Constitutively Active ALK2 Receptor Mutants Require Type II Receptor Cooperation

Structure of the Bone Morphogenetic Protein Receptor ALK2 and Implications for Fibrodysplasia Ossificans Progressiva

(2012) Apirat Chaikuad et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hyperactive BMP signaling induced by ALK2R206Hrequires type II receptor function in aDrosophilamodel for classic fibrodysplasia ossificans progressiva

(2011) Viet Q. Le et al.   DEVELOPMENTAL DYNAMICS

Fibrodysplasia ossificans progressiva

(2008) Frederick S. Kaplan et al.   BEST PRACTICE & RESEARCH IN CLINICAL RHEUMATOLOGY

Stoichiometric imbalance in the receptor complex contributes to dysfunctional BMPR-II mediated signalling in pulmonary arterial hypertension

(2008) M. Talat Nasim et al.   HUMAN MOLECULAR GENETICS

Classic and atypical fibrodysplasia ossificans progressiva (FOP) phenotypes are caused by mutations in the bone morphogenetic protein (BMP) type I receptor ACVR1

(2008) Frederick S. Kaplan et al.   HUMAN MUTATION

Constitutively Activated ALK2 and Increased SMAD1/5 Cooperatively Induce Bone Morphogenetic Protein Signaling in Fibrodysplasia Ossificans Progressiva

(2008) Toru Fukuda et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

BMP type I receptor inhibition reduces heterotopic ossification

(2008) Paul B Yu et al.   NATURE MEDICINE

Constitutive activation of G protein-coupled receptors and diseases: Insights into mechanisms of activation and therapeutics

(2008) Y TAO   PHARMACOLOGY & THERAPEUTICS