Regulation of RhoA GTPase and various transcription factors in the RhoA pathway

MicroRNA-31 inhibits RhoA-mediated tumor invasion and chemotherapy resistance in MKN-45 gastric adenocarcinoma cells

(2017) Alireza Korourian et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

RhoA GTPase oxidation stimulates cell proliferation via nuclear factor-κB activation

(2017) Jae-Gyu Kim et al.   FREE RADICAL BIOLOGY AND MEDICINE

Tyr42 phosphorylation of RhoA GTPase promotes tumorigenesis through nuclear factor (NF)-κB

(2017) Jae-Gyu Kim et al.   FREE RADICAL BIOLOGY AND MEDICINE

Regulation of RhoA activity by the cellular prion protein

(2017) Hee-Jun Kim et al.   Cell Death & Disease

YAP Regulates Actin Dynamics through ARHGAP29 and Promotes Metastasis

(2017) Yiting Qiao et al.   Cell Reports

Hypoxia regulates RhoA and Wnt/β-catenin signaling in a context-dependent way to control re-differentiation of chondrocytes

(2017) Ece Öztürk et al.   Scientific Reports

RhoGDIα Acetylation at K127 and K141 Affects Binding toward Nonprenylated RhoA

(2016) Nora Kuhlmann et al.   BIOCHEMISTRY

MicroRNA-122 regulates polyploidization in the murine liver

(2016) Shu-hao Hsu et al.   HEPATOLOGY

Wnt3A Induces GSK-3β Phosphorylation and β-Catenin Accumulation Through RhoA/ROCK

(2016) Jae-Gyu Kim et al.   JOURNAL OF CELLULAR PHYSIOLOGY

MicroRNA-146a inhibits cell migration and invasion by targeting RhoA in breast cancer

(2016) QIN LIU et al.   ONCOLOGY REPORTS

Phosphorylation and Activation of RhoA by ERK in Response to Epidermal Growth Factor Stimulation

(2016) Junfeng Tong et al.   PLoS One

MiR-133b Promotes Neurite Outgrowth by Targeting RhoA Expression

(2015) Xiao Cheng Lu et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Structural and Mechanistic Insights into the Regulation of the Fundamental Rho Regulator RhoGDIα by Lysine Acetylation

(2015) Nora Kuhlmann et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Acetylation of the RhoA GEF Net1A controls its subcellular localization and activity

(2015) E. H. Song et al.   JOURNAL OF CELL SCIENCE

Nuclear RhoA signaling regulates MRTF-dependent SMC-specific transcription

(2014) Dean P. Staus et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

The RHOA G17V gene mutation occurs frequently in peripheral T-cell lymphoma and is associated with a characteristic molecular signature

(2014) R. Manso et al.   BLOOD

Mutant Gq/11 Promote Uveal Melanoma Tumorigenesis by Activating YAP

(2014) Fa-Xing Yu et al.   CANCER CELL

Hippo-Independent Activation of YAP by the GNAQ Uveal Melanoma Oncogene through a Trio-Regulated Rho GTPase Signaling Circuitry

(2014) Xiaodong Feng et al.   CANCER CELL

MicroRNA 340 Is Involved in UVB-Induced Dendrite Formation through the Regulation of RhoA Expression in Melanocytes

(2014) Q. Jian et al.   MOLECULAR AND CELLULAR BIOLOGY

Metabolic control of YAP and TAZ by the mevalonate pathway

(2014) Giovanni Sorrentino et al.   NATURE CELL BIOLOGY

Recurrent gain-of-function mutations of RHOA in diffuse-type gastric carcinoma

(2014) Miwako Kakiuchi et al.   NATURE GENETICS

A recurrent inactivating mutation in RHOA GTPase in angioimmunoblastic T cell lymphoma

(2014) Hae Yong Yoo et al.   NATURE GENETICS

Somatic RHOA mutation in angioimmunoblastic T cell lymphoma

(2014) Mamiko Sakata-Yanagimoto et al.   NATURE GENETICS

Recurrent mutations in epigenetic regulators, RHOA and FYN kinase in peripheral T cell lymphomas

(2014) Teresa Palomero et al.   NATURE GENETICS

MicroRNA-122 Triggers Mesenchymal-Epithelial Transition and Suppresses Hepatocellular Carcinoma Cell Motility and Invasion by Targeting RhoA

(2014) Sheng-Chun Wang et al.   PLoS One

RHOA inactivation enhances Wnt signalling and promotes colorectal cancer

(2014) Paulo Rodrigues et al.   Nature Communications

Regulation of MKL1 via actin cytoskeleton dynamics drives adipocyte differentiation

(2014) Hiroyuki Nobusue et al.   Nature Communications

Involvement of small GTPase RhoA in the regulation of superoxide production in BV2 cells in response to fibrillar Aβ peptides

(2013) Mi-Young Moon et al.   CELLULAR SIGNALLING

IκB Kinase γ/Nuclear Factor-κB-Essential Modulator (IKKγ/NEMO) Facilitates RhoA GTPase Activation, which, in Turn, Activates Rho-associated Kinase (ROCK) to Phosphorylate IKKβ in Response to Transforming Growth Factor (TGF)-β1

(2013) Hee-Jun Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phosphorylation of Rac1 T108 by Extracellular Signal-Regulated Kinase in Response to Epidermal Growth Factor: a Novel Mechanism To Regulate Rac1 Function

(2013) Junfeng Tong et al.   MOLECULAR AND CELLULAR BIOLOGY

PDK1 decreases TACE-mediated α-secretase activity and promotes disease progression in prion and Alzheimer's diseases

(2013) Mathéa Pietri et al.   NATURE MEDICINE

ROCK has a crucial role in regulating prostate tumor growth through interaction with c-Myc

(2013) C Zhang et al.   ONCOGENE

Hypoxia-inducible factors mediate coordinated RhoA-ROCK1 expression and signaling in breast cancer cells

(2013) D. M. Gilkes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Wnt secretion is required to maintain high levels of Wnt activity in colon cancer cells

(2013) Oksana Voloshanenko et al.   Nature Communications

Small GTPases Rap1 and RhoA regulate superoxide formation by Rac1 GTPases activation during the phagocytosis of IgG-opsonized zymosans in macrophages

(2012) Yi Li et al.   FREE RADICAL BIOLOGY AND MEDICINE

Direct Binding and Regulation of RhoA Protein by Cyclic GMP-dependent Protein Kinase Iα

(2012) Mikio Kato et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MicroRNA-34a Modulates Cytoskeletal Dynamics through Regulating RhoA/Rac1 Cross-talk in Chondroblasts

(2012) Dongkyun Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Modified SH2 domain to phototrap and identify phosphotyrosine proteins from subcellular sites within cells

(2012) A. Uezu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

AMPK Alpha 1-Induced RhoA Phosphorylation Mediates Vasoprotective Effect of Estradiol

(2011) Marion Gayard et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Control of neurite outgrowth by RhoA inactivation

(2011) Chan-Young Jeon et al.   JOURNAL OF NEUROCHEMISTRY

MicroRNA-155 Promotes Resolution of Hypoxia-Inducible Factor 1  Activity during Prolonged Hypoxia

(2011) U. Bruning et al.   MOLECULAR AND CELLULAR BIOLOGY

Taking aim at the extracellular matrix: CCN proteins as emerging therapeutic targets

(2011) Joon-Il Jun et al.   NATURE REVIEWS DRUG DISCOVERY

The Small GTPase RhoA Localizes to the Nucleus and Is Activated by Net1 and DNA Damage Signals

(2011) Adi D. Dubash et al.   PLoS One

Tyrosine Phosphorylation of Rac1: A Role in Regulation of Cell Spreading

(2011) Fumin Chang et al.   PLoS One

Targeting Mitochondrial Glutaminase Activity Inhibits Oncogenic Transformation

(2010) Jian-Bin Wang et al.   CANCER CELL

miR-185 targets RhoA and Cdc42 expression and inhibits the proliferation potential of human colorectal cells

(2010) Ming Liu et al.   CANCER LETTERS

p190RhoGAP and Rap-dependent RhoGAP (ARAP3) inactivate RhoA in response to nerve growth factor leading to neurite outgrowth from PC12 cells

(2010) Chan-Young Jeon et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Neurite outgrowth from PC12 cells by basic fibroblast growth factor (bFGF) is mediated by RhoA inactivation through p190RhoGAP and ARAP3

(2010) Chan-Young Jeon et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Deciphering the transcriptional complex critical for RhoA gene expression and cancer metastasis

(2010) Chia-Hsin Chan et al.   NATURE CELL BIOLOGY

Identification of a co-activator that links growth factor signalling to c-Jun/AP-1 activation

(2010) Clare C. Davies et al.   NATURE CELL BIOLOGY

The Transcriptional Activity of Sox9 in Chondrocytes Is Regulated by RhoA Signaling and Actin Polymerization

(2009) D. Kumar et al.   MOLECULAR AND CELLULAR BIOLOGY

Cyclic GMP Kinase and RhoA Ser188 Phosphorylation Integrate Pro- and Antifibrotic Signals in Blood Vessels

(2009) N. Sawada et al.   MOLECULAR AND CELLULAR BIOLOGY

The proximal STAT6 and NF-κB sites are responsible for IL-13- and TNF-α-induced RhoA transcriptions in human bronchial smooth muscle cells

(2009) Kumiko Goto et al.   PHARMACOLOGICAL RESEARCH

Thrombin receptor and RhoA mediate cell proliferation through integrins and cysteine-rich protein 61

(2008) Colin T. Walsh et al.   FASEB JOURNAL

MicroRNA-155 Is Regulated by the Transforming Growth Factor  /Smad Pathway and Contributes to Epithelial Cell Plasticity by Targeting RhoA

(2008) W. Kong et al.   MOLECULAR AND CELLULAR BIOLOGY

Fasudil-induced hypoxia-inducible factor-1α degradation disrupts a hypoxia-driven vascular endothelial growth factor autocrine mechanism in endothelial cells

(2008) Keiko Takata et al.   MOLECULAR CANCER THERAPEUTICS

Mammalian Rho GTPases: new insights into their functions from in vivo studies

(2008) Sarah J. Heasman et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

High blood pressure arising from a defect in vascular function

(2008) S. K. Michael et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA