TAR DNA-binding protein 43 (TDP-43) liquid–liquid phase separation is mediated by just a few aromatic residues
Published 2018 View Full Article
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Title
TAR DNA-binding protein 43 (TDP-43) liquid–liquid phase separation is mediated by just a few aromatic residues
Authors
Keywords
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Journal
JOURNAL OF BIOLOGICAL CHEMISTRY
Volume 293, Issue 16, Pages 6090-6098
Publisher
American Society for Biochemistry & Molecular Biology (ASBMB)
Online
2018-03-07
DOI
10.1074/jbc.ac117.001037
References
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- (2016) J. Paul Taylor et al. NATURE
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- Polyalanine expansions drive a shift into α-helical clusters without amyloid-fibril formation
- (2015) Saskia Polling et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Polyalanine expansions drive a shift into α-helical clusters without amyloid-fibril formation
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- (2014) Anthony A. Hyman et al. Annual Review of Cell and Developmental Biology
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