Towards the Small and the Beautiful: A Small Dibromotyrosine Derivative from Pseudoceratina sp. Sponge Exhibits Potent Apoptotic Effect through Targeting IKK/NFκB Signaling Pathway

Reactive oxygen species-mediated activation of the Akt/ASK1/p38 signaling cascade and p21Cip1 downregulation are required for shikonin-induced apoptosis

(2013) Jiwon Ahn et al.   APOPTOSIS

Oxidative stress: the mitochondria-dependent and mitochondria-independent pathways of apoptosis

(2013) Krishnendu Sinha et al.   ARCHIVES OF TOXICOLOGY

Brominated Skeletal Components of the Marine Demosponges, Aplysina cavernicola and Ianthella basta: Analytical and Biochemical Investigations

(2013) Kurt Kunze et al.   Marine Drugs

5-Episinuleptolide Acetate, a Norcembranoidal Diterpene from the Formosan Soft Coral Sinularia sp., Induces Leukemia Cell Apoptosis through Hsp90 Inhibition

(2013) Kao-Jean Huang et al.   MOLECULES

The Brominated Compound Aeroplysinin-1 Inhibits Proliferation and the Expression of Key Pro- Inflammatory Molecules in Human Endothelial and Monocyte Cells

(2013) Beatriz Martínez-Poveda et al.   PLoS One

The emerging multiple roles of nuclear Akt

(2012) Alberto M. Martelli et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

The novel NF-κB inhibitor DHMEQ synergizes with celecoxib to exert antitumor effects on human liver cancer cells by a ROS-dependent mechanism

(2012) Nadia Lampiasi et al.   CANCER LETTERS

Oncogenic PI3K Mutations Lead to NF- B-Dependent Cytokine Expression following Growth Factor Deprivation

(2012) J. E. Hutti et al.   CANCER RESEARCH

NF-κB as potential target in the treatment of melanoma

(2012) Gabriele Madonna et al.   Journal of Translational Medicine

Unequivocal13C NMR assignment of cyclohexadienyl rings in bromotyrosine-derived metabolites from marine sponges

(2012) John A. Kalaitzis et al.   MAGNETIC RESONANCE IN CHEMISTRY

The Antiangiogenic Compound Aeroplysinin-1 Induces Apoptosis in Endothelial Cells by Activating the Mitochondrial Pathway

(2012) Beatriz Martínez-Poveda et al.   Marine Drugs

Antileukemia component, dehydroeburicoic acid from Antrodia camphorata induces DNA damage and apoptosis in vitro and in vivo models

(2012) Ying-Chi Du et al.   PHYTOMEDICINE

The Nuclear Factor Kappa-B Signaling Pathway as a Therapeutic Target Against Thyroid Cancers

(2012) Xinying Li et al.   THYROID

Poor adherence is the main reason for loss of CCyR and imatinib failure for chronic myeloid leukemia patients on long-term therapy

(2011) A. R. Ibrahim et al.   BLOOD

Inhibitory kappa B kinases as targets for pharmacological regulation

(2011) Carly Gamble et al.   BRITISH JOURNAL OF PHARMACOLOGY

Brominated Compounds from Marine Sponges of the Genus Aplysina and a Compilation of Their 13C NMR Spectral Data

(2011) Narlize Silva Lira et al.   Marine Drugs

Antiparasitic Bromotyrosine Derivatives from the Marine Sponge Verongula rigida

(2011) Elkin Galeano et al.   Marine Drugs

Role of oxidative stress and DNA damage in human carcinogenesis

(2011) Thomas B. Kryston et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Syntheses of pseudoceramines A–D and a new synthesis of spermatinamine, bromotyrosine natural products from marine sponges

(2011) J. Mikael Hillgren et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Dibromotyrosine derivatives from the ethanol extract of the marine sponge Aplysina sp.: structures, transformations, and origin

(2011) E. A. Santalova et al.   RUSSIAN CHEMICAL BULLETIN

Sense and Sensitivity: FOXO and ROS in Cancer Development and Treatment

(2010) Stephen S. Myatt et al.   ANTIOXIDANTS & REDOX SIGNALING

Design, synthesis, and biological evaluation of dibromotyrosine analogues inspired by marine natural products as inhibitors of human prostate cancer proliferation, invasion, and migration

(2010) Asmaa A. Sallam et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Ceratinadins A–C, new bromotyrosine alkaloids from an Okinawan marine sponge Pseudoceratina sp.

(2010) Yuji Kon et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

A hypoxia-dependent upregulation of hypoxia-inducible factor-1 by nuclear factor-κB promotes gastric tumour growth and angiogenesis

(2010) S Y Nam et al.   BRITISH JOURNAL OF CANCER

Constitutive HIF-1 activity in malignant melanoma

(2010) Silke Kuphal et al.   EUROPEAN JOURNAL OF CANCER

Bioactive Sesterterpenes and Triterpenes from Marine Sponges: Occurrence and Pharmacological Significance

(2010) Sherif S. Ebada et al.   Marine Drugs

PARP-1 inhibition-induced activation of PI-3-kinase-Akt pathway promotes resistance to taxol

(2009) Arpad Szanto et al.   BIOCHEMICAL PHARMACOLOGY

Antiplasmodial Activities of Homogentisic Acid Derivative Protein Kinase Inhibitors Isolated from a Vanuatu Marine Sponge Pseudoceratina sp.

(2009) Nicolas Lebouvier et al.   Marine Drugs

Activation of fibronectin/PI-3K/Akt2 leads to chemoresistance to docetaxel by regulating survivin protein expression in ovarian and breast cancer cells

(2008) Hui Xing et al.   CANCER LETTERS

Aplysamine 6, an Alkaloidal Inhibitor of Isoprenylcysteine Carboxyl Methyltransferase from the SpongePseudoceratinasp.

(2008) Malcolm S. Buchanan et al.   JOURNAL OF NATURAL PRODUCTS