Structure-Based Virtual Screening of Novel Natural Alkaloid Derivatives as Potential Binders of h-telo and c-myc DNA G-Quadruplex Conformations

Docking based virtual screening and molecular dynamics study to identify potential monoacylglycerol lipase inhibitors

(2014) Obaid Afzal et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Targeting unimolecular G-quadruplex nucleic acids: a new paradigm for the drug discovery?

(2014) Lucia Parrotta et al.   Expert Opinion on Drug Discovery

Small Molecules Targeting c-Myc Oncogene: Promising Anti-Cancer Therapeutics

(2014) Bing-Jia Chen et al.   International Journal of Biological Sciences

A spectroscopic investigation of the interaction between c-MYC DNA and tetrapyridinoporphyrazinatozinc(II)

(2014) Leila Hassani et al.   JOURNAL OF BIOLOGICAL PHYSICS

Aryl ethynyl anthraquinones: a useful platform for targeting telomeric G-quadruplex structures

(2014) Claudia Percivalle et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Identification of a natural product-like STAT3 dimerization inhibitor by structure-based virtual screening

(2014) L-J Liu et al.   Cell Death & Disease

Molecular basis of recognition of quadruplexes human telomere and c-myc promoter by the putative anticancer agent sanguinarine

(2013) Saptaparni Ghosh et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Drug repositioning by structure-based virtual screening

(2013) Dik-Lung Ma et al.   CHEMICAL SOCIETY REVIEWS

Toward the design of new DNA G-quadruplex ligands through rational analysis of polymorphism and binding data

(2013) Anna Artese et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Identification and Quantification of the Main Active Anticancer Alkaloids from the Root of Glaucium flavum

(2013) Lamine Bournine et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Identification and Characterization of New DNA G-Quadruplex Binders Selected by a Combination of Ligand and Structure-Based Virtual Screening Approaches

(2013) Stefano Alcaro et al.   JOURNAL OF MEDICINAL CHEMISTRY

Identification of New Natural DNA G-Quadruplex Binders Selected by a Structure-Based Virtual Screening Approach

(2013) Anna Artese et al.   MOLECULES

Quantitative visualization of DNA G-quadruplex structures in human cells

(2013) Giulia Biffi et al.   Nature Chemistry

Conformation and Stability of Intramolecular Telomeric G-Quadruplexes: Sequence Effects in the Loops

(2013) Giovanna Sattin et al.   PLoS One

Electrospray ionization mass spectrometric exploration of the high-affinity binding of three natural alkaloids with the mRNA G-quadruplex in the BCL2 5′-untranslated region

(2013) Wei Tan et al.   RAPID COMMUNICATIONS IN MASS SPECTROMETRY

Electrospray ionization mass spectrometry probing of binding affinity of berbamine, a flexible cyclic alkaloid from traditional Chinese medicine, with G-quadruplex DNA

(2013) Wei Tan et al.   RAPID COMMUNICATIONS IN MASS SPECTROMETRY

Spectroscopic, Molecular Modeling, and NMR-Spectroscopic Investigation of the Binding Mode of the Natural Alkaloids Berberine and Sanguinarine to Human Telomeric G-Quadruplex DNA

(2012) Irene Bessi et al.   ACS Chemical Biology

Discovery of a natural product inhibitor targeting protein neddylation by structure-based virtual screening

(2012) Hai-Jing Zhong et al.   BIOCHIMIE

Novel anticancer therapeutics targeting telomerase

(2012) Maria Ruden et al.   CANCER TREATMENT REVIEWS

Editorial [Hot Topic: The Impact of the G-Quadruplex Conformation in the Development of Novel Therapeutic and Diagnostic Agents Executive (Guest Editor: Stefano Alcaro)]

(2012) Stefano Alcaro   CURRENT PHARMACEUTICAL DESIGN

The Polymorphisms of DNA G-Quadruplex Investigated by Docking Experiments with Telomestatin Enantiomers

(2012) Stefano Alcaro et al.   CURRENT PHARMACEUTICAL DESIGN

Structure–activity relationships of novel substituted naphthalene diimides as anticancer agents

(2012) Andrea Milelli et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Natural Products As Sources of New Drugs over the 30 Years from 1981 to 2010

(2012) David J. Newman et al.   JOURNAL OF NATURAL PRODUCTS

The Major G-Quadruplex Formed in the Human Platelet-Derived Growth Factor Receptor β Promoter Adopts a Novel Broken-Strand Structure in K+ Solution

(2012) Yuwei Chen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The crystal structure of human telomeric DNA complexed with berberine: an interesting case of stacked ligand to G-tetrad ratio higher than 1:1

(2012) Carla Bazzicalupi et al.   NUCLEIC ACIDS RESEARCH

Hybrid ligand–alkylating agents targeting telomeric G-quadruplex structures

(2012) Filippo Doria et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Discovery of a Natural Product-Like c-myc G-Quadruplex DNA Groove-Binder by Molecular Docking

(2012) Dik-Lung Ma et al.   PLoS One

Investigation of non-covalent interaction of natural flexible cyclic molecules with telomeric RNA G-quadruplexes by electrospray ionization mass spectrometry

(2012) Xiaojie Cui et al.   RAPID COMMUNICATIONS IN MASS SPECTROMETRY

Interaction of berberine, palmatine, coralyne, and sanguinarine to quadruplex DNA: A comparative spectroscopic and calorimetric study

(2011) Kakali Bhadra et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Conformational studies and solvent-accessible surface area analysis of known selective DNA G-Quadruplex binders

(2011) Stefano Alcaro et al.   BIOCHIMIE

Formation, recognition and bioactivities of a novel G-quadruplex in the STAT3 gene

(2011) Sen Lin et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

A natural product-like inhibitor of NEDD8-activating enzyme

(2011) Chung-Hang Leung et al.   CHEMICAL COMMUNICATIONS

Quinolino-benzo-[5, 6]-dihydroisoquindolium compounds derived from berberine: A new class of highly selective ligands for G-quadruplex DNA in c-myc oncogene

(2011) Yan Ma et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Formation and recognition of G-quadruplex in promoter of c-myb oncogene by electrospray ionization mass spectrometry

(2011) Xiaojie Cui et al.   JOURNAL OF MASS SPECTROMETRY

Solution Structure of a 2:1 Quindoline–c-MYC G-Quadruplex: Insights into G-Quadruplex-Interactive Small Molecule Drug Design

(2011) Jixun Dai et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Structure-Based Discovery of Natural-Product-like TNF-α Inhibitors

(2010) Daniel Shiu-Hin Chan et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Identification of natural product Fonsecin B as a stabilizing ligand of c-myc G-quadruplex DNA by high-throughput virtual screening

(2010) Ho-Man Lee et al.   CHEMICAL COMMUNICATIONS

Rational Design, Synthesis, Biophysical and Antiproliferative Evaluation of Fluorenone Derivatives with DNA G-Quadruplex Binding Properties

(2010) Stefano Alcaro et al.   ChemMedChem

Structural insights into G-quadruplexes: towards new anticancer drugs

(2010) Danzhou Yang et al.   Future Medicinal Chemistry

Solution Structure of a Unique G-Quadruplex Scaffold Adopted by a Guanosine-Rich Human Intronic Sequence

(2010) Vitaly Kuryavyi et al.   STRUCTURE

The c-MYC NHE III1: Function and Regulation

(2009) Verónica González et al.   Annual Review of Pharmacology and Toxicology

Synthesis and evaluation of 9-O-substituted berberine derivatives containing aza-aromatic terminal group as highly selective telomeric G-quadruplex stabilizing ligands

(2009) Yan Ma et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Anticancer Activity of CX-3543: A Direct Inhibitor of rRNA Biogenesis

(2009) D. Drygin et al.   CANCER RESEARCH

Sanguinarine Interacts with Chromatin, Modulates Epigenetic Modifications, and Transcription in the Context of Chromatin

(2009) Ruthrotha Selvi B et al.   CHEMISTRY & BIOLOGY

G-Quadruplex DNA Structures and Organic Chemistry: More Than One Connection

(2009) Marco Franceschin   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Hunting G-quadruplexes

(2008) J.L. Huppert   BIOCHIMIE

Structures, folding patterns, and functions of intramolecular DNA G-quadruplexes found in eukaryotic promoter regions

(2008) Yong Qin et al.   BIOCHIMIE

9-N-Substituted berberine derivatives: Stabilization of G-quadruplex DNA and down-regulation of oncogene c-myc

(2008) Yan Ma et al.   BIOORGANIC & MEDICINAL CHEMISTRY

G-Quadruplexes: Targets in Anticancer Drug Design

(2008) Tian-miao Ou et al.   ChemMedChem

A novel G-quadruplex-forming GGA repeat region in the c-myb promoter is a critical regulator of promoter activity

(2008) SunMi L. Palumbo et al.   NUCLEIC ACIDS RESEARCH

Targeting telomeres and telomerase

(2007) Anne De Cian et al.   BIOCHIMIE