Heteronemin, a Marine Sesterterpenoid-Type Metabolite, Induces Apoptosis in Prostate LNcap Cells via Oxidative and ER Stress Combined with the Inhibition of Topoisomerase II and Hsp90

Topoisomerases as anticancer targets

(2018) Justine L. Delgado et al.   BIOCHEMICAL JOURNAL

The prognostic significance of topoisomerase II alpha protein in early stage luminal breast cancer

(2018) Xin An et al.   BMC CANCER

The Roles of Protein Tyrosine Phosphatases in Hepatocellular Carcinoma

(2018) Yide Huang et al.   Cancers

Cytotoxic Natural Products from Marine Sponge-Derived Microorganisms

(2017) Huawei Zhang et al.   Marine Drugs

HSP90 promotes cell glycolysis, proliferation and inhibits apoptosis by regulating PKM2 abundance via Thr-328 phosphorylation in hepatocellular carcinoma

(2017) Qiuran Xu et al.   Molecular Cancer

The HSP90 chaperone machinery

(2017) Florian H. Schopf et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Heat Shock Proteins and Cancer

(2017) Jianming Wu et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Luteolin selectively kills STAT3 highly activated gastric cancer cells through enhancing the binding of STAT3 to SHP-1

(2017) Shiyu Song et al.   Cell Death & Disease

Clinical, Prognostic and Therapeutic Significance of Heat Shock Proteins in Cancer

(2017) Jasleen Saini et al.   CURRENT DRUG TARGETS

Improvement and enhancement of antibladder carcinoma cell effects of heteronemin by the nanosized hyaluronan aggregation

(2016) Han Hsiang Huang et al.   International Journal of Nanomedicine

Heteronemin Is a Novel c-Met/STAT3 Inhibitor Against Advanced Prostate Cancer Cells

(2016) Jian-Ching Wu et al.   PROSTATE

Antileukemic Scalarane Sesterterpenoids and Meroditerpenoid from Carteriospongia (Phyllospongia) sp., Induce Apoptosis via Dual Inhibitory Effects on Topoisomerase II and Hsp90

(2016) Kuei-Hung Lai et al.   Scientific Reports

Investigation of the mechanism and apoptotic pathway induced by 4β cinnamido linked podophyllotoxins against human lung cancer cells A549

(2015) Ahmed Kamal et al.   APOPTOSIS

Alantolactone selectively suppresses STAT3 activation and exhibits potent anticancer activity in MDA-MB-231 cells

(2015) Jaemoo Chun et al.   CANCER LETTERS

Preparation of cis-γ-Hydroxycarvone Derivatives for Synthesis of Sesterterpenoid Natural Products: Total Synthesis of Phorbin A

(2015) Jonathan G. Hubert et al.   JOURNAL OF ORGANIC CHEMISTRY

Tackling the Cytotoxic Effect of a Marine Polycyclic Quinone-Type Metabolite: Halenaquinone Induces Molt 4 Cells Apoptosis via Oxidative Stress Combined with the Inhibition of HDAC and Topoisomerase Activities

(2015) Shou-Ping Shih et al.   Marine Drugs

Exploring the Existing Drug Space for Novel pTyr Mimetic and SHP2 Inhibitors

(2015) Rongjun He et al.   ACS Medicinal Chemistry Letters

Heteronemin, a Spongean Sesterterpene, Induces Cell Apoptosis and Autophagy in Human Renal Carcinoma Cells

(2015) Szu-Ying Wu et al.   Biomed Research International

Calcium Homeostasis and ER Stress in Control of Autophagy in Cancer Cells

(2015) Elżbieta Kania et al.   Biomed Research International

Stress Responses from the Endoplasmic Reticulum in Cancer

(2015) Hironori Kato et al.   Frontiers in Oncology

Cracking the Cytotoxicity Code: Apoptotic Induction of 10-Acetylirciformonin B is Mediated through ROS Generation and Mitochondrial Dysfunction

(2014) Huei-Chuan Shih et al.   Marine Drugs

Self-consumption: the interplay of autophagy and apoptosis

(2014) Guillermo Mariño et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Topoisomerase IIα in chromosome instability and personalized cancer therapy

(2014) T Chen et al.   ONCOGENE

In vitro characterisation of the anti-intravasative properties of the marine product heteronemin

(2013) Sabine Kopf et al.   ARCHIVES OF TOXICOLOGY

Cancer statistics, 2013

(2013) Rebecca Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

New Approaches to Prevent LEOPARD Syndrome-associated Cardiac Hypertrophy by Specifically Targeting Shp2-dependent Signaling

(2013) Christine Schramm et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Towards the Small and the Beautiful: A Small Dibromotyrosine Derivative from Pseudoceratina sp. Sponge Exhibits Potent Apoptotic Effect through Targeting IKK/NFκB Signaling Pathway

(2013) Jui-Hsin Su et al.   Marine Drugs

Role of Tyrosine Phosphatase Inhibitors in Cancer Treatment with Emphasis on SH2 Domain-Containing Tyrosine Phosphatases (SHPs)

(2012) Mahban Irandoust et al.   Anti-Cancer Agents in Medicinal Chemistry

Cytotoxic Sesterterpenoids from a Sponge Hippospongia sp.

(2012) Yu-Chia Chang et al.   Marine Drugs

Global cancer statistics

(2011) Ahmedin Jemal et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Marine natural products targeting phospholipases A2

(2010) Florence Folmer et al.   BIOCHEMICAL PHARMACOLOGY

Targeting Protein Tyrosine Phosphatases for Anticancer Drug Discovery

(2010) Latanya M. Scott et al.   CURRENT PHARMACEUTICAL DESIGN

Marine natural product drug discovery: Leads for treatment of inflammation, cancer, infections, and neurological disorders

(2010) Francisco A. Villa et al.   IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY

A Phase II trial of 17-allylamino, 17-demethoxygeldanamycin (17-AAG, tanespimycin) in patients with metastatic melanoma

(2010) Simon Pacey et al.   INVESTIGATIONAL NEW DRUGS

HSP90 at the hub of protein homeostasis: emerging mechanistic insights

(2010) Mikko Taipale et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The natural marine anhydrophytosphingosine, Jaspine B, induces apoptosis in melanoma cells by interfering with ceramide metabolism

(2009) Yahya Salma et al.   BIOCHEMICAL PHARMACOLOGY

Heteronemin, a spongean sesterterpene, inhibits TNFα-induced NF-κB activation through proteasome inhibition and induces apoptotic cell death

(2009) Marc Schumacher et al.   BIOCHEMICAL PHARMACOLOGY

Antimalarial natural products of marine and freshwater origin

(2009) Karl Gademann et al.   CHEMICAL RECORD

DNA Topoisomerase I Inhibitors: Chemistry, Biology, and Interfacial Inhibition

(2009) Yves Pommier   CHEMICAL REVIEWS

17 AAG for HSP90 Inhibition in Cancer – From Bench to Bedside

(2009) Saad Usmani et al.   CURRENT MOLECULAR MEDICINE

AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility

(2009) Garrett M. Morris et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Scalarane Sesterterpenoids: Semisynthesis and Biological Activity

(2009) Haidy N. Kamel et al.   JOURNAL OF NATURAL PRODUCTS

Marine natural products as inhibitors of hypoxic signaling in tumors

(2009) Dale G. Nagle et al.   PHYTOCHEMISTRY REVIEWS

Specific inhibitors of the protein tyrosine phosphatase Shp2 identified by high-throughput docking

(2008) K. Hellmuth et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA