TDP1 deficiency sensitizes human cells to base damage via distinct topoisomerase I and PARP mechanisms with potential applications for cancer therapy

ATM Deficiency Results in Accumulation of DNA-Topoisomerase I Covalent Intermediates in Neural Cells

(2014) Meryem Alagoz et al.   PLoS One

Tyrosyl-DNA phosphodiesterase 1 initiates repair of apurinic/apyrimidinic sites

(2012) Natalia A. Lebedeva et al.   BIOCHIMIE

Trapping of PARP1 and PARP2 by Clinical PARP Inhibitors

(2012) J. Murai et al.   CANCER RESEARCH

Synthetic lethal targeting of DNA double-strand break repair deficient cells by human apurinic/apyrimidinic endonuclease inhibitors

(2012) Rebeka Sultana et al.   INTERNATIONAL JOURNAL OF CANCER

Tyrosyl-DNA Phosphodiesterase 1 (TDP1) Repairs DNA Damage Induced by Topoisomerases I and II and Base Alkylation in Vertebrate Cells

(2012) Junko Murai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Topoisomerase I poisoning results in PARP-mediated replication fork reversal

(2012) Arnab Ray Chaudhuri et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

TDP2 promotes repair of topoisomerase I-mediated DNA damage in the absence of TDP1

(2012) Zhihong Zeng et al.   NUCLEIC ACIDS RESEARCH

SUMO modification of the neuroprotective protein TDP1 facilitates chromosomal single-strand break repair

(2012) Jessica J.R. Hudson et al.   Nature Communications

Development and evaluation of human AP endonuclease inhibitors in melanoma and glioma cell lines

(2011) M Z Mohammed et al.   BRITISH JOURNAL OF CANCER

Phase I Study of PARP Inhibitor ABT-888 in Combination with Topotecan in Adults with Refractory Solid Tumors and Lymphomas

(2011) S. Kummar et al.   CANCER RESEARCH

AP endonuclease independent repair of abasic sites in Schizosaccharomyces pombe

(2011) Line Nilsen et al.   NUCLEIC ACIDS RESEARCH

Ubiquitin ligase UBR3 regulates cellular levels of the essential DNA repair protein APE1 and is required for genome stability

(2011) Cornelia Meisenberg et al.   NUCLEIC ACIDS RESEARCH

TDP1 serine 81 promotes interaction with DNA ligase IIIα and facilitates cell survival following DNA damage

(2010) Shih-Chieh Chiang et al.   CELL CYCLE

Small molecule inhibitors of DNA repair nuclease activities of APE1

(2010) David M. Wilson et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The DNA Damage Response: Making It Safe to Play with Knives

(2010) Alberto Ciccia et al.   MOLECULAR CELL

Poly (ADP-ribose) polymerase (PARP) is not involved in base excision repair but PARP inhibition traps a single-strand intermediate

(2010) C. E. Strom et al.   NUCLEIC ACIDS RESEARCH

Enhanced radiosensitization of human glioma cells by combining inhibition of poly(ADP-ribose) polymerase with inhibition of heat shock protein 90

(2009) F. A. Dungey et al.   MOLECULAR CANCER THERAPEUTICS

Single-strand break repair and genetic disease

(2008) Keith W. Caldecott   NATURE REVIEWS GENETICS

PARP inhibition versus PARP-1 silencing: different outcomes in terms of single-strand break repair and radiation susceptibility

(2008) C. Godon et al.   NUCLEIC ACIDS RESEARCH