Alantolactone, a natural sesquiterpene lactone, has potent antitumor activity against glioblastoma by targeting IKKβ kinase activity and interrupting NF-κB/COX-2-mediated signaling cascades

Itraconazole induces apoptosis and cell cycle arrest via inhibiting Hedgehog signaling in gastric cancer cells

(2017) Qiang Hu et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Prognostic significance of cyclooxygenase-2 expression in patients with hepatocellular carcinoma: a meta-analysis

(2016) Guodong Chen et al.   Archives of Medical Science

Epigenetic blockade of neoplastic transformation by bromodomain and extra-terminal (BET) domain protein inhibitor JQ-1

(2016) Chengyue Zhang et al.   BIOCHEMICAL PHARMACOLOGY

High body clearance and low oral bioavailability of alantolactone, isolated fromInula helenium, in rats: extensive hepatic metabolism and low stability in gastrointestinal fluids

(2016) Jae-Young Lee et al.   BIOPHARMACEUTICS & DRUG DISPOSITION

Mise au point sur les glioblastomes : des thérapies ciblant les cellules tumorales aux thérapies ciblant les cellules immunitaires

(2016) Antoine Schernberg et al.   BULLETIN DU CANCER

Targeting Inflammation in Cancer Prevention and Therapy

(2016) J. Todoric et al.   Cancer Prevention Research

Blood-brain barrier, cytotoxic chemotherapies and glioblastoma

(2016) Antonin Dréan et al.   Expert Review of Neurotherapeutics

Do phosphatase of regenerating liver-3, matrix metalloproteinases-2, matrix metalloproteinases-9, and epidermal growth factor receptor-1 predict response to therapy and survival in glioblastoma multiforme?

(2016) Nuzhat Husain et al.   Indian Journal of Pathology and Microbiology

FAT1 is a novel upstream regulator of HIF1α and invasion of high grade glioma

(2016) Evanka Madan et al.   INTERNATIONAL JOURNAL OF CANCER

Role of Matrix Metalloproteinases in Photoaging and Photocarcinogenesis

(2016) Pavida Pittayapruek et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Upregulation of Akt/NF-κB-regulated inflammation and Akt/Bad-related apoptosis signaling pathway involved in hepatic carcinoma process: suppression by carnosic acid nanoparticle

(2016) Bo Tang et al.   International Journal of Nanomedicine

GANT61, a GLI inhibitor, sensitizes glioma cells to the temozolomide treatment

(2016) Jianlong Li et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Quercetin sensitizes glioblastoma to t-AUCB by dual inhibition of Hsp27 and COX-2 in vitro and in vivo

(2016) Junyang Li et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Epidemiology of Brain Tumors

(2016) Katharine A. McNeill   NEUROLOGIC CLINICS

Blood-brain barrier, cytotoxic chemotherapies and glioblastoma

(2016) Antonin Dréan et al.   Expert Review of Neurotherapeutics

Metabolic therapy: A new paradigm for managing malignant brain cancer

(2015) Thomas N. Seyfried et al.   CANCER LETTERS

Pharmacokinetics, Tissue Distribution and Excretion of Isoalantolactone and Alantolactone in Rats after Oral Administration of Radix Inulae Extract

(2015) Renjie Xu et al.   MOLECULES

Autophagy Protects Monocytes from Wolbachia Heat Shock Protein 60–Induced Apoptosis and Senescence

(2015) Vijayan Kamalakannan et al.   PLoS Neglected Tropical Diseases

Sulforaphane inhibits phorbol ester-stimulated IKK-NF-κB signaling and COX-2 expression in human mammary epithelial cells by targeting NF-κB activating kinase and ERK

(2014) Ha-Na Kim et al.   CANCER LETTERS

Gamabufotalin, a bufadienolide compound from toad venom, suppresses COX-2 expression through targeting IKKβ/NF-κB signaling pathway in lung cancer cells

(2014) Zhenlong Yu et al.   Molecular Cancer

Genistein inhibits phorbol ester-induced NF-κB transcriptional activity and COX-2 expression by blocking the phosphorylation of p65/RelA in human mammary epithelial cells

(2014) Myung-Hoon Chung et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

NF- B, an Active Player in Human Cancers

(2014) Y. Xia et al.   Cancer Immunology Research

Alantolactone inhibits growth of K562/adriamycin cells by downregulating Bcr/Abl and P-glycoprotein expression

(2013) Chunhui Yang et al.   IUBMB LIFE

Blood–brain barrier structure and function and the challenges for CNS drug delivery

(2013) N. Joan Abbott   JOURNAL OF INHERITED METABOLIC DISEASE

Alantolactone induces cell apoptosis partially through down-regulation of testes-specific protease 50 expression

(2013) Xu-Guang Mi et al.   TOXICOLOGY LETTERS

Prostaglandin receptor EP2 in the crosshairs of anti-inflammation, anti-cancer, and neuroprotection

(2013) Jianxiong Jiang et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Loss of p53 in Enterocytes Generates an Inflammatory Microenvironment Enabling Invasion and Lymph Node Metastasis of Carcinogen-Induced Colorectal Tumors

(2012) Sarah Schwitalla et al.   CANCER CELL

Alantolactone induces activation of apoptosis in human hepatoma cells

(2012) Jia-Chuan Lei et al.   FOOD AND CHEMICAL TOXICOLOGY

COX-2 gene expression in colon cancer tissue related to regulating factors and promoter methylation status

(2011) Annika Gustafsson Asting et al.   BMC CANCER

Polymorphisms in cycloxygenase-2 gene and breast cancer prognosis: association between PTGS2 haplotypes and histopathological features

(2011) Juliana S. Festa-Vasconcellos et al.   BREAST CANCER RESEARCH AND TREATMENT

Gallic acid indanone and mangiferin xanthone are strong determinants of immunosuppressive anti-tumour effects of Mangifera indica L. bark in MDA-MB231 breast cancer cells

(2011) Dagmar García-Rivera et al.   CANCER LETTERS

Inhibition of Lipopolysaccharide-Induced Cyclooxygenase-2 and Inducible Nitric Oxide Synthase Expression by 4-[(2′-O-acetyl-α-L-Rhamnosyloxy)Benzyl]Isothiocyanate fromMoringa oleifera

(2011) Eun-Jung Park et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

IL-6 promotion of glioblastoma cell invasion and angiogenesis in U251 and T98G cell lines

(2010) Qinglin Liu et al.   JOURNAL OF NEURO-ONCOLOGY

Activation of caspases and poly (ADP-ribose) polymerase cleavage to induce apoptosis in leukemia HL-60 cells by Inula racemosa

(2010) Harish Chandra Pal et al.   TOXICOLOGY IN VITRO

CSF as a Surrogate for Assessing CNS Exposure: An Industrial Perspective

(2008) Jiunn Lin   CURRENT DRUG METABOLISM

Cancer-related inflammation

(2008) Alberto Mantovani et al.   NATURE