Nicotinic receptor activation contrasts pathophysiological bursting and neurodegeneration evoked by glutamate uptake block on rat hypoglossal motoneurons

NewIn VitroModels to Study Amyotrophic Lateral Sclerosis

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Non-neuronal Cells in ALS: Role of Glial, Immune cells and Blood-CNS Barriers

(2016) Fabiola Puentes et al.   BRAIN PATHOLOGY

Mutant SOD1 mediated pathogenesis of Amyotrophic Lateral Sclerosis

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Smoking-Relevant Nicotine Concentration Attenuates the Unfolded Protein Response in Dopaminergic Neurons

(2016) R. Srinivasan et al.   JOURNAL OF NEUROSCIENCE

Decoding the organization of spinal circuits that control locomotion

(2016) Ole Kiehn   NATURE REVIEWS NEUROSCIENCE

Emerging Roles of Filopodia and Dendritic Spines in Motoneuron Plasticity during Development and Disease

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Anti-inflammatory role of microglial alpha7 nAChRs and its role in neuroprotection

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Developmental changes in the morphology of mouse hypoglossal motor neurons

(2015) Refik Kanjhan et al.   Brain Structure & Function

Developmental nicotine exposure enhances inhibitory synaptic transmission in motor neurons and interneurons critical for normal breathing

(2015) Stuti J. Jaiswal et al.   Developmental Neurobiology

Glycoprotein Quality Control and Endoplasmic Reticulum Stress

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Familial Amyotrophic Lateral Sclerosis

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Inside-out neuropharmacology of nicotinic drugs

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Motor neurons with differential vulnerability to degeneration show distinct protein signatures in health and ALS

(2015) L. Comley et al.   NEUROSCIENCE

Crystal structure of a mycobacterial Insig homolog provides insight into how these sensors monitor sterol levels

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Nicotinic ACh receptors as therapeutic targets in CNS disorders

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Haploid Genetic Screen Reveals a Profound and Direct Dependence on Cholesterol for Hantavirus Membrane Fusion

(2015) Lara M. Kleinfelter et al.   mBio

Acrylic Resin Cytotoxicity for Denture Base: Literature Review

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Evaluation of nicotine and cotinine analogs as potential neuroprotective agents for Alzheimer’s disease

(2014) Jie Gao et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

The potential role of heat shock proteins in acute spinal cord injury

(2014) Yijun Zhou et al.   EUROPEAN SPINE JOURNAL

Translating biological findings into new treatment strategies for amyotrophic lateral sclerosis (ALS)

(2014) Lindsay Poppe et al.   EXPERIMENTAL NEUROLOGY

α7 nicotinic acetylcholine receptors control cytochrome c release from isolated mitochondria through kinase-mediated pathways

(2014) Galyna Gergalova et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Mitochondria express several nicotinic acetylcholine receptor subtypes to control various pathways of apoptosis induction

(2014) Olena Lykhmus et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Mg2+block properties of triheteromeric GluN1-GluN2B-GluN2D NMDA receptors on neonatal rat substantia nigra pars compacta dopaminergic neurones

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ATF3 is a novel nuclear marker for migrating ependymal stem cells in the rat spinal cord

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Expression of the Ly-6 family proteins Lynx1 and Ly6H in the rat brain is compartmentalized, cell-type specific, and developmentally regulated

(2013) Morten Skøtt Thomsen et al.   Brain Structure & Function

Targeting the unfolded protein response in disease

(2013) Claudio Hetz et al.   NATURE REVIEWS DRUG DISCOVERY

Functional Contribution of the Transcription Factor ATF4 to the Pathogenesis of Amyotrophic Lateral Sclerosis

(2013) Soledad Matus et al.   PLoS One

Direct interaction between STAT3 and EIF2AK2 controls fatty acid-induced autophagy

(2012) Mireia Niso-Santano et al.   Autophagy

Excitotoxicity: Bridge to various triggers in neurodegenerative disorders

(2012) Ankita Mehta et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Malectin Forms a Complex with Ribophorin I for Enhanced Association with Misfolded Glycoproteins

(2012) Sheng-Ying Qin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Subunit of Eukaryotic Translation Initiation Factor 2α-Phosphatase (CreP/PPP1R15B) Regulates Membrane Traffic

(2012) Nicole Kloft et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

NMDA induces persistent inward and outward currents that cause rhythmic bursting in adult rodent motoneurons

(2012) Marin Manuel et al.   JOURNAL OF NEUROPHYSIOLOGY

Chemical Synthesis of Intentionally Misfolded Homogeneous Glycoprotein: A Unique Approach for the Study of Glycoprotein Quality Control

(2012) Masayuki Izumi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Excitotoxicity Through NMDA Receptors Mediates Cerebellar Granule Neuron Apoptosis Induced by Prion Protein 90-231 Fragment

(2012) Stefano Thellung et al.   NEUROTOXICITY RESEARCH

Mitochondria Express α7 Nicotinic Acetylcholine Receptors to Regulate Ca2+ Accumulation and Cytochrome c Release: Study on Isolated Mitochondria

(2012) Galyna Gergalova et al.   PLoS One

Direct Association of Unfolded Proteins with Mammalian ER Stress Sensor, IRE1β

(2012) Daisuke Oikawa et al.   PLoS One

Postnatal developmental profile of neurons and glia in motor nuclei of the brainstem and spinal cord, and its comparison with organotypic slice cultures

(2011) Alessandra Cifra et al.   Developmental Neurobiology

Riluzole is a potent drug to protect neonatal rat hypoglossal motoneurons in vitro from excitotoxicity due to glutamate uptake block

(2011) Alessandra Cifra et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Different p97/VCP complexes function in retrotranslocation step of mammalian Er-associated degradation (ERAD)

(2011) Petek Ballar et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Trafficking of α4* Nicotinic Receptors Revealed by Superecliptic Phluorin

(2011) Christopher I. Richards et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Unfolded proteins and endoplasmic reticulum stress in neurodegenerative disorders

(2011) Karen M. Doyle et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Increased nicotinic receptor desensitization in hypoglossal motor neurons following chronic developmental nicotine exposure

(2011) Jason Q. Pilarski et al.   JOURNAL OF NEUROPHYSIOLOGY

Delayed neuroprotection by riluzole against excitotoxic damage evoked by kainate on rat organotypic spinal cord cultures

(2011) G.L. Mazzone et al.   NEUROSCIENCE

Respiratory motoneurons and pathological conditions: Lessons from hypoglossal motoneurons challenged by excitotoxic or oxidative stress

(2011) Alessandra Cifra et al.   RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY

Enhancement of nicotinic receptors alleviates cytotoxicity in neurological disease models

(2011) Jun Kawamata et al.   Therapeutic Advances in Chronic Disease

Localisation of pre- and postsynaptic cholinergic markers in the human brain

(2010) Andrea Wevers   BEHAVIOURAL BRAIN RESEARCH

Transient oxidative stress evokes early changes in the functional properties of neonatal rat hypoglossal motoneuronsin vitro

(2010) Francesca Nani et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Nicotine up-regulates α4β2 nicotinic receptors and ER exit sites via stoichiometry-dependent chaperoning

(2010) Rahul Srinivasan et al.   JOURNAL OF GENERAL PHYSIOLOGY

Redox Reactions Induced by Nitrosative Stress Mediate Protein Misfolding and Mitochondrial Dysfunction in Neurodegenerative Diseases

(2010) Zezong Gu et al.   MOLECULAR NEUROBIOLOGY

Nicotine addiction and nicotinic receptors: lessons from genetically modified mice

(2010) Jean-Pierre Changeux   NATURE REVIEWS NEUROSCIENCE

Kainate-induced delayed onset of excitotoxicity with functional loss unrelated to the extent of neuronal damage in the in vitro spinal cord

(2010) G.L. Mazzone et al.   NEUROSCIENCE

Upregulation of persistent sodium conductances in familial ALS

(2009) S. Vucic et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

A repertoire of rhythmic bursting produced by hypoglossal motoneurons in physiological and pathological conditions

(2009) A. Cifra et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Mammalian Nicotinic Acetylcholine Receptors: From Structure to Function

(2009) Edson X. Albuquerque et al.   PHYSIOLOGICAL REVIEWS

Up-regulation of Nicotinic Receptors by Nicotine Varies with Receptor Subtype

(2008) Heather Walsh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

 4* Nicotinic Receptors in preBotzinger Complex Mediate Cholinergic/Nicotinic Modulation of Respiratory Rhythm

(2008) X. M. Shao et al.   JOURNAL OF NEUROSCIENCE

Cu/Zn Superoxide Dismutase Typical for Familial Amyotrophic Lateral Sclerosis Increases the Vulnerability of Mitochondria and Perturbs Ca2+ Homeostasis in SOD1G93A Mice

(2008) M. K. Jaiswal et al.   MOLECULAR PHARMACOLOGY

N-methyl-d-aspartate triggers neonatal rat hypoglossal motoneurons in vitro to express rhythmic bursting with unusual Mg2+ sensitivity

(2008) E. Sharifullina et al.   NEUROSCIENCE

Postsynaptic mechanisms of excitotoxicity: Involvement of postsynaptic density proteins, radicals, and oxidant molecules

(2008) J.P. Forder et al.   NEUROSCIENCE

Desensitization of neuronal nicotinic receptors of human neuroblastoma SH-SY5Y cells during short or long exposure to nicotine

(2005) Elena Sokolova et al.   BRITISH JOURNAL OF PHARMACOLOGY