BMPR2 inhibits activin and BMP signaling via wild-type ALK2

Variable signaling activity by FOP ACVR1 mutations

(2018) Julia Haupt et al.   BONE

Activin A amplifies dysregulated BMP signaling and induces chondro-osseous differentiation of primary connective tissue progenitor cells in patients with fibrodysplasia ossificans progressiva (FOP)

(2018) Haitao Wang et al.   BONE

Utilizing BMP-2 muteins for treatment of multiple myeloma

(2017) Axel Seher et al.   PLoS One

TGF-β contamination of purified recombinant GDF15

(2017) Oddrun Elise Olsen et al.   PLoS One

Structural insights into BMP receptors: Specificity, activation and inhibition

(2016) David Yadin et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Activin B Induces Noncanonical SMAD1/5/8 Signaling via BMP Type I Receptors in Hepatocytes: Evidence for a Role in Hepcidin Induction by Inflammation in Male Mice

(2016) Susanna Canali et al.   ENDOCRINOLOGY

VOLIN and KJON-Two novel hyperdiploid myeloma cell lines

(2016) Thea Kristin Våtsveen et al.   GENES CHROMOSOMES & CANCER

Transforming Growth Factor-β Family Ligands Can Function as Antagonists by Competing for Type II Receptor Binding

(2016) Senem Aykul et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Differential regulation of translation and endocytosis of alternatively spliced forms of the type II bone morphogenetic protein (BMP) receptor

(2016) Ayelet R. Amsalem et al.   MOLECULAR BIOLOGY OF THE CELL

The ACVR1 R206H mutation found in fibrodysplasia ossificans progressiva increases human induced pluripotent stem cell-derived endothelial cell formation and collagen production through BMP-mediated SMAD1/5/8 signaling

(2016) Emilie Barruet et al.   Stem Cell Research & Therapy

A Survey of Strategies to Modulate the Bone Morphogenetic Protein Signaling Pathway: Current and Future Perspectives

(2016) Jonathan W. Lowery et al.   Stem Cells International

Activin A inhibits BMP-signaling by binding ACVR2A and ACVR2B

(2015) Oddrun Elise Olsen et al.   Cell Communication and Signaling

Loss of BMPR2 leads to high bone mass due to increased osteoblast activity

(2015) J. W. Lowery et al.   JOURNAL OF CELL SCIENCE

Commercially Available Preparations of Recombinant Wnt3a Contain Non-Wnt Related Activities Which May Activate TGF-β Signaling

(2015) Jon M. Carthy et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Neofunction of ACVR1 in fibrodysplasia ossificans progressiva

(2015) Kyosuke Hino et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ACVR1 R206H receptor mutation causes fibrodysplasia ossificans progressiva by imparting responsiveness to activin A

(2015) Sarah J. Hatsell et al.   Science Translational Medicine

MYC amplifications in myeloma cell lines: correlation with MYC-inhibitor efficacy

(2015) Toril Holien et al.   Oncotarget

The role of bone morphogenetic proteins in myeloma cell survival

(2014) Toril Holien et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Bone morphogenetic protein-9 suppresses growth of myeloma cells by signaling through ALK2 but is inhibited by endoglin

(2014) O E Olsen et al.   Blood Cancer Journal

Constitutively Active ALK2 Receptor Mutants Require Type II Receptor Cooperation

(2013) J. Bagarova et al.   MOLECULAR AND CELLULAR BIOLOGY

A New Class of Small Molecule Inhibitor of BMP Signaling

(2013) Caroline E. Sanvitale et al.   PLoS One

Deletion of the Sequence Encoding the Tail Domain of the Bone Morphogenetic Protein type 2 Receptor Reveals a Bone Morphogenetic Protein 7-Specific Gain of Function

(2013) Patricio A. Leyton et al.   PLoS One

Induction of activin B by inflammatory stimuli up-regulates expression of the iron-regulatory peptide hepcidin through Smad1/5/8 signaling

(2012) C. Besson-Fournier et al.   BLOOD

Addiction to c-MYC in multiple myeloma

(2012) T. Holien et al.   BLOOD

A Novel Therapeutic Approach to Treating Obesity through Modulation of TGFβ Signaling

(2012) Alan Koncarevic et al.   ENDOCRINOLOGY

Bone morphogenetic proteins induce apoptosis in multiple myeloma cells by Smad-dependent repression of MYC

(2011) T Holien et al.   LEUKEMIA

In VivoStructure−Activity Relationship Study of Dorsomorphin Analogues Identifies Selective VEGF and BMP Inhibitors

(2009) Jijun Hao et al.   ACS Chemical Biology

CDK2 Phosphorylation of Smad2 Disrupts TGF-  Transcriptional Regulation in Resistant Primary Bone Marrow Myeloma Cells

(2009) L. B. Baughn et al.   JOURNAL OF IMMUNOLOGY

BMP-2/4 and BMP-6/7 Differentially Utilize Cell Surface Receptors to Induce Osteoblastic Differentiation of Human Bone Marrow-derived Mesenchymal Stem Cells

(2008) Karen Lavery et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Overexpression and involvement in migration by the metastasis-associated phosphatase PRL-3 in human myeloma cells

(2007) U.-M. Fagerli et al.   BLOOD