Targeting local vascular and systemic consequences of inflammation on vascular and cardiac valve calcification

Endothelial microparticles mediate inflammation-induced vascular calcification

(2015) Paula Buendía et al.   FASEB JOURNAL

Overexpression of C1q/Tumor Necrosis Factor–Related Protein-3 Promotes Phosphate-Induced Vascular Smooth Muscle Cell Calcification Both In Vivo and In Vitro

(2014) Yun Zhou et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

RANKL–OPG and RAGE modulation in vascular calcification and diabetes: novel targets for therapy

(2014) Agbor Ndip et al.   DIABETOLOGIA

P2Y2 receptor represses IL-6 expression by valve interstitial cells through Akt: Implication for calcific aortic valve disease

(2014) Diala El Husseini et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Osteoprotegerin and kidney disease

(2014) Alejandra Montañez-Barragán et al.   JOURNAL OF NEPHROLOGY

Coronary and Abdominal Aorta Calcification in Rheumatoid Arthritis: Relationships with Traditional Cardiovascular Risk Factors, Disease Characteristics, and Concomitant Treatments

(2014) J. Paccou et al.   JOURNAL OF RHEUMATOLOGY

Proteinuria Increases Plasma Phosphate by Altering Its Tubular Handling

(2014) S. de Seigneux et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Increased Calcification in Osteoprotegerin-Deficient Smooth Muscle Cells: Dependence on Receptor Activator of NF-κB Ligand and Interleukin 6

(2014) Andrea Callegari et al.   JOURNAL OF VASCULAR RESEARCH

Tofacitinib versus Methotrexate in Rheumatoid Arthritis

(2014) Eun Bong Lee et al.   NEW ENGLAND JOURNAL OF MEDICINE

Bone Marrow– or Vessel Wall–Derived Osteoprotegerin Is Sufficient to Reduce Atherosclerotic Lesion Size and Vascular Calcification

(2013) A. Callegari et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Macrophage-Derived Matrix Vesicles

(2013) Sophie E. P. New et al.   CIRCULATION RESEARCH

Prelamin A Accelerates Vascular Calcification Via Activation of the DNA Damage Response and Senescence-Associated Secretory Phenotype in Vascular Smooth Muscle Cells

(2013) Yiwen Liu et al.   CIRCULATION RESEARCH

Biomarkers Associated with Vascular and Valvular Calcification in Chronic Hemodialysis Patients

(2013) Chien-Te Lee et al.   DISEASE MARKERS

High Mobility Group Box 1 (HMGB1) Mediates High-Glucose-Induced Calcification in Vascular Smooth Muscle Cells of Saphenous Veins

(2013) Yongyi Wang et al.   INFLAMMATION

Paricalcitol Effects on Activities and Metabolism of Platelet Activating Factor and on Inflammatory Cytokines in Hemodialysis Patients

(2013) Sophia N. Verouti et al.   INTERNATIONAL JOURNAL OF ARTIFICIAL ORGANS

Nalp3 inflammasome is activated and required for vascular smooth muscle cell calcification

(2013) Chaoyang Wen et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Aortic valvular interstitial cells apoptosis and calcification are mediated by TNF-related apoptosis-inducing ligand

(2013) Antonella Galeone et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

RANKL Inhibition With Denosumab Does Not Influence 3-Year Progression of Aortic Calcification or Incidence of Adverse Cardiovascular Events in Postmenopausal Women With Osteoporosis and High Cardiovascular Risk

(2013) Elizabeth J Samelson et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Fibroblast growth factor 23 accelerates phosphate-induced vascular calcification in the absence of Klotho deficiency

(2013) Rika Jimbo et al.   KIDNEY INTERNATIONAL

Circulating levels of soluble receptor for advanced glycation end product are inversely associated with vascular calcification in patients on haemodialysis independent of S100A12 (EN-RAGE) levels

(2013) Hyung Soo Kim et al.   NEPHROLOGY

Osteoprotegerin Inhibits Aortic Valve Calcification and Preserves Valve Function in Hypercholesterolemic Mice

(2013) Robert M. Weiss et al.   PLoS One

Fetuin-A-Containing Calciprotein Particles Reduce Mineral Stress in the Macrophage

(2013) Edward R. Smith et al.   PLoS One

TRAIL-Deficiency Accelerates Vascular Calcification in Atherosclerosis via Modulation of RANKL

(2013) Belinda A. Di Bartolo et al.   PLoS One

Proinflammation: the key to arterial aging

(2013) Mingyi Wang et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

PERK‐eIF2α‐ATF4‐CHOP Signaling Contributes to TNFα‐Induced Vascular Calcification

(2013) Masashi Masuda et al.   Journal of the American Heart Association

Enhanced Mineralization Potential of Vascular Cells from SM22α-Rankl tg Mice

(2012) S. Morony et al.   CALCIFIED TISSUE INTERNATIONAL

Phosphate: a stealthier killer than previously thought?

(2012) Emilio Gonzalez-Parra et al.   CARDIOVASCULAR PATHOLOGY

Vascular Klotho Deficiency Potentiates the Development of Human Artery Calcification and Mediates Resistance to Fibroblast Growth Factor 23

(2012) Kenneth Lim et al.   CIRCULATION

Clearance of Fetuin-A–Containing Calciprotein Particles Is Mediated by Scavenger Receptor-A

(2012) Marietta Herrmann et al.   CIRCULATION RESEARCH

TNFR1-Activated Reactive Oxidative Species Signals Up-Regulate OsteogenicMsx2Programs in Aortic Myofibroblasts

(2012) Chung-Fang Lai et al.   ENDOCRINOLOGY

Calpain-1 Regulation of Matrix Metalloproteinase 2 Activity in Vascular Smooth Muscle Cells Facilitates Age-Associated Aortic Wall Calcification and Fibrosis

(2012) Liqun Jiang et al.   HYPERTENSION

Effects of Phosphate Binders in Moderate CKD

(2012) G. A. Block et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

RANKL Enhances Macrophage Paracrine Pro-Calcific Activity in High Phosphate-Treated Smooth Muscle Cells: Dependence on IL-6 and TNF-α

(2012) Kate Ann Deuell et al.   JOURNAL OF VASCULAR RESEARCH

Vitamin D receptor agonists increase klotho and osteopontin while decreasing aortic calcification in mice with chronic kidney disease fed a high phosphate diet

(2012) Wei Ling Lau et al.   KIDNEY INTERNATIONAL

Activation of nuclear factor-kappa B accelerates vascular calcification by inhibiting ankylosis protein homolog expression

(2012) Gexin Zhao et al.   KIDNEY INTERNATIONAL

No influence of OPG and its ligands, RANKL and TRAIL, on proliferation and regulation of the calcification process in primary human vascular smooth muscle cells

(2012) Malene Olesen et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Induction of Osteogenesis in Mesenchymal Stem Cells by Activated Monocytes/Macrophages Depends on Oncostatin M Signaling

(2012) Pierre Guihard et al.   STEM CELLS

CTRP family: linking immunity to metabolism

(2012) Andreas Schäffler et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Habitually exercising older men do not demonstrate age-associated vascular endothelial oxidative stress

(2011) Gary L. Pierce et al.   AGING CELL

Aerobic exercise reverses arterial inflammation with aging in mice

(2011) Lisa A. Lesniewski et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Vascular Calcification and Aortic Fibrosis

(2011) Jian-Su Shao et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

TRAIL attenuates the development of atherosclerosis in apolipoprotein E deficient mice

(2011) Victoria Watt et al.   ATHEROSCLEROSIS

Oncostatin M is expressed in atherosclerotic lesions: A role for Oncostatin M in the pathogenesis of atherosclerosis

(2011) Adaia Albasanz-Puig et al.   ATHEROSCLEROSIS

Calcium and osteoprotegerin regulate IGF1R expression to inhibit vascular calcification

(2011) B. A. Di Bartolo et al.   CARDIOVASCULAR RESEARCH

Arterial Calcification in Chronic Kidney Disease: Key Roles for Calcium and Phosphate

(2011) Catherine M. Shanahan et al.   CIRCULATION RESEARCH

Viral and bacterial patterns induce TLR-mediated sustained inflammation and calcification in aortic valve interstitial cells

(2011) Javier López et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Basic Calcium Phosphate Crystals Induce Monocyte/Macrophage IL-1  Secretion through the NLRP3 Inflammasome In Vitro

(2011) B. Pazar et al.   JOURNAL OF IMMUNOLOGY

The Inflammatory Cytokines TWEAK and TNF  Reduce Renal Klotho Expression through NF B

(2011) J. A. Moreno et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Cell-specific effects of TNF-α and IL-1β on alkaline phosphatase: implication for syndesmophyte formation and vascular calcification

(2011) Philippe Lencel et al.   LABORATORY INVESTIGATION

Klotho suppresses RIG-I-mediated senescence-associated inflammation

(2011) Feng Liu et al.   NATURE CELL BIOLOGY

Phosphorylated fetuin-A-containing calciprotein particles are associated with aortic stiffness and a procalcific milieu in patients with pre-dialysis CKD

(2011) Edward R. Smith et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand and Vascular Calcification

(2011) Maud Chasseraud et al.   THERAPEUTIC APHERESIS AND DIALYSIS

Prevalence of CKD and Comorbid Illness in Elderly Patients in the United States: Results From the Kidney Early Evaluation Program (KEEP)

(2010) Lesley A. Stevens et al.   AMERICAN JOURNAL OF KIDNEY DISEASES

HMGB1 and RAGE in Inflammation and Cancer

(2010) Gary P. Sims et al.   Annual Review of Immunology

Deficiency of Interleukin-1 Receptor Antagonist Induces Aortic Valve Disease in BALB/c Mice

(2010) Kikuo Isoda et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Estrogen Inhibits Vascular Calcification via Vascular RANKL System

(2010) Mariana Kiomy Osako et al.   CIRCULATION RESEARCH

TRAIL Promotes VSMC Proliferation and Neointima Formation in a FGF-2–, Sp1 Phosphorylation–, and NFκB-Dependent Manner

(2010) Jeffrey Chan et al.   CIRCULATION RESEARCH

Large Artery Calcification on Dialysis Patients Is Located in the Intima and Related to Atherosclerosis

(2010) B. Coll et al.   Clinical Journal of the American Society of Nephrology

Dietary and genetic evidence for phosphate toxicity accelerating mammalian aging

(2010) Mutsuko Ohnishi et al.   FASEB JOURNAL

Tumor Necrosis Factor-  Accelerates the Calcification of Human Aortic Valve Interstitial Cells Obtained from Patients with Calcific Aortic Valve Stenosis via the BMP2-Dlx5 Pathway

(2010) Z. Yu et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Arterial stiffening with ageing is associated with transforming growth factor-β1-related changes in adventitial collagen: reversal by aerobic exercise

(2010) Bradley S. Fleenor et al.   JOURNAL OF PHYSIOLOGY-LONDON

Klotho Deficiency Causes Vascular Calcification in Chronic Kidney Disease

(2010) M. C. Hu et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

The circulating soluble TRAIL is a negative marker for inflammation inversely associated with the mortality risk in chronic kidney disease patients

(2010) S. Liabeuf et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Inhibition of Receptor Activator of NF-κB Ligand by Denosumab Attenuates Vascular Calcium Deposition in Mice

(2009) Susann Helas et al.   AMERICAN JOURNAL OF PATHOLOGY

Nuclear Factor of Activated T Cells Regulates Osteopontin Expression in Arterial Smooth Muscle in Response to Diabetes-Induced Hyperglycemia

(2009) Lisa M. Nilsson-Berglund et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Tumor necrosis factor-α increases alkaline phosphatase expression in vascular smooth muscle cells via MSX2 induction

(2009) Hye-Lim Lee et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Plasma osteoprotegerin is an independent risk factor for mortality and an early biomarker of coronary vascular calcification in chronic kidney disease

(2009) Maria Mesquita et al.   CLINICAL CHEMISTRY AND LABORATORY MEDICINE

Effects of the new adiponectin paralogous protein CTRP-3 and of LPS on cytokine release from monocytes of patients with type 2 diabetes mellitus

(2009) Andrea Kopp et al.   CYTOKINE

RAGE: therapeutic target and biomarker of the inflammatory response-the evidence mounts

(2009) Ravichandran Ramasamy et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Cholecalciferol Supplementation Alters Calcitriol-Responsive Monocyte Proteins and Decreases Inflammatory Cytokines in ESRD

(2009) J. R. Stubbs et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Advanced Glycation End Products Induce Calcification of Vascular Smooth Muscle Cells through RAGE/p38 MAPK

(2009) Takahisa Tanikawa et al.   JOURNAL OF VASCULAR RESEARCH

Osteoprotegerin Inhibits Vascular Calcification Without Affecting Atherosclerosis in ldlr (−/−) Mice

(2008) Sean Morony et al.   CIRCULATION

Adiponectin Antagonizes Stimulatory Effect of Tumor Necrosis Factor-α on Vascular Smooth Muscle Cell Calcification: Regulation of Growth Arrest-Specific Gene 6-Mediated Survival Pathway by Adenosine 5′-Monophosphate-Activated Protein Kinase

(2008) Bo-Kyung Son et al.   ENDOCRINOLOGY

Angiotensin II-Induced Osteopontin Expression in Vascular Smooth Muscle Cells Involves Gq/11, Ras, ERK, Src and Ets-1

(2008) Keiko ABE et al.   HYPERTENSION RESEARCH

TRAIL Stimulates Proliferation of Vascular Smooth Muscle Cells via Activation of NF-κB and Induction of Insulin-like Growth Factor-1 Receptor

(2008) Mary M. Kavurma et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Peripheral vascular calcification in long-haemodialysis patients: associated factors and survival consequences

(2008) G. Jean et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Association Between Plasma LDL Particle Size, Valvular Accumulation of Oxidized LDL, and Inflammation in Patients With Aortic Stenosis

(2007) Dania Mohty et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY