Synthesis and cytotoxicity studies of Hedgehog enzyme inhibitors SANT-1 and GANT-61 as anticancer agents

The effect of the nitrogen non-bonding electron pair on the NMR and X-ray in 1,3-diazaheterocycles

(2012) Cesar Garcías-Morales et al.   TETRAHEDRON LETTERS

Combined targeting of histone deacetylases and hedgehog signaling enhances cytoxicity in pancreatic cancer

(2010) Stephen G. Chun et al.   CANCER BIOLOGY & THERAPY

Inhibition of GLI, but not Smoothened, induces apoptosis in chronic lymphocytic leukemia cells

(2010) P Desch et al.   ONCOGENE

Interfering with Resistance to Smoothened Antagonists by Inhibition of the PI3K Pathway in Medulloblastoma

(2010) S. Buonamici et al.   Science Translational Medicine

Synthesis and biological evaluation of SANT-2 and analogues as inhibitors of the hedgehog signaling pathway

(2009) Anita Büttner et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Recent patents for Hedgehog pathway inhibitors for the treatment of malignancy

(2009) Martin R Tremblay et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Evidence for Allosteric Interactions of Antagonist Binding to the Smoothened Receptor

(2009) C. M. Rominger et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Small-molecule inhibitors reveal multiple strategies for Hedgehog pathway blockade

(2009) J. M. Hyman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibition of Hedgehog Signaling Enhances Delivery of Chemotherapy in a Mouse Model of Pancreatic Cancer

(2009) K. P. Olive et al.   SCIENCE

An orally bioavailable small-molecule inhibitor of Hedgehog signaling inhibits tumor initiation and metastasis in pancreatic cancer

(2008) G. Feldmann et al.   MOLECULAR CANCER THERAPEUTICS