Article
Oncology
Mackenzie L. Davenport, John B. Echols, Austin D. Silva, Joshua C. Anderson, Philip Owens, Clayton Yates, Qing Wei, Shuko Harada, Douglas R. Hurst, Mick D. Edmonds
Summary: miR-31 demonstrates oncogenic properties in specific subtypes of lung cancer, highlighting its potential as a therapeutic target in these subtypes.
Article
Cell Biology
Min Liang, Wenxia Yao, Boyun Shi, Xiongjie Zhu, Rui Cai, Zhongjian Yu, Weihong Guo, Huaiming Wang, Zhijie Dong, Mingzhen Lin, Xinke Zhou, Yanfang Zheng
Summary: The study identified hsa_circ_0110389 as a novel upregulated circRNA in malignant-transformed gastric cancer cells, and found that it promotes gastric cancer progression via the miR-127-5p/miR-136-5p-SORT1 pathway. This circRNA may serve as a diagnostic/prognostic biomarker and therapeutic target for gastric cancer.
CELL DEATH & DISEASE
(2021)
Article
Cell Biology
Xiaqiong Mao, Tao Ji, Aiguo Liu, Yunqi Weng
Summary: The study revealed that lncRNA SNHG22 is significantly upregulated in gastric cancer tissues and cells, promoting the proliferation and invasion of gastric cancer cells through multiple mechanisms. SNHG22 can be induced by ELK4 and binds EZH2 to suppress tumor suppressor gene expression, while also interacting with miR-200c-3p to increase Notch1 expression. The findings suggest SNHG22 as a potential biomarker for diagnosis and prognosis, as well as a target for gastric cancer treatment.
CELL DEATH & DISEASE
(2021)
Review
Cell Biology
Fang Liu, Yanfen Shi, Zuolong Liu, Ziyi Li, Wei Xu
Summary: Evidence has shown that miRNAs are crucial in the tumorigenesis and progression of various cancers, including gastric cancer, with miR-10a and miR-10b identified as key players in gastric carcinogenesis. Targeting the miR-10 family could be a promising approach for treating gastric cancer, as it regulates multiple aspects of cancer cell behavior and various compounds have shown antitumor activity by targeting these miRNAs.
Article
Oncology
Xinxue Zhang, Zhangyong Ren, Junming Xu, Qing Chen, Jun Ma, Zhe Liu, Jiantao Kou, Xin Zhao, Ren Lang, Qiang He
Summary: This study uncovers the regulatory mechanism of miR-1301-3p on the epithelial-mesenchymal transition (EMT) in pancreatic cancer (PC). The downregulation of miR-1301-3p is associated with poor prognosis in PC patients and it suppresses PC cell malignancy by targeting the RhoA-induced EMT process.
JOURNAL OF ONCOLOGY
(2022)
Article
Endocrinology & Metabolism
Yuewen Gao, Yanqin Wang, Lingxin Meng, Kai Wang, Xiaoyong Liu, Lei Chen
Summary: In this study, the levels of miR-155-5p in gastric cancer tissues and cells were analyzed, and it was found that miR-155-5p was highly expressed in gastric cancer. Further experiments showed that miR-155-5p promotes the growth of NCI-N87 cells, and its enrichment can reverse the inhibitory effects of lobaplatin treatment on gastric cancer cells.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2023)
Article
Biotechnology & Applied Microbiology
Hailin Ke, Songling Wu, Yueyi Zhang, Guowei Zhang
Summary: miR-139-3p suppresses gastric cancer by inhibiting the proliferative, migratory, and invasive abilities of GC cells through targeting KIF18B.
Article
Cell Biology
Zihao Chen, Yong Li, Bibo Tan, Fang Li, Qun Zhao, Liqiao Fan, Zhidong Zhang, Xuefeng Zhao, Yu Liu, Dong Wang
Summary: This study revealed that Lnc_ASNR is highly expressed in gastric cancer and promotes cell proliferation, migration, and invasion by regulating the miR-519e-5p/FGFR2 pathway. Lnc_ASNR functions as a ceRNA targeting miR-519e-5p, and its effects are closely related to epithelial-mesenchymal transition (EMT) in gastric cancer development.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell Biology
Yan Chen, Chong Huang, Zhi-Bin Duan, Yan-Xia Chen, Cheng-Yun Xu
Summary: This study reveals that long noncoding RNA NEAT1 plays a crucial role in renal fibrosis. NEAT1 accelerates fibrosis progression by negatively regulating miR-31 and activating the RhoA/ROCK1 pathway, leading to the upregulation of connective tissue growth factor (CTGF) expression.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Liang Ma, Yunshan Jiang, Ning Wu
Summary: This study revealed that lncRNA CCL2 regulates the proliferation, migration, and invasion of gastric cancer through the miR-128/PARP2 signaling pathway. These findings provide a potential new strategy for the treatment of gastric cancer.
Article
Biochemistry & Molecular Biology
Won Jung Bae, Kyoung-Jin Woo, Ji Mi Ahn, Chan-Mo Yang, You-Sun Kim, Seokhwi Kim, Dakeun Lee
Summary: miR-4742-5p is a microRNA identified in gastric cancer that plays a role in cancer progression and metastasis. Its overexpression promotes the proliferation, migration, and invasion of gastric cancer cells and induces epithelial-mesenchymal transition. Rab43 is identified as a potential target gene, and its expression is associated with the activation of AKT and NF-kB.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Cell Biology
Qian Yang, Shan Kong, Jiajia Yu, Yanhua Xu, Mei Tao, Shuo Ma, Chenxue Tang, Xianjuan Shen, Zhiyuan Tang, Shaoqing Ju
Summary: In this study, it was found that the high expression of fatty acid amide hydrolase (FAAH) is closely related to the occurrence and progression of gastric cancer (GC). Functional tests confirmed that FAAH plays an oncogene role in GC, and silencing FAAH could delay tumor growth, inhibit tumor metastasis, and promote cell apoptosis. FAAH mediates lipid metabolism reprogramming through regulation of the arachidonoyl ethanolamide (AEA)/lysophosphatidic acid (LPA) signaling and activated the cyclooxygenase-2 (COX-2)/prostaglandin E2 (PGE2) axis to promote GC progression.
CELL DEATH & DISEASE
(2023)
Article
Oncology
Xin Xu, Shoulian Wang, Haibo Wang, Chunpeng Pan, Wenyan Yang, Jiwei Yu
Summary: This study investigated the role of hsa_circ_0008434 in gastric cancer (GC) and found that it is highly expressed in GC tissues, promoting proliferation, migration, and invasion of GC cells by acting as a miRNA sponge for miR-6838-5p to upregulate USP9X expression. Animal studies confirmed that hsa_circ_0008434 can promote tumor growth in vivo.
Article
Biochemistry & Molecular Biology
Zhiping Chen, Tianyu Zhong, Tao Li, Jinghua Zhong, Yang Tang, Zhanyu Liu, Baodian Ling, Lanfeng Wang
Summary: The study revealed that SNHG15 exerts oncogenic properties in gastric cancer by targeting miR-506-5p, potentially offering a novel target for GC treatment.
BIOSCIENCE REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Jinxi Huang, Weiwei Yuan, Beibei Chen, Gaofeng Li, Xiaobing Chen
Summary: The study found that long noncoding RNA (lncRNA) extracellular leucine rich repeat and fibronectin type III domain containing 1-antisense RNA 1 (ELFN1-AS1) is upregulated in various tumors. However, its role in gastric cancer (GC) is not well understood. The study showed that ELFN1-AS1 promotes GC cell proliferation, migration, invasion, and EMT, and inhibits apoptosis by acting as a sponge for miR-211-3p and upregulating TRIM29 expression. Thus, the ELFN1-AS1/miR-211-3p/TRIM29 axis may be a potential target for GC treatment in the future.
ACTA BIOCHIMICA ET BIOPHYSICA SINICA
(2023)
Article
Urology & Nephrology
Azadeh Khalvandi, Maryam Abolhasani, Zahra Madjd, Laleh Sharifi, Parisa Bakhshi, Monireh Mohsenzadegan
Summary: The study showed that the expression of MAGE-A2 was significantly increased in PCa tissues compared to HPIN cases. Cytoplasmic expression of MAGE-A2 was inversely correlated with Gleason score and associated with longer biochemical recurrence-free survival and disease-free survival in patients with PCa.
WORLD JOURNAL OF UROLOGY
(2021)
Article
Medicine, Research & Experimental
Sepideh Razi, Asieh Sadeghi, Zeynab Asadi-Lari, Kevin J. Tam, Elham Kalantari, Zahra Madjd
Summary: The study found a significant negative correlation between DCLK1 expression and miR-137 and miR-15a levels in colorectal cancer. DCLK1 may serve as a marker for colorectal cancer stem cells and potentially play a critical role in tumor diagnosis and treatment.
CLINICAL AND EXPERIMENTAL MEDICINE
(2021)
Review
Andrology
Niknam Lakpour, Kioomars Saliminejad, Roya Ghods, Mohammad Reza Sadeghi, Adrian Pilatz, Farhad Khosravi, Zahra Madjd
Summary: Testicular germ cell tumour (TGCT) is a relatively rare malignancy that mainly affects young men between the ages of 15 and 35, with genetic and environmental factors contributing to its development. While most patients are diagnosed in early stages with a high survival rate, approximately 25% show incomplete response to chemotherapy or experience tumor relapse. Novel biomarkers such as miRNA-371-3p have shown potential for diagnosis and monitoring of TGCTs.
Review
Oncology
Mahdieh Razmi, Roya Ghods, Somayeh Vafaei, Maryam Sahlolbei, Leili Saeednejad Zanjani, Zahra Madjd
Summary: The meta-analysis revealed that overexpression of cancer stem cell (CSC) markers is associated with worse outcomes in gastric cancer patients, including TNM stage, lymph node metastasis, survival rate, disease-specific survival, and disease-free survival. Specific CSC markers such as Gli-1, Oct-4, CD44, CD44V6, and CD133 showed stronger correlations with clinical outcomes and reduced survival compared to others like Lgr-5, Nanog, and sonic hedgehog.
CANCER CELL INTERNATIONAL
(2021)
Article
Oncology
Elmira Gheytanchi, Leili Saeednejad Zanjani, Roya Ghods, Maryam Abolhasani, Marzieh Shahin, Somayeh Vafaei, Marzieh Naseri, Fahimeh Fattahi, Zahra Madjd
Summary: This study identified TSG101 gene as a potential biomarker in CRC tissues and exosomes, with significantly increased expression in tumor cells compared to normal tissues, and significant associations with tumor differentiation and distant metastasis. The findings suggest that TSG101, as an exosomal marker, may play a role in the progression and management of CRC, warranting further research on its molecular mechanisms.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2021)
Article
Cell Biology
Marzieh Naseri, Margot Zoller, Jamshid Hadjati, Roya Ghods, Ehsan Ranaei Pirmardan, Jafar Kiani, Leila Eini, Mahmood Bozorgmehr, Zahra Madjd
Summary: CSCenr-EXOs present a novel antigen source that effectively activates CSC-specific T-cell responses, promotes T-cell proliferation, and disrupts colorectal cancer sphere structures.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2021)
Article
Medicine, Research & Experimental
Faezeh Vakhshiteh, Soheila Rahmani, Seyed Nasser Ostad, Zahra Madjd, Rassoul Dinarvand, Fatemeh Atyabi
Summary: The study demonstrated the potential of genetically modified DPSCs to secrete exosomes enriched with therapeutic miRNAs as a tool for gene delivery. However, optimizing gene-loading approaches is necessary before exosomes can be used as carriers of therapeutic miRNAs.
Article
Immunology
Azadeh Khalvandi, Maryam Abolhasani, Zahra Madjd, Mehdi Shekarabi, Masoumeh Kourosh-Arami, Monireh Mohsenzadegan
Summary: MAGE-A3 expression is significantly increased in prostate cancer tissues, correlated with Gleason score, and predicts survival outcomes in patients. It can be considered as a predictor for poor prognosis in prostate cancer patients and an option for vaccine immunotherapy.
Article
Oncology
Elmira Gheytanchi, Marzieh Naseri, Feridoun Karimi-Busheri, Fatemeh Atyabi, Ensie Sadat Mirsharif, Mahmood Bozorgmehr, Roya Ghods, Zahra Madjd
Summary: The study aimed to assess the capability of HT-29 and Caco-2 cell lines in generating spheroids with CSC-related features and detailed morphological and molecular characteristics. Both cell lines formed CSCs-enriched spheroids, identified by their ability to serial sphere formation, up-regulation of stemness genes, and increased expression of CRC-CSC markers. The spheroid culture model without special scaffold/biochemical proved to be a robust, reproducible, simple, and cost-effective method for in vitro research of CRC-CSCs, including self-renewal, drug resistance, and invasion.
CANCER CELL INTERNATIONAL
(2021)
Review
Immunology
Fausto Petrelli, Roberto Ferrara, Diego Signorelli, Antonio Ghidini, Claudia Proto, Raheleh Roudi, Mehrdad N. Sabet, Sara Facelli, Marina C. Garassino, Andrea Luciani, Giandomenico Roviello
Summary: This study conducted a meta-analysis of nine randomized controlled trials in first-line studies, indicating a significant benefit in overall survival by adding immune checkpoint inhibitors to chemotherapy, particularly for patients with PD-L1 positive-high cancers.
Review
Oncology
Navid Sobhani, Dana Rae Tardiel-Cyril, Aram Davtyan, Daniele Generali, Raheleh Roudi, Yong Li
Summary: Immunotherapies have shown promise in cancer treatment but face challenges. Understanding the molecular mechanisms of immune checkpoint inhibitors and the role of regulatory T cells is crucial for improving cancer therapies.
Article
Immunology
Raheleh Roudi, Alberto D'Angelo, Marianna Sirico, Navid Sobhani
Summary: Hepatocellular carcinoma (HCC) is a common and fatal malignancy with surgical resection, ablation, and liver transplantation as common therapeutic approaches in the early stage. Immunotherapeutic options, including checkpoint inhibitors, have shown promising results in various solid tumors, including HCC, in recent clinical trials.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Navid Sobhani, Giandomenico Roviello, Alberto D'Angelo, Raheleh Roudi, Praveen Kumar Neeli, Daniele Generali
Summary: The meta-analysis confirms the diagnostic utility of p53 antibodies for cancer patients in predicting poorer outcomes, indicating the potential usefulness of serum p53 values for future theranostics.
Review
Oncology
Navid Sobhani, Richard Chahwan, Raheleh Roudi, Rachel Morris, Stefano Volinia, Dafei Chai, Alberto D'Angelo, Daniele Generali
Summary: Non-coding RNA plays a crucial role in breast cancer and has predictive and prognostic value. It can be used as biomarkers and therapies. This class of RNA molecules includes both oncogenic and tumor suppressive molecules.
Review
Radiology, Nuclear Medicine & Medical Imaging
Donna M. Peehl, Cristian T. Badea, Thomas L. Chenevert, Heike E. Daldrup-Link, Li Ding, Lacey E. Dobrolecki, A. McGarry Houghton, Paul E. Kinahan, John Kurhanewicz, Michael T. Lewis, Shunqiang Li, Gary D. Luker, Cynthia X. Ma, H. Charles Manning, Yvonne M. Mowery, Peter J. O'Dwyer, Robia G. Pautler, Mark A. Rosen, Raheleh Roudi, Brian D. Ross, Kooresh I. Shoghi, Renuka Sriram, Moshe Talpaz, Richard L. Wahl, Rong Zhou
Summary: The availability of high-fidelity animal models has increased, allowing for preclinical studies relevant to cancer research. Co-clinical trials conducted on animal models that mirror patients' tumors have seen increased opportunities. However, quantitative imaging in co-clinical trials still needs optimization.