Elevated levels of brain homocysteine directly modulate the pathological phenotype of a mouse model of tauopathy

Genetic absence of ALOX5 protects from homocysteine-induced memory impairment, tau phosphorylation and synaptic pathology

(2017) Jian-Guo Li et al.   HUMAN MOLECULAR GENETICS

The direct role of 5-lipoxygenase on tau pathology, synaptic integrity and cognition in a mouse model of tauopathy

(2017) Alana N. Vagnozzi et al.   Translational Psychiatry

Homocysteine modulates 5-lipoxygenase expression level via DNA methylation

(2016) Jian-Guo Li et al.   AGING CELL

2016 Alzheimer's disease facts and figures

(2016)   Alzheimers & Dementia

Homocysteine, B Vitamins, and Cognitive Impairment

(2016) A. David Smith et al.   Annual Review of Nutrition

Tau and tauopathies

(2016) Thomas Arendt et al.   BRAIN RESEARCH BULLETIN

Hyperhomocysteinemia exacerbates Alzheimer's disease pathology by way of the β-amyloid fibrinogen interaction

(2016) Y. C. Chung et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Pharmacologic Inhibition of 5-Lipoxygenase Improves Memory, Rescues Synaptic Dysfunction, and Ameliorates Tau Pathology in a Transgenic Model of Tauopathy

(2015) Phillip F. Giannopoulos et al.   BIOLOGICAL PSYCHIATRY

Homocysteine exacerbates β-amyloid pathology, tau pathology, and cognitive deficit in a mouse model of Alzheimer disease with plaques and tangles

(2014) Jian-Guo Li et al.   ANNALS OF NEUROLOGY

Absence of ALOX5 gene prevents stress-induced memory deficits, synaptic dysfunction and tauopathy in a mouse model of Alzheimer's disease

(2014) Y. B. Joshi et al.   HUMAN MOLECULAR GENETICS

Zileuton restores memory impairments and reverses amyloid and tau pathology in aged Alzheimer's disease mice

(2014) Antonio Di Meco et al.   NEUROBIOLOGY OF AGING

Tau pathology and neurodegeneration

(2013) Maria Grazia Spillantini et al.   LANCET NEUROLOGY

Gene knockout of 5-lipoxygenase rescues synaptic dysfunction and improves memory in the triple-transgenic model of Alzheimer's disease

(2013) P F Giannopoulos et al.   MOLECULAR PSYCHIATRY

5-Lipoxygenase pharmacological blockade decreases tau phosphorylation in vivo: involvement of the cyclin-dependent kinase-5

(2013) Jin Chu et al.   NEUROBIOLOGY OF AGING

5-Lipoxygenase gene transfer worsens memory, amyloid, and tau brain pathologies in a mouse model of alzheimer disease

(2012) Jin Chu et al.   ANNALS OF NEUROLOGY

S-adenosylmethionine reduces the progress of the Alzheimer-like features induced by B-vitamin deficiency in mice

(2012) Andrea Fuso et al.   NEUROBIOLOGY OF AGING

Pharmacologic Blockade of 5-Lipoxygenase Improves the Amyloidotic Phenotype of an Alzheimer's Disease Transgenic Mouse Model

(2011) Jin Chu et al.   AMERICAN JOURNAL OF PATHOLOGY

Is hyperhomocysteinemia an Alzheimer's disease (AD) risk factor, an AD marker, or neither?

(2011) Jia-Min Zhuo et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Diet-Induced Hyperhomocysteinemia Increases Amyloid-β Formation and Deposition in a Mouse Model of Alzheimers Disease

(2010) J.-M. Zhuo et al.   Current Alzheimer Research

Normalization of hyperhomocysteinemia improves cognitive deficits and ameliorates brain amyloidosis of a transgenic mouse model of Alzheimer's disease

(2010) Jia-Min Zhuo et al.   FASEB JOURNAL

High-Dose B Vitamin Supplements and Alzheimer Disease

(2009) Domenico Pratico   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Age-Dependent Impairment of Cognitive and Synaptic Function in the htau Mouse Model of Tau Pathology

(2009) M. Polydoro et al.   JOURNAL OF NEUROSCIENCE

High-Dose B Vitamin Supplementation and Cognitive Decline in Alzheimer Disease

(2008) Paul S. Aisen   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Mechanism and Tissue Specificity of Nicotine-mediated LungS-Adenosylmethionine Reduction

(2008) Camilo A. Moncada et al.   JOURNAL OF BIOLOGICAL CHEMISTRY