Cracking the Cytotoxicity Code: Apoptotic Induction of 10-Acetylirciformonin B is Mediated through ROS Generation and Mitochondrial Dysfunction

Matrine induces caspase-independent program cell death in hepatocellular carcinoma through bid-mediated nuclear translocation of apoptosis inducing factor

(2014) Huan Zhou et al.   Molecular Cancer

Oroxylin A sensitizes non-small cell lung cancer cells to anoikis via glucose-deprivation-like mechanisms: c-Src and hexokinase II

(2013) Libin Wei et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Hexokinase 2 Is Required for Tumor Initiation and Maintenance and Its Systemic Deletion Is Therapeutic in Mouse Models of Cancer

(2013) Krushna C. Patra et al.   CANCER CELL

D-penicillamine and other low molecular weight thiols: Review of anticancer effects and related mechanisms

(2013) Saurabh Wadhwa et al.   CANCER LETTERS

Apoptosis Regulation at the Mitochondrial Outer Membrane

(2013) Laura A. Gillies et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Towards the Small and the Beautiful: A Small Dibromotyrosine Derivative from Pseudoceratina sp. Sponge Exhibits Potent Apoptotic Effect through Targeting IKK/NFκB Signaling Pathway

(2013) Jui-Hsin Su et al.   Marine Drugs

Relevance of Mitochondrial Genetics and Metabolism in Cancer Development

(2013) G. Gasparre et al.   Cold Spring Harbor Perspectives in Biology

Drug-induced histone eviction from open chromatin contributes to the chemotherapeutic effects of doxorubicin

(2013) Baoxu Pang et al.   Nature Communications

Oxidative stress in apoptosis and cancer: an update

(2012) José M. Matés et al.   ARCHIVES OF TOXICOLOGY

Targeting peroxiredoxins against leukemia

(2012) Chuan-Xu Liu et al.   EXPERIMENTAL CELL RESEARCH

10-Acetylirciformonin B, A Sponge Furanoterpenoid, Induces DNA Damage and Apoptosis in Leukemia Cells

(2012) Jui-Hsin Su et al.   MOLECULES

Antileukemia component, dehydroeburicoic acid from Antrodia camphorata induces DNA damage and apoptosis in vitro and in vivo models

(2012) Ying-Chi Du et al.   PHYTOMEDICINE

Chemotherapeutic induction of mitochondrial oxidative stress activates GSK-3α/β and Bax, leading to permeability transition pore opening and tumor cell death

(2012) F Chiara et al.   Cell Death & Disease

Targeting cytosolic proliferating cell nuclear antigen in neutrophil-dominated inflammation

(2012) Alessia De Chiara et al.   Frontiers in Immunology

Exploiting the Cancer Genome: Strategies for the Discovery and Clinical Development of Targeted Molecular Therapeutics

(2011) Timothy A. Yap et al.   Annual Review of Pharmacology and Toxicology

Salinomycin-induced apoptosis of human prostate cancer cells due to accumulated reactive oxygen species and mitochondrial membrane depolarization

(2011) Kwang-Youn Kim et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Unraveling the Biological Roles of Reactive Oxygen Species

(2011) Michael P. Murphy et al.   Cell Metabolism

Cytotoxic C21and C22Terpenoid-Derived Metabolites from the SpongeIrciniasp.

(2011) Jui-Hsin Su et al.   JOURNAL OF NATURAL PRODUCTS

Hexokinase regulates Bax-mediated mitochondrial membrane injury following ischemic stress

(2011) Jonathan M. Gall et al.   KIDNEY INTERNATIONAL

Roles of the Ras/Raf/MEK/ERK pathway in leukemia therapy

(2011) L S Steelman et al.   LEUKEMIA

Structural Basis of Type II Topoisomerase Inhibition by the Anticancer Drug Etoposide

(2011) C.-C. Wu et al.   SCIENCE

Mitochondria in cancer: at the crossroads of life and death

(2011) Vanessa C. Fogg et al.   Chinese Journal of Cancer

Role of oxidative/nitrosative stress-mediated Bcl-2 regulation in apoptosis and malignant transformation

(2010) Neelam Azad et al.   Annals of the New York Academy of Sciences

The pivotal roles of mitochondria in cancer: Warburg and beyond and encouraging prospects for effective therapies

(2010) Saroj P. Mathupala et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Hexokinase II detachment from the mitochondria potentiates cisplatin induced cytotoxicity through a caspase-2 dependent mechanism

(2010) Nataly Shulga et al.   CELL CYCLE

Reactive oxygen species, cellular redox systems, and apoptosis

(2010) Magdalena L. Circu et al.   FREE RADICAL BIOLOGY AND MEDICINE

Mono- or Double-Site Phosphorylation Distinctly Regulates the Proapoptotic Function of Bax

(2010) Qinhong Wang et al.   PLoS One

Mitochondria as targets for chemotherapy

(2009) Vladimir Gogvadze et al.   APOPTOSIS

Role of reactive oxygen species-mediated mitochondrial dysregulation in 3-bromopyruvate induced cell death in hepatoma cells

(2008) Ji Su Kim et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Design and Endpoints of Clinical Trials in Hepatocellular Carcinoma

(2008) Josep M. Llovet et al.   JNCI-Journal of the National Cancer Institute