Cell-free circulating tumour DNA as a liquid biopsy in breast cancer

PIK3CA mutations in serum DNA are predictive of recurrence in primary breast cancer patients

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Serial Next-Generation Sequencing of Circulating Cell-Free DNA Evaluating Tumor Clone Response To Molecularly Targeted Drug Administration

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Rapid Identification of Plasma DNA Samples with Increased ctDNA Levels by a Modified FAST-SeqS Approach

(2015) J. Belic et al.   CLINICAL CHEMISTRY

Noninvasive Detection of Activating Estrogen Receptor 1 (ESR1) Mutations in Estrogen Receptor-Positive Metastatic Breast Cancer

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Brain Tumor Mutations Detected in Cerebral Spinal Fluid

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Serial monitoring of circulating tumor DNA in patients with primary breast cancer for detection of occult metastatic disease

(2015) Eleonor Olsson et al.   EMBO Molecular Medicine

Feasibility of Large-Scale Genomic Testing to Facilitate Enrollment Onto Genomically Matched Clinical Trials

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Memorial Sloan Kettering-Integrated Mutation Profiling of Actionable Cancer Targets (MSK-IMPACT)

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Molecularly targeted therapy based on tumour molecular profiling versus conventional therapy for advanced cancer (SHIVA): a multicentre, open-label, proof-of-concept, randomised, controlled phase 2 trial

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Subclonal diversification of primary breast cancer revealed by multiregion sequencing

(2015) Lucy R Yates et al.   NATURE MEDICINE

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(2015) Florent Mouliere et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Clonal status of actionable driver events and the timing of mutational processes in cancer evolution

(2015) Nicholas McGranahan et al.   Science Translational Medicine

Mutation tracking in circulating tumor DNA predicts relapse in early breast cancer

(2015) Isaac Garcia-Murillas et al.   Science Translational Medicine

Analysis of ESR1 mutation in circulating tumor DNA demonstrates evolution during therapy for metastatic breast cancer

(2015) Gaia Schiavon et al.   Science Translational Medicine

Cerebrospinal fluid-derived circulating tumour DNA better represents the genomic alterations of brain tumours than plasma

(2015) Leticia De Mattos-Arruda et al.   Nature Communications

Multifocal clonal evolution characterized using circulating tumour DNA in a case of metastatic breast cancer

(2015) Muhammed Murtaza et al.   Nature Communications

Actionable mutations in plasma cell-free DNA in patients with advanced cancers referred for experimental targeted therapies

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Presymptomatic Identification of Cancers in Pregnant Women During Noninvasive Prenatal Testing

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Capturing intra-tumor genetic heterogeneity by de novo mutation profiling of circulating cell-free tumor DNA: a proof-of-principle

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Plasma circulating tumor DNA as an alternative to metastatic biopsies for mutational analysis in breast cancer

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Personalized treatments of cancer patients: A reality in daily practice, a costly dream or a shared vision of the future from the oncology community?

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Detection of Cancer DNA in Plasma of Patients with Early-Stage Breast Cancer

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Circulating tumor DNA and circulating tumor cells in metastatic triple negative breast cancer patients

(2014) Jordan Madic et al.   INTERNATIONAL JOURNAL OF CANCER

Liquid Biopsies: Genotyping Circulating Tumor DNA

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Comparative genomic hybridisation array and DNA sequencing to direct treatment of metastatic breast cancer: a multicentre, prospective trial (SAFIR01/UNICANCER)

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Detection of Circulating Tumor DNA in Early- and Late-Stage Human Malignancies

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Escaping Out of the Brain

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Brain Tumor Cells in Circulation Are Enriched for Mesenchymal Gene Expression

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Blood-Based Analyses of Cancer: Circulating Tumor Cells and Circulating Tumor DNA

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D538G Mutation in Estrogen Receptor- : A Novel Mechanism for Acquired Endocrine Resistance in Breast Cancer

(2013) K. Merenbakh-Lamin et al.   CANCER RESEARCH

Noninvasive Detection of HER2 Amplification with Plasma DNA Digital PCR

(2013) H. Gevensleben et al.   CLINICAL CANCER RESEARCH

A new genome-driven integrated classification of breast cancer and its implications

(2013) Sarah-Jane Dawson et al.   EMBO JOURNAL

Establishment of tumor-specific copy number alterations from plasma DNA of patients with cancer

(2013) Ellen Heitzer et al.   INTERNATIONAL JOURNAL OF CANCER

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(2013) Philippe L. Bedard et al.   NATURE

The shaping and functional consequences of the microRNA landscape in breast cancer

(2013) Heidi Dvinge et al.   NATURE

Non-invasive analysis of acquired resistance to cancer therapy by sequencing of plasma DNA

(2013) Muhammed Murtaza et al.   NATURE

ESR1 ligand-binding domain mutations in hormone-resistant breast cancer

(2013) Weiyi Toy et al.   NATURE GENETICS

Activating ESR1 mutations in hormone-resistant metastatic breast cancer

(2013) Dan R Robinson et al.   NATURE GENETICS

Circulating tumour cells and cell-free DNA as tools for managing breast cancer

(2013) Leticia De Mattos-Arruda et al.   Nature Reviews Clinical Oncology

Implementing personalized cancer genomics in clinical trials

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Analysis of Circulating Tumor DNA to Monitor Metastatic Breast Cancer

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The Implications of Clonal Genome Evolution for Cancer Medicine

(2013) Samuel Aparicio et al.   NEW ENGLAND JOURNAL OF MEDICINE

Pilot Studies for Personalized Cancer Medicine: Focusing on the Patient for Treatment Selection

(2013) L. De Mattos-Arruda et al.   ONCOLOGIST

BEAMing and Droplet Digital PCR Analysis of Mutant IDH1 mRNA in Glioma Patient Serum and Cerebrospinal Fluid Extracellular Vesicles

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Cross-talk between HER2 and MED1 Regulates Tamoxifen Resistance of Human Breast Cancer Cells

(2012) J. Cui et al.   CANCER RESEARCH

Med1 plays a critical role in the development of tamoxifen resistance

(2012) Arumugam Nagalingam et al.   CARCINOGENESIS

The Life History of 21 Breast Cancers

(2012) Serena Nik-Zainal et al.   CELL

Detection of Tumor PIK3CA Status in Metastatic Breast Cancer Using Peripheral Blood

(2012) M. J. Higgins et al.   CLINICAL CANCER RESEARCH

Molecular Profiling of Patients with Colorectal Cancer and Matched Targeted Therapy in Phase I Clinical Trials

(2012) R. Dienstmann et al.   MOLECULAR CANCER THERAPEUTICS

The landscape of cancer genes and mutational processes in breast cancer

(2012) Philip J. Stephens et al.   NATURE

The clonal and mutational evolution spectrum of primary triple-negative breast cancers

(2012) Sohrab P. Shah et al.   NATURE

Comprehensive molecular portraits of human breast tumours

(2012) Daniel C. Koboldt et al.   NATURE

The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups

(2012) Christina Curtis et al.   NATURE

Intratumor Heterogeneity and Branched Evolution Revealed by Multiregion Sequencing

(2012) Marco Gerlinger et al.   NEW ENGLAND JOURNAL OF MEDICINE

Noninvasive Identification and Monitoring of Cancer Mutations by Targeted Deep Sequencing of Plasma DNA

(2012) T. Forshew et al.   Science Translational Medicine

Detection of Chromosomal Alterations in the Circulation of Cancer Patients with Whole-Genome Sequencing

(2012) R. J. Leary et al.   Science Translational Medicine

Tumour evolution inferred by single-cell sequencing

(2011) Nicholas Navin et al.   NATURE

Serum DNA can define tumor-specific genetic and epigenetic markers in gliomas of various grades

(2011) I. Lavon et al.   NEURO-ONCOLOGY

Detection of PIK3CA mutations in circulating free DNA in patients with breast cancer

(2010) Ruth E. Board et al.   BREAST CANCER RESEARCH AND TREATMENT

Use of cancer-specific genomic rearrangements to quantify disease burden in plasma from patients with solid tumors

(2010) David J. McBride et al.   GENES CHROMOSOMES & CANCER

Development of Personalized Tumor Biomarkers Using Massively Parallel Sequencing

(2010) R. J. Leary et al.   Science Translational Medicine

Novel Mechanism of Lapatinib Resistance in HER2-Positive Breast Tumor Cells: Activation of AXL

(2009) L. Liu et al.   CANCER RESEARCH

Mutational evolution in a lobular breast tumour profiled at single nucleotide resolution

(2009) Sohrab P. Shah et al.   NATURE

Analysis of Cancer Mutation Signatures in Blood by a Novel Ultra-Sensitive Assay: Monitoring of Therapy or Recurrence in Non-Metastatic Breast Cancer

(2009) Zhenbin Chen et al.   PLoS One