Integrin Activation Controls Regulatory T Cell–Mediated Peripheral Tolerance

TRPM8 inhibits endothelial cell migration via a non-channel function by trapping the small GTPase Rap1

(2017) Tullio Genova et al.   JOURNAL OF CELL BIOLOGY

Talin – the master of integrin adhesions

(2017) Benjamin Klapholz et al.   JOURNAL OF CELL SCIENCE

Class II MHC–independent suppressive adhesion of dendritic cells by regulatory T cells in vivo

(2017) Jiacong Yan et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Strong adhesion by regulatory T cells induces dendritic cell cytoskeletal polarization and contact-dependent lethargy

(2017) Jiahuan Chen et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Not Just an Adhesion Molecule: LFA-1 Contact Tunes the T Lymphocyte Program

(2017) Navin Kumar Verma et al.   JOURNAL OF IMMUNOLOGY

Talin Plays a Critical Role in the Maintenance of the Regulatory T Cell Pool

(2017) Jane E. Klann et al.   JOURNAL OF IMMUNOLOGY

Integrin-based therapeutics: biological basis, clinical use and new drugs

(2016) Klaus Ley et al.   NATURE REVIEWS DRUG DISCOVERY

Relating conformation to function in integrin α5β1

(2016) Yang Su et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A ligand-independent integrin β1 mechanosensory complex guides spindle orientation

(2016) Nicoletta I. Petridou et al.   Nature Communications

Blocking neutrophil integrin activation prevents ischemia–reperfusion injury

(2015) Tadayuki Yago et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A talin mutant that impairs talin-integrin binding in platelets decelerates  IIb 3 activation without pathological bleeding

(2014) L. Stefanini et al.   BLOOD

Regulatory T-cell homeostasis: steady-state maintenance and modulation during inflammation

(2014) Kate S. Smigiel et al.   IMMUNOLOGICAL REVIEWS

Promiscuous Foxp3-cre activity reveals a differential requirement for CD28 in Foxp3+ and Foxp3− T cells

(2014) Dean Franckaert et al.   IMMUNOLOGY AND CELL BIOLOGY

Early specification of CD8+ T lymphocyte fates during adaptive immunity revealed by single-cell gene-expression analyses

(2014) Janilyn Arsenio et al.   NATURE IMMUNOLOGY

Id2 and Id3 maintain the regulatory T cell pool to suppress inflammatory disease

(2014) Masaki Miyazaki et al.   NATURE IMMUNOLOGY

CCR7 provides localized access to IL-2 and defines homeostatically distinct regulatory T cell subsets

(2013) Kate S. Smigiel et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Integrin-modulating therapy prevents fibrosis and autoimmunity in mouse models of scleroderma

(2013) Elizabeth E. Gerber et al.   NATURE

Talins and kindlins: partners in integrin-mediated adhesion

(2013) David A. Calderwood et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Pull and push: Talin activation for integrin signaling

(2012) Jia-huai Wang   CELL RESEARCH

Integrin signalling and function in immune cells

(2012) Yanbo Zhang et al.   IMMUNOLOGY

Human FoxP3+ regulatory T cells in systemic autoimmune diseases

(2011) Makoto Miyara et al.   AUTOIMMUNITY REVIEWS

Control of TH17/Treg Balance by Hypoxia-Inducible Factor 1

(2011) Eric V. Dang et al.   CELL

Contact-Dependent T Cell Activation and T Cell Stopping Require Talin1

(2011) S. A. Wernimont et al.   JOURNAL OF IMMUNOLOGY

Talin-dependent integrin activation is required for fibrin clot retraction by platelets

(2010) J. R. Haling et al.   BLOOD

Interleukin-2 Receptor Signaling: At the Interface between Tolerance and Immunity

(2010) Thomas R. Malek et al.   IMMUNITY

The final steps of integrin activation: the end game

(2010) Sanford J. Shattil et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Co-engagement of α4β1 integrin (VLA-4) and CD4 or CD8 is necessary to induce maximal Erk1/2 phosphorylation and cytokine production in human T cells

(2009) Tae Kon Kim et al.   HUMAN IMMUNOLOGY

Integrin signalling at a glance

(2009) D. S. Harburger et al.   JOURNAL OF CELL SCIENCE

Regulatory T Cell-Derived Interleukin-10 Limits Inflammation at Environmental Interfaces

(2008) Yuri P. Rubtsov et al.   IMMUNITY

Talin at a glance

(2008) D. R. Critchley et al.   JOURNAL OF CELL SCIENCE

Dicer-dependent microRNA pathway safeguards regulatory T cell function

(2008) Adrian Liston et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Foxp3+ natural regulatory T cells preferentially form aggregates on dendritic cells in vitro and actively inhibit their maturation

(2008) Y. Onishi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulatory T Cells: Mechanisms of Differentiation and Function

(2007) Steven Z. Josefowicz et al.   Annual Review of Immunology