Molecular Mechanisms of Drug Tolerance in Mycobacterium tuberculosis

Confocal microscopy imaging of the biofilm matrix

(2017) Sebastian Schlafer et al.   JOURNAL OF MICROBIOLOGICAL METHODS

Parallel reaction monitoring of clinical Mycobacterium tuberculosis lineages reveals pre-existent markers of rifampicin tolerance in the emerging Beijing lineage

(2017) Jeroen de Keijzer et al.   Journal of Proteomics

Cmr is a redox-responsive regulator of DosR that contributes to M. tuberculosis virulence

(2017) Laura J. Smith et al.   NUCLEIC ACIDS RESEARCH

Rifamycin action on RNA polymerase in antibiotic-tolerantMycobacterium tuberculosisresults in differentially detectable populations

(2017) Kohta Saito et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Antibiotic tolerance facilitates the evolution of resistance

(2017) Irit Levin-Reisman et al.   SCIENCE

Sustained expression of DevR/DosR during long-term hypoxic culture of Mycobacterium tuberculosis

(2017) Priyanka Kumari et al.   TUBERCULOSIS

Down-regulation of malate synthase in Mycobacterium tuberculosis H37Ra leads to reduced stress tolerance, persistence and survival in macrophages

(2017) Kumar Sachin Singh et al.   TUBERCULOSIS

The Capacity of Mycobacterium tuberculosis To Survive Iron Starvation Might Enable It To Persist in Iron-Deprived Microenvironments of Human Granulomas

(2017) Krishna Kurthkoti et al.   mBio

Rv3723/LucA coordinates fatty acid and cholesterol uptake in Mycobacterium tuberculosis

(2017) Evgeniya V Nazarova et al.   eLife

Mycobacterial Dormancy Systems and Host Responses in Tuberculosis

(2017) Vidyullatha Peddireddy et al.   Frontiers in Immunology

Co-expression network analysis of toxin-antitoxin loci in Mycobacterium tuberculosis reveals key modulators of cellular stress

(2017) Amita Gupta et al.   Scientific Reports

Delayed effects of transcriptional responses in Mycobacterium tuberculosis exposed to nitric oxide suggest other mechanisms involved in survival

(2017) Teresa Cortes et al.   Scientific Reports

Stringent Response Factors PPX1 and PPK2 Play an Important Role in Mycobacterium tuberculosis Metabolism, Biofilm Formation, and Sensitivity to IsoniazidIn Vivo

(2016) Yu-Min Chuang et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Profiling persistent tubercule bacilli from patient sputa during therapy predicts early drug efficacy

(2016) Isobella Honeyborne et al.   BMC Medicine

Chewing the fat: lipid metabolism and homeostasis during M. tuberculosis infection

(2016) Rustin R Lovewell et al.   CURRENT OPINION IN MICROBIOLOGY

Mycobacterium tuberculosis Transcription Machinery: Ready To Respond to Host Attacks

(2016) Kelly Flentie et al.   JOURNAL OF BACTERIOLOGY

Elucidating population-wide mycobacterial replication dynamics at the single-cell level

(2016) Jacoba M. Mouton et al.   MICROBIOLOGY-SGM

σE-dependent activation of RbpA controls transcription of thefurA-katGoperon in response to oxidative stress in mycobacteria

(2016) Yangbo Hu et al.   MOLECULAR MICROBIOLOGY

Distinguishing between resistance, tolerance and persistence to antibiotic treatment

(2016) Asher Brauner et al.   NATURE REVIEWS MICROBIOLOGY

VapCs of Mycobacterium tuberculosis cleave RNAs essential for translation

(2016) Kristoffer Winther et al.   NUCLEIC ACIDS RESEARCH

tRNA is a new target for cleavage by a MazF toxin

(2016) Jason M. Schifano et al.   NUCLEIC ACIDS RESEARCH

70S-scanning initiation is a novel and frequent initiation mode of ribosomal translation in bacteria

(2016) Hiroshi Yamamoto et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sequencing-relative to hybridization-based transcriptomics approaches better define Mycobacterium tuberculosis stress-response regulons

(2016) Ashley V. Veatch et al.   TUBERCULOSIS

Dual-Reporter Mycobacteriophages (Φ 2 DRMs) Reveal Preexisting Mycobacterium tuberculosis Persistent Cells in Human Sputum

(2016) Paras Jain et al.   mBio

Thiol reductive stress induces cellulose-anchored biofilm formation in Mycobacterium tuberculosis

(2016) Abhishek Trivedi et al.   Nature Communications

Eagle Effect in Nonreplicating Persister Mycobacteria

(2015) Mu-Lu Wu et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Phenotypic resistance in mycobacteria: is it because I am old or fat that I resist you?

(2015) Robert J. H. Hammond et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Transcriptional Adaptation of Drug-tolerantMycobacterium tuberculosisDuring Treatment of Human Tuberculosis

(2015) Nicholas D. Walter et al.   JOURNAL OF INFECTIOUS DISEASES

Genetic code flexibility in microorganisms: novel mechanisms and impact on physiology

(2015) Jiqiang Ling et al.   NATURE REVIEWS MICROBIOLOGY

A functional role of Rv1738 inMycobacterium tuberculosispersistence suggested by racemic protein crystallography

(2015) Richard D. Bunker et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Growth-regulating Mycobacterium tuberculosis VapC-mt4 toxin is an isoacceptor-specific tRNase

(2015) Jonathan W. Cruz et al.   Nature Communications

MazF ribonucleases promote Mycobacterium tuberculosis drug tolerance and virulence in guinea pigs

(2015) Prabhakar Tiwari et al.   Nature Communications

Molecular Mechanisms Underlying Bacterial Persisters

(2014) Etienne Maisonneuve et al.   CELL

Quorum sensing and biofilm formation in mycobacteria: Role of c-di-GMP and methods to study this second messenger

(2014) Indra Mani Sharma et al.   IUBMB LIFE

Optimization of lag time underlies antibiotic tolerance in evolved bacterial populations

(2014) Ofer Fridman et al.   NATURE

Mycobacterium RbpA cooperates with the stress-response σB subunit of RNA polymerase in promoter DNA unwinding

(2014) Yangbo Hu et al.   NUCLEIC ACIDS RESEARCH

Replication Rates of Mycobacterium tuberculosis in Human Macrophages Do Not Correlate with Mycobacterial Antibiotic Susceptibility

(2014) Johanna Raffetseder et al.   PLoS One

Mycobacterial mistranslation is necessary and sufficient for rifampicin phenotypic resistance

(2014) B. Javid et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Latent tuberculosis infection: What we know about its genetic control?

(2014) Tatiana Kondratieva et al.   TUBERCULOSIS

Isocitrate lyase mediates broad antibiotic tolerance in Mycobacterium tuberculosis

(2014) Madhumitha Nandakumar et al.   Nature Communications

Reduced Drug Uptake in Phenotypically Resistant Nutrient-Starved Nonreplicating Mycobacterium tuberculosis

(2013) Jansy Sarathy et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Aminoglycoside Cross-Resistance in Mycobacterium tuberculosis Due to Mutations in the 5′ Untranslated Region ofwhiB7

(2013) Analise Z. Reeves et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

RETRACTED: (p)ppGpp Controls Bacterial Persistence by Stochastic Induction of Toxin-Antitoxin Activity

(2013) Etienne Maisonneuve et al.   CELL

The Normalcy of Dormancy: Common Themes in Microbial Quiescence

(2013) Emily S.C. Rittershaus et al.   Cell Host & Microbe

Proteomic Profiling ofMycobacterium tuberculosisIdentifies Nutrient-starvation-responsive Toxin–antitoxin Systems

(2013) Jakob Albrethsen et al.   MOLECULAR & CELLULAR PROTEOMICS

Multifunctional essentiality of succinate metabolism in adaptation to hypoxia in Mycobacterium tuberculosis

(2013) H. Eoh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dynamic Persistence of Antibiotic-Stressed Mycobacteria

(2013) Y. Wakamoto et al.   SCIENCE

The Polyphosphate Kinase Gene ppk2 Is Required for Mycobacterium tuberculosis Inorganic Polyphosphate Regulation and Virulence

(2013) Y.-M. Chuang et al.   mBio

VapC20 of Mycobacterium tuberculosis cleaves the Sarcin–Ricin loop of 23S rRNA

(2013) Kristoffer S. Winther et al.   Nature Communications

Genome-wide Mapping of Transcriptional Start Sites Defines an Extensive Leaderless Transcriptome in Mycobacterium tuberculosis

(2013) Teresa Cortes et al.   Cell Reports

The Dormancy Regulator DosR Controls Ribosome Stability in Hypoxic Mycobacteria

(2012) Andrej Trauner et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Global analysis of mRNA stability in Mycobacterium tuberculosis

(2012) Tige R. Rustad et al.   NUCLEIC ACIDS RESEARCH

Comprehensive analysis of methods used for the evaluation of compounds against Mycobacterium tuberculosis

(2012) Scott G. Franzblau et al.   TUBERCULOSIS

Drug Tolerance in Replicating Mycobacteria Mediated by a Macrophage-Induced Efflux Mechanism

(2011) Kristin N. Adams et al.   CELL

Selective Translation of Leaderless mRNAs by Specialized Ribosomes Generated by MazF in Escherichia coli

(2011) Oliver Vesper et al.   CELL

The Polyketide Pks1 Contributes to Biofilm Formation in Mycobacterium tuberculosis

(2011) J. M. Pang et al.   JOURNAL OF BACTERIOLOGY

The Mycobacterial Transcriptional RegulatorwhiB7Gene Links Redox Homeostasis and Intrinsic Antibiotic Resistance

(2011) Ján Burian et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

RtcB, a Novel RNA Ligase, Can Catalyze tRNA Splicing andHAC1mRNA Splicingin Vivo

(2011) Naoko Tanaka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The challenge of new drug discovery for tuberculosis

(2011) Anil Koul et al.   NATURE

Unusual regioversatility of acetyltransferase Eis, a cause of drug resistance in XDR-TB

(2011) W. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bacterial persistence by RNA endonucleases

(2011) Etienne Maisonneuve et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Metabolic Regulation of Mycobacterial Growth and Antibiotic Sensitivity

(2011) Seung-Hun Baek et al.   PLOS BIOLOGY

Fumarate Reductase Activity Maintains an Energized Membrane in Anaerobic Mycobacterium tuberculosis

(2011) Shinya Watanabe et al.   PLoS Pathogens

Human Antimicrobial Peptide LL-37 Induces MefE/Mel-Mediated Macrolide Resistance in Streptococcus pneumoniae

(2010) D. Zahner et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Toxin–antitoxin systems: why so many, what for?

(2010) Laurence Van Melderen   CURRENT OPINION IN MICROBIOLOGY

Caseation of human tuberculosis granulomas correlates with elevated host lipid metabolism

(2010) Mi-Jeong Kim et al.   EMBO Molecular Medicine

Carbon flux rerouting during Mycobacterium tuberculosis growth arrest

(2010) Lanbo Shi et al.   MOLECULAR MICROBIOLOGY

Functional roles for noise in genetic circuits

(2010) Avigdor Eldar et al.   NATURE

The Mycobacterium tuberculosis protein LdtMt2 is a nonclassical transpeptidase required for virulence and resistance to amoxicillin

(2010) Radhika Gupta et al.   NATURE MEDICINE

The biofilm matrix

(2010) Hans-Curt Flemming et al.   NATURE REVIEWS MICROBIOLOGY

Mycobacterium tuberculosis persistence mutants identified by screening in isoniazid-treated mice

(2010) N. Dhar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Resuscitation-promoting Factors Reveal an Occult Population of Tubercle Bacilli in Sputum

(2009) Galina V. Mukamolova et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

The sigma factors of Mycobacterium tuberculosis: regulation of the regulators

(2009) Preeti Sachdeva et al.   FEBS Journal

Phosphate Depletion: A Novel Trigger forMycobacterium tuberculosisPersistence

(2009) Dalin Rifat et al.   JOURNAL OF INFECTIOUS DISEASES

Role of an RNA polymerase interacting protein, MsRbpA, from Mycobacterium smegmatis in phenotypic tolerance to rifampicin

(2009) A. Dey et al.   MICROBIOLOGY-SGM

A replication clock for Mycobacterium tuberculosis

(2009) Wendy P Gill et al.   NATURE MEDICINE

Non-genetic heterogeneity — a mutation-independent driving force for the somatic evolution of tumours

(2009) Amy Brock et al.   NATURE REVIEWS GENETICS

A Novel In Vitro Multiple-Stress Dormancy Model for Mycobacterium tuberculosis Generates a Lipid-Loaded, Drug-Tolerant, Dormant Pathogen

(2009) Chirajyoti Deb et al.   PLoS One

Comprehensive Functional Analysis of Mycobacterium tuberculosis Toxin-Antitoxin Systems: Implications for Pathogenesis, Stress Responses, and Evolution

(2009) Holly R. Ramage et al.   PLoS Genetics

Tuberculous Granulomas Are Hypoxic in Guinea Pigs, Rabbits, and Nonhuman Primates

(2008) L. E. Via et al.   INFECTION AND IMMUNITY

The Peptidoglycan of Stationary-Phase Mycobacterium tuberculosis Predominantly Contains Cross-Links Generated by L,D-Transpeptidation

(2008) M. Lavollay et al.   JOURNAL OF BACTERIOLOGY

Growth ofMycobacterium tuberculosisbiofilms containing free mycolic acids and harbouring drug-tolerant bacteria

(2008) Anil K. Ojha et al.   MOLECULAR MICROBIOLOGY

DnaA protein interacts with RNA polymerase and partially protects it from the effect of rifampicin

(2008) Ingvild Flåtten et al.   MOLECULAR MICROBIOLOGY

The Enduring Hypoxic Response of Mycobacterium tuberculosis

(2008) Tige R. Rustad et al.   PLoS One

Mycobacterial persistence requires the utilization of host cholesterol

(2008) A. K. Pandey et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cytological and Transcript Analyses Reveal Fat and Lazy Persister-Like Bacilli in Tuberculous Sputum

(2008) Natalie J Garton et al.   PLOS MEDICINE