Intratumor Hypoxia Promotes Immune Tolerance by Inducing Regulatory T Cells via TGF-β1 in Gastric Cancer

Increased T Regulatory Cells Are Associated with Adverse Clinical Features and Predict Progression in Multiple Myeloma

(2012) Karthick Raja Muthu Raja et al.   PLoS One

Hypoxia-inducible factors: mediators of cancer progression and targets for cancer therapy

(2012) Gregg L. Semenza   TRENDS IN PHARMACOLOGICAL SCIENCES

Hypoxia Promotes Tumor Growth in Linking Angiogenesis to Immune Escape

(2012) Salem Chouaib et al.   Frontiers in Immunology

Control of TH17/Treg Balance by Hypoxia-Inducible Factor 1

(2011) Eric V. Dang et al.   CELL

Regulatory T cell: a protection for tumour cells

(2011) Yi Wang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

The ratio of intra-tumoral regulatory T cells (Foxp3+)/helper T cells (CD4+) is a prognostic factor and associated with recurrence pattern in gastric cardia cancer

(2011) Hyoung-Il Kim et al.   JOURNAL OF SURGICAL ONCOLOGY

Tumour hypoxia promotes tolerance and angiogenesis via CCL28 and Treg cells

(2011) Andrea Facciabene et al.   NATURE

Hypoxia Potentiates Glioma-Mediated Immunosuppression

(2011) Jun Wei et al.   PLoS One

Regulatory T cells in gastrointestinal tumors

(2011) Sukanya Raghavan et al.   Expert Review of Gastroenterology & Hepatology

HIF-1α and HIF-2α correlate with migration and invasion in gastric cancer

(2010) Yanxia Wang et al.   CANCER BIOLOGY & THERAPY

Hypoxia upregulates adhesion ability to peritoneum through a transforming growth factor-β-dependent mechanism in diffuse-type gastric cancer cells

(2010) Satoru Noda et al.   EUROPEAN JOURNAL OF CANCER

CD4+CD25+CD127low/− regulatory T cells express Foxp3 and suppress effector T cell proliferation and contribute to gastric cancers progression

(2009) Li-Song Shen et al.   CLINICAL IMMUNOLOGY

Elevated expression of Foxp3 in tumor-infiltrating Treg cells suppresses T-cell proliferation and contributes to gastric cancer progression in a COX-2-dependent manner

(2009) Xiang-Liang Yuan et al.   CLINICAL IMMUNOLOGY

TGF-  and 'Adaptive' Foxp3+ Regulatory T cells

(2009) W. Chen et al.   Journal of Molecular Cell Biology

Resveratrol inhibits hypoxia-induced metastasis potential enhancement by restricting hypoxia-induced factor-1α expression in colon carcinoma cells

(2008) Hongzhong Wu et al.   BIOMEDICINE & PHARMACOTHERAPY

Intratumoural FOXP3-positive regulatory T cells are associated with adverse prognosis in radically resected gastric cancer

(2008) Giuseppe Perrone et al.   EUROPEAN JOURNAL OF CANCER

Hypoxia controls CD4+CD25+ regulatory T-cell homeostasis via hypoxia-inducible factor-1α

(2008) Jeremy Ben-Shoshan et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Peripherally Induced Treg: Mode, Stability, and Role in Specific Tolerance

(2008) Irina Apostolou et al.   JOURNAL OF CLINICAL IMMUNOLOGY

A critical function for TGF-β signaling in the development of natural CD4+CD25+Foxp3+ regulatory T cells

(2008) Yongzhong Liu et al.   NATURE IMMUNOLOGY

The tumor microenvironment and its role in promoting tumor growth

(2008) T L Whiteside   ONCOGENE