Bexarotene Modulates Retinoid-X-Receptor Expression and Is Protective Against Neurotoxic Endoplasmic Reticulum Stress Response and Apoptotic Pathway Activation

PTPN11 induces endoplasmic stress and apoptosis in SH-SY5Y cells

(2017) Nitin Chitranshi et al.   NEUROSCIENCE

Neuronally-directed effects of RXR activation in a mouse model of Alzheimer’s disease

(2017) M. M. Mariani et al.   Scientific Reports

One protein, multiple pathologies: multifaceted involvement of amyloid β in neurodegenerative disorders of the brain and retina

(2016) Vivek Gupta et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Amyloid β accumulation and inner retinal degenerative changes in Alzheimer’s disease transgenic mouse

(2016) Vivek K. Gupta et al.   NEUROSCIENCE LETTERS

Bexarotene targets autophagy and is protective against thromboembolic stroke in aged mice with tauopathy

(2016) Mikko T. Huuskonen et al.   Scientific Reports

RXR controlled regulatory networks identified in mouse brain counteract deleterious effects of Aβ oligomers

(2016) Kyong Nyon Nam et al.   Scientific Reports

Double-blind, placebo-controlled, proof-of-concept trial of bexarotene in moderate Alzheimer’s disease

(2016) Jeffrey L. Cummings et al.   Alzheimers Research & Therapy

Bexarotene-Activated Retinoid X Receptors Regulate Neuronal Differentiation and Dendritic Complexity

(2015) A. Mounier et al.   JOURNAL OF NEUROSCIENCE

Neuroprotective Effect of Bexarotene in the SOD1G93A Mouse Model of Amyotrophic Lateral Sclerosis

(2015) Javier Riancho et al.   Frontiers in Cellular Neuroscience

Brain derived neurotrophic factor is involved in the regulation of glycogen synthase kinase 3β (GSK3β) signalling

(2014) Vivek Gupta et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

BDNF impairment is associated with age-related changes in the inner retina and exacerbates experimental glaucoma

(2014) Vivek Gupta et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Dysregulation of TrkB Receptors and BDNF Function by Amyloid-β Peptide is Mediated by Calpain

(2014) André Jerónimo-Santos et al.   CEREBRAL CORTEX

Amyloid-β Pathology andAPOEGenotype Modulate Retinoid X Receptor Agonist Activityin Vivo

(2014) Leon M. Tai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ocular-specific ER stress reduction rescues glaucoma in murine glucocorticoid-induced glaucoma

(2014) Gulab S. Zode et al.   JOURNAL OF CLINICAL INVESTIGATION

Reversal of apoE4-Driven Brain Pathology and Behavioral Deficits by Bexarotene

(2014) A. Boehm-Cagan et al.   JOURNAL OF NEUROSCIENCE

Ligand Binding Shifts Highly Mobile Retinoid X Receptor to the Chromatin-Bound State in a Coactivator-Dependent Manner, as Revealed by Single-Cell Imaging

(2014) P. Brazda et al.   MOLECULAR AND CELLULAR BIOLOGY

Bexarotene reduces network excitability in models of Alzheimer's disease and epilepsy

(2014) Valerie Bomben et al.   NEUROBIOLOGY OF AGING

Post-Injury Treatment with 7,8-Dihydroxyflavone, a TrkB Receptor Agonist, Protects against Experimental Traumatic Brain Injury via PI3K/Akt Signaling

(2014) Chun-Hu Wu et al.   PLoS One

Low Dose Bexarotene Treatment Rescues Dopamine Neurons and Restores Behavioral Function in Models of Parkinson’s Disease

(2013) Krista McFarland et al.   ACS Chemical Neuroscience

Activation of the endoplasmic reticulum stress response by the amyloid-beta 1–40 peptide in brain endothelial cells

(2013) Ana Catarina R.G. Fonseca et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

TrkB Receptor Signalling: Implications in Neurodegenerative, Psychiatric and Proliferative Disorders

(2013) Vivek Gupta et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The Role of  -Amyloid in Alzheimer's Disease-Related Neurodegeneration

(2013) M. R. Goldsworthy et al.   JOURNAL OF NEUROSCIENCE

Upregulation of CHOP/GADD153 during Coronavirus Infectious Bronchitis Virus Infection Modulates Apoptosis by Restricting Activation of the Extracellular Signal-Regulated Kinase Pathway

(2013) Y. Liao et al.   JOURNAL OF VIROLOGY

In vivo measurement of apolipoprotein E from the brain interstitial fluid using microdialysis

(2013) Jason D Ulrich et al.   Molecular Neurodegeneration

Treatment with bexarotene, a compound that increases apolipoprotein-E, provides no cognitive benefit in mutant APP/PS1 mice

(2013) Katherine D LaClair et al.   Molecular Neurodegeneration

Why Alzheimer trials fail: removing soluble oligomeric beta amyloid is essential, inconsistent, and difficult

(2013) William I. Rosenblum   NEUROBIOLOGY OF AGING

7,8-Dihydroxyflavone Prevents Synaptic Loss and Memory Deficits in a Mouse Model of Alzheimer’s Disease

(2013) Zhentao Zhang et al.   NEUROPSYCHOPHARMACOLOGY

Comment on "ApoE-Directed Therapeutics Rapidly Clear  -Amyloid and Reverse Deficits in AD Mouse Models"

(2013) N. F. Fitz et al.   SCIENCE

Comment on "ApoE-Directed Therapeutics Rapidly Clear  -Amyloid and Reverse Deficits in AD Mouse Models"

(2013) I. Tesseur et al.   SCIENCE

Comment on "ApoE-Directed Therapeutics Rapidly Clear  -Amyloid and Reverse Deficits in AD Mouse Models"

(2013) K. Veeraraghavalu et al.   SCIENCE

Comment on "ApoE-Directed Therapeutics Rapidly Clear  -Amyloid and Reverse Deficits in AD Mouse Models"

(2013) A. R. Price et al.   SCIENCE

The unfolded protein response in Alzheimer’s disease

(2013) Víctor Hugo Cornejo et al.   Seminars in Immunopathology

Reactive oxygen species-mediated endoplasmic reticulum stress contributes to aldosterone-induced apoptosis in tubular epithelial cells

(2012) Wei Ding et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Stimulation of the Retinoid X Receptor Facilitates Beta-Amyloid Clearance Across the Blood–Brain Barrier

(2012) Corbin Bachmeier et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Protective Effects of 7,8-Dihydroxyflavone on Retinal Ganglion and RGC-5 Cells Against Excitotoxic and Oxidative Stress

(2012) Vivek K. Gupta et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Vorinostat combined with bexarotene for treatment of cutaneous T-cell lymphoma:in vitroand phase I clinical evidence supporting augmentation of retinoic acid receptor/retinoid X receptor activation by histone deacetylase inhibition

(2012) Reinhard Dummer et al.   LEUKEMIA & LYMPHOMA

ApoE-Directed Therapeutics Rapidly Clear  -Amyloid and Reverse Deficits in AD Mouse Models

(2012) P. E. Cramer et al.   SCIENCE

Nuclear receptors as therapeutic targets for Alzheimer's disease

(2011) Shweta Mandrekar-Colucci et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Integrating the mechanisms of apoptosis induced by endoplasmic reticulum stress

(2011) Ira Tabas et al.   NATURE CELL BIOLOGY

Plasma apolipoprotein E and Alzheimer disease risk: The AIBL study of aging

(2011) V. B. Gupta et al.   NEUROLOGY

7,8-Dihydroxyflavone, a Small-Molecule TrkB Agonist, Reverses Memory Deficits and BACE1 Elevation in a Mouse Model of Alzheimer's Disease

(2011) Latha Devi et al.   NEUROPSYCHOPHARMACOLOGY

Alzheimer's disease: clinical trials and drug development

(2010) Francesca Mangialasche et al.   LANCET NEUROLOGY

Identification of amyloid plaques in retinas from Alzheimer's patients and noninvasive in vivo optical imaging of retinal plaques in a mouse model

(2010) Maya Koronyo-Hamaoui et al.   NEUROIMAGE

Cyclotraxin-B, the First Highly Potent and Selective TrkB Inhibitor, Has Anxiolytic Properties in Mice

(2010) Maxime Cazorla et al.   PLoS One

Retinoid X receptors: common heterodimerization partners with distinct functions

(2010) Philippe Lefebvre et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Neuroprotective effects of brain-derived neurotrophic factor in rodent and primate models of Alzheimer's disease

(2009) Alan H Nagahara et al.   NATURE MEDICINE

TrkB signalling pathways in LTP and learning

(2009) Liliana Minichiello   NATURE REVIEWS NEUROSCIENCE

STI571 prevents apoptosis, tau phosphorylation and behavioural impairments induced by Alzheimer's β-amyloid deposits

(2008) Gonzalo I. Cancino et al.   BRAIN

Retinoic Acid Attenuates  -Amyloid Deposition and Rescues Memory Deficits in an Alzheimer's Disease Transgenic Mouse Model

(2008) Y. Ding et al.   JOURNAL OF NEUROSCIENCE

Retinoid Hyposignaling Contributes to Aging-Related Decline in Hippocampal Function in Short-Term/Working Memory Organization and Long-Term Declarative Memory Encoding in Mice

(2008) F. Mingaud et al.   JOURNAL OF NEUROSCIENCE

Long-term effects of Aβ42 immunisation in Alzheimer's disease: follow-up of a randomised, placebo-controlled phase I trial

(2008) Clive Holmes et al.   LANCET

Neuroprotection by NGF and BDNF Against Neurotoxin-Exerted Apoptotic Death in Neural Stem Cells Are Mediated Through Trk Receptors, Activating PI3-Kinase and MAPK Pathways

(2008) Nga Nguyen et al.   NEUROCHEMICAL RESEARCH