Simvastatin improves oral implant osseointegration via enhanced autophagy and osteogenesis of BMSCs and inhibited osteoclast activity

Novel strategies for anti-aging drug discovery

(2017) Komal Saraswat et al.   Expert Opinion on Drug Discovery

Local Application of Growth Hormone to Enhance Osseointegration in Osteoporotic Bones: A Morphometric and Densitometric Study

(2017) Elena Martin-Monge et al.   INTERNATIONAL JOURNAL OF ORAL & MAXILLOFACIAL IMPLANTS

The combined effects of nanotopography and Sr ion for enhanced osteogenic activity of bone marrow mesenchymal stem cells (BMSCs)

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The Role of Reactive Oxygen Species and Autophagy in Periodontitis and Their Potential Linkage

(2017) Chengcheng Liu et al.   Frontiers in Physiology

Enhanced autophagy as a potential mechanism for the improved physiological function by simvastatin in muscular dystrophy

(2016) Nicholas P. Whitehead   Autophagy

Activation of autophagy by FOXO3 regulates redox homeostasis during osteogenic differentiation

(2016) M. C. Gómez-Puerto et al.   Autophagy

Novel antioxidant capability of titanium induced by UV light treatment

(2016) Takeshi Ueno et al.   BIOMATERIALS

Role of Simvastatin on fracture healing and osteoporosis: a systematic review onin vivoinvestigations

(2016) Ali Moshiri et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Promotion of osteointegration under diabetic conditions by tantalum coating-based surface modification on 3-dimensional printed porous titanium implants

(2016) Lin Wang et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Transplantation of osteoporotic bone marrow stromal cells rejuvenated by the overexpression of SATB2 prevents alveolar bone loss in ovariectomized rats

(2016) Rongyao Xu et al.   EXPERIMENTAL GERONTOLOGY

Enhancement of Orthodontic Anchor Screw Stability Under Immediate Loading by Ultraviolet Photofunctionalization Technology

(2016) Maiko Takahashi et al.   INTERNATIONAL JOURNAL OF ORAL & MAXILLOFACIAL IMPLANTS

Simvastatin improves the homing of BMSCsviathe PI3K/AKT/miR-9 pathway

(2016) Weidong Bing et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Simvastatin-doped pre-mixed calcium phosphate cement inhibits osteoclast differentiation and resorption

(2016) M. Montazerolghaem et al.   JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE

The influence of statins on osseointegration: a systematic review of animal model studies

(2016) D. I. Sendyk et al.   JOURNAL OF ORAL REHABILITATION

Hepatotoxicity of statins and other lipid-lowering agents

(2016) Einar S. Björnsson   LIVER INTERNATIONAL

In vivoevaluation of a simvastatin-loaded nanostructured lipid carrier for bone tissue regeneration

(2016) Xinxin Yue et al.   NANOTECHNOLOGY

Role of ROS and RNS Sources in Physiological and Pathological Conditions

(2016) Sergio Di Meo et al.   Oxidative Medicine and Cellular Longevity

Simvastatin alleviates airway inflammation and remodelling through up-regulation of autophagy in mouse models of asthma

(2016) Wen Gu et al.   RESPIROLOGY

Nano-thick calcium oxide armed titanium: boosts bone cells against methicillin-resistant Staphylococcus aureus

(2016) Huiliang Cao et al.   Scientific Reports

Osseointegration of chitosan coated porous titanium alloy implant by reactive oxygen species-mediated activation of the PI3K/AKT pathway under diabetic conditions

(2015) Xiang Li et al.   BIOMATERIALS

Dental Follicle Cells Participate in Tooth Eruption via the RUNX2-MiR-31-SATB2 Loop

(2015) J. Ge et al.   JOURNAL OF DENTAL RESEARCH

A new therapeutic effect of simvastatin revealed by functional improvement in muscular dystrophy

(2015) Nicholas P. Whitehead et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Role of Reactive Oxygen Species in Mesenchymal Stem Cell Adipogenic and Osteogenic Differentiation: A Review

(2015) Fatemeh Atashi et al.   STEM CELLS AND DEVELOPMENT

Neuroprotective Effect of Simvastatin via Inducing the Autophagy on Spinal Cord Injury in the Rat Model

(2015) Kai Gao et al.   Biomed Research International

Effects of simvastatin on the osteogenic differentiation and immunomodulation of bone marrow mesenchymal stem cells

(2015) JIANYI NIU et al.   Molecular Medicine Reports

Silver Nanoparticles and Growth Factors Incorporated Hydroxyapatite Coatings on Metallic Implant Surfaces for Enhancement of Osteoinductivity and Antibacterial Properties

(2014) Chao-Ming Xie et al.   ACS Applied Materials & Interfaces

Autophagy in osteoblasts is involved in mineralization and bone homeostasis

(2014) Marie Nollet et al.   Autophagy

Autophagy induction is a survival response against oxidative stress in bone marrow–derived mesenchymal stromal cells

(2014) Chunjuan Song et al.   CYTOTHERAPY

Histone deacetylase 8 suppresses osteogenic differentiation of bone marrow stromal cells by inhibiting histone H3K9 acetylation and RUNX2 activity

(2014) Yu Fu et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Synthesis and characterization of cationic polymeric nanoparticles as simvastatin carriers for enhancing the osteogenesis of bone marrow mesenchymal stem cells

(2014) Chau-Zen Wang et al.   JOURNAL OF COLLOID AND INTERFACE SCIENCE

Simvastatin prevents alveolar bone loss in an experimental rat model of periodontitis after ovariectomy

(2014) Xin-chen Xu et al.   Journal of Translational Medicine

Glucocorticoids induce autophagy in rat bone marrow mesenchymal stem cells

(2014) LONG WANG et al.   Molecular Medicine Reports

Bone regeneration around N-acetyl cysteine-loaded nanotube titanium dental implant in rat mandible

(2013) Young-Hee Lee et al.   BIOMATERIALS

A pre-clinical murine model of oral implant osseointegration

(2013) S. Mouraret et al.   BONE

Trehalose Maintains Bioactivity and Promotes Sustained Release of BMP-2 from Lyophilized CDHA Scaffolds for Enhanced Osteogenesis In Vitro and In Vivo

(2013) Jun Zhao et al.   PLoS One

Stimulation of Osteoclast Formation by RANKL Requires Interferon Regulatory Factor-4 and Is Inhibited by Simvastatin in a Mouse Model of Bone Loss

(2013) Yoshiki Nakashima et al.   PLoS One

Simvastatin Alleviates the Progression of Periapical Lesions by Modulating Autophagy and Apoptosis in Osteoblasts

(2012) Eddie Hsiang-Hua Lai et al.   JOURNAL OF ENDODONTICS

Apoptosis, autophagy and ER stress in mevalonate cascade inhibition-induced cell death of human atrial fibroblasts

(2012) S Ghavami et al.   Cell Death & Disease

The acceleration of implant osseointegration by liposomal Wnt3a

(2010) Antoine Popelut et al.   BIOMATERIALS

Simvastatin induces osteogenic differentiation of murine embryonic stem cells

(2010) Joseph Pagkalos et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Simvastatin promotes osteoblast viability and differentiation via Ras/Smad/Erk/BMP-2 signaling pathway

(2010) Pei-Yu Chen et al.   NUTRITION RESEARCH

Simvastatin inhibits osteoclast differentiation induced by bone morphogenetic protein-2 and RANKL through regulating MAPK, AKT and Src signaling

(2010) Misuzu Yamashita et al.   REGULATORY PEPTIDES

Simvastatin Induces the Odontogenic Differentiation of Human Dental Pulp Stem Cells In Vitro and In Vivo

(2009) Yosuke Okamoto et al.   JOURNAL OF ENDODONTICS

Simvastatin, 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor, suppresses osteoclastogenesis induced by receptor activator of nuclear factor-κB ligand through modulation of NF-κB pathway

(2008) Kwang Seok Ahn et al.   INTERNATIONAL JOURNAL OF CANCER

Influence of collagen-fibril-based coatings containing decorin and biglycan on osteoblast behavior

(2007) Timothy Douglas et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A