site-Specific Antibody–Drug Conjugation through Glycoengineering

(2014) Qun Zhou et al.   BIOCONJUGATE CHEMISTRY

Tyrosine-Directed Conjugation of Large Glycans to Proteins via Copper-Free Click Chemistry

(2014) Alberto Nilo et al.   BIOCONJUGATE CHEMISTRY

Aldehyde Tag Coupled with HIPS Chemistry Enables the Production of ADCs Conjugated Site-Specifically to Different Antibody Regions with Distinct in Vivo Efficacy and PK Outcomes

(2014) Penelope M. Drake et al.   BIOCONJUGATE CHEMISTRY

A solid-phase PEGylation strategy for protein therapeutics using a potent FGF21 analog

(2014) Lintao Song et al.   BIOMATERIALS

Defined Conjugation of Glycans to the Lysines of CRM197Guided by their Reactivity Mapping

(2014) Stefano Crotti et al.   CHEMBIOCHEM

Chemical Biology Approaches to Designing Defined Carbohydrate Vaccines

(2014) Chakkumkal Anish et al.   CHEMISTRY & BIOLOGY

Serogroup-Specific Bacterial Engineered Glycoproteins as Novel Antigenic Targets for Diagnosis of Shiga Toxin-Producing-Escherichia coli-Associated Hemolytic-Uremic Syndrome

(2014) Luciano J. Melli et al.   JOURNAL OF CLINICAL MICROBIOLOGY

Nonenzymatic Polyubiquitination of Expressed Proteins

(2014) Hosahalli P. Hemantha et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Understanding and applying tyrosine biochemical diversity

(2014) Lyn H. Jones et al.   Molecular BioSystems

Native Chemical Ligation: A Boon to Peptide Chemistry

(2014) Parashar Thapa et al.   MOLECULES

GlycoDelete engineering of mammalian cells simplifies N-glycosylation of recombinant proteins

(2014) Leander Meuris et al.   NATURE BIOTECHNOLOGY

Optimized orthogonal translation of unnatural amino acids enables spontaneous protein double-labelling and FRET

(2014) Kaihang Wang et al.   Nature Chemistry

Fine-tuning antibody–drug conjugates

(2014) Alexandra Flemming   NATURE REVIEWS DRUG DISCOVERY

Next generation maleimides enable the controlled assembly of antibody–drug conjugates via native disulfide bond bridging

(2014) Felix F. Schumacher et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

In Vitro and In Vivo Evaluation of Cysteine and Site Specific Conjugated Herceptin Antibody-Drug Conjugates

(2014) Dowdy Jackson et al.   PLoS One

A general approach to site-specific antibody drug conjugates

(2014) Feng Tian et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Engineered red blood cells as carriers for systemic delivery of a wide array of functional probes

(2014) J. Shi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Next Generation of Antibody Drug Conjugates

(2014) Fiona Mack et al.   SEMINARS IN ONCOLOGY

Comparison of filgrastim and pegfilgrastim to prevent neutropenia and maintain dose intensity of adjuvant chemotherapy in patients with breast cancer

(2014) Georgia Kourlaba et al.   SUPPORTIVE CARE IN CANCER

A bacterial engineered glycoprotein as a novel antigen for diagnosis of bovine brucellosis

(2014) Andrés E. Ciocchini et al.   VETERINARY MICROBIOLOGY

Deciphering the structure–immunogenicity relationship of anti-Candida glycoconjugate vaccines

(2014) Roberto Adamo et al.   Chemical Science

Targeting TLR2 for Vaccine Development

(2014) Afonso P. Basto et al.   Journal of Immunology Research

TLR Agonists for Cancer Immunotherapy: Tipping the Balance between the Immune Stimulatory and Inhibitory Effects

(2014) Hailing Lu   Frontiers in Immunology

Recent Mechanistic Insights on Glycoconjugate Vaccines and Future Perspectives

(2013) Francesco Berti et al.   ACS Chemical Biology

Metabolic Engineering of Monoclonal Antibody Carbohydrates for Antibody–Drug Conjugation

(2013) Nicole M. Okeley et al.   BIOCONJUGATE CHEMISTRY

Polyethylene Glycol Modified FGF21 Engineered to Maximize Potency and Minimize Vacuole Formation

(2013) Jing Xu et al.   BIOCONJUGATE CHEMISTRY

A Potent Anti-CD70 Antibody–Drug Conjugate Combining a Dimeric Pyrrolobenzodiazepine Drug with Site-Specific Conjugation Technology

(2013) Scott C. Jeffrey et al.   BIOCONJUGATE CHEMISTRY

Hydrazino-Pictet-Spengler Ligation as a Biocompatible Method for the Generation of Stable Protein Conjugates

(2013) Paresh Agarwal et al.   BIOCONJUGATE CHEMISTRY

Mass Spectrometric Characterization of Transglutaminase Based Site-Specific Antibody–Drug Conjugates

(2013) Santiago E. Farias et al.   BIOCONJUGATE CHEMISTRY

Chemoenzymatic synthesis and lectin recognition of a selectively fluorinated glycoprotein

(2013) Jared Orwenyo et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Recent progress and future options in the development of GLP-1 receptor agonists for the treatment of diabesity

(2013) Martin Lorenz et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

SGN-CD33A: a novel CD33-targeting antibody-drug conjugate using a pyrrolobenzodiazepine dimer is active in models of drug-resistant AML

(2013) M. S. Kung Sutherland et al.   BLOOD

Acid-cleavable thiomaleamic acid linker for homogeneous antibody–drug conjugation

(2013) Lourdes Castañeda et al.   CHEMICAL COMMUNICATIONS

Location Matters: Site of Conjugation Modulates Stability and Pharmacokinetics of Antibody Drug Conjugates

(2013) Pavel Strop et al.   CHEMISTRY & BIOLOGY

Protein engineering with unnatural amino acids

(2013) William H Zhang et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Carbohydrate-Mediated Polyethylene Glycol Conjugation of TSH Improves Its Pharmacological Properties

(2013) Anna Park et al.   ENDOCRINOLOGY

Molecular Analysis of an AlternativeN-Glycosylation Machinery by Functional Transfer fromActinobacillus pleuropneumoniaetoEscherichia coli

(2013) Andreas Naegeli et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Prevention of Staphylococcus aureus Infections by Glycoprotein Vaccines Synthesized in Escherichia coli

(2013) Michael Wacker et al.   JOURNAL OF INFECTIOUS DISEASES

Design, Synthesis, and Biological Activity of Novel Dicoumarol Glucagon-like Peptide 1 Conjugates

(2013) Jing Han et al.   JOURNAL OF MEDICINAL CHEMISTRY

Characterization of Host-Cell Line Specific Glycosylation Profiles of Early Transmitted/Founder HIV-1 gp120 Envelope Proteins

(2013) Eden P. Go et al.   JOURNAL OF PROTEOME RESEARCH

The Glycosyltransferase Involved in Thurandacin Biosynthesis Catalyzes Both O- and S-Glycosylation

(2013) Huan Wang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Site-Specific Protein Transamination Using N-Methylpyridinium-4-carboxaldehyde

(2013) Leah S. Witus et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Optimizing treatment for HCV genotype 4: PEG-IFN alfa 2a vs. PEG-IFN alfa 2b; the debate continues

(2013) Gamal Esmat et al.   LIVER INTERNATIONAL

Sortase-catalyzed in vitro functionalization of a HER2-specific recombinant Fab for tumor targeting of the plant cytotoxin gelonin

(2013) Petra Kornberger et al.   mAbs

Site-specific antibody drug conjugates for cancer therapy

(2013) Siler Panowski et al.   mAbs

Antibody conjugation via one and two C-terminal selenocysteines

(2013) Xiuling Li et al.   METHODS

An efficient, chemically-defined semisynthetic lipid-adjuvanted nanoparticulate vaccine development system

(2013) Peter M. Moyle et al.   Nanomedicine-Nanotechnology Biology and Medicine

Synthetic glycopeptides reveal the glycan specificity of HIV-neutralizing antibodies

(2013) Mohammed N Amin et al.   Nature Chemical Biology

Key roles of adjuvants in modern vaccines

(2013) Steven G Reed et al.   NATURE MEDICINE

Site-specific N-terminal labeling of proteins using sortase-mediated reactions

(2013) Christopher S Theile et al.   Nature Protocols

Development of orally active inhibitors of protein and cellular fucosylation

(2013) N. M. Okeley et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bispecific small molecule-antibody conjugate targeting prostate cancer

(2013) C. H. Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crystal Structure of a Soluble Cleaved HIV-1 Envelope Trimer

(2013) J.-P. Julien et al.   SCIENCE

Synthesis of a well-defined glycoconjugate vaccine by a tyrosine-selective conjugation strategy

(2013) Qi-Ying Hu et al.   Chemical Science

Synthetically defined glycoprotein vaccines: current status and future directions

(2013) Roberto Adamo et al.   Chemical Science

Amide-Forming Ligation of Acyltrifluoroborates and Hydroxylamines in Water

(2012) Aaron M. Dumas et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Synthesis of Heterobifunctional Protein Fusions Using Copper-Free Click Chemistry and the Aldehyde Tag

(2012) Jason E. Hudak et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A Combined System for Engineering Glycosylation Efficiency and Glycan Structure in Saccharomyces cerevisiae

(2012) Farnoush Parsaie Nasab et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

High-yield cell-free protein synthesis for site-specific incorporation of unnatural amino acids at two sites

(2012) Kiyoshi Ozawa et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Atrial Natriuretic Peptide-Fc, ANP-Fc, Fusion Proteins: Semisynthesis, In Vitro Activity and Pharmacokinetics in Rats

(2012) Adam R. Mezo et al.   BIOCONJUGATE CHEMISTRY

Fucose-specific conjugation of hydrazide derivatives to a vascular-targeting monoclonal antibody in IgG format

(2012) Kathrin Zuberbühler et al.   CHEMICAL COMMUNICATIONS

GA201 (RG7160): A Novel, Humanized, Glycoengineered Anti-EGFR Antibody with Enhanced ADCC and Superior In Vivo Efficacy Compared with Cetuximab

(2012) C. A. Gerdes et al.   CLINICAL CANCER RESEARCH

Glycoconjugate vaccines

(2012) David Pace   EXPERT OPINION ON BIOLOGICAL THERAPY

Engineering, conjugation, and immunogenicity assessment of Escherichia coli O121 O antigen for its potential use as a typhoid vaccine component

(2012) Michael Wetter et al.   GLYCOCONJUGATE JOURNAL

Recent developments in bacterial protein glycan coupling technology and glycoconjugate vaccine design

(2012) V. S. Terra et al.   JOURNAL OF MEDICAL MICROBIOLOGY

Site-Specific Traceless Coupling of Potent Cytotoxic Drugs to Recombinant Antibodies for Pharmacodelivery

(2012) Giulio Casi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Direct Peptide Bioconjugation/PEGylation at Tyrosine with Linear and Branched Polymeric Diazonium Salts

(2012) Mathew W. Jones et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

An Endoglycosidase with Alternative Glycan Specificity Allows Broadened Glycoprotein Remodelling

(2012) Jonathan J. Goodfellow et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Synthesis of Bispecific Antibodies using Genetically Encoded Unnatural Amino Acids

(2012) Chan Hyuk Kim et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The impact of glycosylation on monoclonal antibody conformation and stability

(2012) Kai Zheng et al.   mAbs

Marketing approval of mogamulizumab

(2012) Alain Beck et al.   mAbs

Glycoengineering of host mimicking type-2 LacNAc polymers and Lewis X antigens on bacterial cell surfaces

(2012) Manuela Mally et al.   MOLECULAR MICROBIOLOGY

The discovery and development of brentuximab vedotin for use in relapsed Hodgkin lymphoma and systemic anaplastic large cell lymphoma

(2012) Peter D Senter et al.   NATURE BIOTECHNOLOGY

Conjugation site modulates the in vivo stability and therapeutic activity of antibody-drug conjugates

(2012) Ben-Quan Shen et al.   NATURE BIOTECHNOLOGY

A Pictet-Spengler ligation for protein chemical modification

(2012) P. Agarwal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Synthesis of site-specific antibody-drug conjugates using unnatural amino acids

(2012) J. Y. Axup et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Spacer length shapes drug release and therapeutic efficacy of traceless disulfide-linked ADCs targeting the tumor neovasculature

(2012) Martina Steiner et al.   Chemical Science

Selenenylsulfide-Linked Homogeneous Glycopeptides and Glycoproteins: Synthesis of Human “Hepatic Se Metabolite A”

(2011) Omar Boutureira et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A Coordinated Synthesis and Conjugation Strategy for the Preparation of Homogeneous Glycoconjugate Vaccine Candidates

(2011) Elizabeth J. Grayson et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Site-Selective Traceless Staudinger Ligation for Glycoprotein Synthesis Reveals Scope and Limitations

(2011) Gonçalo J. L. Bernardes et al.   CHEMBIOCHEM

Protein Modification by Strain-Promoted Alkyne-Azide Cycloaddition

(2011) Jan C. M. van Hest et al.   CHEMBIOCHEM

Tunable reagents for multi-functional bioconjugation: reversible or permanent chemical modification of proteins and peptides by control of maleimide hydrolysis

(2011) Chris P. Ryan et al.   CHEMICAL COMMUNICATIONS

Enzymes in the Synthesis of Glycoconjugates

(2011) Ryan M. Schmaltz et al.   CHEMICAL REVIEWS

Selective Formation of Covalent Protein Heterodimers with an Unnatural Amino Acid

(2011) Benjamin M. Hutchins et al.   CHEMISTRY & BIOLOGY

Strategies for extended serum half-life of protein therapeutics

(2011) Roland E Kontermann   CURRENT OPINION IN BIOTECHNOLOGY

FGF21 Analogs of Sustained Action Enabled by Orthogonal Biosynthesis Demonstrate Enhanced Antidiabetic Pharmacology in Rodents

(2011) J. Mu et al.   DIABETES

The design of semi-synthetic and synthetic glycoconjugate vaccines

(2011) Paolo Costantino et al.   Expert Opinion on Drug Discovery

Pharma interest surges in antibody drug conjugates

(2011) Sarah Webb   NATURE BIOTECHNOLOGY

Sublancin is not a lantibiotic but an S-linked glycopeptide

(2011) Trent J Oman et al.   Nature Chemical Biology

Choosing an effective protein bioconjugation strategy

(2011) Nicholas Stephanopoulos et al.   Nature Chemical Biology

A mechanism for glycoconjugate vaccine activation of the adaptive immune system and its implications for vaccine design

(2011) Fikri Y Avci et al.   NATURE MEDICINE

Twenty-first century vaccines

(2011) R. Rappuoli   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Optimized clinical performance of growth hormone with an expanded genetic code

(2011) H. Cho et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Methods for converting cysteine to dehydroalanine on peptides and proteins

(2011) Justin M. Chalker et al.   Chemical Science

Site-Specific and Stoichiometric Modification of Antibodies by Bacterial Transglutaminase

(2010) Simone Jeger et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Chemoselective ligation techniques: Modern applications of time-honored chemistry

(2010) Theresa K. Tiefenbrunn et al.   BIOPOLYMERS

PEGylation of therapeutic proteins

(2010) Simona Jevševar et al.   Biotechnology Journal

Hormone-like (endocrine) Fgfs: their evolutionary history and roles in development, metabolism, and disease

(2010) Nobuyuki Itoh   CELL AND TISSUE RESEARCH

Cu-free click cycloaddition reactions in chemical biology

(2010) John C. Jewett et al.   CHEMICAL SOCIETY REVIEWS

Protein Chemical Modification on Endogenous Amino Acids

(2010) Emmanuel Baslé et al.   CHEMISTRY & BIOLOGY

Engineered Thio-Trastuzumab-DM1 Conjugate with an Improved Therapeutic Index to Target Human Epidermal Growth Factor Receptor 2-Positive Breast Cancer

(2010) J. R. Junutula et al.   CLINICAL CANCER RESEARCH

Residue-specific incorporation of non-canonical amino acids into proteins: recent developments and applications

(2010) Jeremiah A Johnson et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Chemoenzymatic methods for site-specific protein modification

(2010) David Rabuka   CURRENT OPINION IN CHEMICAL BIOLOGY

Vinyl Sulfone Bifunctional Tag Reagents for Single-Point Modification of Proteins

(2010) Julia Morales-Sanfrutos et al.   JOURNAL OF ORGANIC CHEMISTRY

Tyrosine Bioconjugation through Aqueous Ene-Type Reactions: A Click-Like Reaction for Tyrosine

(2010) Hitoshi Ban et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Protein Modification, Bioconjugation, and Disulfide Bridging Using Bromomaleimides

(2010) Mark E. B. Smith et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Certolizumab Pegol

(2010) Niti Goel et al.   mAbs

Envelope glycans of immunodeficiency virions are almost entirely oligomannose antigens

(2010) K. J. Doores et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Glycoconjugate vaccines and immune interference: A review

(2010) Ron Dagan et al.   VACCINE

Fast and Sensitive Pretargeted Labeling of Cancer Cells through a Tetrazine/trans-Cyclooctene Cycloaddition

(2009) Neal K. Devaraj et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

How Bacterial Carbohydrates Influence the Adaptive Immune System

(2009) Fikri Y. Avci et al.   Annual Review of Immunology

Tailored PEG for rh-G-CSF Analogue Site-Specific Conjugation

(2009) Stefano Salmaso et al.   BIOCONJUGATE CHEMISTRY

Nonnatural Amino Acids for Site-Specific Protein Conjugation

(2009) Albert J. de Graaf et al.   BIOCONJUGATE CHEMISTRY

A Minimalist Substrate for Enzymatic Peptide and Protein Conjugation

(2009) James W. Wollack et al.   CHEMBIOCHEM

Phosphine-mediated one-pot thiol–ene “click” approach to polymer–protein conjugates

(2009) Mathew W. Jones et al.   CHEMICAL COMMUNICATIONS

Chemical Modification of Proteins at Cysteine: Opportunities in Chemistry and Biology

(2009) Justin M. Chalker et al.   Chemistry-An Asian Journal

The promise and potential pitfalls of chimeric antigen receptors

(2009) Michel Sadelain et al.   CURRENT OPINION IN IMMUNOLOGY

Enhanced circulation half-life of site-specific PEGylated rhG-CSF: Optimization of PEG molecular weight

(2009) Yanqin Zhai et al.   JOURNAL OF BIOTECHNOLOGY

Chemoenzymatic Synthesis of Glycosylated Glucagon-like Peptide 1: Effect of Glycosylation on Proteolytic Resistance and in Vivo Blood Glucose-Lowering Activity

(2009) Taichi Ueda et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Site-Specific N- and C-Terminal Labeling of a Single Polypeptide Using Sortases of Different Specificity

(2009) John M. Antos et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Glycosynthases Enable a Highly Efficient Chemoenzymatic Synthesis ofN-Glycoproteins Carrying Intact NaturalN-Glycans

(2009) Wei Huang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Site-specific chemical modification of recombinant proteins produced in mammalian cells by using the genetically encoded aldehyde tag

(2009) P. Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chemoselective Peptide Cyclization by Traceless Staudinger Ligation

(2008) Rolf Kleineweischede et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

From Disulfide- to Thioether-Linked Glycoproteins

(2008) Gonçalo J. L. Bernardes et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Copper-Free Azide–Alkyne Cycloadditions: New Insights and Perspectives

(2008) Jean-François Lutz   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Contribution of Linker Stability to the Activities of Anticancer Immunoconjugates

(2008) Stephen C. Alley et al.   BIOCONJUGATE CHEMISTRY

High-level cell-free synthesis yields of proteins containing site-specific non-natural amino acids

(2008) Aaron R. Goerke et al.   BIOTECHNOLOGY AND BIOENGINEERING

Chemoenzymatic synthesis of glycopeptides and glycoproteins through endoglycosidase-catalyzed transglycosylation

(2008) Lai-Xi Wang   CARBOHYDRATE RESEARCH

Glycoprotein Synthesis: An Update

(2008) David P. Gamblin et al.   CHEMICAL REVIEWS

Tetrazine Ligation: Fast Bioconjugation Based on Inverse-Electron-Demand Diels−Alder Reactivity

(2008) Melissa L. Blackman et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Site-specific conjugation of a cytotoxic drug to an antibody improves the therapeutic index

(2008) Jagath R Junutula et al.   NATURE BIOTECHNOLOGY

Ex vivo glycan engineering of CD44 programs human multipotent mesenchymal stromal cell trafficking to bone

(2008) Robert Sackstein et al.   NATURE MEDICINE

Synthetic glycopeptide vaccines combining  -mannan and peptide epitopes induce protection against candidiasis

(2008) H. Xin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Attachment of Peptide Building Blocks to Proteins Through Tyrosine Bioconjugation

(2007) Dante W. Romanini et al.   BIOCONJUGATE CHEMISTRY

Preparation of glycoconjugates by dialkyl squarate chemistry revisited

(2007) Shu-jie Hou et al.   CARBOHYDRATE RESEARCH