Utility of PBPK Absorption Modeling to Guide Modified Release Formulation Development of Gaboxadol, a Highly Soluble Compound With Region-Dependent Absorption

Title
Utility of PBPK Absorption Modeling to Guide Modified Release Formulation Development of Gaboxadol, a Highly Soluble Compound With Region-Dependent Absorption
Authors
Keywords
in vitro/in vivo, correlations (IVIVC), controlled release, preclinical pharmacokinetics, physiologically based pharmacokinetic modeling, site-specific absorption, bioavailability, intestinal absorption
Journal
JOURNAL OF PHARMACEUTICAL SCIENCES
Volume 105, Issue 2, Pages 722-728
Publisher
Elsevier BV
Online
2015-10-14
DOI
10.1002/jps.24674

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