An update on computational oral absorption simulation

Utility of Physiologically Based Absorption Modeling in Implementing Quality by Design in Drug Development

(2011) Xinyuan Zhang et al.   AAPS Journal

Physiologically-Based Pharmacokinetics in Drug Development and Regulatory Science

(2011) Malcolm Rowland et al.   Annual Review of Pharmacology and Toxicology

Interplay of Metabolism and Transport in Determining Oral Drug Absorption and Gut Wall Metabolism: A Simulation Assessment Using the “Advanced Dissolution, Absorption, Metabolism (ADAM)” Model

(2011) A. S. Darwich et al.   CURRENT DRUG METABOLISM

A Computational Systems Biology Software Platform for Multiscale Modeling and Simulation: Integrating Whole-Body Physiology, Disease Biology, and Molecular Reaction Networks

(2011) Thomas Eissing   Frontiers in Physiology

In Vitro–In Vivo Correlation for Gliclazide Immediate-Release Tablets Based on Mechanistic Absorption Simulation

(2010) Sandra Grbic et al.   AAPS PHARMSCITECH

Physiologically Based Pharmacokinetic/Pharmacodynamic Animal-to-Man Prediction of Therapeutic Dose in a Model of Epilepsy

(2010) Anne Brochot et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

Predictions of Metabolic Drug-Drug Interactions Using Physiologically Based Modelling

(2010) Nathalie Perdaems et al.   CLINICAL PHARMACOKINETICS

Applications of Physiologically Based Pharmacokinetic (PBPK) Modeling and Simulation During Regulatory Review

(2010) P Zhao et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Interplay of Dissolution, Solubility, and Nonsink Permeation Determines the Oral Absorption of the Hedgehog Pathway Inhibitor GDC-0449 in Dogs: An Investigation Using Preclinical Studies and Physiologically Based Pharmacokinetic Modeling

(2010) H. Wong et al.   DRUG METABOLISM AND DISPOSITION

Whole-Body Physiologically Based Pharmacokinetic Model for Nutlin-3a in Mice after Intravenous and Oral Administration

(2010) F. Zhang et al.   DRUG METABOLISM AND DISPOSITION

Assessing Children’s Dietary Pesticide Exposure: Direct Measurement 
of Pesticide Residues in 24-Hr Duplicate Food Samples

(2010) Chensheng Lu et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Mechanism-based prediction of particle size-dependent dissolution and absorption: Cilostazol pharmacokinetics in dogs

(2010) Stefan Willmann et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Forecasting in vivo oral absorption and food effect of micronized and nanosized aprepitant formulations in humans

(2010) Yasushi Shono et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Whole-body physiologically based pharmacokinetic population modelling of oral drug administration: inter-individual variability of cimetidine absorption

(2010) Stefan Willmann et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Assessment of Bisphenol a Exposure in Korean Pregnant Women by Physiologically Based Pharmacokinetic Modeling

(2010) Beom Soo Shin et al.   JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES

A physiologically based pharmacokinetic model for valnemulin in rats and extrapolation to pigs

(2010) L. G. YUAN et al.   JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS

The Biowaiver Extension for BCS Class III Drugs: The Effect of Dissolution Rate on the Bioequivalence of BCS Class III Immediate-Release Drugs Predicted by Computer Simulation

(2010) Yasuhiro Tsume et al.   MOLECULAR PHARMACEUTICS

Blood concentrations of acrylonitrile in humans after oral administration extrapolated from in vivo rat pharmacokinetics, in vitro human metabolism, and physiologically based pharmacokinetic modeling

(2010) Ryohji Takano et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Physiologically Based Pharmacokinetic Modeling of Deltamethrin: Development of a Rat and Human Diffusion-Limited Model

(2010) Stephen J. Godin et al.   TOXICOLOGICAL SCIENCES

PBPK modelling of inter-individual variability in the pharmacokinetics of environmental chemicals

(2010) Frédéric Y. Bois et al.   TOXICOLOGY

Evaluation of deltamethrin kinetics and dosimetry in the maturing rat using a PBPK model

(2010) Rogelio Tornero-Velez et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Human Blood Concentrations of Cotinine, a Biomonitoring Marker for Tobacco Smoke, Extrapolated from Nicotine Metabolism in Rats and Humans and Physiologically Based Pharmacokinetic Modeling

(2010) Hiroshi Yamazaki et al.   International Journal of Environmental Research and Public Health

Practical Anticipation of Human Efficacious Doses and Pharmacokinetics Using In Vitro and Preclinical In Vivo Data

(2009) Tycho Heimbach et al.   AAPS Journal

Predicting Pharmacokinetics of Drugs Using Physiologically Based Modeling—Application to Food Effects

(2009) N. Parrott et al.   AAPS Journal

Simulations of the Nonlinear Dose Dependence for Substrates of Influx and Efflux Transporters in the Human Intestine

(2009) Michael B. Bolger et al.   AAPS Journal

An Investigation into the Importance of “Very Rapid Dissolution” Criteria for Drug Bioequivalence Demonstration using Gastrointestinal Simulation Technology

(2009) Ivan Kovačevi et al.   AAPS Journal

Prediction of Modified Release Pharmacokinetics and Pharmacodynamics from In Vitro, Immediate Release, and Intravenous Data

(2009) Viera Lukacova et al.   AAPS Journal

Population-Based Mechanistic Prediction of Oral Drug Absorption

(2009) Masoud Jamei et al.   AAPS Journal

Risk to the Breast-Fed Neonate From Codeine Treatment to the Mother: A Quantitative Mechanistic Modeling Study

(2009) S Willmann et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Physiologically Based Pharmacokinetics of Matrine in the Rat after Oral Administration of Pure Chemical and ACAPHA

(2009) G. Gao et al.   DRUG METABOLISM AND DISPOSITION

Prediction of food effects on the absorption of celecoxib based on biorelevant dissolution testing coupled with physiologically based pharmacokinetic modeling

(2009) Yasushi Shono et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Physiologically based pharmacokinetic modeling of cyclotrimethylenetrinitramine in male rats

(2009) Kannan Krishnan et al.   JOURNAL OF APPLIED TOXICOLOGY

Development of a novel method for predicting human volume of distribution at steady-state of basic drugs and comparative assessment with existing methods

(2009) Patrick Poulin et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Absorption Barriers in the Rat Intestinal Mucosa: 2. Application of Physiologically Based Mathematical Models to Quantify Mechanisms of Drug Permeation and Metabolism

(2009) Daniel R. Mudra et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Analysis of Nifedipine Absorption from Soft Gelatin Capsules Using PBPK Modeling and Biorelevant Dissolution Testing

(2009) Kirstin Thelen et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Physiologically Based Pharmacokinetics of Zearalenone

(2009) Beom Soo Shin et al.   JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES

Database for Physiologically Based Pharmacokinetic (PBPK) Modeling: Physiological Data for Healthy and Health-Impaired Elderly

(2009) Chad M. Thompson et al.   JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART B-CRITICAL REVIEWS

Prediction of Phase I single-dose pharmacokinetics using recombinant cytochromes P450 and physiologically based modelling

(2009) C. R. Gibson et al.   XENOBIOTICA

Drug Absorption Modeling as a Tool to Define the Strategy in Clinical Formulation Development

(2008) Martin Kuentz   AAPS Journal

Application of Gastrointestinal Simulation for Extensions for Biowaivers of Highly Permeable Compounds

(2008) Marija Tubic-Grozdanis et al.   AAPS Journal

Physiologically Motivated Time-Delay Model to Account for Mechanisms Underlying Enterohepatic Circulation of Piroxicam in Human Beings

(2008) Martina Tvrdonova et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

Identification of Intestinal Loss of a Drug through Physiologically Based Pharmacokinetic??Simulation of Plasma??Concentration-Time Profiles

(2008) Sheila Annie Peters   CLINICAL PHARMACOKINETICS

Physiology-Based Simulations of a Pathological Condition

(2008) Andrea N Edginton et al.   CLINICAL PHARMACOKINETICS

Towards Quantitative Prediction of Oral Drug Absorption

(2008) Jennifer B Dressman et al.   CLINICAL PHARMACOKINETICS

Physicochemical Properties of the Nucleoside Prodrug R1626 Leading to High Oral Bioavailability

(2008) Michael Brandl et al.   DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY

Predicting Plasma Concentrations of Bisphenol A in Children Younger Than 2 Years of Age after Typical Feeding Schedules, using a Physiologically Based Toxicokinetic Model

(2008) Andrea N. Edginton et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Physicochemical characterization of five glyburide powders: A BCS based approach to predict oral absorption

(2008) H WEI et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Computer simulations using GastroPlus™ to justify a biowaiver for etoricoxib solid oral drug products

(2008) Arthur Okumu et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Whole body physiologically-based pharmacokinetic models: their use in clinical drug development

(2008) Andrea N Edginton et al.   Expert Opinion on Drug Metabolism & Toxicology

Simulation Modelling of Human Intestinal Absorption using Caco-2 Permeability and Kinetic Solubility Data for Early Drug Discovery

(2008) Simon Thomas et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Methodology for development of a physiological model incorporating CYP3A and P-glycoprotein for the prediction of intestinal drug absorption

(2008) Raj Badhan et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Justification of Biowaiver for Carbamazepine, a Low Soluble High Permeable Compound, in Solid Dosage Forms Based on IVIVC and Gastrointestinal Simulation

(2008) Ivan Kovačević et al.   MOLECULAR PHARMACEUTICS

Rate-Limiting Steps of Oral Absorption for Poorly Water-Soluble Drugs in Dogs; Prediction from a Miniscale Dissolution Test and a Physiologically-Based Computer Simulation

(2008) Ryusuke Takano et al.   PHARMACEUTICAL RESEARCH

Dynamic Dissolution Testing To Establish In Vitro/In Vivo Correlations for Montelukast Sodium, a Poorly Soluble Drug

(2008) Arthur Okumu et al.   PHARMACEUTICAL RESEARCH

Pre-clinical pharmacokinetics of UK-453,061, a novel non-nucleoside reverse transcriptase inhibitor (NNRTI), and use ofin silicophysiologically based prediction tools to predict the oral pharmacokinetics of UK-453,061 in man

(2008) G. Allan et al.   XENOBIOTICA

Designing biorelevant dissolution tests for lipid formulations: Case example – Lipid suspension of RZ-50

(2007) Ekarat Jantratid et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS