Article
Immunology
Dun Niu, Yiwen Wu, Ziyao Lei, Ming Zhang, Zhizhong Xie, Shengsong Tang
Summary: Lactic acid plays a crucial role in the transformation and oncogenic function of stromal cells in the tumor microenvironment. It not only provides energy for stromal cells but also acts as a signaling molecule to regulate their activity. Activated stromal cells, in turn, support tumor development.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Yanlin Deng, Yatian Fu, Song Lin Chua, Bee Luan Khoo
Summary: Components of the tumor microenvironment, such as tumor-associated macrophages (TAMs), have a dual impact on tumor development and treatment. A novel bladder tumor model is developed to study the impact of bacterial distribution on immunomodulation within the tumor microenvironment. It is shown that biofilms induce inflammatory conditions that promote macrophage polarization towards a pro-tumor state. Additionally, extratumoral biofilms can shield tumors from immune attack by TAMs. These findings provide insights into the role of biofilm-mediated inflammation in tumor progression and suggest new therapeutic strategies.
Article
Immunology
Xiaolu Zhu, Yanli Xu, Juan Wang, Zhuowei Xue, Tian Qiu, Jing Chen
Summary: The interaction between endometrial cancer cells and intratumoral macrophages is crucial for the development of the disease. NLRP3-mediated ROS production plays a role in the polarization of macrophages and subsequent growth and metastasis of endometrial cancer.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Multidisciplinary Sciences
Jiawei Xu, Yunpeng Zhang, Rong Gan, Zhuoqi Liu, Yan Deng
Summary: This study investigates the relationship between lactate metabolism and retinopathy of prematurity (ROP) and reveals the functions and internal mechanisms of lactate metabolism-related genes. The findings provide valuable information for future directions of ROP treatment.
SCIENTIFIC REPORTS
(2023)
Article
Engineering, Biomedical
Sumanta Samanta, Vignesh K. Rangasami, Heela Sarlus, Jay R. K. Samal, Austin D. Evans, Vijay S. Parihar, Oommen P. Varghese, Robert A. Harris, Oommen P. Oommen
Summary: Innovative scaffold designs that modulate the local inflammatory microenvironment through favorable macrophage polarization and suppressing oxidative stress are needed for successful clinical translation of regenerative cell therapies and graft integration. We herein report the derivation of a hydrazone-crosslinked gallol-functionalized hyaluronic acid-based hydrogel that displayed outstanding viscoelastic properties and immunomodulatory characteristics.
ACTA BIOMATERIALIA
(2022)
Article
Immunology
Fangchao Zhao, Zengying Wang, Zhirong Li, Shiquan Liu, Shujun Li
Summary: Lactic acid metabolism-related genes (LRGs) play a significant role in lung adenocarcinoma (LUAD), with the identification of distinct molecular subtypes and the development of a prognostic signature. Patients with low LRG_score demonstrate better prognosis, higher immune score, lower somatic mutation rate, and increased responsiveness to anti-PD-1/PD-L1 medications. The stability and reliability of LRG_score were validated in cell lines, clinical tissue samples, and HPA databases, indicating its potential to improve prognostic information and guide drug treatment strategies for LUAD patients.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Food Science & Technology
Dominika Juraskova, Susana C. Ribeiro, Celia C. G. Silva
Summary: This article provides a detailed overview of the applications and potential health effects of exopolysaccharides (EPS) produced by lactic acid bacteria (LAB) in the food industry. EPS act as biothickeners and can improve the quality of fermented foods. Furthermore, EPS have positive effects on the gut microbiome and overall health.
Article
Chemistry, Multidisciplinary
Shuheng Tian, Yuchen Jiao, Zirui Gao, Yao Xu, Linke Fu, Hui Fu, Wu Zhou, Chaoquan Hu, Guosheng Liu, Meng Wang, Ding Ma
Summary: A one-pot catalytic method has been demonstrated to convert polylactic acid into alanine using a Ru/TiO2 catalyst and ammonia solution treatment. The process achieves a 77% yield of alanine at 140 degrees C with an overall selectivity of 94% through recycling experiments.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2021)
Article
Oncology
Pu Sun, Xi Zhang, Rong-Jing Wang, Qing-Yang Ma, Lan Xu, Yi Wang, Hui-Ping Liao, Hai-Long Wang, Lan-Dian Hu, Xiangyin Kong, Jian Ding, Ling-Hua Meng
Summary: CYH33 induces immune activation and synergizes with FASN inhibitor to further promote antitumor immunity. It provides insights into how PI3K inhibitors modulate TME and supports the concurrent targeting of PI3K and FASN in breast cancer treatment.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Biotechnology & Applied Microbiology
Carla Graca, Ana Lima, Anabela Raymundo, Isabel Sousa
Summary: Cereal products have decreased in popularity due to the presence of compounds such as gluten, affecting consumers' preferences. Sourdough fermentation, a traditional method for bread leavening, can improve the taste and digestibility of cereal products, while also positively impacting their nutritional and health benefits.
FERMENTATION-BASEL
(2021)
Review
Polymer Science
Jiaming Yu, Shengchao Xu, Biao Liu, Hailan Wang, Fengmin Qiao, Xiulian Ren, Qifeng Wei
Summary: Poly(lactic acid) (PLA) plastics are of great significance to the sustainable development of the world. The production of PLA involves the synthesis of lactide (LT) from lactic acid (LA) and the subsequent ring-opening polymerization. The quality and capacity of LA and LT directly affect the production and properties of PLA. This review summarizes the recent research progress on LA, LT, and PLA, and highlights the latest methods with significant advantages in energy consumption, reaction integration, efficiency, and yield in the production process.
EUROPEAN POLYMER JOURNAL
(2023)
Article
Immunology
Zhenzi Peng, Suguru Saito
Summary: This study demonstrates that creatine supplementation enhances anti-tumor immunity by upregulating the function of macrophages through increased ATP production. Creatine supplementation significantly inhibits tumor growth and increases tumor antigen-specific CD8+ T cells. The enhancement of macrophage function by creatine is achieved through increased ATP levels, ultimately contributing to enhanced anti-tumor immunity orchestrated by CD8+ T cells.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Oncology
Gabriela A. Pizzurro, Chang Liu, Kathryn Bridges, Amanda F. Alexander, Alice Huang, Janani P. Baskaran, Julie Ramseier, Marcus W. Bosenberg, Michael Mak, Kathryn Miller-Jensen
Summary: The study developed a tumor-in-a-dish experimental system to investigate early events promoting tumor growth and immune suppression in metastatic melanoma. Through co-culturing murine melanoma tumor cells, fibroblasts, and macrophages in a 3D collagen matrix, the researchers found that macrophages acquired features consistent with those in in vivo melanoma tumors over 7 days. This system provides a platform for studying macrophage-stromal interactions in the melanoma microenvironment and testing potential therapies to stimulate immune activity in macrophages.
Article
Chemistry, Multidisciplinary
Chunzheng Yang, Man Wang, Mengyu Chang, Meng Yuan, Wenying Zhang, Jia Tan, Binbin Ding, Ping'an Ma, Jun Lin
Summary: An activatable immunomodulatory nanoadjuvant, CSC@Syro, is constructed to relieve the immunosuppressive tumor microenvironment and boost tumor immune response. The nanoadjuvant induces tumor cell ferroptosis and immunogenic cell death, while blocking lactate metabolism and neutralizing acidic tumor microenvironment. This synergistic therapy integrates tumor metabolic regulation and ferroptosis with immunotherapy, effectively suppressing tumor proliferation and metastasis.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Hematology
Sameera Peraramelli, Qi Zhou, Qin Zhou, Bettina Wanko, Lei Zhao, Toshihiko Nishimura, Thomas H. Leung, Seiya Mizuno, Mamoru Ito, Timothy Myles, Thomas M. Stulnig, John Morser, Lawrence L. K. Leung
Summary: Thrombin cleavage of osteopontin plays a crucial role in tumor development and metastasis, by modulating tumor-associated macrophages to suppress tumor growth and metastasis.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2022)
Review
Physiology
Diana A. Yanez, Richard K. Lacher, Aurobind Vidyarthi, Oscar R. Colegio
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
(2017)
Editorial Material
Immunology
Rachel K. Rosenstein, Christine J. Ko, Oscar R. Colegio
Letter
Dermatology
Mariam B. Totonchy, Oscar R. Colegio, Sean R. Christensen
Article
Dermatology
Giorgia L. Garrett, Paul D. Blanc, John Boscardin, Amanda Abramson Lloyd, Rehana L. Ahmed, Tiffany Anthony, Kristin Bibee, Andrew Breithaupt, Jennifer Cannon, Amy Chen, Joyce Y. Cheng, Zelma Chiesa-Fuxench, Oscar R. Colegio, Clara Curiel-Lewandrowski, Christina A. Del Guzzo, Max Disse, Margaret Dowd, Robert Eilers, Arisa Elena Ortiz, Caroline Morris, Spring K. Golden, Michael S. Graves, John R. Griffin, Samuel Hopkins, Conway C. Huang, Gordon Hyeonjin Bae, Anokhi Jambusaria, Thomas A. Jennings, Shang I. Brian Jiang, Pritesh S. Karia, Shilpi Khetarpal, Changhyun Kim, Goran Klintmalm, Kathryn Konicke, Shlomo A. Koyfman, Charlene Lam, Peter Lee, Justin J. Leitenberger, Tiffany Loh, Stefan Lowenstein, Reshmi Madankumar, Jacqueline F. Moreau, Rajiv I. Nijhawan, Shari Ochoa, Edit B. Olasz, Elaine Otchere, Clark Otley, Jeremy Oulton, Parth H. Patel, Vishal Anil Patel, Arpan V. Prabhu, Melissa Pugliano-Mauro, Chrysalyne D. Schmults, Sarah Schram, Allen F. Shih, Thuzar Shin, Seaver Soon, Teresa Soriano, Divya Srivastava, Jennifer A. Stein, Kara Sternhell-Blackwell, Stan Taylor, Allison Vidimos, Peggy Wu, Nicholas Zajdel, Daniel Zelac, Sarah T. Arron
Article
Dermatology
Giorgia L. Garrett, Joyce T. Yuan, Thuzar M. Shin, Sarah T. Arron
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2018)
Article
Dermatology
Joyce Y. Cheng, Fang-Yong Li, Christine J. Ko, Oscar R. Colegio
Article
Immunology
Aurobind Vidyarthi, Nargis Khan, Tapan Agnihotri, Shikha Negi, Deepjyoti K. Das, Mohammad Aqdas, Deepyan Chatterjee, Oscar R. Colegio, Manoj K. Tewari, Javed N. Agrewala
FRONTIERS IN IMMUNOLOGY
(2018)
Letter
Dermatology
Allen F. Shih, Wendy Sun, Cameron Yick, Suzanne Xu, Rance J. T. Fujiwara, Oscar R. Colegio
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2019)
Letter
Dermatology
Joyce Y. Cheng, Fang-Yong Li, Mike Wang, Oscar R. Colegio
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2019)
Article
Chemistry, Multidisciplinary
Eftekhar Rajab Bolookat, Laurie J. Rich, Gyorgy Paragh, Oscar R. Colegio, Anurag K. Singh, Mukund Seshadri
APPLIED SCIENCES-BASEL
(2020)
Article
Multidisciplinary Sciences
Xiaodong Jiang, Mike Wang, Nika Cyrus, Diana A. Yanez, Richard K. Lacher, Anne Marie Rhebergen, Carolyn Brokowski, Anjela Galan, Samuel Book, Oscar R. Colegio
Review
Surgery
M. Ilyas, O. R. Colegio, B. Kaplan, A. Sharma
AMERICAN JOURNAL OF TRANSPLANTATION
(2017)
Review
Surgery
A. Mittal, O. R. Colegio
AMERICAN JOURNAL OF TRANSPLANTATION
(2017)
