Natural Alkaloids and Heterocycles as G-Quadruplex Ligands and Potential Anticancer Agents

Synthesis and evaluation of 7-substituted-5,6-dihydrobenzo[ c ]acridine derivatives as new c- KIT promoter G-quadruplex binding ligands

(2017) Qian-Liang Guo et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Design, Synthesis, and Evaluation of New Selective NM23-H2 Binders as c-MYC Transcription Inhibitors via Disruption of the NM23-H2/G-Quadruplex Interaction

(2017) Yu-Qing Wang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Design, Synthesis, and Evaluation of Isaindigotone Derivatives To Downregulate c-myc Transcription via Disrupting the Interaction of NM23-H2 with G-Quadruplex

(2017) Chan Shan et al.   JOURNAL OF MEDICINAL CHEMISTRY

Discovery of Small Molecules for Repressing Cap-Independent Translation of Human Vascular Endothelial Growth Factor (hVEGF) as Novel Antitumor Agents

(2017) Shi-Ke Wang et al.   JOURNAL OF MEDICINAL CHEMISTRY

New Disubstituted Quindoline Derivatives Inhibiting Burkitt’s Lymphoma Cell Proliferation by Impeding c-MYC Transcription

(2017) Hui-Yun Liu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Discovery of Novel 11-Triazole Substituted Benzofuro[3,2-b]quinolone Derivatives as c-myc G-Quadruplex Specific Stabilizers via Click Chemistry

(2017) De-Ying Zeng et al.   JOURNAL OF MEDICINAL CHEMISTRY

Adaptive and Specific Recognition of Telomeric G-Quadruplexes via Polyvalency Induced Unstacking of Binding Units

(2017) Jibin Abraham Punnoose et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

G-quadruplex–forming promoter sequences enable transcriptional activation in response to oxidative stress

(2017) Bogdan I. Fedeles   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Accurate high-throughput identification of parallel G-quadruplex topology by a new tetraaryl-substituted imidazole

(2016) Ming-Hao Hu et al.   BIOSENSORS & BIOELECTRONICS

Design, synthesis and biological evaluation of 4-anilinoquinazoline derivatives as new c-myc G-quadruplex ligands

(2016) Yin Jiang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Visualization of NRAS RNA G-Quadruplex Structures in Cells with an Engineered Fluorogenic Hybridization Probe

(2016) Shuo-Bin Chen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

G-quadruplex structures mark human regulatory chromatin

(2016) Robert Hänsel-Hertsch et al.   NATURE GENETICS

rG4-seq reveals widespread formation of G-quadruplex structures in the human transcriptome

(2016) Chun Kit Kwok et al.   NATURE METHODS

Specific targeting of telomeric multimeric G-quadruplexes by a new triaryl-substituted imidazole

(2016) Ming-Hao Hu et al.   NUCLEIC ACIDS RESEARCH

RNA G-quadruplexes are globally unfolded in eukaryotic cells and depleted in bacteria

(2016) J. U. Guo et al.   SCIENCE

Development of a highly sensitive fluorescent light-up probe for G-quadruplexes

(2015) Ming-Hao Hu et al.   ANALYST

Editorial (Thematic Issue: Biological Function of G-Quadruplex Nucleic Acids and Potential Application in Medicinal Chemistry)

(2015) Z.-S. Huang et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Recent Development of G-Quadruplex Probes for Cellular Imaging

(2015) Dik-Lung Ma et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Visualization of RNA-Quadruplexes in Live Cells

(2015) Aurélien Laguerre et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

High-throughput sequencing of DNA G-quadruplex structures in the human genome

(2015) Vicki S Chambers et al.   NATURE BIOTECHNOLOGY

Chemical intervention of the NM23-H2 transcriptional programme onc-MYCvia a novel small molecule

(2015) Chan Shan et al.   NUCLEIC ACIDS RESEARCH

A newly identified berberine derivative induces cancer cell senescence by stabilizing endogenous G-quadruplexes and sparking a DNA damage response at the telomere region

(2015) Yun-Xia Xiong et al.   Oncotarget

A new application of click chemistry in situ: development of fluorescent probe for specific G-quadruplex topology

(2015) Ming-Hao Hu et al.   Scientific Reports

Development of a new colorimetric and red-emitting fluorescent dual probe for G-quadruplex nucleic acids

(2014) Jin-Wu Yan et al.   CHEMICAL COMMUNICATIONS

Discovery of a new fluorescent light-up probe specific to parallel G-quadruplexes

(2014) Shuo-Bin Chen et al.   CHEMICAL COMMUNICATIONS

A Twice-As-Smart Synthetic G-Quartet: PyroTASQ Is Both a Smart Quadruplex Ligand and a Smart Fluorescent Probe

(2014) Aurélien Laguerre et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Structure-Based Virtual Screening of Novel Natural Alkaloid Derivatives as Potential Binders of h-telo and c-myc DNA G-Quadruplex Conformations

(2014) Roberta Rocca et al.   MOLECULES

RNA G-quadruplexes cause eIF4A-dependent oncogene translation in cancer

(2014) Andrew L. Wolfe et al.   NATURE

G-quadruplex interacting small molecules and drugs: from bench toward bedside

(2014) Sebastian Müller et al.   Expert Review of Clinical Pharmacology

Nonlinear optical dye TSQ1 as an efficiently selective fluorescent probe for G-quadruplex DNA

(2014) Yuqi Chen et al.   Organic Chemistry Frontiers

Solution Structure of a G-quadruplex Bound to the Bisquinolinium Compound Phen-DC3

(2013) Wan Jun Chung et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Fluorescent Probes for G-Quadruplex Structures

(2013) Balayeshwanth R. Vummidi et al.   CHEMBIOCHEM

New quinazoline derivatives for telomeric G-quadruplex DNA: Effects of an added phenyl group on quadruplex binding ability

(2013) Jin-Hui He et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Solution Structure of an Intramolecular (3 + 1) Human Telomeric G-Quadruplex Bound to a Telomestatin Derivative

(2013) Wan Jun Chung et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Visualization and selective chemical targeting of RNA G-quadruplex structures in the cytoplasm of human cells

(2013) Giulia Biffi et al.   Nature Chemistry

Quantitative visualization of DNA G-quadruplex structures in human cells

(2013) Giulia Biffi et al.   Nature Chemistry

Synthesis and Evaluation of Quinazolone Derivatives as a New Class of c-KIT G-Quadruplex Binding Ligands

(2013) Xiaoxiao Wang et al.   ACS Medicinal Chemistry Letters

Interaction of Berberine derivative with protein POT1 affect telomere function in cancer cells

(2012) Nannan Xiao et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Benzofuroquinoline Derivatives Had Remarkable Improvement of their Selectivity for Telomeric G-Quadruplex DNA over Duplex DNA upon Introduction of Peptidyl Group

(2012) Yi Long et al.   BIOCONJUGATE CHEMISTRY

G-Quadruplex Binding Ligands: from Naturally Occurring to Rationally Designed Molecules

(2012) Tuong Vy Thi Le et al.   CURRENT PHARMACEUTICAL DESIGN

12-N-Methylated 5,6-dihydrobenzo[c]acridine derivatives: A new class of highly selective ligands for c-myc G-quadruplex DNA

(2012) Sheng-Rong Liao et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Structural Basis for Telomeric G-Quadruplex Targeting by Naphthalene Diimide Ligands

(2012) Gavin W. Collie et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A FRET-based screening assay for nucleic acid ligands

(2012) Daniel Renčiuk et al.   METHODS

Small-molecule–induced DNA damage identifies alternative DNA structures in human genes

(2012) Raphaël Rodriguez et al.   Nature Chemical Biology

The crystal structure of human telomeric DNA complexed with berberine: an interesting case of stacked ligand to G-tetrad ratio higher than 1:1

(2012) Carla Bazzicalupi et al.   NUCLEIC ACIDS RESEARCH

Pyridostatin analogues promote telomere dysfunction and long-term growth inhibition in human cancer cells

(2012) Sebastian Müller et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Benzothiazole-substituted benzofuroquinolinium dye: a selective switch-on fluorescent probe for G-quadruplex

(2011) Yu-Jing Lu et al.   CHEMICAL COMMUNICATIONS

Disubstituted quinazoline derivatives as a new type of highly selective ligands for telomeric G-quadruplex DNA

(2011) Zeng Li et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Structural Basis of Telomeric RNA Quadruplex−Acridine Ligand Recognition

(2011) Gavin W. Collie et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Solution Structure of a 2:1 Quindoline–c-MYC G-Quadruplex: Insights into G-Quadruplex-Interactive Small Molecule Drug Design

(2011) Jixun Dai et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Targeting G-quadruplexes in gene promoters: a novel anticancer strategy?

(2011) Shankar Balasubramanian et al.   NATURE REVIEWS DRUG DISCOVERY

Impact of planarity of unfused aromatic molecules on G-quadruplex binding: Learning from isaindigotone derivatives

(2011) Jin-Qiang Hou et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Pharmacophore-based discovery of triaryl-substituted imidazole as new telomeric G-quadruplex ligand

(2010) Shuo-Bin Chen et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis and evaluation of 9-O-substituted berberine derivatives containing aza-aromatic terminal group as highly selective telomeric G-quadruplex stabilizing ligands

(2009) Yan Ma et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Anticancer Activity of CX-3543: A Direct Inhibitor of rRNA Biogenesis

(2009) D. Drygin et al.   CANCER RESEARCH

The structures of quadruplex nucleic acids and their drug complexes

(2009) Stephen Neidle   CURRENT OPINION IN STRUCTURAL BIOLOGY

Isaindigotone Derivatives: A New Class of Highly Selective Ligands for Telomeric G-Quadruplex DNA

(2009) Jia-Heng Tan et al.   JOURNAL OF MEDICINAL CHEMISTRY

Tandem Application of Virtual Screening and NMR Experiments in the Discovery of Brand New DNA Quadruplex Groove Binders

(2009) Sandro Cosconati et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Fast screening and structural elucidation of G-quadruplex ligands from a mixture via G-quadruplex recognition and NMR methods

(2008) Qiuju Zhou et al.   BIOCHIMIE

9-N-Substituted berberine derivatives: Stabilization of G-quadruplex DNA and down-regulation of oncogene c-myc

(2008) Yan Ma et al.   BIOORGANIC & MEDICINAL CHEMISTRY

G-Quadruplexes: Targets in Anticancer Drug Design

(2008) Tian-miao Ou et al.   ChemMedChem

5-N-Methylated Quindoline Derivatives as Telomeric G-Quadruplex Stabilizing Ligands: Effects of 5-NPositive Charge on Quadruplex Binding Affinity and Cell Proliferation

(2008) Yu-Jing Lu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Modelling Myc inhibition as a cancer therapy

(2008) Laura Soucek et al.   NATURE

Metastases suppressor NM23-H2 interaction with G-quadruplex DNA within c-MYC promoter nuclease hypersensitive element induces c-MYC expression

(2008) Ram Krishna Thakur et al.   NUCLEIC ACIDS RESEARCH