Hyperhomocysteinemia exacerbates Alzheimer's disease pathology by way of the β-amyloid fibrinogen interaction

Chronic Hypertension Leads to Neurodegeneration in the TgSwDI Mouse Model of Alzheimer’s DiseaseNovelty and Significance

(2015) Anna Kruyer et al.   HYPERTENSION

Cerebrospinal Fluid Biomarkers of Neurovascular Dysfunction in Mild Dementia and Alzheimer'S Disease

(2015) Melanie D Sweeney et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Fibrin deposited in the Alzheimer's disease brain promotes neuronal degeneration

(2015) Marta Cortes-Canteli et al.   NEUROBIOLOGY OF AGING

Ablation of MMP9 Gene Ameliorates Paracellular Permeability and Fibrinogen–Amyloid Beta Complex Formation during Hyperhomocysteinemia

(2014) Nino Muradashvili et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

A novel Aβ-fibrinogen interaction inhibitor rescues altered thrombosis and cognitive decline in Alzheimer’s disease mice

(2014) Hyung Jin Ahn et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Identification of N-homocysteinylation sites in plasma proteins

(2013) Marta Sikora et al.   AMINO ACIDS

The APOE ε4/ε4 Genotype Potentiates Vascular Fibrin(Ogen) Deposition in Amyloid-Laden Vessels in the Brains of Alzheimer's Disease Patients

(2013) Karin Hultman et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Vascular Aspects of Cognitive Impairment and Dementia

(2013) Maximilian Wiesmann et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Innate immunity receptor CD36 promotes cerebral amyloid angiopathy

(2013) L. Park et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A  delays fibrin clot lysis by altering fibrin structure and attenuating plasminogen binding to fibrin

(2012) D. Zamolodchikov et al.   BLOOD

Cerebral Microinfarcts: A Systematic Review of Neuropathological Studies

(2012) Manon Brundel et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Contrast-Enhanced Magnetic Resonance Microangiography Reveals Remodeling of the Cerebral Microvasculature in Transgenic ArcA  Mice

(2012) J. Klohs et al.   JOURNAL OF NEUROSCIENCE

Spatial learning and memory impairment and increased locomotion in a transgenic amyloid precursor protein mouse model of Alzheimer's disease

(2011) J.M. Walker et al.   BEHAVIOURAL BRAIN RESEARCH

Plasma Biomarkers of Brain Atrophy in Alzheimer's Disease

(2011) Madhav Thambisetty et al.   PLoS One

Is hyperhomocysteinemia an Alzheimer's disease (AD) risk factor, an AD marker, or neither?

(2011) Jia-Min Zhuo et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Reversal of autophagy dysfunction in the TgCRND8 mouse model of Alzheimer's disease ameliorates amyloid pathologies and memory deficits

(2010) Dun-Sheng Yang et al.   BRAIN

Converging Perturbed Microvasculature and Microglial Clusters Characterize Alzheimer Disease Brain

(2010) N. Jantaratnotai et al.   Current Alzheimer Research

Diet-Induced Hyperhomocysteinemia Increases Amyloid-β Formation and Deposition in a Mouse Model of Alzheimers Disease

(2010) J.-M. Zhuo et al.   Current Alzheimer Research

Fibrinogen and β-Amyloid Association Alters Thrombosis and Fibrinolysis: A Possible Contributing Factor to Alzheimer's Disease

(2010) Marta Cortes-Canteli et al.   NEURON

Alzheimer's disease peptide  -amyloid interacts with fibrinogen and induces its oligomerization

(2010) H. J. Ahn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Homocysteine and arterial thrombosis: Challenge and opportunity

(2010) Elena Tremoli et al.   THROMBOSIS AND HAEMOSTASIS

Mechanisms of fibrinogen-induced microvascular dysfunction during cardiovascular disease

(2009) D. Lominadze et al.   Acta Physiologica

Acceleration of brain amyloidosis in an Alzheimer’s disease mouse model by a folate, vitamin B6 and B12-deficient diet

(2009) Jia-Min Zhuo et al.   EXPERIMENTAL GERONTOLOGY

Cerebral emboli in the genesis of dementia

(2009) Nitin Purandare et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Homocysteine Level and Coronary Heart Disease Incidence: A Systematic Review and Meta-analysis

(2009) Linda L. Humphrey et al.   MAYO CLINIC PROCEEDINGS

Cerebral amyloid angiopathy and its relationship to Alzheimer’s disease

(2008) Dietmar Rudolf Thal et al.   ACTA NEUROPATHOLOGICA

Mutations in cystathionine β-synthase or methylenetetrahydrofolate reductase gene increase N-homocysteinylated protein levels in humans

(2008) Hieronim Jakubowski et al.   FASEB JOURNAL

Fibrinogen drives dystrophic muscle fibrosis via a TGF /alternative macrophage activation pathway

(2008) B. Vidal et al.   GENES & DEVELOPMENT

A leaky blood-brain barrier, fibrinogen infiltration and microglial reactivity in inflamed Alzheimer’s disease brain

(2008) Jae K. Ryu et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

B-vitamin deprivation induces hyperhomocysteinemia and brain S-adenosylhomocysteine, depletes brain S-adenosylmethionine, and enhances PS1 and BACE expression and amyloid-β deposition in mice

(2008) Andrea Fuso et al.   MOLECULAR AND CELLULAR NEUROSCIENCE