Cracking novel shared targets between epilepsy and Alzheimer’s disease: need of the hour

Age at first febrile seizure correlates with perinatal maternal emotional symptoms

(2017) Fanny Thébault-Dagher et al.   EPILEPSY RESEARCH

Regulation of brain PPARgamma2 contributes to ketogenic diet anti-seizure efficacy

(2017) Timothy A. Simeone et al.   EXPERIMENTAL NEUROLOGY

Management of Alzheimer’s disease—An insight of the enzymatic and other novel potential targets

(2017) Badar ul Islam et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Dysregulation of PINCH signaling in mesial temporal epilepsy

(2017) Charles Liu et al.   JOURNAL OF CLINICAL NEUROSCIENCE

Epileptic activity in Alzheimer's disease: causes and clinical relevance

(2017) Keith A Vossel et al.   LANCET NEUROLOGY

Alzheimer-Demenz und Epilepsie

(2017) R. Haussmann et al.   NERVENARZT

Synapsin I phosphorylation is dysregulated by beta-amyloid oligomers and restored by valproic acid

(2017) Jade Marsh et al.   NEUROBIOLOGY OF DISEASE

Blockade of the IL-1R1/TLR4 pathway mediates disease-modification therapeutic effects in a model of acquired epilepsy

(2017) Valentina Iori et al.   NEUROBIOLOGY OF DISEASE

Inflammatory aspects of epileptogenesis: contribution of molecular inflammatory mechanisms

(2016) Feyza Alyu et al.   ACTA NEUROPSYCHIATRICA

Microglial response to LPS increases in wild-type mice during aging but diminishes in an Alzheimer's mouse model: Implication of TLR4 signaling in disease progression

(2016) Michelle Go et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Sodium selenate retards epileptogenesis in acquired epilepsy models reversing changes in protein phosphatase 2A and hyperphosphorylated tau

(2016) Shi-jie Liu et al.   BRAIN

Leptin Dysfunction and Alzheimer’s Disease: Evidence from Cellular, Animal, and Human Studies

(2016) Matthew J. McGuire et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Environmental Enrichment Mitigates Detrimental Cognitive Effects of Ketogenic Diet in Weanling Rats

(2016) John M. Scichilone et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

CSF and plasma adipokines after tonic–clonic seizures

(2016) Johanna Palmio et al.   SEIZURE-EUROPEAN JOURNAL OF EPILEPSY

A role of antioxidants in the complex treatment of epilepsy

(2016) A. G. Korotkov et al.   Zhurnal Nevrologii I Psikhiatrii imeni S S Korsakova

Transient increase of interleukin-1β after prolonged febrile seizures promotes adult epileptogenesis through long-lasting upregulating endocannabinoid signaling

(2016) Bo Feng et al.   Scientific Reports

Beneficial Effect of Leptin on Spatial Learning and Memory in Streptozotocin-Induced Diabetic Rats

(2016) Mohsen Ghasemi et al.   Balkan Medical Journal

Inflammatory aspects of epileptogenesis: contribution of molecular inflammatory mechanisms

(2016) Feyza Alyu et al.   ACTA NEUROPSYCHIATRICA

The emerging role of adiponectin in cerebrovascular and neurodegenerative diseases

(2015) Yang Yang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Sodium selenate reduces hyperphosphorylated tau and improves outcomes after traumatic brain injury

(2015) Sandy R. Shultz et al.   BRAIN

Valproic Acid Modifies Synaptic Structure and Accelerates Neurite Outgrowth Via the Glycogen Synthase Kinase-3β Signaling Pathway in an Alzheimer's Disease Model

(2015) Zhi-Min Long et al.   CNS Neuroscience & Therapeutics

Rufinamide Improves Functional and Behavioral Deficits via Blockade of Tetrodotoxin-Resistant Sodium Channels in Diabetic Neuropathy

(2015) Shivsharan Kharatmal et al.   CURRENT NEUROVASCULAR RESEARCH

Anti-ictogenic and antiepileptogenic properties of brivaracetam in mature and immature rats

(2015) Nina Dupuis et al.   EPILEPSIA

Low brain ascorbic acid increases susceptibility to seizures in mouse models of decreased brain ascorbic acid transport and Alzheimer's disease

(2015) Timothy A. Warner et al.   EPILEPSY RESEARCH

Ethosuximide Induces Hippocampal Neurogenesis and Reverses Cognitive Deficits in an Amyloid-β Toxin-induced Alzheimer Rat Model via the Phosphatidylinositol 3-Kinase (PI3K)/Akt/Wnt/β-Catenin Pathway

(2015) Shashi Kant Tiwari et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Differential TGF-β Signaling in Glial Subsets Underlies IL-6–Mediated Epileptogenesis in Mice

(2015) Nitzan Levy et al.   JOURNAL OF IMMUNOLOGY

AMPK-mediated regulation of neuronal metabolism and function in brain diseases

(2015) Yu-Ju Liu et al.   JOURNAL OF NEUROGENETICS

Peroxisome proliferator-activated receptor-γ agonist inhibits the mammalian target of rapamycin signaling pathway and has a protective effect in a rat model of status epilepticus

(2015) YONG-ZHI SAN et al.   Molecular Medicine Reports

Loss of Munc18-1 long splice variant in GABAergic terminals is associated with cognitive decline and increased risk of dementia in a community sample

(2015) Alfredo Ramos-Miguel et al.   Molecular Neurodegeneration

Role of fractalkine–CX3CR1 pathway in seizure-induced microglial activation, neurodegeneration, and neuroblast production in the adult rat brain

(2015) Idrish Ali et al.   NEUROBIOLOGY OF DISEASE

mTOR signaling in aging and neurodegeneration: At the crossroad between metabolism dysfunction and impairment of autophagy

(2015) Marzia Perluigi et al.   NEUROBIOLOGY OF DISEASE

Comorbidities in Neurology: Is adenosine the common link?

(2015) Detlev Boison et al.   NEUROPHARMACOLOGY

Clinical trials of N-acetylcysteine in psychiatry and neurology: A systematic review

(2015) Deepmala et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Lacosamide reduces HDAC levels in the brain and improves memory: Potential for treatment of Alzheimer's disease

(2015) Shraddha R. Bang et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Targeting LDH enzymes with a stiripentol analog to treat epilepsy

(2015) N. Sada et al.   SCIENCE

Brivaracetam, but not ethosuximide, reverses memory impairments in an Alzheimer’s disease mouse model

(2015) Haakon B Nygaard et al.   Alzheimers Research & Therapy

Differential DNA methylation profiles of coding and non-coding genes define hippocampal sclerosis in human temporal lobe epilepsy

(2015) Suzanne F.C. Miller-Delaney et al.   BRAIN

Low Dose Zinc Supplementation Beneficially Affects Seizure Development in Experimental Seizure Models in Rats

(2014) Hemant Kumar et al.   BIOLOGICAL TRACE ELEMENT RESEARCH

Targeting pharmacoresistant epilepsy and epileptogenesis with a dual-purpose antiepileptic drug

(2014) Anna Doeser et al.   BRAIN

Valproate Improves Memory Deficits in an Alzheimer’s disease Mouse Model: Investigation of Possible Mechanisms of Action

(2014) Zhi-Gang Yao et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Obesity as a risk factor for Alzheimer’s disease: the role of adipocytokines

(2014) Liliana Letra et al.   METABOLIC BRAIN DISEASE

Valproic Acid Alleviates Memory Deficits and Attenuates Amyloid-β Deposition in Transgenic Mouse Model of Alzheimer’s Disease

(2014) Ai-Guo Xuan et al.   MOLECULAR NEUROBIOLOGY

Lamotrigine attenuates deficits in synaptic plasticity and accumulation of amyloid plaques in APP/PS1 transgenic mice

(2014) Mao-Ying Zhang et al.   NEUROBIOLOGY OF AGING

Regional upregulation of hippocampal melatonin MT2 receptors by valproic acid: Therapeutic implications for Alzheimer's disease

(2014) Sarra G. Bahna et al.   NEUROSCIENCE LETTERS

Agmatine Improves Cognitive Dysfunction and Prevents Cell Death in a Streptozotocin-Induced Alzheimer Rat Model

(2014) Juhyun Song et al.   YONSEI MEDICAL JOURNAL

Antiepileptics Topiramate and Levetiracetam Alleviate Behavioral Deficits and Reduce Neuropathology in APPswe/PS1dE9 Transgenic Mice

(2013) Jian-Quan Shi et al.   CNS Neuroscience & Therapeutics

Valproic Acid Attenuates Neuronal Loss in the Brain of APP/PS1 Double Transgenic Alzheimer’s Disease Mice Model

(2013) Zhimin Long et al.   Current Alzheimer Research

Autophagy Enhancer Carbamazepine Alleviates Memory Deficits and Cerebral Amyloid-β Pathology in a Mouse Model of Alzheimer's Disease

(2013) Lixi Li et al.   Current Alzheimer Research

Fractalkine/CX3CL1 modulates GABAAcurrents in human temporal lobe epilepsy

(2013) Cristina Roseti et al.   EPILEPSIA

Antisense Reduction of Tau in Adult Mice Protects against Seizures

(2013) S. L. DeVos et al.   JOURNAL OF NEUROSCIENCE

Effects of antiparkinsonian agents on β-amyloid and α-synuclein oligomer formation in vitro

(2013) Kenjiro Ono et al.   JOURNAL OF NEUROSCIENCE RESEARCH

GSK-3β may be involved in hippocampal mossy fiber sprouting in the pentylenetetrazole-kindling model

(2013) WEN-JIAO HUANG et al.   Molecular Medicine Reports

Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease

(2013) Jean-Charles Lambert et al.   NATURE GENETICS

Global changes in DNA methylation and hydroxymethylation in Alzheimer's disease human brain

(2013) Natacha Coppieters et al.   NEUROBIOLOGY OF AGING

Effects of levetiracetam, an antiepileptic drug, on memory impairments associated with aging and Alzheimer’s disease in mice

(2013) Latha Devi et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Alzheimer’s disease: amino acid levels and brain metabolic status

(2013) Maria Concetta Gueli et al.   NEUROLOGICAL SCIENCES

PINCH in the Cellular Stress Response to Tau-Hyperphosphorylation

(2013) Ahmet Yunus Ozdemir et al.   PLoS One

Whole-blood global DNA methylation is increased in amyotrophic lateral sclerosis independently of age of onset

(2013) Lucio Tremolizzo et al.   Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration

Altered Expression of CX3CL1 in Patients with Epilepsy and in a Rat Model

(2012) Yali Xu et al.   AMERICAN JOURNAL OF PATHOLOGY

Rufinamide Attenuates Mechanical Allodynia in a Model of Neuropathic Pain in the Mouse and Stabilizes Voltage-gated Sodium Channel Inactivated State

(2012) Marc R. Suter et al.   ANESTHESIOLOGY

Preclinical Alzheimer disease: identification of cases at risk among cognitively intact older individuals

(2012) Maciej J Lazarczyk et al.   BMC Medicine

Inhibitory Interneuron Deficit Links Altered Network Activity and Cognitive Dysfunction in Alzheimer Model

(2012) Laure Verret et al.   CELL

Alpha-Secretase Cleavage of the Amyloid Precursor Protein: Proteolysis Regulated by Signaling Pathways and Protein Trafficking

(2012) Stefan F. Lichtenthaler   Current Alzheimer Research

The Role of Reactive Species in Epileptogenesis and Influence of Antiepileptic Drug Therapy on Oxidative Stress

(2012) Bostjan Martinc et al.   Current Neuropharmacology

SCN1A mutations in Dravet syndrome: Impact of interneuron dysfunction on neural networks and cognitive outcome

(2012) Alex C. Bender et al.   EPILEPSY & BEHAVIOR

IgG Leakage May Contribute to Neuronal Dysfunction in Drug-Refractory Epilepsies With Blood-Brain Barrier Disruption

(2012) Zuzanna Michalak et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Cognitive dysfunction in psychiatric disorders: characteristics, causes and the quest for improved therapy

(2012) Mark J. Millan et al.   NATURE REVIEWS DRUG DISCOVERY

Repeat expansions in the C9ORF72 gene contribute to Alzheimer's disease in Caucasians

(2012) Martin A. Kohli et al.   NEUROBIOLOGY OF AGING

Reduction of Hippocampal Hyperactivity Improves Cognition in Amnestic Mild Cognitive Impairment

(2012) Arnold Bakker et al.   NEURON

Brain-derived neurotrophic factor–estrogen interactions in the hippocampal mossy fiber pathway: Implications for normal brain function and disease

(2012) L.C. Harte-Hargrove et al.   NEUROSCIENCE

TREM2 Variants in Alzheimer's Disease

(2012) Rita Guerreiro et al.   NEW ENGLAND JOURNAL OF MEDICINE

Zinc diet and Alzheimer's disease: a systematic review

(2012) Martin Loef et al.   NUTRITIONAL NEUROSCIENCE

Pharmacodynamic potentiation of antiepileptic drugs’ effects by some HMG-CoA reductase inhibitors against audiogenic seizures in DBA/2 mice

(2012) Emilio Russo et al.   PHARMACOLOGICAL RESEARCH

Lovastatin Modulates Glycogen Synthase Kinase-3β Pathway and Inhibits Mossy Fiber Sprouting after Pilocarpine-Induced Status Epilepticus

(2012) Chun-Yao Lee et al.   PLoS One

The role of default network deactivation in cognition and disease

(2012) Alan Anticevic et al.   TRENDS IN COGNITIVE SCIENCES

Neuropsychiatric symptoms in Alzheimer’s disease

(2011) Constantine G. Lyketsos et al.   Alzheimers & Dementia

Too Many Cooks? Intrinsic and Synaptic Homeostatic Mechanisms in Cortical Circuit Refinement

(2011) Gina Turrigiano   Annual Review of Neuroscience

Neurofibrillary tangle pathology and Braak staging in chronic epilepsy in relation to traumatic brain injury and hippocampal sclerosis: a post-mortem study

(2011) Maria Thom et al.   BRAIN

Adiponectin receptor signalling in the brain

(2011) John Thundyil et al.   BRITISH JOURNAL OF PHARMACOLOGY

Seizures and Epilepsy in Alzheimer's Disease

(2011) Daniel Friedman et al.   CNS Neuroscience & Therapeutics

A perfect storm: Converging paths of epilepsy and Alzheimer’s dementia intersect in the hippocampal formation

(2011) Jeffrey Noebels   EPILEPSIA

Anxiety symptoms in epilepsy: Salient issues for future research

(2011) Hamada Hamid et al.   EPILEPSY & BEHAVIOR

Presenilin-1 mutation Alzheimer's disease: A genetic epilepsy syndrome?

(2011) A.J. Larner   EPILEPSY & BEHAVIOR

Spontaneous epileptiform discharges in a mouse model of Alzheimer's disease are suppressed by antiepileptic drugs that block sodium channels

(2011) Sofya Ziyatdinova et al.   EPILEPSY RESEARCH

Effect of Sodium Valproate Administration on Brain Neprilysin Expression and Memory in Rats

(2011) Natalia N. Nalivaeva et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Amyloid- /Fyn-Induced Synaptic, Network, and Cognitive Impairments Depend on Tau Levels in Multiple Mouse Models of Alzheimer's Disease

(2011) E. D. Roberson et al.   JOURNAL OF NEUROSCIENCE

Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease

(2011) Paul Hollingworth et al.   NATURE GENETICS

Targeting hyperphosphorylated tau with sodium selenate suppresses seizures in rodent models

(2011) Nigel C. Jones et al.   NEUROBIOLOGY OF DISEASE

Attention-modulating effects of cognitive enhancers

(2011) Edward D. Levin et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

APP processing in Alzheimer's disease

(2011) Yun-wu Zhang et al.   Molecular Brain

Neuroprotective properties of resveratrol in different neurodegenerative disorders

(2010) Diego Albani et al.   BIOFACTORS

Alzheimer’s disease phenotypes and genotypes associated with mutations in presenilin 2

(2010) Suman Jayadev et al.   BRAIN

Exogenous neuropeptide Y promotes in vivo hippocampal neurogenesis

(2010) Mickael Decressac et al.   HIPPOCAMPUS

Calcium Signaling and Amyloid Toxicity in Alzheimer Disease

(2010) Angelo Demuro et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Memantine Preferentially Blocks Extrasynaptic over Synaptic NMDA Receptor Currents in Hippocampal Autapses

(2010) P. Xia et al.   JOURNAL OF NEUROSCIENCE

BACE1 Deficiency Causes Altered Neuronal Activity and Neurodegeneration

(2010) X. Hu et al.   JOURNAL OF NEUROSCIENCE

The role of inflammation in epilepsy

(2010) Annamaria Vezzani et al.   Nature Reviews Neurology

The functional neurophysiology of the amyloid precursor protein (APP) processing pathway

(2010) A.D. Randall et al.   NEUROPHARMACOLOGY

Inhibition of mTOR by Rapamycin Abolishes Cognitive Deficits and Reduces Amyloid-β Levels in a Mouse Model of Alzheimer's Disease

(2010) Patricia Spilman et al.   PLoS One

Uncovering Molecular Biomarkers That Correlate Cognitive Decline with the Changes of Hippocampus' Gene Expression Profiles in Alzheimer's Disease

(2010) Martín Gómez Ravetti et al.   PLoS One

Neurovascular mechanisms and blood–brain barrier disorder in Alzheimer’s disease

(2009) Robert D. Bell et al.   ACTA NEUROPATHOLOGICA

Mechanisms of tau-induced neurodegeneration

(2009) Khalid Iqbal et al.   ACTA NEUROPATHOLOGICA

Epilepsy in the elderly

(2009) Ilo E. Leppik et al.   Annals of the New York Academy of Sciences

Increased Concentrations of Nerve Growth Factor and Brain-Derived Neurotrophic Factor in the Rat Cerebellum After Exposure to Environmental Enrichment

(2009) Francesco Angelucci et al.   CEREBELLUM

Use of Gabapentin in the Treatment of Behavioural and Psychological Symptoms of Dementia

(2009) Yunie Kim et al.   DRUGS & AGING

Psychiatric issues in epilepsy: The complex relation of mood, anxiety disorders, and epilepsy

(2009) Andres M. Kanner   EPILEPSY & BEHAVIOR

Epilepsy, psychosocial and cognitive functioning

(2009) Jane McCagh et al.   EPILEPSY RESEARCH

Bacopa monnieri and Bacoside-A for ameliorating epilepsy associated behavioral deficits

(2009) Jobin Mathew et al.   FITOTERAPIA

Regulation of mitochondrial dynamics in acute kidney injury in cell culture and rodent models

(2009) Craig Brooks et al.   JOURNAL OF CLINICAL INVESTIGATION

Amyloid  -Induced Neuronal Hyperexcitability Triggers Progressive Epilepsy

(2009) R. Minkeviciene et al.   JOURNAL OF NEUROSCIENCE

Neuroprotective effects of brain-derived neurotrophic factor in rodent and primate models of Alzheimer's disease

(2009) Alan H Nagahara et al.   NATURE MEDICINE

Epileptic Seizures in AD Patients

(2009) A. J. Larner   NEUROMOLECULAR MEDICINE

Small molecule blockers of the Alzheimer A  calcium channel potently protect neurons from A  cytotoxicity

(2009) J. C. Diaz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rapamycin prevents epilepsy in a mouse model of tuberous sclerosis complex

(2008) Ling-Hui Zeng et al.   ANNALS OF NEUROLOGY

The ketogenic diet: Uses in epilepsy and other neurologic illnesses

(2008) Kristin W. Barañano et al.   Current Treatment Options in Neurology

Recurrent seizures in patients with dementia: Frequency, seizure types, and treatment outcome

(2008) Satish C. Rao et al.   EPILEPSY & BEHAVIOR

Long-term decrease in calbindin-D28K expression in the hippocampus of epileptic rats following pilocarpine-induced status epilepticus

(2008) Dawn S. Carter et al.   EPILEPSY RESEARCH

Acetylcholine-induced seizure-like activity and modified cholinergic gene expression in chronically epileptic rats

(2008) Gabriel Zimmerman et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

EstrogenGrowth Factor Interactions and Their Contributions to Neurological Disorders

(2008) Helen E. Scharfman et al.   HEADACHE

Folate Deficiency Induces In Vitro and Mouse Brain Region-Specific Downregulation of Leucine Carboxyl Methyltransferase-1 and Protein Phosphatase 2A B  Subunit Expression That Correlate with Enhanced Tau Phosphorylation

(2008) J.-M. Sontag et al.   JOURNAL OF NEUROSCIENCE

Structure of a Protein Phosphatase 2A Holoenzyme: Insights into B55-Mediated Tau Dephosphorylation

(2008) Yanhui Xu et al.   MOLECULAR CELL

Reversal of learning deficits in a Tsc2 +/− mouse model of tuberous sclerosis

(2008) Dan Ehninger et al.   NATURE MEDICINE

Tiagabine is neuroprotective in the N171-82Q and R6/2 mouse models of Huntington's disease

(2008) Naoki Masuda et al.   NEUROBIOLOGY OF DISEASE

Loss of microRNA cluster miR-29a/b-1 in sporadic Alzheimer's disease correlates with increased BACE1/ -secretase expression

(2008) S. S. Hebert et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Leptin inhibits 4-aminopyridine– and pentylenetetrazole-induced seizures and AMPAR-mediated synaptic transmission in rodents

(2007) Lin Xu et al.   JOURNAL OF CLINICAL INVESTIGATION

BACE1 gene deletion: Impact on behavioral function in a model of Alzheimer's disease

(2007) Dione Kobayashi et al.   NEUROBIOLOGY OF AGING