Hypoexcitability precedes denervation in the large fast-contracting motor units in two unrelated mouse models of ALS

PICs in motoneurons do not scale with the size of the animal: a possible mechanism for faster speed of muscle contraction in smaller species

(2017) Seoan Huh et al.   JOURNAL OF NEUROPHYSIOLOGY

Chronic electromyograms in treadmill running SOD1 mice reveal early changes in muscle activation

(2017) Katharina A. Quinlan et al.   JOURNAL OF PHYSIOLOGY-LONDON

Distinct roles for motor neuron autophagy early and late in the SOD1G93Amouse model of ALS

(2017) Noam D. Rudnick et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Reduced high-frequency motor neuron firing, EMG fractionation, and gait variability in awake walking ALS mice

(2016) Muhamed Hadzipasic et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

4-Aminopyridine Induced Activity Rescues Hypoexcitable Motor Neurons from Amyotrophic Lateral Sclerosis Patient-Derived Induced Pluripotent Stem Cells

(2016) Maximilian Naujock et al.   STEM CELLS

ALS-associated mutant FUS induces selective motor neuron degeneration through toxic gain of function

(2016) Aarti Sharma et al.   Nature Communications

TBK1 controls autophagosomal engulfment of polyubiquitinated mitochondria through p62/SQSTM1 phosphorylation

(2015) Gen Matsumoto et al.   HUMAN MOLECULAR GENETICS

Human iPSC-derived motoneurons harbouring TARDBP or C9ORF72 ALS mutations are dysfunctional despite maintaining viability

(2015) Anna-Claire Devlin et al.   Nature Communications

Human induced pluripotent stem cells are a novel source of neural progenitor cells (iNPCs) that migrate and integrate in the rodent spinal cord

(2014) Dhruv Sareen et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Adult spinal motoneurones are not hyperexcitable in a mouse model of inherited amyotrophic lateral sclerosis

(2014) Nicolas Delestrée et al.   JOURNAL OF PHYSIOLOGY-LONDON

A Computational Model of Motor Neuron Degeneration

(2014) Gwendal Le Masson et al.   NEURON

Neuronal Matrix Metalloproteinase-9 Is a Determinant of Selective Neurodegeneration

(2014) Artem Kaplan et al.   NEURON

Selective degeneration of a physiological subtype of spinal motor neuron in mice with SOD1-linked ALS

(2014) Muhamed Hadzipasic et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intrinsic Membrane Hyperexcitability of Amyotrophic Lateral Sclerosis Patient-Derived Motor Neurons

(2014) Brian J. Wainger et al.   Cell Reports

Early intrinsic hyperexcitability does not contribute to motoneuron degeneration in amyotrophic lateral sclerosis

(2014) Félix Leroy et al.   eLife

Chondrolectin affects cell survival and neuronal outgrowth in in vitro and in vivo models of spinal muscular atrophy

(2013) James N. Sleigh et al.   HUMAN MOLECULAR GENETICS

The Effect of Cell Size and Channel Density on Neuronal Information Encoding and Energy Efficiency

(2013) Biswa Sengupta et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Embryonic alteration of motoneuronal morphology induces hyperexcitability in the mouse model of amyotrophic lateral sclerosis

(2013) Elodie Martin et al.   NEUROBIOLOGY OF DISEASE

Neuroprotection through Excitability and mTOR Required in ALS Motoneurons to Delay Disease and Extend Survival

(2013) Smita Saxena et al.   NEURON

Chondrolectin Mediates Growth Cone Interactions of Motor Axons with an Intermediate Target

(2012) Z. Zhong et al.   JOURNAL OF NEUROSCIENCE

Reduced Calreticulin Levels Link Endoplasmic Reticulum Stress and Fas-Triggered Cell Death in Motoneurons Vulnerable to ALS

(2012) N. Bernard-Marissal et al.   JOURNAL OF NEUROSCIENCE

NIH Image to ImageJ: 25 years of image analysis

(2012) Caroline A Schneider et al.   NATURE METHODS

Rapid Determination of Myosin Heavy Chain Expression in Rat, Mouse, and Human Skeletal Muscle Using Multicolor Immunofluorescence Analysis

(2012) Darin Bloemberg et al.   PLoS One

Rapamycin treatment augments motor neuron degeneration in SOD1G93Amouse model of amyotrophic lateral sclerosis

(2011) Xiaojie Zhang et al.   Autophagy

A decerebrate adult mouse model for examining the sensorimotor control of locomotion

(2011) Stan T. Nakanishi et al.   JOURNAL OF NEUROPHYSIOLOGY

Adult Mouse Motor Units Develop Almost All of Their Force in the Subprimary Range: A New All-or-None Strategy for Force Recruitment?

(2011) M. Manuel et al.   JOURNAL OF NEUROSCIENCE

Altered postnatal maturation of electrical properties in spinal motoneurons in a mouse model of amyotrophic lateral sclerosis

(2011) K. A. Quinlan et al.   JOURNAL OF PHYSIOLOGY-LONDON

Chemical and Genetic Engineering of Selective Ion Channel-Ligand Interactions

(2011) C. J. Magnus et al.   SCIENCE

Identification of novel spinal cholinergic genetic subtypes disclose Chodl and Pitx2 as markers for fast motor neurons and partition cells

(2010) Anders Enjin et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Intrinsic Properties of Mouse Lumbar Motoneurons Revealed by Intracellular Recording In Vivo

(2010) C. F. Meehan et al.   JOURNAL OF NEUROPHYSIOLOGY

Evidence from Computer Simulations for Alterations in the Membrane Biophysical Properties and Dendritic Processing of Synaptic Inputs in Mutant Superoxide Dismutase-1 Motoneurons

(2010) S. M. ElBasiouny et al.   JOURNAL OF NEUROSCIENCE

Early Excitability Changes in Lumbar Motoneurons of Transgenic SOD1G85R and SOD1G93A-Low Mice

(2009) Arnaud Pambo-Pambo et al.   JOURNAL OF NEUROPHYSIOLOGY

Fast Kinetics, High-Frequency Oscillations, and Subprimary Firing Range in Adult Mouse Spinal Motoneurons

(2009) M. Manuel et al.   JOURNAL OF NEUROSCIENCE

A role for motoneuron subtype–selective ER stress in disease manifestations of FALS mice

(2009) Smita Saxena et al.   NATURE NEUROSCIENCE

Reduced VGLUT2 expression increases motor neuron viability in Sod1G93A mice

(2009) Hanna Wootz et al.   NEUROBIOLOGY OF DISEASE

Neonatal Neuronal Circuitry Shows Hyperexcitable Disturbance in a Mouse Model of the Adult-Onset Neurodegenerative Disease Amyotrophic Lateral Sclerosis

(2008) B. van Zundert et al.   JOURNAL OF NEUROSCIENCE

Preferential motor unit loss in the SOD1G93Atransgenic mouse model of amyotrophic lateral sclerosis

(2008) J. Hegedus et al.   JOURNAL OF PHYSIOLOGY-LONDON