TRPM8 inhibits endothelial cell migration via a non-channel function by trapping the small GTPase Rap1

SHANK proteins limit integrin activation by directly interacting with Rap1 and R-Ras

(2017) Johanna Lilja et al.   NATURE CELL BIOLOGY

Beyond ion-conduction: Channel-dependent and -independent roles of TRP channels during development and tissue homeostasis

(2016) Kirsten S. Vrenken et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

L-type calcium channels regulate filopodia stability and cancer cell invasion downstream of integrin signalling

(2016) Guillaume Jacquemet et al.   Nature Communications

Functional and Modeling Studies of the Transmembrane Region of the TRPM8 Channel

(2015) Gabriel Bidaux et al.   BIOPHYSICAL JOURNAL

TRP channel–associated factors are a novel protein family that regulates TRPM8 trafficking and activity

(2015) Dimitra Gkika et al.   JOURNAL OF CELL BIOLOGY

Anti-angiogenic activity of PSA-derived peptides

(2015) Kailash C. Chadha et al.   PROSTATE

Activation of Cold-Sensing Transient Receptor Potential Melastatin Subtype 8 Antagonizes Vasoconstriction and Hypertension Through Attenuating RhoA/Rho Kinase Pathway

(2014) Jing Sun et al.   HYPERTENSION

A polarized Ca2+, diacylglycerol and STIM1 signalling system regulates directed cell migration

(2014) Feng-Chiao Tsai et al.   NATURE CELL BIOLOGY

Functional properties of ion channels and transporters in tumour vascularization

(2014) A. Fiorio Pla et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

14-3-3 Proteins Interact with a Hybrid Prenyl-Phosphorylation Motif to Inhibit G Proteins

(2013) Philippe Riou et al.   CELL

Functional significance of thermosensitive transient receptor potential melastatin channel 8 (TRPM8) expression in immortalized human corneal endothelial cells

(2013) Stefan Mergler et al.   EXPERIMENTAL EYE RESEARCH

TRPV1 structures in distinct conformations reveal activation mechanisms

(2013) Erhu Cao et al.   NATURE

Structure of the TRPV1 ion channel determined by electron cryo-microscopy

(2013) Maofu Liao et al.   NATURE

Emerging role of TRP channels in cell migration: from tumor vascularization to metastasis

(2013) Alessandra Fiorio Pla et al.   Frontiers in Physiology

The R-Ras/RIN2/Rab5 complex controls endothelial cell adhesion and morphogenesis via active integrin endocytosis and Rac signaling

(2012) Chiara Sandri et al.   CELL RESEARCH

Modeling the influence of nucleus elasticity on cell invasion in fiber networks and microchannels

(2012) Marco Scianna et al.   JOURNAL OF THEORETICAL BIOLOGY

Multiscale Developments of the Cellular Potts Model

(2012) M. Scianna et al.   MULTISCALE MODELING & SIMULATION

Direct inhibition of the cold-activated TRPM8 ion channel by Gαq

(2012) Xuming Zhang et al.   NATURE CELL BIOLOGY

The TRPM8 ion channel comprises direct Gq protein-activating capacity

(2012) Katharina Klasen et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Role of Ion Channels and Transporters in Cell Migration

(2012) Albrecht Schwab et al.   PHYSIOLOGICAL REVIEWS

Plexins Are GTPase-Activating Proteins for Rap and Are Activated by Induced Dimerization

(2012) Y. Wang et al.   Science Signaling

Ion channels and transporters in cancer. 6. Vascularizing the tumor: TRP channels as molecular targets

(2011) Alessandra Fiorio Pla et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

TRP channels in prostate cancer: the good, the bad and the ugly?

(2011) Dimitra Gkika et al.   ASIAN JOURNAL OF ANDROLOGY

Basic and Therapeutic Aspects of Angiogenesis

(2011) Michael Potente et al.   CELL

Hydrogen sulfide promotes calcium signals and migration in tumor-derived endothelial cells

(2011) Emanuela Pupo et al.   FREE RADICAL BIOLOGY AND MEDICINE

TRPV4 mediates tumor-derived endothelial cell migration via arachidonic acid-activated actin remodeling

(2011) A Fiorio Pla et al.   ONCOGENE

A multiscale hybrid approach for vasculogenesis and related potential blocking therapies

(2011) Marco Scianna et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

Regulating Rap small G-proteins in time and space

(2011) Martijn Gloerich et al.   TRENDS IN CELL BIOLOGY

Transient receptor potential channel TRPM8 is over-expressed and required for cellular proliferation in pancreatic adenocarcinoma

(2010) Nelson S. Yee et al.   CANCER LETTERS

Endothelial  5 and  v integrins cooperate in remodeling of the vasculature during development

(2010) A. van der Flier et al.   DEVELOPMENT

Targeting TRPC6 channels in oesophageal carcinoma growth

(2010) Xia Ding et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

The Transient Receptor Potential Channel TRPM8 Is Inhibited via the α2A Adrenoreceptor Signaling Pathway

(2010) Alexis Bavencoffe et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Multiple Roles of Protein Kinase A in Arachidonic Acid-Mediated Ca2+ Entry and Tumor-Derived Human Endothelial Cell Migration

(2010) A. Fiorio Pla et al.   MOLECULAR CANCER RESEARCH

PSA reduces prostate cancer cell motility by stimulating TRPM8 activity and plasma membrane expression

(2010) D Gkika et al.   ONCOGENE

Loss of human Greatwall results in G2 arrest and multiple mitotic defects due to deregulation of the cyclin B-Cdc2/PP2A balance

(2010) Andrew Burgess et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ion channels and the hallmarks of cancer

(2010) Natalia Prevarskaya et al.   TRENDS IN MOLECULAR MEDICINE

Transient receptor potential melastatin 8 channel involvement in the regulation of vascular tone

(2009) Christopher D. Johnson et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

TRPV4 Channels Mediate Cyclic Strain–Induced Endothelial Cell Reorientation Through Integrin-to-Integrin Signaling

(2009) Charles K. Thodeti et al.   CIRCULATION RESEARCH

Control of cell adhesion dynamics by Rap1 signaling

(2009) Benjamin Boettner et al.   CURRENT OPINION IN CELL BIOLOGY

The functional role of cell adhesion molecules in tumor angiogenesis

(2009) Chiara Francavilla et al.   SEMINARS IN CANCER BIOLOGY

HGF/SF and menthol increase human glioblastoma cell calcium and migration

(2008) Robert Wondergem et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Molecular mechanisms of TRP regulation in tumor growth and metastasis

(2008) Dimitra Gkika et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Role of the small GTPase Rap1 for integrin activity regulation in endothelial cells and angiogenesis

(2008) G. Carmona et al.   BLOOD

Arachidonic Acid-Induced Ca2+ Entry Is Involved in Early Steps of Tumor Angiogenesis

(2008) A. F. Pla et al.   MOLECULAR CANCER RESEARCH