HIF-1α inhibitor echinomycin reduces acute graft-versus-host disease and preserves graft-versus-leukemia effect

Milestones of Hematopoietic Stem Cell Transplantation – From First Human Studies to Current Developments

(2016) Mateja Kralj Juric et al.   Frontiers in Immunology

Targeting HIF1α Peri-operatively Increased Post-surgery Survival in a Tongue Cancer Animal Model

(2015) Soon-Hyun Ahn et al.   ANNALS OF SURGICAL ONCOLOGY

CD4+ T cell STAT3 phosphorylation precedes acute GVHD, and subsequent Th17 tissue invasion correlates with GVHD severity and therapeutic response

(2015) Brian C. Betts et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Echinomycin protects mice against relapsed acute myeloid leukemia without adverse effect on hematopoietic stem cells

(2014) Y. Wang et al.   BLOOD

Metabolic control of the Treg/Th17 axis

(2013) Joseph Barbi et al.   IMMUNOLOGICAL REVIEWS

Dissecting graft-versus-leukemia from graft-versus-host-disease using novel strategies

(2013) E. H. Warren et al.   TISSUE ANTIGENS

Can Treg therapy prevent GVHD?

(2011) K. V. Komanduri et al.   BLOOD

Prevention of GVHD while sparing GVL effect by targeting Th1 and Th17 transcription factor T-bet and ROR t in mice

(2011) Y. Yu et al.   BLOOD

Effector CD4+ T cells, the cytokines they generate, and GVHD: something old and something new

(2011) J. M. Coghill et al.   BLOOD

Tregs prevent GVHD and promote immune reconstitution in HLA-haploidentical transplantation

(2011) M. Di Ianni et al.   BLOOD

Control of TH17/Treg Balance by Hypoxia-Inducible Factor 1

(2011) Eric V. Dang et al.   CELL

HIF1α–dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Tregcells

(2011) Lewis Z. Shi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Human TH17 Cells Are Long-Lived Effector Memory Cells

(2011) I. Kryczek et al.   Science Translational Medicine

Regulatory dendritic cells program generation of interleukin-4-producing alternative memory CD4 T cells with suppressive activity

(2010) X. Xu et al.   BLOOD

Graft-versus-leukemia effects of transplantation and donor lymphocytes

(2008) H.-J. Kolb   BLOOD

IL-17 contributes to CD4-mediated graft-versus-host disease

(2008) L. W. Kappel et al.   BLOOD

Regulatory T Cells and Immune Tolerance

(2008) Shimon Sakaguchi et al.   CELL