A Physiologically Based Pharmacokinetic Model of the Minipig: Data Compilation and Model Implementation

Gastrointestinal peptides and regulation of gastric acid secretion

(2016) Erik C von Rosenvinge et al.   Current Opinion in Endocrinology Diabetes and Obesity

Xenobiotic Metabolizing Cytochrome P450 in Pig, a Promising Animal Model

(2013) Emanuela Puccinelli et al.   CURRENT DRUG METABOLISM

From preclinical to human - prediction of oral absorption and drug-drug interaction potential using physiologically based pharmacokinetic (PBPK) modeling approach in an industrial setting: a workflow by using case example

(2012) Vikash Kumar Sinha et al.   BIOPHARMACEUTICS & DRUG DISPOSITION

Minipig as a potential translatable model for monoclonal antibody pharmacokinetics after intravenous and subcutaneous administration

(2012) Yanan Zheng et al.   mAbs

The Pharmacokinetics and Hepatic Disposition of Repaglinide in Pigs: Mechanistic Modeling of Metabolism and Transport

(2012) Erik Sjögren et al.   MOLECULAR PHARMACEUTICS

Simulation of Human Intravenous and Oral Pharmacokinetics of 21 Diverse Compounds Using Physiologically Based Pharmacokinetic Modelling

(2011) Hannah M. Jones et al.   CLINICAL PHARMACOKINETICS

Cytochrome P450 Pig Liver Pie: Determination of Individual Cytochrome P450 Isoform Contents in Microsomes from Two Pig Livers Using Liquid Chromatography in Conjunction with Mass Spectrometry

(2011) B. Achour et al.   DRUG METABOLISM AND DISPOSITION

An update on computational oral absorption simulation

(2011) Jennifer B Dressman et al.   Expert Opinion on Drug Metabolism & Toxicology

Lead PK Commentary: Predicting Human Pharmacokinetics

(2011) Malcolm Rowland et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Evolution of a detailed physiological model to simulate the gastrointestinal transit and absorption process in humans, Part 1: Oral solutions

(2011) Kirstin Thelen et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Evolution of a Detailed Physiological Model to Simulate the Gastrointestinal Transit and Absorption Process in Humans, Part II: Extension to Describe Performance of Solid Dosage Forms

(2011) Kirstin Thelen et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Cardiovascular performance of adult breeding sows fails to obey allometric scaling laws1

(2010) G. J. van Essen et al.   JOURNAL OF ANIMAL SCIENCE

Combinatorial QSAR Modeling of Human Intestinal Absorption

(2010) Claudia Suenderhauf et al.   MOLECULAR PHARMACEUTICS

Membrane transporters in drug development

(2010)   NATURE REVIEWS DRUG DISCOVERY

Expression and inducibility by phenobarbital of CYP2C33, CYP2C42, CYP2C49, CYP2B22, and CYP3As in porcine liver, kidney, small intestine, and nasal tissues

(2010) Emanuela Puccinelli et al.   XENOBIOTICA

The RETHINK project on minipigs in the toxicity testing of new medicines and chemicals: Conclusions and recommendations

(2010) Roy Forster et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS

Genetic management of the Göttingen Minipig population

(2010) Henner Simianer et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS

The utility of the minipig as an animal model in regulatory toxicology

(2010) Gerd Bode et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS

Predicting Pharmacokinetics of Drugs Using Physiologically Based Modeling—Application to Food Effects

(2009) N. Parrott et al.   AAPS Journal

Population-Based Mechanistic Prediction of Oral Drug Absorption

(2009) Masoud Jamei et al.   AAPS Journal

Gastric exocrine and endocrine secretion

(2009) Mitchell L Schubert   CURRENT OPINION IN GASTROENTEROLOGY

Enterohepatic Disposition of Rosuvastatin in Pigs and the Impact of Concomitant Dosing with Cyclosporine and Gemfibrozil

(2009) E. Bergman et al.   DRUG METABOLISM AND DISPOSITION

Different Effects of Ketoconazole on the Stereoselective First-Pass Metabolism of R/S-Verapamil in the Intestine and the Liver: Important for the Mechanistic Understanding of First-Pass Drug-Drug Interactions

(2009) H. A. Thorn et al.   DRUG METABOLISM AND DISPOSITION

Does cardiovascular performance of modern fattening pigs obey allometric scaling laws?

(2009) G. J. van Essen et al.   JOURNAL OF ANIMAL SCIENCE

Analyses of CYP2C in Porcine Microsomes

(2008) Mette T. Skaanild et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

Intestinal and Hepatobiliary Transport of Ximelagatran and Its Metabolites in Pigs

(2008) E. Sjodin et al.   DRUG METABOLISM AND DISPOSITION

Applications of Physiologically Based Absorption Models in Drug Discovery and Development

(2008) Neil Parrott et al.   MOLECULAR PHARMACEUTICS

Dissolution Media Simulating Conditions in the Proximal Human Gastrointestinal Tract: An Update

(2008) Ekarat Jantratid et al.   PHARMACEUTICAL RESEARCH

The association between renal function and structural parameters: a pig study

(2008) Anders B Lødrup et al.   BMC Nephrology

Organ weights and blood flows of sheep and pig for physiological pharmacokinetic modelling

(2008) Richard N. Upton   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS