The neuroprotective effect of nicotine in Parkinson’s disease models is associated with inhibiting PARP-1 and caspase-3 cleavage

Stimulating Nicotinic Receptors Trigger Multiple Pathways Attenuating Cytotoxicity in Models of Alzheimer's and Parkinson's Diseases

(2018) Jun Kawamata et al.   JOURNAL OF ALZHEIMERS DISEASE

Gut Permeability and Microbiota in Parkinson’s Disease: Role of Depression, Tryptophan Catabolites, Oxidative and Nitrosative Stress and Melatonergic Pathways

(2016) George Anderson et al.   CURRENT PHARMACEUTICAL DESIGN

Inhibition of endoplasmic reticulum stress-activated IRE1α-TRAF2-caspase-12 apoptotic pathway is involved in the neuroprotective effects of telmisartan in the rotenone rat model of Parkinson's disease

(2016) Qiang Tong et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Role of pedunculopontine cholinergic neurons in the vulnerability of nigral dopaminergic neurons in Parkinson's disease

(2016) Manale Bensaid et al.   EXPERIMENTAL NEUROLOGY

Caspases Connect Cell-Death Signaling to Organismal Homeostasis

(2016) Lorenzo Galluzzi et al.   IMMUNITY

The clinical symptoms of Parkinson's disease

(2016) Sigurlaug Sveinbjornsdottir   JOURNAL OF NEUROCHEMISTRY

Smoking-Relevant Nicotine Concentration Attenuates the Unfolded Protein Response in Dopaminergic Neurons

(2016) R. Srinivasan et al.   JOURNAL OF NEUROSCIENCE

The epidemiology of Parkinson's disease: risk factors and prevention

(2016) Alberto Ascherio et al.   LANCET NEUROLOGY

Caspase-1 Deficiency Alleviates Dopaminergic Neuronal Death via Inhibiting Caspase-7/AIF Pathway in MPTP/p Mouse Model of Parkinson’s Disease

(2016) Chen Qiao et al.   MOLECULAR NEUROBIOLOGY

Acteoside Binds to Caspase-3 and Exerts Neuroprotection in the Rotenone Rat Model of Parkinson's Disease

(2016) Jiawen Yuan et al.   PLoS One

Caspase-1 causes truncation and aggregation of the Parkinson’s disease-associated protein α-synuclein

(2016) Wei Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Parp mutations protect against mitochondrial dysfunction and neurodegeneration in a PARKIN model of Parkinson’s disease

(2016) S Lehmann et al.   Cell Death & Disease

Pathophysiology of Motor Dysfunction in Parkinson’s Disease as the Rationale for Drug Treatment and Rehabilitation

(2016) Francesca Magrinelli et al.   Parkinsons Disease

Genetic Profile, Environmental Exposure, and Their Interaction in Parkinson’s Disease

(2016) Letizia Polito et al.   Parkinsons Disease

Association between Parkinson’s Disease and Cigarette Smoking, Rural Living, Well-Water Consumption, Farming and Pesticide Use: Systematic Review and Meta-Analysis

(2016) Charles B. Breckenridge et al.   PLoS One

Substantial Neuroprotective and Neurite Outgrowth-Promoting Activities by Bis(propyl)-cognitin via the Activation of Alpha7-nAChR, a Promising Anti-Alzheimer’s Dimer

(2015) Shengquan Hu et al.   ACS Chemical Neuroscience

Alpha7 nicotinic receptors as therapeutic targets for Parkinson's disease

(2015) Maryka Quik et al.   BIOCHEMICAL PHARMACOLOGY

The α7 nicotinic receptor agonist ABT-107 protects against nigrostriatal damage in rats with unilateral 6-hydroxydopamine lesions

(2015) Tanuja Bordia et al.   EXPERIMENTAL NEUROLOGY

PARP-1 involvement in neurodegeneration: A focus on Alzheimer’s and Parkinson’s diseases

(2015) Sara Martire et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Preclinical Evidence for a Role of the Nicotinic Cholinergic System in Parkinson’s Disease

(2015) Xiomara A. Perez   NEUROPSYCHOLOGY REVIEW

Beneficial effects of nicotine, cotinine and its metabolites as potential agents for Parkinson’s disease

(2015) George E. Barreto et al.   Frontiers in Aging Neuroscience

Loss of angiotensin II receptor expression in dopamine neurons in Parkinson’s disease correlates with pathological progression and is accompanied by increases in Nox4- and 8-OH guanosine-related nucleic acid oxidation and caspase-3 activation

(2015) W Michael Zawada et al.   Acta Neuropathologica Communications

Nicotine exerts neuroprotective effects against β-amyloid-induced neurotoxicity in SH-SY5Y cells through the Erk1/2-p38-JNK-dependent signaling pathway

(2014) MAO QIANG XUE et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Pharmacological Treatment of Parkinson Disease

(2014) Barbara S. Connolly et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Parkinson disease and smoking revisited: Ease of quitting is an early sign of the disease

(2014) B. Ritz et al.   NEUROLOGY

Heat Shock Protein-70 (Hsp-70) Suppresses Paraquat-Induced Neurodegeneration by Inhibiting JNK and Caspase-3 Activation in Drosophila Model of Parkinson's Disease

(2014) Arvind Kumar Shukla et al.   PLoS One

Methyllycaconitine Alleviates Amyloid-β Peptides-Induced Cytotoxicity in SH-SY5Y Cells

(2014) XiaoLei Zheng et al.   PLoS One

Neurodegeneration in Parkinson's Disease: Interactions of Oxidative Stress, Tryptophan Catabolites and Depression with Mitochondria and Sirtuins

(2013) George Anderson et al.   MOLECULAR NEUROBIOLOGY

(ADP-ribose) polymerase 1 and AMP-activated protein kinase mediate progressive dopaminergic neuronal degeneration in a mouse model of Parkinson’s disease

(2013) T W Kim et al.   Cell Death & Disease

3-[(2,4-dimethoxy)benzylidene]-anabaseine dihydrochloride protects against 6-hydroxydopamine-induced parkinsonian neurodegeneration through α7 nicotinic acetylcholine receptor stimulation in rats

(2012) Syuuichirou Suzuki et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Development of a Unilaterally-lesioned 6-OHDA Mouse Model of Parkinson's Disease

(2012) Sherri L. Thiele et al.   Jove-Journal of Visualized Experiments

PARP-1 cleavage fragments: signatures of cell-death proteases in neurodegeneration

(2011) Ganta Chaitanya et al.   Cell Communication and Signaling

Generation of a model of l-DOPA-induced dyskinesia in two different mouse strains

(2011) Sherri L. Thiele et al.   JOURNAL OF NEUROSCIENCE METHODS

Environmental tobacco smoke and Parkinson's disease

(2011) Susan Searles Nielsen et al.   MOVEMENT DISORDERS

Genome-Wide Expression Analysis Reveals Diverse Effects of Acute Nicotine Exposure on Neuronal Function-Related Genes and Pathways

(2011) Ju Wang et al.   Frontiers in Psychiatry

Gene disruption of caspase-3 prevents MPTP-induced Parkinson’s disease in mice

(2010) Marina Yamada et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

NAD+ Depletion Is Necessary and Sufficient forPoly(ADP-Ribose) Polymerase-1-Mediated Neuronal Death

(2010) C. C. Alano et al.   JOURNAL OF NEUROSCIENCE

Caspase-Cleaved Transactivation Response DNA-Binding Protein 43 in Parkinson’s Disease and Dementia with Lewy Bodies

(2010) Polina Kokoulina et al.   Neurodegenerative Diseases