Rv3723/LucA coordinates fatty acid and cholesterol uptake in Mycobacterium tuberculosis

Unravelling the pleiotropic role of the MceGATPase in M ycobacterium smegmatis

(2017) Julia García-Fernández et al.   ENVIRONMENTAL MICROBIOLOGY

How to move an amphipathic molecule across a lipid bilayer: different mechanisms for different ABC transporters?

(2016) F. L. Theodoulou et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

pqiABC and yebST , Putative mce Operons of Escherichia coli, Encode Transport Pathways and Contribute to Membrane Integrity

(2016) Takayuki Nakayama et al.   JOURNAL OF BACTERIOLOGY

The Structure of the Transcriptional Repressor KstR in Complex with CoA Thioester Cholesterol Metabolites Sheds Light on the Regulation of Cholesterol Catabolism inMycobacterium tuberculosis

(2016) Ngoc Anh Thu Ho et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Immune activation of the host cell induces drug tolerance inMycobacterium tuberculosisboth in vitro and in vivo

(2016) Yancheng Liu et al.   JOURNAL OF EXPERIMENTAL MEDICINE

An orphaned Mce-associated membrane protein ofMycobacterium tuberculosisis a virulence factor that stabilizes Mce transporters

(2016) Ellen Foot Perkowski et al.   MOLECULAR MICROBIOLOGY

Disruption of lipid homeostasis in the Gram-negative cell envelope activates a novel cell death pathway

(2016) Holly A. Sutterlin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Defining key roles for auxiliary proteins in an ABC transporter that maintains bacterial outer membrane lipid asymmetry

(2016) Shuhua Thong et al.   eLife

The Essential Role of Cholesterol Metabolism in the Intracellular Survival of Mycobacterium leprae Is Not Coupled to Central Carbon Metabolism and Energy Production

(2015) Maria Angela M. Marques et al.   JOURNAL OF BACTERIOLOGY

Label-free Quantitative Proteomics Reveals a Role for theMycobacterium tuberculosisSecA2 Pathway in Exporting Solute Binding Proteins and Mce Transporters to the Cell Wall

(2015) Meghan E. Feltcher et al.   MOLECULAR & CELLULAR PROTEOMICS

The Phyre2 web portal for protein modeling, prediction and analysis

(2015) Lawrence A Kelley et al.   Nature Protocols

Novel Inhibitors of Cholesterol Degradation in Mycobacterium tuberculosis Reveal How the Bacterium’s Metabolism Is Constrained by the Intracellular Environment

(2015) Brian C. VanderVen et al.   PLoS Pathogens

Biosynthesis of mycobacterial lipids by polyketide synthases and beyond

(2014) Luis E. N. Quadri   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Methylcitrate cycle defines the bactericidal essentiality of isocitrate lyase for survival ofMycobacterium tuberculosison fatty acids

(2014) Hyungjin Eoh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role of the Mce1 transporter in the lipid homeostasis of Mycobacterium tuberculosis

(2014) Marina Andrea Forrellad et al.   TUBERCULOSIS

Exploitation of Mycobacterium tuberculosis Reporter Strains to Probe the Impact of Vaccination at Sites of Infection

(2014) Neelima Sukumar et al.   PLoS Pathogens

IntracellularMycobacterium tuberculosisExploits Host-derived Fatty Acids to Limit Metabolic Stress

(2013) Wonsik Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Free mycolic acid accumulation in the cell wall of the mce1 operon mutant strain of Mycobacterium tuberculosis

(2013) Sally A. Cantrell et al.   JOURNAL OF MICROBIOLOGY

Infection of macrophages withMycobacterium tuberculosisinduces global modifications to phagosomal function

(2012) Maria Podinovskaia et al.   CELLULAR MICROBIOLOGY

Cholesterol Catabolism by Mycobacterium tuberculosis Requires Transcriptional and Metabolic Adaptations

(2012) Jennifer E. Griffin et al.   CHEMISTRY & BIOLOGY

A Novel Role of the PrpR as a Transcription Factor Involved in the Regulation of Methylcitrate Pathway in Mycobacterium tuberculosis

(2012) Paweł Masiewicz et al.   PLoS One

Magnesium depletion triggers production of an immune modulating diterpenoid in Mycobacterium tuberculosis

(2011) Francis M. Mann et al.   MOLECULAR MICROBIOLOGY

aprABC: a Mycobacterium tuberculosis complex-specific locus that modulates pH-driven adaptation to the macrophage phagosome

(2011) Robert B. Abramovitch et al.   MOLECULAR MICROBIOLOGY

Arabidopsis chloroplast lipid transport protein TGD2 disrupts membranes and is part of a large complex

(2011) Rebecca Roston et al.   PLANT JOURNAL

Central carbon metabolism in Mycobacterium tuberculosis: an unexpected frontier

(2011) Kyu Y. Rhee et al.   TRENDS IN MICROBIOLOGY

Metabolic Regulation of Mycobacterial Growth and Antibiotic Sensitivity

(2011) Seung-Hun Baek et al.   PLOS BIOLOGY

High-Resolution Phenotypic Profiling Defines Genes Essential for Mycobacterial Growth and Cholesterol Catabolism

(2011) Jennifer E. Griffin et al.   PLoS Pathogens

Mycobacterium tuberculosis Uses Host Triacylglycerol to Accumulate Lipid Droplets and Acquires a Dormancy-Like Phenotype in Lipid-Loaded Macrophages

(2011) Jaiyanth Daniel et al.   PLoS Pathogens

Mycobacterium tuberculosis Wears What It Eats

(2010) David G. Russell et al.   Cell Host & Microbe

Metabolomics of Mycobacterium tuberculosis Reveals Compartmentalized Co-Catabolism of Carbon Substrates

(2010) Luiz Pedro S. de Carvalho et al.   CHEMISTRY & BIOLOGY

Caseation of human tuberculosis granulomas correlates with elevated host lipid metabolism

(2010) Mi-Jeong Kim et al.   EMBO Molecular Medicine

A Flavin-dependent Monooxygenase fromMycobacterium tuberculosisInvolved in Cholesterol Catabolism

(2010) Carola Dresen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Gluconeogenic carbon flow of tricarboxylic acid cycle intermediates is critical for Mycobacterium tuberculosis to establish and maintain infection

(2010) J. Marrero et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cholesterol Metabolism Increases the Metabolic Pool of Propionate inMycobacterium tuberculosis

(2009) Xinxin Yang et al.   BIOCHEMISTRY

A Thiolase of Mycobacterium tuberculosis Is Required for Virulence and Production of Androstenedione and Androstadienedione from Cholesterol

(2009) N. M. Nesbitt et al.   INFECTION AND IMMUNITY

Mycobacterial Cytochrome P450 125 (Cyp125) Catalyzes the Terminal Hydroxylation of C27 Steroids

(2009) Jenna K. Capyk et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

3-Ketosteroid 9α-hydroxylase is an essential factor in the pathogenesis ofMycobacterium tuberculosis

(2009) Yanmin Hu et al.   MOLECULAR MICROBIOLOGY

An ABC transport system that maintains lipid asymmetry in the Gram-negative outer membrane

(2009) J. C. Malinverni et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Studies of a Ring-Cleaving Dioxygenase Illuminate the Role of Cholesterol Metabolism in the Pathogenesis of Mycobacterium tuberculosis

(2009) Katherine C. Yam et al.   PLoS Pathogens

Functional Characterization of a Vitamin B12-Dependent Methylmalonyl Pathway in Mycobacterium tuberculosis: Implications for Propionate Metabolism during Growth on Fatty Acids

(2008) S. Savvi et al.   JOURNAL OF BACTERIOLOGY

The Actinobacterialmce4Locus Encodes a Steroid Transporter

(2008) William W. Mohn et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lipid Trafficking between the Endoplasmic Reticulum and the Plastid in Arabidopsis Requires the Extraplastidic TGD4 Protein

(2008) C. Xu et al.   PLANT CELL

Mycobacterial persistence requires the utilization of host cholesterol

(2008) A. K. Pandey et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Foamy Macrophages from Tuberculous Patients' Granulomas Constitute a Nutrient-Rich Reservoir for M. tuberculosis Persistence

(2008) Pascale Peyron et al.   PLoS Pathogens