Animal models of toxicology testing: the role of pigs

Xenobiotic Metabolizing Cytochrome P450 in Pig, a Promising Animal Model

(2013) Emanuela Puccinelli et al.   CURRENT DRUG METABOLISM

Drug metabolism of CYP3A4, CYP2C9 and CYP2D6 substrates in pigs and humans

(2011) Helena Anna Thörn et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Substrate- and Species-dependent Inhibition of P-glycoprotein-mediated Transport: Implications for Predicting in vivo Drug Interactions

(2011) Joseph K. Zolnerciks et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

A metabolic system-wide characterisation of the pig: a model for human physiology

(2011) Claire A. Merrifield et al.   Molecular BioSystems

Swine as Models in Biomedical Research and Toxicology Testing

(2011) M. M. Swindle et al.   VETERINARY PATHOLOGY

Comparison of the substrate kinetics of pig CYP3A29 with pig liver microsomes and human CYP3A4

(2010) Min Yao et al.   BIOSCIENCE REPORTS

Pig genome sequence - analysis and publication strategy

(2010) Alan L Archibald et al.   BMC GENOMICS

Assessment of gastrointestinal pH, fluid and lymphoid tissue in the guinea pig, rabbit and pig, and implications for their use in drug development

(2010) Hamid A. Merchant et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Coexistence of passive and carrier-mediated processes in drug transport

(2010) Kiyohiko Sugano et al.   NATURE REVIEWS DRUG DISCOVERY

Membrane transporters in drug development

(2010)   NATURE REVIEWS DRUG DISCOVERY

Expression and inducibility by phenobarbital of CYP2C33, CYP2C42, CYP2C49, CYP2B22, and CYP3As in porcine liver, kidney, small intestine, and nasal tissues

(2010) Emanuela Puccinelli et al.   XENOBIOTICA

Familial hypercholesterolaemic downsized pig with human-like coronary atherosclerosis: a model for preclinical studies

(2010) Troels Thim et al.   EuroIntervention

The RETHINK project

(2010) Roy Forster et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS

Ethical implications of using the minipig in regulatory toxicology studies

(2010) John Webster et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS

Genetic management of the Göttingen Minipig population

(2010) Henner Simianer et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS

The minipig as a platform for new technologies in toxicology

(2010) Roy Forster et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS

Regulatory acceptability of the minipig in the development of pharmaceuticals, chemicals and other products

(2010) Jan Willem van der Laan et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS

The utility of the minipig as an animal model in regulatory toxicology

(2010) Gerd Bode et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS

Population-Based Mechanistic Prediction of Oral Drug Absorption

(2009) Masoud Jamei et al.   AAPS Journal

Cytochrome P450-depedent Drug Oxidation Activity of Liver Microsomes from Microminipigs, A Possible New Animal Model for Humans in Non-clinical Studies

(2009) Norie Murayama et al.   Drug Metabolism and Pharmacokinetics

Tissue distribution of CYP3A29 mRNA expression in Bama miniature pig by quantitative reverse transcriptase-polymerase chain reaction (RT-PCR)

(2009) H. Shang et al.   XENOBIOTICA

Improved understanding of the effect of food on drug absorption and bioavailability for lipophilic compounds using an intestinal pig perfusion model

(2008) E.M. Persson et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Implications of hepatic cytochrome P450-related biotransformation processes in veterinary sciences

(2008) Johanna Fink-Gremmels   EUROPEAN JOURNAL OF PHARMACOLOGY

Large-scale survey of porcine endogenous retrovirus in Chinese miniature pigs

(2007) Jianmin Wu et al.   COMPARATIVE IMMUNOLOGY MICROBIOLOGY AND INFECTIOUS DISEASES