PDK1 decreases TACE-mediated α-secretase activity and promotes disease progression in prion and Alzheimer's diseases

Pathogenic prions deviate PrPC signaling in neuronal cells and impair A-beta clearance

(2013) E Pradines et al.   Cell Death & Disease

The Complex PrPc-Fyn Couples Human Oligomeric A  with Pathological Tau Changes in Alzheimer's Disease

(2012) M. Larson et al.   JOURNAL OF NEUROSCIENCE

Alzheimer amyloid-β oligomer bound to postsynaptic prion protein activates Fyn to impair neurons

(2012) Ji Won Um et al.   NATURE NEUROSCIENCE

Small-Animal PET Imaging of Amyloid-Beta Plaques with [11C]PiB and Its Multi-Modal Validation in an APP/PS1 Mouse Model of Alzheimer's Disease

(2012) André Manook et al.   PLoS One

Tumor Necrosis Factor Signaling Requires iRhom2 to Promote Trafficking and Activation of TACE

(2012) C. Adrain et al.   SCIENCE

ApoE-Directed Therapeutics Rapidly Clear  -Amyloid and Reverse Deficits in AD Mouse Models

(2012) P. E. Cramer et al.   SCIENCE

Study of the PDK1/AKT signaling pathway using selective PDK1 inhibitors, HCS, and enhanced biochemical assays

(2011) Alexandra Hofler et al.   ANALYTICAL BIOCHEMISTRY

Neuritogenesis: the prion protein controls β1 integrin signaling activity

(2011) Damien Loubet et al.   FASEB JOURNAL

β-Amyloid Peptide Variants in Brains and Cerebrospinal Fluid from Amyloid Precursor Protein (APP) Transgenic Mice

(2011) Heinke Schieb et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Naturally Occurring C-terminal Fragment of the Prion Protein (PrP) Delays Disease and Acts as a Dominant-negative Inhibitor of PrPScFormation

(2011) Laura Westergard et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Proteolytic processing of Alzheimer’s β-amyloid precursor protein

(2011) Han Zhang et al.   JOURNAL OF NEUROCHEMISTRY

Inflammatory markers in population studies of aging

(2010) Tushar Singh et al.   AGEING RESEARCH REVIEWS

Age and gene overexpression interact to abolish nesting behavior in Tg2576 amyloid precursor protein (APP) mice

(2010) Daniel W. Wesson et al.   BEHAVIOURAL BRAIN RESEARCH

ADAM-17: the enzyme that does it all

(2010) Monika Gooz   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Prion protein in Alzheimer's pathogenesis: a hot and controversial issue

(2010) Iryna Benilova et al.   EMBO Molecular Medicine

The secretases: enzymes with therapeutic potential in Alzheimer disease

(2010) Bart De Strooper et al.   Nature Reviews Neurology

Critical role of PI3K signaling for NF- B-dependent survival in a subset of activated B-cell-like diffuse large B-cell lymphoma cells

(2010) B. Kloo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MiR-16 Targets the Serotonin Transporter: A New Facet for Adaptive Responses to Antidepressants

(2010) A. Baudry et al.   SCIENCE

Stable-isotope dilution LC–MS for quantitative biomarker analysis

(2010) Eugene Ciccimaro et al.   Bioanalysis

Regulation of Mature ADAM17 by Redox Agents for L-Selectin Shedding

(2009) Y. Wang et al.   JOURNAL OF IMMUNOLOGY

Cellular prion protein coupling to TACE-dependent TNF-α shedding controls neurotransmitter catabolism in neuronal cells

(2009) Elodie Pradines et al.   JOURNAL OF NEUROCHEMISTRY

Cellular prion protein mediates impairment of synaptic plasticity by amyloid-β oligomers

(2009) Juha Laurén et al.   NATURE

Systemic inflammation and disease progression in Alzheimer disease

(2009) C. Holmes et al.   NEUROLOGY

Early dysfunction of central 5-HT system in a murine model of bovine spongiform encephalopathy

(2009) C. Vidal et al.   NEUROSCIENCE

The Prion's Elusive Reason for Being

(2008) Adriano Aguzzi et al.   Annual Review of Neuroscience

The two faces of protein misfolding: gain- and loss-of-function in neurodegenerative diseases

(2008) Konstanze F Winklhofer et al.   EMBO JOURNAL

Prions Impair Bioaminergic Functions through Serotonin- or Catecholamine-derived Neurotoxins in Neuronal Cells

(2008) Sophie Mouillet-Richard et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The ADAM metalloproteinases

(2008) D EDWARDS et al.   MOLECULAR ASPECTS OF MEDICINE