The pig as a preclinical model for predicting oral bioavailability and in vivo performance of pharmaceutical oral dosage forms: a PEARRL review
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Title
The pig as a preclinical model for predicting oral bioavailability and in vivo performance of pharmaceutical oral dosage forms: a PEARRL review
Authors
Keywords
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Journal
JOURNAL OF PHARMACY AND PHARMACOLOGY
Volume -, Issue -, Pages -
Publisher
Wiley
Online
2018-04-11
DOI
10.1111/jphp.12912
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Note: Only part of the references are listed.- Exploring gastric emptying rate in minipigs: Effect of food type and pre-dosing of metoclopramide
- (2018) Laura J. Henze et al. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
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- (2016) Makoto Kataoka et al. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
- Buccal absorption of diazepam is improved when administered in bioadhesive tablets—An in vivo study in conscious Göttingen mini-pigs
- (2016) Emil Meng-Lund et al. INTERNATIONAL JOURNAL OF PHARMACEUTICS
- Utility of PBPK Absorption Modeling to Guide Modified Release Formulation Development of Gaboxadol, a Highly Soluble Compound With Region-Dependent Absorption
- (2016) Filippos Kesisoglou et al. JOURNAL OF PHARMACEUTICAL SCIENCES
- Characterization of Pharmacokinetics in the Göttingen Minipig with Reference Human Drugs: An In Vitro and In Vivo Approach
- (2016) Floriane Lignet et al. PHARMACEUTICAL RESEARCH
- A Dual-Biotic System for the Concurrent Delivery of Antibiotics and Probiotics: In Vitro, Ex Vivo, In Vivo and In Silico Evaluation and Correlation
- (2016) Mershen Govender et al. PHARMACEUTICAL RESEARCH
- The Use of Minipigs for Preclinical Safety Assessment by the Pharmaceutical Industry
- (2016) Curtis Colleton et al. TOXICOLOGIC PATHOLOGY
- Applying Biopharmaceutical Classification System (BCS) Criteria to Predict Oral Absorption of Drugs in Dogs: Challenges and Pitfalls
- (2015) Mark G. Papich et al. AAPS Journal
- Enhanced colonic delivery of ciclosporin A self-emulsifying drug delivery system encapsulated in coated minispheres
- (2015) Kieran Keohane et al. DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY
- Lipidic dispersion to reduce food dependent oral bioavailability of fenofibrate: In vitro, in vivo and in silico assessments
- (2015) Joseph P. O’Shea et al. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
- Evaluation of the Use of Göttingen Minipigs to Predict Food Effects on the Oral Absorption of Drugs in Humans
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- (2015) Claes Hjalmarsson et al. Surgical Infections
- In Vitro Lipolysis Data Does Not Adequately Predict the In Vivo Performance of Lipid-Based Drug Delivery Systems Containing Fenofibrate
- (2014) Nicky Thomas et al. AAPS Journal
- In vivo methods for drug absorption – Comparative physiologies, model selection, correlations with in vitro methods (IVIVC), and applications for formulation/API/excipient characterization including food effects
- (2014) Erik Sjögren et al. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
- Intestinal absorption of the antiepileptic drug substance vigabatrin in Göttingen mini-pigs is unaffected by co-administration of amino acids
- (2014) Martha Kampp Nøhr et al. INTERNATIONAL JOURNAL OF PHARMACEUTICS
- The Biopharmaceutics Risk Assessment Roadmap for Optimizing Clinical Drug Product Performance
- (2014) Arzu Selen et al. JOURNAL OF PHARMACEUTICAL SCIENCES
- A physiologically based pharmacokinetic model for quinoxaline-2-carboxylic acid in rats, extrapolation to pigs
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- Pharmacokinetics of Paracetamol in Göttingen Minipigs: In Vivo Studies and Modeling to Elucidate Physiological Determinants of Absorption
- (2014) Claudia Suenderhauf et al. PHARMACEUTICAL RESEARCH
- Biopharmaceutical Modeling of Drug Supersaturation During Lipid-Based Formulation Digestion Considering an Absorption Sink
- (2014) Cordula Stillhart et al. PHARMACEUTICAL RESEARCH
- Xenobiotic Metabolizing Cytochrome P450 in Pig, a Promising Animal Model
- (2013) Emanuela Puccinelli et al. CURRENT DRUG METABOLISM
- In vitro, ex vivo and in vivo examination of buccal absorption of metoprolol with varying pH in TR146 cell culture, porcine buccal mucosa and Göttingen minipigs
- (2013) René Holm et al. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
- Effects of verapamil on the pharmacokinetics and hepatobiliary disposition of fexofenadine in pigs
- (2013) Erik Sjögren et al. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
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- (2013) Edmund S. Kostewicz et al. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
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- (2013) Helen Musther et al. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
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- (2013) Marcel Arndt et al. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
- Analysis of the enhanced oral bioavailability of fenofibrate lipid formulations in fasted humans using an in vitro–in silico–in vivo approach
- (2013) Yang Fei et al. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
- Comparison of in vitro tests at various levels of complexity for the prediction of in vivo performance of lipid-based formulations: Case studies with fenofibrate
- (2013) Brendan T. Griffin et al. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
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- (2013) D. Burrin et al. JOURNAL OF ANIMAL SCIENCE
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- Principles of early drug discovery
- (2010) JP Hughes et al. BRITISH JOURNAL OF PHARMACOLOGY
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- (2010) Hamid A. Merchant et al. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
- Comparison of the Gastrointestinal Absorption and Bioavailability of Fenofibrate and Fenofibric Acid in Humans
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- Species comparison of enantioselective oral bioavailability and pharmacokinetics of ketoprofen
- (2010) E. Neirinckx et al. RESEARCH IN VETERINARY SCIENCE
- The RETHINK project
- (2010) Roy Forster et al. JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS
- Genetic management of the Göttingen Minipig population
- (2010) Henner Simianer et al. JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS
- Regulatory acceptability of the minipig in the development of pharmaceuticals, chemicals and other products
- (2010) Jan Willem van der Laan et al. JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS
- The utility of the minipig as an animal model in regulatory toxicology
- (2010) Gerd Bode et al. JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS
- Physiologically Based Pharmacokinetics of Zearalenone
- (2009) Beom Soo Shin et al. JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES
- Species-Specific and Age-Dependent Bile Acid Composition: Aspects on CYP8B and CYP4A Subfamilies in Bile Acid Biosynthesis
- (2008) Kerstin Lundell et al. CURRENT DRUG METABOLISM
- Bioavailability of probucol from lipid and surfactant based formulations in minipigs: Influence of droplet size and dietary state
- (2008) Flemming Seier Nielsen et al. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
- The Pig as an Experimental Model for Elucidating the Mechanisms Governing Dietary Influence on Mineral Absorption
- (2008) Jannine K. Patterson et al. EXPERIMENTAL BIOLOGY AND MEDICINE
- Estimating meat withdrawal times in pigs exposed to melamine contaminated feed using a physiologically based pharmacokinetic model
- (2008) Jennifer L. Buur et al. REGULATORY TOXICOLOGY AND PHARMACOLOGY
- A physiologically based pharmacokinetic model linking plasma protein binding interactions with drug disposition
- (2008) J.L. Buur et al. RESEARCH IN VETERINARY SCIENCE
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