Circulating tumor DNA and liquid biopsy: opportunities, challenges, and recent advances in detection technologies

Magnetic Nanowire Networks for Dual-Isolation and Detection of Tumor-Associated Circulating Biomarkers

(2018) HyungJae Lee et al.   Theranostics

Circulating Cell Free Tumor DNA Detection as a Routine Tool forLung Cancer Patient Management

(2017) Julie Vendrell et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Simple multiplexed PCR-based barcoding of DNA for ultrasensitive mutation detection by next-generation sequencing

(2017) Anders Ståhlberg et al.   Nature Protocols

Integrating liquid biopsies into the management of cancer

(2017) Giulia Siravegna et al.   Nature Reviews Clinical Oncology

Osimertinib or Platinum–Pemetrexed in EGFR T790M–Positive Lung Cancer

(2017) Tony S. Mok et al.   NEW ENGLAND JOURNAL OF MEDICINE

The clinical role of circulating free tumor DNA in gastrointestinal malignancy

(2017) Jessica A. Howell et al.   Translational Research

Single copy-sensitive electrochemical assay for circulating methylated DNA in clinical samples with ultrahigh specificity based on a sequential discrimination–amplification strategy

(2017) Xuyao Wang et al.   Chemical Science

The performance of the SEPT9 gene methylation assay and a comparison with other CRC screening tests: A meta-analysis

(2017) Lele Song et al.   Scientific Reports

Ultrasensitive colorimetric detection of circulating tumor DNA using hybridization chain reaction and the pivot of triplex DNA

(2017) Ruimin Li et al.   Scientific Reports

Discovery of targetable genetic alterations in advanced non-small cell lung cancer using a next-generation sequencing-based circulating tumor DNA assay

(2017) Helei Hou et al.   Scientific Reports

Development and Evaluation of a Duplex Real-Time PCR Assay With a Novel Internal Standard for Precise Quantification of Plasma DNA

(2017) Dan Chen et al.   Annals of Laboratory Medicine

Prognostic value of circulating tumor DNA in patients with colon cancer: Systematic review

(2017) Gaowei Fan et al.   PLoS One

Circulating Tumor DNA Mutation Profiling by Targeted Next Generation Sequencing Provides Guidance for Personalized Treatments in Multiple Cancer Types

(2017) Yongqian Shu et al.   Scientific Reports

Methodological, biological and clinical aspects of circulating free DNA in metastatic colorectal cancer

(2016) Karen-Lise G. Spindler   ACTA ONCOLOGICA

Detection of Circulating Tumor DNA in Human Blood via DNA-Mediated Surface-Enhanced Raman Spectroscopy of Single-Walled Carbon Nanotubes

(2016) Qifeng Zhou et al.   ANALYTICAL CHEMISTRY

Implementing a strategy for on-chip detection of cell-free DNA fragments using GMR sensors: A translational application in cancer diagnostics using ALU elements

(2016) T. M. Dias et al.   Analytical Methods

A novel strategy for highly efficient isolation and analysis of circulating tumor-specific cell-free DNA from lung cancer patients using a reusable conducting polymer nanostructure

(2016) HyungJae Lee et al.   BIOMATERIALS

Nitrogen-doped multiple graphene aerogel/gold nanostar as the electrochemical sensing platform for ultrasensitive detection of circulating free DNA in human serum

(2016) Li Ruiyi et al.   BIOSENSORS & BIOELECTRONICS

MonitoringEGFRT790M with plasma DNA from lung cancer patients in a prospective observational study

(2016) Naoko Sueoka-Aragane et al.   CANCER SCIENCE

Circulating Tumor DNA as an Early Indicator of Response to T-cell Transfer Immunotherapy in Metastatic Melanoma

(2016) Liqiang Xi et al.   CLINICAL CANCER RESEARCH

Methylated circulating tumor DNA in blood: power in cancer prognosis and response

(2016) Kristina Warton et al.   ENDOCRINE-RELATED CANCER

The potential use of cell-free-circulating-tumor DNA as a biomarker for prostate cancer

(2016) Wendy (Shuwen) He et al.   EXPERT REVIEW OF MOLECULAR DIAGNOSTICS

Circulating Tumor Cells and Circulating Tumor DNA Provide New Insights into Pancreatic Cancer

(2016) Yang Gao et al.   International Journal of Medical Sciences

Association Between Plasma Genotyping and Outcomes of Treatment With Osimertinib (AZD9291) in Advanced Non–Small-Cell Lung Cancer

(2016) Geoffrey R. Oxnard et al.   JOURNAL OF CLINICAL ONCOLOGY

Ultrasensitive Detection of Multiplexed Somatic Mutations Using MALDI-TOF Mass Spectrometry

(2016) Michael J. Mosko et al.   JOURNAL OF MOLECULAR DIAGNOSTICS

DNA Clutch Probes for Circulating Tumor DNA Analysis

(2016) Jagotamoy Das et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Cell-free DNA (cfDNA): Clinical Significance and Utility in Cancer Shaped By Emerging Technologies

(2016) S. Volik et al.   MOLECULAR CANCER RESEARCH

Reversible acetylation on Lys501 regulates the activity of RNase II

(2016) Limin Song et al.   NUCLEIC ACIDS RESEARCH

Distinct biological subtypes and patterns of genome evolution in lymphoma revealed by circulating tumor DNA

(2016) F. Scherer et al.   Science Translational Medicine

The Long and Short of Circulating Cell-Free DNA and the Ins and Outs of Molecular Diagnostics

(2016) Peiyong Jiang et al.   TRENDS IN GENETICS

Circulating tumor DNA as a liquid biopsy target for detection of pancreatic cancer

(2016) Erina Takai et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Cell-free DNA as a diagnostic marker for cancer: current insights

(2016) Samanta Salvi et al.   OncoTargets and Therapy

Circulating tumour DNA profiling reveals heterogeneity of EGFR inhibitor resistance mechanisms in lung cancer patients

(2016) Jacob J. Chabon et al.   Nature Communications

Detection rate of actionable mutations in diverse cancers using a biopsy-free (blood) circulating tumor cell DNA assay

(2016) Maria Schwaederle et al.   Oncotarget

Quantification of Somatic Chromosomal Rearrangements in Circulating Cell-Free DNA from Ovarian Cancers

(2016) Faye R. Harris et al.   Scientific Reports

Simple, Sensitive and Accurate Multiplex Detection of Clinically Important Melanoma DNA Mutations in Circulating Tumour DNA with SERS Nanotags

(2016) Eugene J.H. Wee et al.   Theranostics

Fragment Length of Circulating Tumor DNA

(2016) Hunter R. Underhill et al.   PLoS Genetics

Exploratory Analysis of TP53 Mutations in Circulating Tumour DNA as Biomarkers of Treatment Response for Patients with Relapsed High-Grade Serous Ovarian Carcinoma: A Retrospective Study

(2016) Christine A. Parkinson et al.   PLOS MEDICINE

Sensitive and direct electrochemical detection of double-stranded DNA utilizing alkaline phosphatase-labelled zinc finger proteins

(2015) Soodong Noh et al.   ANALYST

Comprehensive evaluation of methods to isolate, quantify, and characterize circulating cell-free DNA from small volumes of plasma

(2015) Florence Mauger et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Nanoplasmonic biosensor: Detection and amplification of dual bio-signatures of circulating tumor DNA

(2015) Anh H. Nguyen et al.   BIOSENSORS & BIOELECTRONICS

A label-free ultrasensitive electrochemical DNA sensor based on thin-layer MoS2 nanosheets with high electrochemical activity

(2015) Xinxing Wang et al.   BIOSENSORS & BIOELECTRONICS

Serial Next-Generation Sequencing of Circulating Cell-Free DNA Evaluating Tumor Clone Response To Molecularly Targeted Drug Administration

(2015) J. S. Frenel et al.   CLINICAL CANCER RESEARCH

Circulating Tumor Cells and Circulating Tumor DNA: Challenges and Opportunities on the Path to Clinical Utility

(2015) M. Ignatiadis et al.   CLINICAL CANCER RESEARCH

Bias-Corrected Targeted Next-Generation Sequencing for Rapid, Multiplexed Detection of Actionable Alterations in Cell-Free DNA from Advanced Lung Cancer Patients

(2015) C. P. Paweletz et al.   CLINICAL CANCER RESEARCH

Noninvasive Detection of Activating Estrogen Receptor 1 (ESR1) Mutations in Estrogen Receptor-Positive Metastatic Breast Cancer

(2015) D. S. Guttery et al.   CLINICAL CHEMISTRY

Circulating Tumor DNA Outperforms Circulating Tumor Cells for KRAS Mutation Detection in Thoracic Malignancies

(2015) M. B. Freidin et al.   CLINICAL CHEMISTRY

Serial monitoring of circulating tumor DNA in patients with primary breast cancer for detection of occult metastatic disease

(2015) Eleonor Olsson et al.   EMBO Molecular Medicine

A microfluidic device for rapid quantification of cell-free DNA in patients with severe sepsis

(2015) Jun Yang et al.   LAB ON A CHIP

Impacts of degraded DNA on restriction enzyme associated DNA sequencing (RADSeq)

(2015) Carly F. Graham et al.   Molecular Ecology Resources

Cell-free circulating tumour DNA as a liquid biopsy in breast cancer

(2015) Leticia De Mattos-Arruda et al.   Molecular Oncology

An electrochemical clamp assay for direct, rapid analysis of circulating nucleic acids in serum

(2015) Jagotamoy Das et al.   Nature Chemistry

Clonal evolution and resistance to EGFR blockade in the blood of colorectal cancer patients

(2015) Giulia Siravegna et al.   NATURE MEDICINE

Detection of tumor-derived DNA in cerebrospinal fluid of patients with primary tumors of the brain and spinal cord

(2015) Yuxuan Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mutation tracking in circulating tumor DNA predicts relapse in early breast cancer

(2015) Isaac Garcia-Murillas et al.   Science Translational Medicine

Analysis of ESR1 mutation in circulating tumor DNA demonstrates evolution during therapy for metastatic breast cancer

(2015) Gaia Schiavon et al.   Science Translational Medicine

Detection of Clonal and Subclonal Copy-Number Variants in Cell-Free DNA from Patients with Breast Cancer Using a Massively Multiplexed PCR Methodology

(2015) Eser Kirkizlar et al.   Translational Oncology

Multifocal clonal evolution characterized using circulating tumour DNA in a case of metastatic breast cancer

(2015) Muhammed Murtaza et al.   Nature Communications

Comparison of four digital PCR platforms for accurate quantification of DNA copy number of a certified plasmid DNA reference material

(2015) Lianhua Dong et al.   Scientific Reports

Monitoring response to therapy in melanoma by quantifying circulating tumour DNA with droplet digital PCR for BRAF and NRAS mutations

(2015) Simon Chang-Hao Tsao et al.   Scientific Reports

Analytical and Clinical Validation of a Digital Sequencing Panel for Quantitative, Highly Accurate Evaluation of Cell-Free Circulating Tumor DNA

(2015) Richard B. Lanman et al.   PLoS One

SNPase-ARMS qPCR: Ultrasensitive Mutation-Based Detection of Cell-Free Tumor DNA in Melanoma Patients

(2015) Julia Stadler et al.   PLoS One

Clinical utility of circulating tumor DNA for molecular assessment in pancreatic cancer

(2015) Erina Takai et al.   Scientific Reports

Towards standardisation of cell-free DNA measurement in plasma: controls for extraction efficiency, fragment size bias and quantification

(2014) Alison S. Devonshire et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Circulating tumor cells and circulating tumor DNA for precision medicine: dream or reality?

(2014) M. Ignatiadis et al.   ANNALS OF ONCOLOGY

Plasma circulating tumor DNA as an alternative to metastatic biopsies for mutational analysis in breast cancer

(2014) F. Rothé et al.   ANNALS OF ONCOLOGY

Plasma DNA integrity as a biomarker for primary and metastatic breast cancer and potential marker for early diagnosis

(2014) Dharanija Madhavan et al.   BREAST CANCER RESEARCH AND TREATMENT

Postoperative serum methylation levels ofTAC1andSEPT9are independent predictors of recurrence and survival of patients with colorectal cancer

(2014) CheeKian Tham et al.   CANCER

Double-stranded DNA in exosomes: a novel biomarker in cancer detection

(2014) Basant Kumar Thakur et al.   CELL RESEARCH

Detection of Cancer DNA in Plasma of Patients with Early-Stage Breast Cancer

(2014) J. A. Beaver et al.   CLINICAL CANCER RESEARCH

Circulating Tumor DNA as a Liquid Biopsy for Cancer

(2014) E. Heitzer et al.   CLINICAL CHEMISTRY

Dielectrophoretic isolation and detection of cancer-related circulating cell-free DNA biomarkers from blood and plasma

(2014) Avery Sonnenberg et al.   ELECTROPHORESIS

Changes in mutational status during third-line treatment for metastatic colorectal cancer-Results of consecutive measurement of cell free DNA,KRASandBRAFin the plasma

(2014) Karen-Lise Garm Spindler et al.   INTERNATIONAL JOURNAL OF CANCER

Circulating tumor DNA and circulating tumor cells in metastatic triple negative breast cancer patients

(2014) Jordan Madic et al.   INTERNATIONAL JOURNAL OF CANCER

Gefitinib Treatment in EGFR Mutated Caucasian NSCLC: Circulating-Free Tumor DNA as a Surrogate for Determination of EGFR Status

(2014) Jean-Yves Douillard et al.   Journal of Thoracic Oncology

Multi-marker analysis of circulating cell-free DNA toward personalized medicine for colorectal cancer

(2014) Florent Mouliere et al.   Molecular Oncology

Circulating tumor DNA as a non-invasive substitute to metastasis biopsy for tumor genotyping and personalized medicine in a prospective trial across all tumor types

(2014) Ronald Lebofsky et al.   Molecular Oncology

An ultrasensitive method for quantitating circulating tumor DNA with broad patient coverage

(2014) Aaron M Newman et al.   NATURE MEDICINE

Clinical validation of the detection of KRAS and BRAF mutations from circulating tumor DNA

(2014) Alain R Thierry et al.   NATURE MEDICINE

Clonal Hematopoiesis and Blood-Cancer Risk Inferred from Blood DNA Sequence

(2014) Giulio Genovese et al.   NEW ENGLAND JOURNAL OF MEDICINE

Direct Quantification of Cell-Free, Circulating DNA from Unpurified Plasma

(2014) Sarah Breitbach et al.   PLoS One

Detection of Circulating Tumor DNA in Early- and Late-Stage Human Malignancies

(2014) C. Bettegowda et al.   Science Translational Medicine

Blood-Based Analyses of Cancer: Circulating Tumor Cells and Circulating Tumor DNA

(2014) D. A. Haber et al.   Cancer Discovery

Fragmentation of DNA affects the accuracy of the DNA quantitation by the commonly used methods

(2013) Tatiana Sedlackova et al.   BIOLOGICAL PROCEDURES ONLINE

First-line gefitinib in Caucasian EGFR mutation-positive NSCLC patients: a phase-IV, open-label, single-arm study

(2013) J-Y Douillard et al.   BRITISH JOURNAL OF CANCER

Early detection of nasopharyngeal carcinoma by plasma Epstein-Barr virus DNA analysis in a surveillance program

(2013) K. C. Allen Chan et al.   CANCER

Circulating cell free DNA: Preanalytical considerations

(2013) Safia El Messaoudi et al.   CLINICA CHIMICA ACTA

High-Resolution Profiling of Fetal DNA Clearance from Maternal Plasma by Massively Parallel Sequencing

(2013) S. C. Y. Yu et al.   CLINICAL CHEMISTRY

Rapid Electrokinetic Isolation of Cancer-Related Circulating Cell-Free DNA Directly from Blood

(2013) A. Sonnenberg et al.   CLINICAL CHEMISTRY

Prospective evaluation of methylatedSEPT9in plasma for detection of asymptomatic colorectal cancer

(2013) Timothy Robert Church et al.   GUT

Establishment of tumor-specific copy number alterations from plasma DNA of patients with cancer

(2013) Ellen Heitzer et al.   INTERNATIONAL JOURNAL OF CANCER

Localized surface plasmon resonance: a unique property of plasmonic nanoparticles for nucleic acid detection

(2013) Kah Ee Fong et al.   Nanoscale

Non-invasive analysis of acquired resistance to cancer therapy by sequencing of plasma DNA

(2013) Muhammed Murtaza et al.   NATURE

Circulating tumour cells and cell-free DNA as tools for managing breast cancer

(2013) Leticia De Mattos-Arruda et al.   Nature Reviews Clinical Oncology

Circulating Tumor DNA to Monitor Metastatic Breast Cancer

(2013)   NEW ENGLAND JOURNAL OF MEDICINE

Analysis of Circulating Tumor DNA to Monitor Metastatic Breast Cancer

(2013) Sarah-Jane Dawson et al.   NEW ENGLAND JOURNAL OF MEDICINE

Circulating Methylated XAF1 DNA Indicates Poor Prognosis for Gastric Cancer

(2013) Zhi-Qiang Ling et al.   PLoS One

Noninvasive detection of cancer-associated genome-wide hypomethylation and copy number aberrations by plasma DNA bisulfite sequencing

(2013) K. C. A. Chan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Circulating tumor cells and DNA as liquid biopsies

(2013) Ellen Heitzer et al.   Genome Medicine

Tumor-associated copy number changes in the circulation of patients with prostate cancer identified through whole-genome sequencing

(2013) Ellen Heitzer et al.   Genome Medicine

A surface-initiated enzymatic polymerization strategy for electrochemical DNA sensors

(2012) Ying Wan et al.   BIOSENSORS & BIOELECTRONICS

An electrochemiluminescent DNA sensor based on nano-gold enhancement and ferrocene quenching

(2012) Wu Yao et al.   BIOSENSORS & BIOELECTRONICS

Quantitative Cell-Free DNA, KRAS, and BRAF Mutations in Plasma from Patients with Metastatic Colorectal Cancer during Treatment with Cetuximab and Irinotecan

(2012) K.-L. G. Spindler et al.   CLINICAL CANCER RESEARCH

Detection of Tumor PIK3CA Status in Metastatic Breast Cancer Using Peripheral Blood

(2012) M. J. Higgins et al.   CLINICAL CANCER RESEARCH

Pyrophosphorolysis-Activated Polymerization Detects Circulating Tumor DNA in Metastatic Uveal Melanoma

(2012) J. Madic et al.   CLINICAL CANCER RESEARCH

Cancer Genome Scanning in Plasma: Detection of Tumor-Associated Copy Number Aberrations, Single-Nucleotide Variants, and Tumoral Heterogeneity by Massively Parallel Sequencing

(2012) K. C. A. Chan et al.   CLINICAL CHEMISTRY

MSH2 promoter hypermethylation in circulating tumor DNA is a valuable predictor of disease-free survival for patients with esophageal squamous cell carcinoma

(2012) Z.Q. Ling et al.   EJSO

Influence of Temperature during Transportation on Cell-Free DNA Analysis

(2012) Mats Hidestrand et al.   FETAL DIAGNOSIS AND THERAPY

The molecular evolution of acquired resistance to targeted EGFR blockade in colorectal cancers

(2012) Luis A. Diaz Jr et al.   NATURE

Performance comparison of benchtop high-throughput sequencing platforms

(2012) Nicholas J Loman et al.   NATURE BIOTECHNOLOGY

Digital PCR hits its stride

(2012) Monya Baker   NATURE METHODS

Plasmonics for future biosensors

(2012) Alexandre G. Brolo   Nature Photonics

Improving Indel Detection Specificity of the Ion Torrent PGM Benchtop Sequencer

(2012) Zhen Xuan Yeo et al.   PLoS One

Noninvasive Identification and Monitoring of Cancer Mutations by Targeted Deep Sequencing of Plasma DNA

(2012) T. Forshew et al.   Science Translational Medicine

Detection of Chromosomal Alterations in the Circulation of Cancer Patients with Whole-Genome Sequencing

(2012) R. J. Leary et al.   Science Translational Medicine

High-Throughput Droplet Digital PCR System for Absolute Quantitation of DNA Copy Number

(2011) Benjamin J. Hindson et al.   ANALYTICAL CHEMISTRY

Circulating Tumor Cells and Circulating Tumor DNA

(2011) Catherine Alix-Panabières et al.   Annual Review of Medicine

Plasma Epstein-Barr virus DNA level strongly predicts survival in metastatic/recurrent nasopharyngeal carcinoma treated with palliative chemotherapy

(2011) Xin An et al.   CANCER

Genomic analysis of circulating cell-free DNA infers breast cancer dormancy

(2011) J. A. Shaw et al.   GENOME RESEARCH

A new method for non-labeling attomolar detection of diseases based on an individual gold nanorod immunosensor

(2011) Phuoc Long Truong et al.   LAB ON A CHIP

Quantitative and sensitive detection of rare mutations using droplet-based microfluidics

(2011) Deniz Pekin et al.   LAB ON A CHIP

High Fragmentation Characterizes Tumour-Derived Circulating DNA

(2011) Florent Mouliere et al.   PLoS One

Detection and quantification of rare mutations with massively parallel sequencing

(2011) I. Kinde et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Prognostic Value of Circulating Mutant DNA in Unresectable Metastatic Colorectal Cancer

(2010) Benoit Lefebure et al.   ANNALS OF SURGERY

Detection of PIK3CA mutations in circulating free DNA in patients with breast cancer

(2010) Ruth E. Board et al.   BREAST CANCER RESEARCH AND TREATMENT

Plasma cell-free DNA in ovarian cancer

(2010) Aparna A. Kamat et al.   CANCER

Cell-free DNA in the blood as a solid tumor biomarker—A critical appraisal of the literature

(2010) Klaus Jung et al.   CLINICA CHIMICA ACTA

Quantifying EGFR Alterations in the Lung Cancer Genome with Nanofluidic Digital PCR Arrays

(2010) J. Wang et al.   CLINICAL CHEMISTRY

Use of cancer-specific genomic rearrangements to quantify disease burden in plasma from patients with solid tumors

(2010) David J. McBride et al.   GENES CHROMOSOMES & CANCER

Methylation patterns in cell-free plasma DNA reflect removal of the primary tumor and drug treatment of breast cancer patients

(2010) Thomas E. Liggett et al.   INTERNATIONAL JOURNAL OF CANCER

Decoding Circulating Nucleic Acids in Human Serum Using Microfluidic Single Molecule Spectroscopy

(2010) Kelvin J. Liu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Origin and quantification of circulating DNA in mice with human colorectal cancer xenografts

(2010) Alain R. Thierry et al.   NUCLEIC ACIDS RESEARCH

Development of Personalized Tumor Biomarkers Using Massively Parallel Sequencing

(2010) R. J. Leary et al.   Science Translational Medicine

The Origin of Elevated Levels of Circulating DNA in Blood Plasma of Premature Neonates

(2009) N. O. Tuaeva et al.   Annals of the New York Academy of Sciences

Cell-Surface-Bound Circulating DNA as a Prognostic Factor in Lung Cancer

(2009) Svetlana N. Tamkovich et al.   Annals of the New York Academy of Sciences

Identification of microbial DNA in human cancer

(2009) Christopher G Duncan et al.   BMC Medical Genomics

Optimizing the yield and utility of circulating cell-free DNA from plasma and serum

(2009) Xiaoyan Xue et al.   CLINICA CHIMICA ACTA

Single-Molecule Detection of Epidermal Growth Factor Receptor Mutations in Plasma by Microfluidics Digital PCR in Non-Small Cell Lung Cancer Patients

(2009) T. K.F. Yung et al.   CLINICAL CANCER RESEARCH

Multimarker Circulating DNA Assay for Assessing Blood of Prostate Cancer Patients

(2009) E. Sunami et al.   CLINICAL CHEMISTRY

Circulating Methylated SEPT9 DNA in Plasma Is a Biomarker for Colorectal Cancer

(2009) T. deVos et al.   CLINICAL CHEMISTRY

An Electrochemical Sensor for Single Nucleotide Polymorphism Detection in Serum Based on a Triple-Stem DNA Probe

(2009) Yi Xiao et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Optimized Quantification of Fragmented, Free Circulating DNA in Human Blood Plasma Using a Calibrated Duplex Real-Time PCR

(2009) Martin Horlitz et al.   PLoS One

Analysis of Cancer Mutation Signatures in Blood by a Novel Ultra-Sensitive Assay: Monitoring of Therapy or Recurrence in Non-Metastatic Breast Cancer

(2009) Zhenbin Chen et al.   PLoS One

Quantification of circulating cell-free DNA in the plasma of cancer patients during radiation therapy

(2008) Chao Cheng et al.   CANCER SCIENCE

Circulating mutant DNA to assess tumor dynamics

(2008) Frank Diehl et al.   NATURE MEDICINE