Article
Oncology
Wen Li, Guangzhi Ma, Yunfu Deng, Wenjie Chen, Zhenkun Liu, Fang Chen, Qiang Wu
Summary: The preoperative systemic immune-inflammation index (SII) is significantly associated with prognosis in breast cancer patients, with high SII correlating with younger age, PR status, and HER2 status. Both univariate and multivariate analysis confirmed that high SII is an independent adverse prognostic factor for disease-free survival (DFS) and overall survival (OS) in all enrolled patients. Additionally, subgroup analysis showed that SII is significantly linked to prognosis in all molecular subtypes.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Toshiya Abe, Kohei Nakata, So Nakamura, Noboru Ideno, Naoki Ikenaga, Nobuhiro Fujita, Kousei Ishigami, Kazuyoshi Nishihara, Masafumi Nakamura
Summary: The study aimed to evaluate the impact of preoperative osteosarcopenia on the prognosis of patients with pancreatic ductal adenocarcinoma (PDAC). It was found that patients with osteosarcopenia had significantly shorter overall survival and disease-free survival compared to patients without osteosarcopenia. Osteosarcopenia may be a useful prognostic factor, and further research is needed to evaluate whether perioperative nutritional interventions and rehabilitation contribute to improving the prognosis of these patients.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Gastroenterology & Hepatology
Jan Grosek, Hana Zavrtanik, Ales Tomazic
Summary: This study found that the extent of resection did not affect daily functioning in gastric cancer patients, but those who underwent total gastrectomy may experience more dysphagia and eating restrictions. Moreover, patients with Roux-en-Y reconstruction after subtotal distal gastrectomy had better physical and role functioning compared to those with Billroth II reconstruction.
WORLD JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Oncology
Yu-Ying Liu, Guo-Tian Ruan, Yi-Zhong Ge, Qin-Qin Li, Qi Zhang, Xi Zhang, Meng Tang, Meng-Meng Song, Xiao-Wei Zhang, Xiang-Rui Li, Kang-Ping Zhang, Ming Yang, Chun-Lei Hu, Tong Liu, Hai-Lun Xie, Xiao-Yue Liu, Shi-Qi Lin, Min Weng, Qing-Hua Yao, Zheng-Ping Wang, Ming-Hua Cong, Han-Ping Shi
Summary: This study evaluated the prognostic influence of platelet count, platelet lymphocyte ratio, and systemic immune inflammation index on the survival of patients with gastric cancer. A prognostic SS score was established and found to be a reliable predictor of overall survival in gastric cancer patients.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Oncology
Gaya Spolverato, Giulia Capelli, Valentina Mari, Giulia Lorenzoni, Dario Gregori, George Poultsides, Ryan C. Fields, Sharon M. Weber, Konstantinos Votanopoulos, Clifford S. Cho, Jin He, Shishir K. Maithel, Salvatore Pucciarelli, Timothy M. Pawlik
Summary: This study aimed to identify predictors of very early recurrence (VER) in gastric cancer patients who underwent curative-intent surgery. The study found that preoperative symptoms, comorbidities, tumor grade, lymph node ratio, and T stage were associated with an increased likelihood of VER. The predictive model performed well in predicting VER and two nomograms were built based on the model.
ANNALS OF SURGICAL ONCOLOGY
(2022)
Article
Oncology
Yihui Tang, Jianxian Lin, Junpeng Lin, Jiabin Wang, Jun Lu, Qiyue Chen, Longlong Cao, Mi Lin, Ruhong Tu, Changming Huang, Ping Li, Chaohui Zheng, Jianwei Xie
Summary: The study found that lymph node status is the most important factor associated with recurrence patterns in completely resected gastric adenocarcinoma. It can be used as an adjunct in clinical decision-making about postoperative therapeutic and follow-up strategies.
CHINESE JOURNAL OF CANCER RESEARCH
(2021)
Article
Oncology
Dimei Huang, Shaochu Zheng, Fang Huang, Jingyu Chen, Yuexiang Zhang, Yusha Chen, Bixun Li
Summary: This study aims to establish novel nomograms based on the combined detection of preoperative blood lipids and systemic inflammatory indicators to predict the overall survival and cancer-specific survival of CRC patients. The results showed that preoperative TG/HDL-C ratio (THR) ≥ 1.93 and prognostic nutritional index (PNI) ≥ 42.55 were independently associated with favorable outcomes in CRC patients. The nomograms based on these predictors showed better discrimination ability, calibration ability, and clinical effectiveness than the TNM staging system.
FRONTIERS IN ONCOLOGY
(2023)
Article
Surgery
Hordur Kolbeinsson, Allison Hoppe, Aqieda Bayat, Benjamin Kogelschatz, Chineze Mbanugo, Mathew Chung, Andrea Wolf, M. Mura Assifi, G. Paul Wright
Summary: Pancreatic ductal adenocarcinoma has a high rate of recurrence after resection, with liver metastasis being the most common distant site of recurrence. Patients with poorly differentiated tumors are more likely to recur in the liver. Liver-directed therapies should be a focus for future studies.
Article
Oncology
Gaya Spolverato, Danila Azzolina, Alessandro Paro, Giulia Lorenzoni, Dario Gregori, George Poultsides, Ryan C. Fields, Sharon M. Weber, Konstantinos Votanopoulos, Shishir K. Maithel, Salvatore Pucciarelli, Timothy M. Pawlik
Summary: This study designed and validated an online dynamic prognostic tool to predict overall survival (OS) and disease-free survival (DFS) following resection of gastric adenocarcinoma. The landmark analysis based on follow-up time may be helpful for surgeons and patients.
Article
Oncology
Tai Xu, Si-Ming Zhang, He-Ming Wu, Xiao-Min Wen, Dong-Qin Qiu, Yu-Yang Yang, Li-Zhen Wang, Wen-Biao Zhu, Li-Shan He, Jian-Juan Li
Summary: This study aimed to investigate the prognostic impact of prognostic nutritional index (PNI), systemic immune-inflammation index (SII), neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) on breast cancer patients. The results showed that high PNI was associated with longer disease-free survival (DFS), indicating the importance of nutritional status and systemic immune function in patient prognosis.
Article
Gastroenterology & Hepatology
Liang Huang, Shuangling Luo, Sicong Lai, Zhanzhen Liu, Huanxin Hu, Mian Chen, Liang Kang
Summary: The prognostic value of mucinous adenocarcinoma histotype on early-stage colorectal cancer is still unclear. This study analyzed the clinicopathologic characteristics and long-term outcome of stage I colorectal mucinous adenocarcinomas (MAC), finding that MAC patients were more likely to be located in the colon, have deficient mismatch repair phenotype, and have a higher frequency of T2 stage. However, mucinous histology was not found to be a significant predictor of recurrence and prognosis in stage I CRC.
BMC GASTROENTEROLOGY
(2022)
Article
Immunology
Chaobin He, Chongyu Zhao, Yu Zhang, Cheng Chen, Xiaojun Lin
Summary: A novel prognostic nomogram was established for patients with intrahepatic cholangiocarcinoma after resection, showing powerful efficacy in survival prediction by utilizing the modified Glasgow Prognostic Score as a prognostic factor. The nomograms demonstrated significantly higher predictive ability compared to other staging systems, providing new personalized management options for these patients.
JOURNAL OF INFLAMMATION RESEARCH
(2021)
Article
Gastroenterology & Hepatology
Yun-he Tang, Lin-lin Ren, Ya-Nan Yu, Shao-hua Zhang, Zi-Bin Tian, Tao Mao
Summary: This study aimed to investigate the predictive validity of Systemic Immune-Inflammation Index (SII) for non-curative resection (NCR) in early gastric cancer (EGC) patients who underwent endoscopic submucosal dissection (ESD). The results showed that SII was associated with larger tumor size, male gender, older age, submucosal invasion, and a greater risk of NCR. Compared to platelet-to-lymphocyte ratio (PLR) and neutrophil-to-lymphocyte ratio (NLR), SII showed better predictivity of NCR.
EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY
(2023)
Article
Oncology
Hanbaro Kim, Han Zo Choi, Ji Min Choi, Byung Mo Kang, Jung Woo Lee, Ji Woong Hwang
Summary: This study reveals the prognostic significance of sarcopenia combined with systemic inflammation in patients with hepatocellular carcinoma (HCC) undergoing curative hepatectomy. It shows that sarcopenia and high platelet lymphocyte ratio (PLR) are significantly associated with poor overall survival (OS), and the combination of sarcopenia and high PLR status can be useful in predicting survival in these patients.
JOURNAL OF GASTROINTESTINAL ONCOLOGY
(2022)
Article
Gastroenterology & Hepatology
Noriyuki Hirahara, Yoshitsugu Tajima, Takeshi Matsubara, Yusuke Fujii, Shunsuke Kaji, Yasunari Kawabata, Ryoji Hyakudomi, Tetsu Yamamoto, Yuki Uchida, Takahito Taniura
Summary: The systemic immune-inflammation index (SII) is an independent prognostic indicator in gastric cancer patients, especially in the elderly population. Factors such as operative procedure, age, and pathological stage were also found to be associated with patient outcomes.
JOURNAL OF GASTROINTESTINAL SURGERY
(2021)
Article
Biochemistry & Molecular Biology
Liying Wang, Hongfeng Zhang, Jiaxin Zheng, Xiaoli Wei, Jingwen Du, Haibo Lu, Qiuying Sun, Weiyu Zhou, Rui Zhang, Yu Han
MOLECULAR CARCINOGENESIS
(2018)
Article
Biotechnology & Applied Microbiology
Xuefeng Yu, Fulan Hu, Chunfeng Li, Qiang Yao, Hongfeng Zhang, Yingwei Xue
ONCOTARGETS AND THERAPY
(2018)
Article
Oncology
Sen Li, Xiliang Cong, Hongyu Gao, Xiuwen Lan, Zhiguo Li, Wenpeng Wang, Shubin Song, Yimin Wang, Chunfeng Li, Hongfeng Zhang, Yingwei Xue, Yuzhou Zhao
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2019)
Article
Oncology
Heng-Heng Yuan, Xin-Chen Zhang, Xiao-Li Wei, Wen-Jie Zhang, Xiao-Xue Du, Peng Huang, Hao Chen, Lu Bai, Hong-Feng Zhang, Yu Han
Summary: This study elucidates the detailed role of UCA1 in cetuximab resistance in colorectal cancer (CRC) and its underlying molecular mechanism. UCA1 decreases CRC cell sensitivity to cetuximab by suppressing apoptosis and activating the HGF/c-MET pathway. This discovery provides evidence for UCA1 as a predictor and therapeutic target for cetuximab resistance.