Sequence determinants of subtype-specific actions of KCNQ channel openers

Potent KCNQ2/3-Specific Channel Activator Suppresses In Vivo Epileptic Activity and Prevents the Development of Tinnitus

(2015) B. I. Kalappa et al.   JOURNAL OF NEUROSCIENCE

Atomic basis for therapeutic activation of neuronal potassium channels

(2015) Robin Y. Kim et al.   Nature Communications

Asymmetric functional contributions of acidic and aromatic side chains in sodium channel voltage-sensor domains

(2014) Stephan A. Pless et al.   JOURNAL OF GENERAL PHYSIOLOGY

Capturing distinct KCNQ2 channel resting states by metal ion bridges in the voltage-sensor domain

(2014) Orit Gourgy-Hacohen et al.   JOURNAL OF GENERAL PHYSIOLOGY

The gating charge pathway of an epilepsy-associated potassium channel accommodates chemical ligands

(2013) Ping Li et al.   CELL RESEARCH

Decomposition of Slide Helix Contributions to ATP-dependent Inhibition of Kir6.2 Channels

(2013) Jenny B. W. Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Pore Residue of the KCNQ3 Potassium M-Channel Subunit Controls Surface Expression

(2013) J. C. Gomez-Posada et al.   JOURNAL OF NEUROSCIENCE

Genotype–phenotype correlations in neonatal epilepsies caused by mutations in the voltage sensor of Kv7.2 potassium channel subunits

(2013) Francesco Miceli et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The new KCNQ2 activator 4-Chlor-N-(6-chlor-pyridin-3-yl)-benzamid displays anticonvulsant potential

(2012) A Boehlen et al.   BRITISH JOURNAL OF PHARMACOLOGY

The urinary safety profile and secondary renal effects of retigabine (ezogabine): A first-in-class antiepileptic drug that targets KCNQ (Kv7) potassium channels

(2012) Neil Brickel et al.   EPILEPSIA

The efficacy and safety of retigabine and other adjunctive treatments for refractory partial epilepsy: A systematic review and indirect comparison

(2012) Marrissa Martyn-St James et al.   SEIZURE-EUROPEAN JOURNAL OF EPILEPSY

Discovery, Synthesis, and Structure–Activity Relationship of a Series of N-Aryl-bicyclo[2.2.1]heptane-2-carboxamides: Characterization of ML213 as a Novel KCNQ2 and KCNQ4 Potassium Channel Opener

(2011) Haibo Yu et al.   ACS Chemical Neuroscience

Contributions of counter-charge in a potassium channel voltage-sensor domain

(2011) Stephan A Pless et al.   Nature Chemical Biology

The Voltage-Sensing Domain of Kv7.2 Channels as a Molecular Target for Epilepsy-Causing Mutations and Anticonvulsants

(2011) Francesco Miceli et al.   Frontiers in Pharmacology

Isoform-specific Prolongation of Kv7 (KCNQ) Potassium Channel Opening Mediated by New Molecular Determinants for Drug-Channel Interactions

(2010) Zhaobing Gao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Differential Effects of ICA-27243 on Cloned KV7 Channels

(2010) Sigrid Marie Blom et al.   PHARMACOLOGY

Targeting the voltage sensor of Kv7.2 voltage-gated K+ channels with a new gating-modifier

(2010) A. Peretz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Gating Charge Transfer Center in Voltage Sensors

(2010) X. Tao et al.   SCIENCE

The KCNQ2/3 selective channel opener ICA-27243 binds to a novel voltage-sensor domain site

(2009) Karen Padilla et al.   NEUROSCIENCE LETTERS

Refinement of the Binding Site and Mode of Action of the Anticonvulsant Retigabine on KCNQ K+ Channels

(2008) W. Lange et al.   MOLECULAR PHARMACOLOGY

Activation of Kv7 (KCNQ) voltage-gated potassium channels by synthetic compounds

(2008) Q XIONG et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Molecular pharmacology and therapeutic potential of neuronal Kv7-modulating drugs

(2007) F MICELI et al.   CURRENT OPINION IN PHARMACOLOGY