TrkB Receptor Signalling: Implications in Neurodegenerative, Psychiatric and Proliferative Disorders

Optic neuropathies: characteristic features and mechanisms of retinal ganglion cell loss

(2013) Yuyi You et al.   REVIEWS IN THE NEUROSCIENCES

Shp-2 regulates the TrkB receptor activity in the retinal ganglion cells under glaucomatous stress

(2012) Vivek K. Gupta et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Neuroprotective Strategies for the Treatment of Inherited Photoreceptor Degeneration

(2012) D. Trifunovic et al.   CURRENT MOLECULAR MEDICINE

Truncated TrkB: Beyond a dominant negative receptor

(2012) Barbara M. Fenner   CYTOKINE & GROWTH FACTOR REVIEWS

Stimulation of the neurotrophin receptor TrkB on astrocytes drives nitric oxide production and neurodegeneration

(2012) Emanuela Colombo et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Protective Effects of 7,8-Dihydroxyflavone on Retinal Ganglion and RGC-5 Cells Against Excitotoxic and Oxidative Stress

(2012) Vivek K. Gupta et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Vagal Nerve Stimulation Rapidly Activates Brain-Derived Neurotrophic Factor Receptor TrkB in Rat Brain

(2012) Havan Furmaga et al.   PLoS One

N-acetyl serotonin derivatives as potent neuroprotectants for retinas

(2012) J. Shen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neurotrophic Tyrosine Kinase Receptor B/Neurotrophin 4 Signaling Axis Is Perturbed in Clinical and Experimental Pulmonary Fibrosis

(2011) Sibel Avcuoglu et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

The effect of P75 on Trk receptors in neuroblastomas

(2011) Ruth Ho et al.   CANCER LETTERS

Neurotrophins Acting Via TRKB Receptors Activate the JAGGED1-NOTCH2 Cell-Cell Communication Pathway to Facilitate Early Ovarian Development

(2011) Mauricio D. Dorfman et al.   ENDOCRINOLOGY

Glucocorticoid suppresses BDNF-stimulated MAPK/ERK pathway via inhibiting interaction of Shp2 with TrkB

(2011) Emi Kumamaru et al.   FEBS LETTERS

Tyrosine kinase B protein expression is reduced in the cerebellum of patients with bipolar disorder

(2011) Benchawanna Soontornniyomkij et al.   JOURNAL OF AFFECTIVE DISORDERS

7,8-dihydroxyflavone exhibits therapeutic efficacy in a mouse model of Rett syndrome

(2011) Rebecca A. Johnson et al.   JOURNAL OF APPLIED PHYSIOLOGY

TrkB and Protein Kinase M   Regulate Synaptic Localization of PSD-95 in Developing Cortex

(2011) A. Yoshii et al.   JOURNAL OF NEUROSCIENCE

Decreased BDNF, trkB-TK+ and GAD67 mRNA expression in the hippocampus of individuals with schizophrenia and mood disorders

(2011) Mia Thompson Ray   JOURNAL OF PSYCHIATRY & NEUROSCIENCE

Phosphorylated Grb14 Is an Endogenous Inhibitor of Retinal Protein Tyrosine Phosphatase 1B, and Light-Dependent Activation of Src Phosphorylates Grb14

(2011) D. K. Basavarajappa et al.   MOLECULAR AND CELLULAR BIOLOGY

The novel TrkB receptor agonist 7,8-dihydroxyflavone enhances neuromuscular transmission

(2011) Carlos B. Mantilla et al.   MUSCLE & NERVE

Acetylcholinesterase inhibitors rapidly activate Trk neurotrophin receptors in the mouse hippocampus

(2011) Henri Autio et al.   NEUROPHARMACOLOGY

7,8-Dihydroxyflavone, a Small-Molecule TrkB Agonist, Reverses Memory Deficits and BACE1 Elevation in a Mouse Model of Alzheimer's Disease

(2011) Latha Devi et al.   NEUROPSYCHOPHARMACOLOGY

Antidepressant Drugs Transactivate TrkB Neurotrophin Receptors in the Adult Rodent Brain Independently of BDNF and Monoamine Transporter Blockade

(2011) Tomi Rantamäki et al.   PLoS One

Brain-Derived Neurotrophic Factor in Patients with Huntington's Disease

(2011) Chiara Zuccato et al.   PLoS One

Expression of brain-derived neurotrophic factor and TrkB receptor in the sudden infant death syndrome brainstem

(2011) Samantha Tang et al.   RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY

Glia- and neuron-specific functions of TrkB signalling during retinal degeneration and regeneration

(2011) Chikako Harada et al.   Nature Communications

A Deletion in Tropomyosin-Related Kinase B and the Development of Human Anxiety

(2010) Carl Ernst et al.   BIOLOGICAL PSYCHIATRY

TrkB is highly expressed in NSCLC and mediates BDNF-induced the activation of Pyk2 signaling and the invasion of A549 cells

(2010) Siyang Zhang et al.   BMC CANCER

Lentiviral shRNA silencing of BDNF inhibitsin vivomultiple myeloma growth and angiogenesis via down-regulated stroma-derived VEGF expression in the bone marrow milieu

(2010) Lu Zhang et al.   CANCER SCIENCE

Inhibition of Brain-Derived Neurotrophic Factor/Tyrosine Kinase B Signaling Suppresses Choriocarcinoma Cell Growth

(2010) Nanami Kawamura et al.   ENDOCRINOLOGY

LINGO-1 negatively regulates TrkB phosphorylation after ocular hypertension

(2010) Qing-Ling Fu et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Chronic deprivation of TrkB signaling leads to selective late-onset nigrostriatal dopaminergic degeneration

(2010) Maryna Baydyuk et al.   EXPERIMENTAL NEUROLOGY

Neurotrophic factors in Alzheimer’s disease: role of axonal transport

(2010) K. Schindowski et al.   GENES BRAIN AND BEHAVIOR

Increased BDNF levels and NTRK2 gene association suggest a disruption of BDNF/TrkB signaling in autism

(2010) C. T. Correia et al.   GENES BRAIN AND BEHAVIOR

K252a induces anoikis-sensitization with suppression of cellular migration in Epstein-Barr Virus (EBV)—associated nasopharyngeal carcinoma cells

(2010) Yuen-Keng Ng et al.   INVESTIGATIONAL NEW DRUGS

Small molecule BDNF mimetics activate TrkB signaling and prevent neuronal degeneration in rodents

(2010) Stephen M. Massa et al.   JOURNAL OF CLINICAL INVESTIGATION

A Synthetic 7,8-Dihydroxyflavone Derivative Promotes Neurogenesis and Exhibits Potent Antidepressant Effect

(2010) Xia Liu et al.   JOURNAL OF MEDICINAL CHEMISTRY

The Studies on the Correlation for Gene Expression of Tyrosine-kinase Receptors and Vascular Endothelial Growth Factor in Human Neuroblastomas

(2010) Jihong Zhang et al.   JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY

BDNF and TrkB in neuronal differentiation of Fmr1-knockout mouse

(2010) Verna Louhivuori et al.   NEUROBIOLOGY OF DISEASE

Lowering Corticosterone Levels Reinstates Hippocampal Brain-Derived Neurotropic Factor and Trkb Expression without Influencing Deficits in Hypothalamic Brain-Derived Neurotropic Factor Expression in Leptin Receptor-Deficient Mice

(2010) Alexis M. Stranahan et al.   NEUROENDOCRINOLOGY

TrkB induces EMT and has a key role in invasion of head and neck squamous cell carcinoma

(2010) M E Kupferman et al.   ONCOGENE

Placental BDNF/TrkB Signaling System is Modulated by Fetal Growth Disturbances in Rat and Human

(2010) S. Mayeur et al.   PLACENTA

Deoxygedunin, a Natural Product with Potent Neurotrophic Activity in Mice

(2010) Sung-Wuk Jang et al.   PLoS One

Higher serum tropomyosin-related kinase B protein level in major depression

(2010) Yi-Yung Hung et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Dendrite plasticity in the lateral geniculate nucleus in primate glaucoma

(2010) Tina Ly et al.   VISION RESEARCH

Tyrosine kinase B receptor and BDNF expression in ovarian cancers – Effect on cell migration, angiogenesis and clinical outcome

(2009) Christy W.H. Au et al.   CANCER LETTERS

Trk Receptor Expression and Inhibition in Neuroblastomas

(2009) G. M. Brodeur et al.   CLINICAL CANCER RESEARCH

TrkB-T1 Receptors on Muller Cells Play Critical Role in Brain-Derived Neurotrophic Factor-Mediated Photoreceptor Protection against Phototoxicity

(2009) Takae Saito et al.   CURRENT EYE RESEARCH

Neurotrophin roles in retinal ganglion cell survival: Lessons from rat glaucoma models

(2009) Elaine C. Johnson et al.   EXPERIMENTAL EYE RESEARCH

TrkB as a therapeutic target for ovarian cancer

(2009) Michelle KY Siu et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Markers of ınflammatıon and thrombın generatıon: Addıtıonal guıdes ın determınıng the therapeutıc strategy for malıgn ventrıcular arrhythmıas after an acute myocardıal ınfarctıon?

(2009) Kenan Yalta et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Mixed Lineage Kinase Phosphorylates Transcription Factor E47 and Inhibits TrkB Expression to Link Neuronal Death and Survival Pathways

(2009) Neus Pedraza et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TrkB Signaling Is Required for Both the Induction and Maintenance of Tissue and Nerve Injury-Induced Persistent Pain

(2009) X. Wang et al.   JOURNAL OF NEUROSCIENCE

Brain-Derived Neurotrophic Factor Controls Activity-Dependent Maturation of CA1 Synapses by Downregulating Tonic Activationof Presynaptic Kainate Receptors

(2009) M. Sallert et al.   JOURNAL OF NEUROSCIENCE

Neurotrophic receptor, tropomyosin-related kinase B as an independent prognostic marker in gastric cancer patients

(2009) Koji Tanaka et al.   JOURNAL OF SURGICAL ONCOLOGY

TrkB signalling pathways in LTP and learning

(2009) Liliana Minichiello   NATURE REVIEWS NEUROSCIENCE

The lamellar cells in human Meissner corpuscles express TrkB

(2009) M.G. Calavia et al.   NEUROSCIENCE LETTERS

Gene–Gene Interactions of the Brain-Derived Neurotrophic-Factor and Neurotrophic Tyrosine Kinase Receptor 2 Genes in Geriatric Depression

(2009) Eugene Lin et al.   REJUVENATION RESEARCH

Design of a Conformationally Defined and Proteolytically Stable Circular Mimetic of Brain-derived Neurotrophic Factor

(2008) Jordan M. Fletcher et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Controlled contusion injury alters molecular systems associated with cognitive performance

(2008) Grace Sophia Griesbach et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Brain-derived neurotrophic factor enhances the excitability of rat sensory neurons through activation of the p75 neurotrophin receptor and the sphingomyelin pathway

(2008) Y. H. Zhang et al.   JOURNAL OF PHYSIOLOGY-LONDON

Higher expression of BDNF receptor gp145trkB is associated with lower apoptosis intensity in T cell lines in multiple sclerosis

(2008) Lorenzo De Santi et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Retinal TrkB receptors regulate neural development in the inner, but not outer, retina

(2008) Ruslan N. Grishanin et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

The molecular neurobiology of depression

(2008) Vaishnav Krishnan et al.   NATURE

Protective effect of BDNF against beta-amyloid induced neurotoxicity in vitro and in vivo in rats

(2008) S. Arancibia et al.   NEUROBIOLOGY OF DISEASE

TrkB Regulates Hippocampal Neurogenesis and Governs Sensitivity to Antidepressive Treatment

(2008) Yun Li et al.   NEURON

A Cross-Talk between TrkB and Ret Tyrosine Kinases Receptors Mediates Neuroblastoma Cells Differentiation

(2008) Carla Lucia Esposito et al.   PLoS One

Genetic Association of Neurotrophic Tyrosine Kinase Receptor Type 2 (NTRK2) With Alzheimer's Disease

(2007) Zuomin Chen et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS

TrkB Agonists Ameliorate Obesity and Associated Metabolic Conditions in Mice

(2007) David Tsao et al.   ENDOCRINOLOGY