The design of semi-synthetic and synthetic glycoconjugate vaccines

A structurally diversified linker enhances the immune response to a small carbohydrate hapten

(2011) Tomasz Lipinski et al.   GLYCOCONJUGATE JOURNAL

Virus-like particle based vaccines for Alzheimer disease

(2011) Bryce Chackerian   Human vaccines & immunotherapeutics

Comparative effects of carrier proteins on vaccine-induced immune response

(2011) Markus Knuf et al.   VACCINE

Synthetic Antitumor Vaccines from Tetanus Toxoid Conjugates of MUC1 Glycopeptides with the Thomsen-Friedenreich Antigen and a Fluorine-Substituted Analogue

(2010) Anja Hoffmann-Röder et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

This month in APR

(2010) Kwang Woo Hwang   ARCHIVES OF PHARMACAL RESEARCH

Immunochemical studies of Shigella flexneri 2a and 6, and Shigella dysenteriae type 1 O-specific polysaccharide-core fragments and their protein conjugates as vaccine candidates

(2010) Joanna Kubler-Kielb et al.   CARBOHYDRATE RESEARCH

Effects of Hapten Density on the Induced Antibody Repertoire

(2010) Qian Li et al.   CHEMBIOCHEM

Randomized Trial on the Safety, Tolerability, and Immunogenicity of MenACWY-CRM, an Investigational Quadrivalent Meningococcal Glycoconjugate Vaccine, Administered Concomitantly with a Combined Tetanus, Reduced Diphtheria, and Acellular Pertussis Vaccine in Adolescents and Young Adults

(2010) R. Gasparini et al.   Clinical and Vaccine Immunology

Impact of the Conjugation Method on the Immunogenicity ofStreptococcus pneumoniaeSerotype 19F Polysaccharide in Conjugate Vaccines

(2010) Jan Poolman et al.   Clinical and Vaccine Immunology

Safety and Immunogenicity of a 13-Valent Pneumococcal Conjugate Vaccine Compared to Those of a 7-Valent Pneumococcal Conjugate Vaccine Given as a Three-Dose Series with Routine Vaccines in Healthy Infants and Toddlers

(2010) S. Esposito et al.   Clinical and Vaccine Immunology

Vaccines in the management of hypertension

(2010) Thong Huy Do et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Investigating the candidacy of LPS-based glycoconjugates to prevent invasive meningococcal disease: chemical strategies to prepare glycoconjugates with good carbohydrate loading

(2010) Andrew D. Cox et al.   GLYCOCONJUGATE JOURNAL

Investigating the candidacy of LPS-based glycoconjugates to prevent invasive meningococcal disease: immunology of glycoconjugates with high carbohydrate loading

(2010) Andrew D. Cox et al.   GLYCOCONJUGATE JOURNAL

Vaccines against nicotine

(2010) Erich H. Cerny et al.   Human vaccines & immunotherapeutics

Production of glycoprotein vaccines in Escherichia coli

(2010) Julian Ihssen et al.   Microbial Cell Factories

Carbohydrate vaccines: developing sweet solutions to sticky situations?

(2010) Rena D. Astronomo et al.   NATURE REVIEWS DRUG DISCOVERY

Can Alzheimer disease be prevented by amyloid-β immunotherapy?

(2010) Cynthia A. Lemere et al.   Nature Reviews Neurology

Immunization Therapy for Alzheimer Disease: A Comprehensive Review of Active Immunization Strategies

(2010) Takeshi Tabira   TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE

Evaluation of a Group A Streptococcus synthetic oligosaccharide as vaccine candidate

(2010) Anna Kabanova et al.   VACCINE

Comparison of the safety and immunogenicity of an investigational and a licensed quadrivalent meningococcal conjugate vaccine in children 2–10 years of age

(2010) Scott A. Halperin et al.   VACCINE

Overview of the development and current use of CRM197 conjugate vaccines for pediatric use

(2010) Henry R. Shinefield   VACCINE

Glycoconjugate vaccines and immune interference: A review

(2010) Ron Dagan et al.   VACCINE

Beta-glucan-CRM197 conjugates as candidates antifungal vaccines

(2010) Carla Bromuro et al.   VACCINE

Vi-CRM197 as a new conjugate vaccine against Salmonella Typhi

(2010) F. Micoli et al.   VACCINE

Bioanalysis of meningococcal vaccines

(2010) Neil Ravenscroft et al.   Bioanalysis

Thiyl Glycosylation of Olefinic Proteins: S-Linked Glycoconjugate Synthesis

(2009) Nicola Floyd et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A Synthetic Vaccine Consisting of a Tumor-Associated Sialyl-TN-MUC1 Tandem-Repeat Glycopeptide and Tetanus Toxoid: Induction of a Strong and Highly Selective Immune Response

(2009) Anton Kaiser et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

How Bacterial Carbohydrates Influence the Adaptive Immune System

(2009) Fikri Y. Avci et al.   Annual Review of Immunology

A virosomal formulated Her-2/neu multi-peptide vaccine induces Her-2/neu-specific immune responses in patients with metastatic breast cancer: a phase I study

(2009) Ursula Wiedermann et al.   BREAST CANCER RESEARCH AND TREATMENT

Immunotherapy for cancer: synthetic carbohydrate-based vaccines

(2009) Therese Buskas et al.   CHEMICAL COMMUNICATIONS

Phase III Comparison of an Investigational Quadrivalent Meningococcal Conjugate Vaccine with the Licensed Meningococcal ACWY Conjugate Vaccine in Adolescents

(2009) Lisa A. Jackson et al.   CLINICAL INFECTIOUS DISEASES

Pneumococcal conjugated vaccine: PHiD-CV

(2009) Ener Cagri Dinleyici et al.   Expert Review of Anti-Infective Therapy

Synthetic carbohydrate-based anticancer vaccines: the Memorial Sloan-Kettering experience

(2009) Jianglong Zhu et al.   Expert Review of Vaccines

Quadrivalent meningococcal ACYW-135 glycoconjugate vaccine for broader protection from infancy

(2009) David Pace   Expert Review of Vaccines

Current knowledge regarding the investigational 13-valent pneumococcal conjugate vaccine

(2009) Ener Cagri Dinleyici et al.   Expert Review of Vaccines

10-valent pneumococcal nontypeableHaemophilus influenzaePD conjugate vaccine: Synflorix™

(2009) Roman Prymula et al.   Expert Review of Vaccines

Anti-drug vaccines to treat substance abuse

(2009) Berma M Kinsey et al.   IMMUNOLOGY AND CELL BIOLOGY

Synthetic  -(1->6)-Linked N-Acetylated and Nonacetylated Oligoglucosamines Used To Produce Conjugate Vaccines for Bacterial Pathogens

(2009) M. L. Gening et al.   INFECTION AND IMMUNITY

A Synthetic Carbohydrate-Protein Conjugate Vaccine Candidate against Shigella flexneri 2a Infection

(2009) A. Phalipon et al.   JOURNAL OF IMMUNOLOGY

From Synthesis to Biologics: Preclinical Data on a Chemistry Derived Anticancer Vaccine

(2009) Jianglong Zhu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Immunogenicity of Routinely Used Childhood Vaccines When Coadministered With the 10-Valent Pneumococcal Non-typeable Haemophilus influenzae Protein D Conjugate Vaccine (PHiD-CV)

(2009) Markus Knuf et al.   PEDIATRIC INFECTIOUS DISEASE JOURNAL

Immunopharmacotherapy: Vaccination strategies as a treatment for drug abuse and dependence

(2009) Amira Y. Moreno et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Synthesis, characterization, and immunogenicity in mice of Shigella sonnei O-specific oligosaccharide-core-protein conjugates

(2009) J. B. Robbins et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Antigen processing of glycoconjugate vaccines; the polysaccharide portion of the pneumococcal CRM197 conjugate vaccine co-localizes with MHC II on the antigen processing cell surface

(2009) Zengzu Lai et al.   VACCINE

The common Cryptococcus neoformans glucuronoxylomannan M2 motif elicits non-protective antibodies

(2009) Antonio Nakouzi et al.   VACCINE

The influence of carrier protein on the immunogenicity of simultaneously administered conjugate vaccines in infants

(2009) Eva Maria Pöllabauer et al.   VACCINE

Chemistry of a new investigational quadrivalent meningococcal conjugate vaccine that is immunogenic at all ages

(2009) Michael Bröker et al.   VACCINE

Immunogenicity and tolerability of a quadrivalent meningococcal glycoconjugate vaccine in children 2–10 years of age

(2009) S. Black et al.   VACCINE

Towards a Self-Adjuvanting Multivalent B and T cell Epitope Containing Synthetic Glycolipopeptide Cancer Vaccine

(2008) Olivier Renaudet et al.   ChemMedChem

Immunogenicity of a Reduced Schedule of Meningococcal Group C Conjugate Vaccine Given Concomitantly with the Prevenar and Pediacel Vaccines in Healthy Infants in the United Kingdom

(2008) J. Southern et al.   Clinical and Vaccine Immunology

Reduction of Human Melanoma Tumor Growth in Severe Combined Immunodeficient Mice by Passive Transfer of Antibodies Induced by a High Molecular Weight Melanoma-Associated Antigen Mimotope Vaccine

(2008) S. Wagner et al.   CLINICAL CANCER RESEARCH

Protein D of Haemophilus influenzae: A Protective Nontypeable H. influenzae Antigen and a Carrier for Pneumococcal Conjugate Vaccines

(2008) A. Forsgren et al.   CLINICAL INFECTIOUS DISEASES

Recent Developments in Synthetic Oligosaccharide-Based Bacterial Vaccines

(2008) Vince Pozsgay   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Identification of the Smallest Structure Capable of Evoking Opsonophagocytic Antibodies against Streptococcus pneumoniae Type 14

(2008) D. Safari et al.   INFECTION AND IMMUNITY

Immunogenicity of a Tetravalent Meningococcal Glycoconjugate Vaccine in Infants

(2008) Matthew D. Snape et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Cancer Immunology

(2008) Olivera J. Finn   NEW ENGLAND JOURNAL OF MEDICINE

Toward solution-phase automated iterative synthesis: fluorous-tag assisted solution-phase synthesis of linear and branched mannose oligomers

(2008) Firoz A. Jaipuri et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Synthetic glycopeptide vaccines combining  -mannan and peptide epitopes induce protection against candidiasis

(2008) H. Xin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Physicochemical characterisation of glycoconjugate vaccines for prevention of meningococcal diseases

(2008) Angela Bardotti et al.   VACCINE

A clinical trial examining the effect of increased total CRM197 carrier protein dose on the antibody response to Haemophilus influenzae type b CRM197 conjugate vaccine

(2008) Vytautas Usonis et al.   VACCINE

Immunogenicity, reactogenicity and persistence of meningococcal A, C, W-135 and Y-tetanus toxoid candidate conjugate (MenACWY-TT) vaccine formulations in adolescents aged 15–25 years

(2008) Lars Østergaard et al.   VACCINE

Automated oligosaccharide synthesis

(2007) Peter H. Seeberger   CHEMICAL SOCIETY REVIEWS