Journal
PHARMACOLOGY
Volume 96, Issue 3-4, Pages 131-136Publisher
KARGER
DOI: 10.1159/000436974
Keywords
Cognition; Alzheimer's disease; Sigma(1) receptors; Donepezil; Neurodegeneration; Neurite outgrowth
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Funding
- UCB
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Background/Aims: To this date, the only available drugs for treating Alzheimer's disease are cognitive enhancers, which may improve the cognitive function of patients for a few years while the disease continues to progress. As such, there are intense investigations to develop disease-modifying drugs to suppress progressive neurodegeneration. Methods: In this study, a range of procognitive compounds are tested in a primary neuronal culture to determine their relative potential for promoting neuritogenesis. Results: We report that donepezil, memantine, dimebon, Pre-084 and 4-IBP are neuritogenic while tacrine, rosemarinic acid, memoquin and a BACE1 inhibitor suppress neurite out-growth of neurons. Conclusions: The results of this study indicate that some procognitive compounds may possess a disease-modifying potential. (C) 2015 S. Karger AG, Basel
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