Antileukemic Scalarane Sesterterpenoids and Meroditerpenoid from Carteriospongia (Phyllospongia) sp., Induce Apoptosis via Dual Inhibitory Effects on Topoisomerase II and Hsp90

Endoplasmic-reticulum stress pathway-associated mechanisms of action of proteasome inhibitors in multiple myeloma

(2016) Masaki Ri   INTERNATIONAL JOURNAL OF HEMATOLOGY

Natural Products as Sources of New Drugs from 1981 to 2014

(2016) David J. Newman et al.   JOURNAL OF NATURAL PRODUCTS

Deguelin Analogue SH-1242 Inhibits Hsp90 Activity and Exerts Potent Anticancer Efficacy with Limited Neurotoxicity

(2015) S.-C. Lee et al.   CANCER RESEARCH

Novel biological insights in T-cell acute lymphoblastic leukemia

(2015) Kaat Durinck et al.   EXPERIMENTAL HEMATOLOGY

Targeting cancer with sesterterpenoids: the new potential antitumor drugs

(2015) Caiguo Zhang et al.   Journal of Natural Medicines

Preparation of cis-γ-Hydroxycarvone Derivatives for Synthesis of Sesterterpenoid Natural Products: Total Synthesis of Phorbin A

(2015) Jonathan G. Hubert et al.   JOURNAL OF ORGANIC CHEMISTRY

New Scalarane Sesterterpenoids from the Formosan Sponge Ircinia felix

(2015) Ya-Yuan Lai et al.   Marine Drugs

Tackling the Cytotoxic Effect of a Marine Polycyclic Quinone-Type Metabolite: Halenaquinone Induces Molt 4 Cells Apoptosis via Oxidative Stress Combined with the Inhibition of HDAC and Topoisomerase Activities

(2015) Shou-Ping Shih et al.   Marine Drugs

C-terminal heat shock protein 90 modulators produce desirable oncogenic properties

(2015) Y. Wang et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Anticancer drugs for the modulation of endoplasmic reticulum stress and oxidative stress

(2015) Ammad Ahmad Farooqi et al.   TUMOR BIOLOGY

Ganetespib: research and clinical development

(2015) Shanu Modi et al.   OncoTargets and Therapy

Targeting HSF1 disrupts HSP90 chaperone function in chronic lymphocytic leukemia

(2015) Siddhartha Ganguly et al.   Oncotarget

EGCG regulates the cross-talk between JWA and topoisomerase IIα in non-small-cell lung cancer (NSCLC) cells

(2015) Yuan Li et al.   Scientific Reports

A Novel Mechanism for Small Heat Shock Proteins to Function as Molecular Chaperones

(2015) Kaiming Zhang et al.   Scientific Reports

Proteotoxic stress targeted therapy (PSTT): induction of protein misfolding enhances the antitumor effect of the proteasome inhibitor bortezomib

(2015) Nickolay Neznanov et al.   Oncotarget

Topoisomerase II and leukemia

(2014) MaryJean Pendleton et al.   Annals of the New York Academy of Sciences

Suppression of Heat Shock Protein 27 Using OGX-427 Induces Endoplasmic Reticulum Stress and Potentiates Heat Shock Protein 90 Inhibitors to Delay Castrate-resistant Prostate Cancer

(2014) François Lamoureux et al.   EUROPEAN UROLOGY

A Cytosolic Relay of Heat Shock Proteins HSP70-1A and HSP90β Monitors the Folding Trajectory of the Serotonin Transporter

(2014) Ali El-Kasaby et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cracking the Cytotoxicity Code: Apoptotic Induction of 10-Acetylirciformonin B is Mediated through ROS Generation and Mitochondrial Dysfunction

(2014) Huei-Chuan Shih et al.   Marine Drugs

Translational and posttranslational regulation of XIAP by eIF2α and ATF4 promotes ER stress–induced cell death during the unfolded protein response

(2014) Nobuhiko Hiramatsu et al.   MOLECULAR BIOLOGY OF THE CELL

Mitochondrial Reactive Oxygen Species (ROS) and ROS-Induced ROS Release

(2014) Dmitry B. Zorov et al.   PHYSIOLOGICAL REVIEWS

HSP90 empowers evolution of resistance to hormonal therapy in human breast cancer models

(2014) Luke Whitesell et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

HER2/ErbB2 activates HSF1 and thereby controls HSP90 clients including MIF in HER2-overexpressing breast cancer

(2014) R Schulz et al.   Cell Death & Disease

Molecular docking studies of curcumin natural derivatives with DNA topoisomerase I and II-DNA complexes

(2014) Anil Kumar et al.   Interdisciplinary Sciences-Computational Life Sciences

Cancer wars: natural products strike back

(2014) Christine Basmadjian et al.   Frontiers in Chemistry

ER stress-induced cell death mechanisms

(2013) Renata Sano et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Towards the Small and the Beautiful: A Small Dibromotyrosine Derivative from Pseudoceratina sp. Sponge Exhibits Potent Apoptotic Effect through Targeting IKK/NFκB Signaling Pathway

(2013) Jui-Hsin Su et al.   Marine Drugs

OSU-03012 suppresses GRP78/BiP expression that causes PERK-dependent increases in tumor cell killing

(2012) Laurence Booth et al.   CANCER BIOLOGY & THERAPY

Targeting the molecular chaperone heat shock protein 90 (HSP90): Lessons learned and future directions

(2012) David S. Hong et al.   CANCER TREATMENT REVIEWS

Heat Shock Factor Hsf1 Cooperates with ErbB2 (Her2/Neu) Protein to Promote Mammary Tumorigenesis and Metastasis

(2012) Caixia Xi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cytotoxic Sesterterpenoids from a Sponge Hippospongia sp.

(2012) Yu-Chia Chang et al.   Marine Drugs

T-cell acute lymphoblastic leukaemia: recent molecular biology findings

(2011) Monika D. Kraszewska et al.   BRITISH JOURNAL OF HAEMATOLOGY

Mitochondrial glutathione transferases involving a new function for membrane permeability transition pore regulation

(2011) Yoko Aniya et al.   DRUG METABOLISM REVIEWS

Reactive oxygen species-mediated endoplasmic reticulum stress and mitochondrial dysfunction contribute to polydatin-induced apoptosis in human nasopharyngeal carcinoma CNE cells

(2011) Huanhai Liu et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Green tea constituents (-)-epigallocatechin-3-gallate (EGCG) and gallic acid induce topoisomerase I- and topoisomerase II-DNA complexes in cells mediated by pyrogallol-induced hydrogen peroxide

(2011) M. Lopez-Lazaro et al.   MUTAGENESIS

Targeting heat shock proteins in cancer

(2010) Gaëtan Jego et al.   CANCER LETTERS

Discovery and development of Hsp90 inhibitors: a promising pathway for cancer therapy

(2010) James R Porter et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Heat shock factors: integrators of cell stress, development and lifespan

(2010) Malin Åkerfelt et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

17 AAG for HSP90 Inhibition in Cancer – From Bench to Bedside

(2009) Saad Usmani et al.   CURRENT MOLECULAR MEDICINE

AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility

(2009) Garrett M. Morris et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Scalarane-Based Sesterterpenoid RCE-Protease Inhibitors Isolated from the Indonesian Marine SpongeCarteriospongia foliascens

(2009) David E. Williams et al.   JOURNAL OF NATURAL PRODUCTS

Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?

(2009) Dunyaporn Trachootham et al.   NATURE REVIEWS DRUG DISCOVERY

Bimodal Recognition of DNA Geometry by Human Topoisomerase IIα: Preferential Relaxation of Positively Supercoiled DNA Requires Elements in the C-Terminal Domain†

(2008) A. Kathleen McClendon et al.   BIOCHEMISTRY

Prospective tracing of MLL-FRYL clone with low MEIS1 expression from emergence during neuroblastoma treatment to diagnosis of myelodysplastic syndrome

(2008) B. W. Robinson et al.   BLOOD

Bortezomib-induced apoptosis in mature T-cell lymphoma cells partially depends on upregulation of Noxa and functional repression of Mcl-1

(2008) Masaki Ri et al.   CANCER SCIENCE

The DNA cleavage reaction of topoisomerase II: wolf in sheep's clothing

(2008) J. E. Deweese et al.   NUCLEIC ACIDS RESEARCH