Simvastatin improves the homing of BMSCsviathe PI3K/AKT/miR-9 pathway

The AKT/mTOR signaling pathway plays a key role in statin-induced myotoxicity

(2015) Annalisa Bonifacio et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Nuclear localized Akt enhances breast cancer stem-like cells through counter-regulation of p21Waf1/Cip1and p27kip1

(2015) Mayur Vilas Jain et al.   CELL CYCLE

SEMA3F prevents metastasis of colorectal cancer by PI3K-AKT-dependent down-regulation of the ASCL2-CXCR4 axis

(2015) Zhi-hang Zhou et al.   JOURNAL OF PATHOLOGY

miR-146a controls CXCR4 expression in a pathway that involves PLZF and can be used to inhibit HIV-1 infection of CD4+ T lymphocytes

(2015) Maria Teresa Quaranta et al.   VIROLOGY

Role of phosphatase activity of soluble epoxide hydrolase in regulating simvastatin-activated endothelial nitric oxide synthase

(2015) Hsin-Han Hou et al.   Scientific Reports

COMP-angiopoietin 1 increases proliferation, differentiation, and migration of stem-like cells through Tie-2-mediated activation of p38 MAPK and PI3K/Akt signal transduction pathways

(2014) Sung-Ho Kook et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Cell adhesion molecules and their relation to (cancer) cell stemness

(2014) Ensieh Farahani et al.   CARCINOGENESIS

Synthesis and characterization of cationic polymeric nanoparticles as simvastatin carriers for enhancing the osteogenesis of bone marrow mesenchymal stem cells

(2014) Chau-Zen Wang et al.   JOURNAL OF COLLOID AND INTERFACE SCIENCE

CXCR4 Inhibition Ameliorates Severe Obliterative Pulmonary Hypertension and Accumulation of C-Kit+ Cells in Rats

(2014) Daniela Farkas et al.   PLoS One

MicroRNA-494-3p targets CXCR4 to suppress the proliferation, invasion, and migration of prostate cancer

(2014) Peng-fei Shen et al.   PROSTATE

Bone marrow stromal cells as a therapeutic treatment for ischemic stroke

(2014) Zizhen Yang et al.   Neuroscience Bulletin

Mesenchymal Stem Cells for Treatment of Myocardial Infarction

(2014) Il-Kwon Ko et al.   International Journal of Stem Cells

Complement inhibition and statins prevent fetal brain cortical abnormalities in a mouse model of preterm birth

(2013) Silvia M.A. Pedroni et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Overexpression of the Mesenchymal Stem Cell Cxcr4 Gene in Irradiated Mice Increases the Homing Capacity of These Cells

(2013) Wei Chen et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

Simvastatin attenuates the additive effects of TNF-α and IL-18 on the connexin 43 up-regulation and over-proliferation of cultured aortic smooth muscle cells

(2013) Yu-Chun Lin et al.   CYTOKINE

PTEN loss mediated Akt activation promotes prostate tumor growth and metastasis via CXCL12/CXCR4 signaling

(2013) M Conley-LaComb et al.   Molecular Cancer

Transcriptional Regulation of CXCR4 in Prostate Cancer: Significance of TMPRSS2-ERG Fusions

(2013) R. Singareddy et al.   MOLECULAR CANCER RESEARCH

MicroRNA-9 inhibits the proliferation of oral squamous cell carcinoma cells by suppressing expression of CXCR4 via the Wnt/β-catenin signaling pathway

(2013) T Yu et al.   ONCOGENE

miR-27b Represses Migration of Mouse MSCs to Burned Margins and Prolongs Wound Repair through Silencing SDF-1a

(2013) Mu-Han Lü et al.   PLoS One

Establishing a Bone Marrow Stromal Cell Transplant Program at the National Institutes of Health Clinical Center

(2013) David F. Stroncek et al.   TISSUE ENGINEERING PART B-REVIEWS

Enhancing the Migration Ability of Mesenchymal Stromal Cells by Targeting the SDF-1/CXCR4 Axis

(2013) Leah A. Marquez-Curtis et al.   Biomed Research International

Vein graft neointimal hyperplasia is exacerbated by CXCR4 signaling in vein graft-extrinsic cells

(2012) Lisheng Zhang et al.   JOURNAL OF VASCULAR SURGERY

FSP-1 Silencing in Bone Marrow Cells Suppresses Neointima Formation in Vein Graft

(2011) Jizhong Cheng et al.   CIRCULATION RESEARCH

microRNA-150 Regulates Mobilization and Migration of Bone Marrow-Derived Mononuclear Cells by Targeting Cxcr4

(2011) Nobuko Tano et al.   PLoS One

The Role of Chemokines in Mesenchymal Stem Cell Homing to Myocardium

(2011) Yaojiong Wu et al.   Stem Cell Reviews and Reports

Hypoxic preconditioning advances CXCR4 and CXCR7 expression by activating HIF-1α in MSCs

(2010) Hongbao Liu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

SDF-1α as a therapeutic stem cell homing factor in myocardial infarction

(2010) Santhosh K. Ghadge et al.   PHARMACOLOGY & THERAPEUTICS

Combined Therapy With Simvastatin and Bone Marrow–Derived Mesenchymal Stem Cells Increases Benefits in Infarcted Swine Hearts

(2009) Yue-Jin Yang et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Stromal cell-derived factor 1/CXCR4 signaling is critical for the recruitment of mesenchymal stem cells to the fracture site during skeletal repair in a mouse model

(2009) Toshiyuki Kitaori et al.   ARTHRITIS AND RHEUMATISM

Cyclic stretch upregulates SDF-1α/CXCR4 axis in human saphenous vein smooth muscle cells

(2009) Fei Li et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Many roads to maturity: microRNA biogenesis pathways and their regulation

(2009) Julia Winter et al.   NATURE CELL BIOLOGY

Chemokine, vascular and therapeutic effects of combination Simvastatin and BMSC treatment of stroke

(2009) Xu Cui et al.   NEUROBIOLOGY OF DISEASE

Simvastatin enhances bone marrow stromal cell differentiation into endothelial cells via notch signaling pathway

(2008) Jian Xu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

HMG-CoA reductase inhibition induces IL-1  release through Rac1/PI3K/PKB-dependent caspase-1 activation

(2008) L. M. Kuijk et al.   BLOOD

The stem cell niche

(2008) MR Walker et al.   JOURNAL OF PATHOLOGY

Mesenchymal Stem Cells Differentiate into an Endothelial Phenotype, Reduce Neointimal Formation, and Enhance Endothelial Function in a Rat Vein Grafting Model

(2008) Wei-Ming Yue et al.   STEM CELLS AND DEVELOPMENT