Article
Biochemical Research Methods
Beatriz B. Oliveira, Beatriz Costa, Barbara Morao, Sandra Faias, Bruno Veigas, Lucilia Pebre Pereira, Cristina Albuquerque, Rui Maio, Marilia Cravo, Alexandra R. Fernandes, Pedro Viana Baptista
Summary: The success of personalized medicine relies on biomarker discovery for identifying patients who will benefit from specific targeted drugs. Liquid biopsies, particularly the analysis of circulating tumor DNA, are emerging as a useful tool for diagnosis, prognosis, and biomarker discovery. In this study, an ARMS-HRMA method was developed for detecting KRAS mutations, showing simplicity, shorter time to result, high sensitivity, and specificity compared to traditional sequencing and digital PCR methods. The proposed ARMS-HRMA method has the potential to improve liquid biopsy-based diagnosis and prognosis schemes.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2023)
Article
Oncology
Cloud P. Paweletz, Grace A. Heavey, Yanan Kuang, Emily Durlacher, Thian Kheoh, Richard C. Chao, Alexander I. Spira, Konstantinos Leventakos, Melissa L. Johnson, Sai-Hong Ignatius Ou, Gregory J. Riely, Kenna Anderes, Wenjing Yang, James G. Christensen, Pasi A. Janne
Summary: This study reports on early ctDNA changes of KRAS G12C in lung cancer patients and suggests that ctDNA changes can be used as a potential measure for early prediction of clinical response.
CLINICAL CANCER RESEARCH
(2023)
Article
Multidisciplinary Sciences
Yuki Nakamura, Shozo Yokoyama, Kenji Matsuda, Koichi Tamura, Yasuyuki Mitani, Hiromitsu Iwamoto, Yuki Mizumoto, Daisuke Murakami, Yuji Kitahata, Hiroki Yamaue
Summary: This study investigated the relationship between preoperative KRAS mutated ctDNA status and postoperative recurrence in patients with CRC. The detection of KRAS mutation in ctDNA before surgery was found to be an independent factor associated with inferior recurrence-free interval and recurrence-free survival, suggesting its potential utility in guiding postoperative treatment decisions.
SCIENTIFIC REPORTS
(2021)
Article
Health Care Sciences & Services
Chien-Yu Lin, Ming-Yin Shen, William Tzu-Liang Chen, Chin-An Yang
Summary: This study retrospectively reviewed the clinical course of colorectal cancer patients with low-frequency KRAS mutations detected in plasma ctDNA. The findings suggest that these mutations could be used as predictors of treatment response in these patients.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Review
Biotechnology & Applied Microbiology
Can Li, Wei He, Nan Wang, Zhipeng Xi, Rongrong Deng, Xiyu Liu, Ran Kang, Lin Xie, Xin Liu
Summary: This paper reviews the recent research progress of microfluidic technology in CTCs separation and detection, discusses the potential application of microfluidic technology in the treatment of tumor metastasis, and briefly explores the development prospect of microfluidic biosensors.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Chemistry, Analytical
Yanmin Wang, Wanlei Gao, Man Wu, Xiaofen Zhang, Wei Liu, Yang Zhou, Chunping Jia, Hui Cong, Xiang Chen, Jianlong Zhao
Summary: A multifunctional microfluidic chip was developed for the capture, lysis and nucleic acid detection of CTCs, successfully detecting gene mutations in lung cancer cells.
Article
Medical Laboratory Technology
Wenlong Guo, Lei Jin, Jianhao Liang, Guowang Lin, Jiantao Zheng, Dong Zhou, Shengquan Zhan, Haitao Sun, Xiaodan Jiang
Summary: This study tested the application of cerebrospinal fluid (CSF)-derived ctDNA in the detection and diagnosis of glioma. The results showed a high detection rate of ctDNA in CSF and a high concordance rate with tumor DNA. Additionally, CSF ctDNA TMB exhibited a strong correlation with tumor DNA TMB, and age was significantly associated with CSF ctDNA TMB in glioma patients.
CLINICA CHIMICA ACTA
(2022)
Article
Chemistry, Analytical
Xiaoyan Gan, Feng Qiu, Ruo Yuan, Yun Xiang
Summary: This study presents a highly sensitive, label-free, and specific electrochemical sensing assay for detecting circulating tumor cells (CTCs) in blood. By isolating target CTCs from sample solutions using aptamer-conjugated magnetic beads and biobarcode DNA-functionalized polystyrene beads, the release of biobarcode DNA triggers the liberation of enzymes from nanocapsules, leading to enhanced catalytic current for detecting CTCs at a detection limit of 8 cell mL-1 in a non-label approach.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Article
Biophysics
Ying Peng, Sha Ou, Menglu Li, Zuquan Hu, Zhu Zeng, Ninghan Feng
Summary: The identification and detection of mesenchymal circulating tumor cells (mCTCs) is crucial for early warning of tumor metastasis. A label-free biosensor has been developed for sensitive electrochemical assay of mCTCs, which can overcome the technical challenges posed by epithelial-mesenchymal transition (EMT)-induced phenotypic alteration. This biosensor shows high specificity in recognizing vimentin on the surface of mCTCs, allowing for accurate and sensitive quantification and recovery tests in whole blood.
BIOSENSORS & BIOELECTRONICS
(2023)
Article
Chemistry, Analytical
Xiaoyan Gan, Feng Qiu, Ruo Yuan, Yun Xiang
Summary: This study reports a highly sensitive, label-free and specific electrochemical sensing assay for detecting CTCs in blood. The target CTCs are selectively isolated and detected by coupling aptamer-conjugated magnetic beads and biobarcode DNA-functionalized polystyrene beads, offering great potential for various biomedical applications.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Article
Oncology
Yang Chen, Yanyan Li, Changsong Qi, Cheng Zhang, Dan Liu, Youping Deng, Yuanyuan Fu, Vedbar S. Khadka, Daisy Dandan Wang, Shanyang Tan, Shujun Liu, Zhi Peng, Jifang Gong, Peter Ping Lin, Xiaotian Zhang, Jian Li, Yilin Li, Lin Shen
Summary: This study revealed that heterogeneous-sized CTCs in gastric cancer patients are associated with poor treatment response and prognosis. Small and large CTCs showed distinct gene variations, indicating different mechanisms of therapy resistance.
Article
Biophysics
Soochul Shin, Sun Han, Juyoung Kim, Yumi Shin, Ji-Joon Song, Sungchul Hohng
Summary: SIMUL is a multiplexed ctDNA detection technique that can sensitively and specifically detect multiple single-nucleotide mutations in early cancer stages. It accurately measures mutant fractions and holds immense potential for clinical applications.
BIOSENSORS & BIOELECTRONICS
(2023)
Article
Oncology
Yuanrui Liu, Rong Zhao, Zaichun Xie, Zhiyu Pang, Shengjie Chen, Qian Xu, Zhanfeng Zhang
Summary: In this study, circulating tumor cells (CTCs) were detected in the peripheral blood of tumor patients, and their numbers and subtypes were found to be related to different tumor diseases and stages. CTCs with mesenchymal phenotypes were closely associated with lymph node or vascular metastasis. CTC detection can aid in early diagnosis of tumor diseases and monitoring of disease progression.
Article
Oncology
Andi K. Cani, Emily M. Dolce, Elizabeth P. Darga, Kevin Hu, Chia-Jen Liu, Jackie Pierce, Kieran Bradbury, Elaine Kilgour, Kimberly Aung, Gaia Schiavon, Danielle Carroll, T. Hedley Carr, Teresa Klinowska, Justin Lindemann, Gayle Marshall, Vicky Rowlands, Elizabeth A. Harrington, J. Carl Barrett, Nitharsan Sathiyayogan, Christopher Morrow, Valeria Sero, Anne C. Armstrong, Richard Baird, Erika Hamilton, Seock-Ah Im, Komal Jhaveri, Manish R. Patel, Caroline Dive, Scott A. Tomlins, Aaron M. Udager, Daniel F. Hayes, Costanza Paoletti
Summary: Research has shown that analyzing circulating tumor cells (CTC) in the blood can provide information about genomic alterations in breast cancer, potentially enabling more precise cancer treatment. By analyzing CTC, potential drug targets within patients can be identified, guiding the selection of targeted therapies, with feasible treatment opportunities discovered in 73% of patients.
MOLECULAR ONCOLOGY
(2022)
Article
Oncology
Zhouhong Ge, Jean C. A. Helmijr, Maurice P. H. M. Jansen, Patrick P. C. Boor, Lisanne Noordam, Maikel Peppelenbosch, Jaap Kwekkeboom, Jaco Kraan, Dave Sprengers
Summary: The study found that oncogenic mutations could be detected in ctDNA from advanced HCC patients, with TERT C228T mutation present in all patients with detectable ctDNA mutations or CTCs. CtDNA analysis may serve as a promising liquid biopsy to identify druggable mutations.
TRANSLATIONAL ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Melody Kasher, Frances M. K. Williams, Maxim B. Freidin, Ida Malkin, Stacey S. Cherny, Gregory Livshits
Summary: Rheumatoid arthritis and osteoporosis are two complex inflammatory conditions with shared genetic background and causal relationships. This study aimed to clarify the genetic architecture underlying these conditions and their relationship with C-reactive protein. The findings suggest that RA is a causal risk factor for CRP and there is evidence of shared genetic regions between CRP and OP.
HUMAN MOLECULAR GENETICS
(2022)
Article
Clinical Neurology
Frances M. K. Williams, Elizaveta E. Elgaeva, Maxim B. Freidin, Olga O. Zaytseva, Yurii S. Aulchenko, Yakov A. Tsepilov, Pradeep Suri
Summary: There are causal associations between education, smoking, alcohol consumption, major depressive disorder, and the risk of chronic back pain (CBP). CBP also has causal associations with greater alcohol consumption and smoking.
EUROPEAN SPINE JOURNAL
(2022)
Article
Medicine, General & Internal
Olga Yu Fedorenko, Diana Z. Paderina, Elena G. Kornetova, Evgeniya G. Poltavskaya, Ivan Pozhidaev, Anastasiia A. Goncharova, Maxim B. Freidin, Anna Bocharova, Nikolay A. Bokhan, Anton J. M. Loonen, Svetlana A. Ivanova
Summary: This study investigated the role of glutamatergic system genes in the pathogenesis of tardive dyskinesia (TD). The results suggest that genes encoding for mGlu3, EAAT2, and EAAT1 may be involved in the development of TD in schizophrenia patients.
Review
Oncology
Raymond Uyiosa Osarogiagbon, Paul Van Schil, Dorothy J. Giroux, Eric Lim, Paul Martin Putora, Yolande Lievens, Giuseppe Cardillo, Hong Kwan Kim, Gaetano Rocco, Andrea Bille, Helmut Prosch, Francisco Suarez Vasquez, Katherine K. Nishimura, Frank Detterbeck, Ramon Rami-Porta, Valerie W. Rusch, Hisao Asamura, James Huang
Summary: The status of lymph node involvement is a crucial aspect of the TNM staging system for lung cancer. This study reviews the evidence for alternative approaches to classifying lymph node involvement and discusses the potential revisions for the next edition of the staging system. The findings contribute to the progress of lung cancer staging research.
JOURNAL OF THORACIC ONCOLOGY
(2023)
Article
Immunology
Sergey Yu. Tereshchenko, Marina V. V. Smolnikova, Maxim B. B. Freidin
Summary: This study provides new insights on the prevalence of FCN3 rs532781899 and MASP2 rs72550870 variants among the newborns of aboriginal Siberian Arctic populations and Russians. The genetic data of other proteins in the lectin pathway were also analyzed. A total of 926 dried blood spot specimens were genotyped.
SCANDINAVIAN JOURNAL OF IMMUNOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Giuseppe Cardillo, Rene Horsleben Petersen, Sara Ricciardi, Akshay Patel, Joshil Lodhia, Michael R. Gooseman, Alessandro Brunelli, Joel Dunning, Wentao Fang, Dominique Gossot, Peter B. Licht, Eric Lim, Eric Dominique Roessner, Marco Scarci, Milan Milojevic
Summary: Pulmonary nodules are commonly encountered by respiratory physicians, radiologists, and thoracic surgeons. A collaborative effort by the European Association of Cardio-Thoracic Surgery and the European Society of Thoracic Surgeons aims to provide a comprehensive review of the management of pure ground-glass opacities and part-solid nodules. The literature suggests an increasing detection of early-stage lung cancer, emphasizing the importance of surgical resection and the need for guidelines. Multidisciplinary decision-making is recommended, considering radiologic characteristics, lesion evolution, patient fitness, and co-morbidities.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2023)
Article
Cell Biology
Maxim B. Freidin, Nathan Cheetham, Emma L. Duncan, Claire J. Steves, Katherine J. Doores, Michael H. Malim, Niccolo Rossi, Janet M. Lord, Paul W. Franks, Alessandra Borsini, Isabelle Granville Smith, Mario Falchi, Carmine Pariante, Frances M. K. Williams
Summary: Chronic fatigue is a common symptom of post-COVID syndrome, and this study suggests that elevated levels of IL-6 prior to COVID-19 infection may contribute to the development of chronic fatigue.
INFLAMMATION RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Elena Yu. Bragina, Densema E. Gomboeva, Olga V. Saik, Vladimir A. Ivanisenko, Maxim B. Freidin, Maria S. Nazarenko, Valery P. Puzyrev
Summary: Cancer and neurodegenerative disorders pose significant challenges in healthcare worldwide. A study suggests that genes associated with apoptosis and Huntington's disease (HD) might also play a role in carcinogenesis, leading to a decrease in cancer rates among patients with neurodegenerative disorders. By reconstructing gene networks and analyzing genomic data, several high-priority candidate genes, including APOE, PSEN1, and IL6, were identified for further investigation of the molecular relationship between cancer and HD. Functional analysis and expression profiling of these genes were performed using publicly available datasets, revealing their potential roles in disease-specific tissues.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Alexander M. Frankell, Michelle Dietzen, Maise Al Bakir, Emilia L. Lim, Takahiro Karasaki, Sophia Ward, Selvaraju Veeriah, Emma Colliver, Ariana Huebner, Abigail Bunkum, Mark S. Hill, Kristiana Grigoriadis, David A. Moore, James R. M. Black, Wing Kin Liu, Kerstin Thol, Oriol Pich, Thomas B. K. Watkins, Cristina Naceur-Lombardelli, Daniel E. Cook, Roberto Salgado, Gareth A. Wilson, Chris Bailey, Mihaela Angelova, Robert Bentham, Carlos Martinez-Ruiz, Christopher Abbosh, Andrew G. Nicholson, John Le Quesne, Dhruva Biswas, Rachel Rosenthal, Clare Puttick, Sonya Hessey, Claudia Lee, Paulina Prymas, Antonia Toncheva, Jon Smith, Wei Xing, Jerome Nicod, Gillian Price, Keith M. Kerr, Babu Naidu, Gary Middleton, Kevin G. Blyth, Dean A. Fennell, Martin D. Forster, Siow Ming Lee, Mary Falzon, Madeleine Hewish, Michael J. Shackcloth, Eric Lim, Sarah Benafif, Peter Russell, Ekaterini Boleti, Matthew G. Krebs, Jason F. Lester, Dionysis Papadatos-Pastos, Tanya Ahmad, Ricky M. Thakrar, David Lawrence, Neal Navani, Sam M. Janes, Caroline Dive, Fiona H. Blackhall, Yvonne Summers, Judith Cave, Teresa Marafioti, Javier Herrero, Sergio A. Quezada, Karl S. Peggs, Roland F. Schwarz, Peter Van Loo, Daniel M. Miedema, Nicolai J. Birkbak, Crispin T. Hiley, Allan Hackshaw, Simone Zaccaria, Mariam Jamal-Hanjani, Nicholas McGranahan, Charles Swanton, Amrita Bajaj, Apostolos Nakas, Azmina Sodha-Ramdeen, Keng Ang, Mohamad Tufail, Mohammed Fiyaz Chowdhry, Molly Scotland, Rebecca Boyles, Sridhar Rathinam, Claire Wilson, Domenic Marrone, Sean Dulloo, Gurdeep Matharu, Jacqui A. Shaw, Joa Riley, Lindsay Primrose, Heather Cheyne, Mohammed Khalil, Shirley Richardson, Tracey Cruickshank, Kayleigh Gilbert, Akshay J. Patel, Aya Osman, Christer Lacson, Gerald Langman, Helen Shackleford, Madava Djearaman, Salma Kadiri, Angela Leek, Jack Davies Hodgkinson, Nicola Totten, Angeles Montero, Elaine Smith, Eustace Fontaine, Felice Granato, Helen Doran, Juliette Novasio, Kendadai Rammohan, Leena Joseph, Paul Bishop, Rajesh Shah, Stuart Moss, Vijay Joshi, Philip Crosbie, Fabio Gomes, Kate Brown, Mathew Carter, Anshuman Chaturvedi, Lynsey Priest, Pedro Oliveira, Colin R. Lindsay, Alexandra Clipson, Jonathan Tugwood, Alastair Kerr, Dominic G. Rothwell, Elaine Kilgour, Hugo J. W. L. Aerts, Tom L. Kaufmann, Zoltan Szallasi, Judit Kisistok, Mateo Sokac, Miklos Diossy, Jonas Demeulemeester, Aengus Stewart, Alastair Magness, Andrew Rowan, Angeliki Karamani, Benny Chain, Brittany B. Campbell, Carla Castignani, Clare E. Weeden, Corentin Richard, David R. Pearce, Despoina Karagianni, Dina Levi, Elena Hoxha, Elizabeth Larose Cadieux, Emma Nye, Eva Gronroos, Felip Galvez-Cancino, Foteini Athanasopoulou, Francisco Gimeno-Valiente, George Kassiotis, Georgia Stavrou, Gerasimos Mastrokalos, Haoran L. Zhai, Helen L. Lowe, Ignacio Matos, Jacki Goldman, James L. Reading, Jayant K. Rane, Jie Min Lam, John A. Hartley, Katey S. S. Enfield, Kayalvizhi Selvaraju, Kevin Litchfield, Kevin W. Ng, Kezhong Chen, Krijn Dijkstra, Krupa Thakkar, Leah Ensell, Mansi Shah, Marcos Vasquez, Maria Litovchenko, Mariana Werner Sunderland, Michelle Leung, Mickael Escudero, Miljana Tanic, Monica Sivakumar, Nnennaya Kanu, Olga Chervova, Olivia Lucas, Othman Al-Sawaf, Philip Hobson, Piotr Pawlik, Richard Kevin Stone, Robert E. Hynds, Roberto Vendramin, Sadegh Saghafinia, Saioa Lopez, Samuel Gamble, Seng Kuong Anakin Ung, Sharon Vanloo, Stefan Boeing, Stephan Beck, Supreet Kaur Bola, Tamara Denner, Thanos P. Mourikis, Victoria Spanswick, Vittorio Barbe, Wei-Ting Lu, William Hill, Yin Wu, Yutaka Naito, Zoe Ramsden, Catarina Veiga, Gary Royle, Charles-Antoine Collins-Fekete, Francesco Fraioli, Paul Ashford, Tristan Clark, Elaine Borg, James Wilson, Alexander James Procter, Asia Ahmed, Magali N. Taylor, Arjun Nair, Davide Patrini, Emilie Martinoni Hoogenboom, Fleur Monk, James W. Holding, Junaid Choudhary, Kunal Bhakhri, Marco Scarci, Martin Hayward, Nikolaos Panagiotopoulos, Pat Gorman, Reena Khiroya, Robert C. M. Stephens, Yien Ning Sophia Wong, Steve Bandula, Abigail Sharp, Sean Smith, Nicole Gower, Harjot Kaur Dhanda, Kitty Chan, Camilla Pilotti, Rachel Leslie, Anca Grapa, Hanyun Zhang, Khalid AbdulJabbar, Xiaoxi Pan, Yinyin Yuan, David Chuter, Mairead MacKenzie, Serena Chee, Aiman Alzetani, Lydia Scarlett, Jennifer Richards, Papawadee Ingram, Silvia Austin, Paulo De Sousa, Simon Jordan, Alexandra Rice, Hilgardt Raubenheimer, Harshil Bhayani, Lyn Ambrose, Anand Devaraj, Hema Chavan, Sofina Begum, Silviu Buderi, Daniel Kaniu, Mpho Malima, Sarah Booth, Nadia Fernandes, Pratibha Shah, Chiara Proli, Sarah Danson, Lily Robinson, Craig Dick, Alan Kirk, Mo Asif, Rocco Bilancia, Nikos Kostoulas, Mathew Thomas
Summary: This study analyzed 1,644 tumor regions and found various gene mutations and evolutionary processes in lung adenocarcinoma. It was discovered that clonal expansion and whole genome doubling play important roles in the development and relapse of non-small cell lung cancer. The findings also revealed similarities in etiology and pathogenesis between lung adenocarcinoma in smokers and never-smokers.
Article
Genetics & Heredity
Ksenia A. Kobzeva, Maria O. Soldatova, Tatiana A. Stetskaya, Vladislav O. Soldatov, Alexey V. Deykin, Maxim B. Freidin, Marina A. Bykanova, Mikhail I. Churnosov, Alexey V. Polonikov, Olga Y. Bushueva
Summary: This pilot study examined the relationship between HSPA8 SNPs and the risk of ischemic stroke. The results showed that SNPs rs10892958 and rs1136141 in the HSPA8 gene were associated with an increased risk of stroke, especially in smokers and patients with low fruit and vegetable intake.
Article
Health Care Sciences & Services
Yakov A. Tsepilov, Elizaveta E. Elgaeva, Arina V. Nostaeva, Roger Compte, Ivan A. Kuznetsov, Lennart C. Karssen, Maxim B. Freidin, Pradeep Suri, Frances M. K. Williams, Yurii S. Aulchenko
Summary: Chronic back pain (CBP) is a complex heritable trait and a major cause of disability worldwide. We developed and validated a genome-wide polygenic risk score (PRS) for CBP using a large-scale GWAS based on UK Biobank participants of European ancestry (N = 265,000). The PRS showed poor overall predictive ability (AUC = 0.56 and OR = 1.24 per SD, 95% CI: 1.22-1.26), but individuals from the 99th percentile of PRS distribution had a nearly two-fold increased risk of CBP (OR = 1.82, 95% CI: 1.60-2.06). We validated the PRS on an independent TwinsUK sample, obtaining a similar magnitude of effect. The PRS was significantly associated with various ICD-10 and OPCS-4 diagnostic codes, including chronic ischemic heart disease (OR = 1.1, p-value = 4.8 x 10(-15)), obesity, metabolism-related traits, spine disorders, disc degeneration, and arthritis-related disorders. PRS and environment interaction analysis with twelve known CBP risk factors revealed no significant results, suggesting that the magnitude of G x E interactions with studied factors is small. The limited predictive ability of the PRS that we developed is likely explained by the complexity, heterogeneity, and polygenicity of CBP, for which sample sizes of a few hundred thousand are insufficient to estimate small genetic effects robustly.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Respiratory System
Mark E. Roberts, Najib M. Rahman, Nick A. Maskell, Anna C. Bibby, Kevin G. Blyth, John P. Corcoran, Anthony Edey, Matthew Evison, Duneesha de Fonseka, Rob Hallifax, Susan Harden, Iain Lawrie, Eric Lim, David McCracken, Rachel Mercer, Eleanor K. Mishra, Andrew G. Nicholson, Farinaz Noorzad, Kirstie S. Opstad, Maria Parsonage, Andrew E. Stanton, Steven Walker
Article
Respiratory System
Mark E. Roberts, Najib M. Rahman, Nick A. Maskell, Anna C. Bibby, Kevin G. Blyth, John P. Corcoran, Anthony Edey, Matthew Evison, Duneesha de Fonseka, Rob Hallifax, Susan Harden, Iain Lawrie, Eric Lim, David McCracken, Rachel Mercer, Eleanor K. Mishra, Andrew G. Nicholson, Farinaz Noorzad, Kirstie S. Opstad, Maria Parsonage, Andrew E. Stanton, Steven Walker, BTS Pleural Guideline Dev Grp
Article
Genetics & Heredity
Irina V. Zorkoltseva, Elizaveta E. Elgaeva, Nadezhda M. Belonogova, Anatoliy V. Kirichenko, Gulnara R. Svishcheva, Maxim B. Freidin, Frances M. K. Williams, Pradeep Suri, Yakov A. Tsepilov, Tatiana I. Axenovich
Summary: This study utilized exome sequencing data to analyze the genetics of back pain and identified the SLC13A1 and FSCN3 genes as contributors to chronic back pain. These findings offer new insights into the genetic mechanisms of back pain and potential drug targets.
Article
Respiratory System
Ashiq Abdul Khader, Aina Pons, Abigail Palmares, Sarah Booth, Alexander Smith, Chiara Proli, Paulo De Sousa, Eric Lim
Summary: This study aimed to evaluate the safety of using air leak criteria alone for chest drain removal in thoracic surgery. The results showed that using digital assessment of air leak as the sole criteria for drain removal maintained acceptable levels of safety in selected patients undergoing general thoracic surgery.
JOURNAL OF THORACIC DISEASE
(2023)