Signaling Crosstalk of TGF-β/ALK5 and PAR2/PAR1: A Complex Regulatory Network Controlling Fibrosis and Cancer

Thrombin promotes PAI-1 expression and migration in keratinocytes via ERK dependent Smad linker region phosphorylation

(2018) Nirali Talati et al.   CELLULAR SIGNALLING

G protein coupled receptors can transduce signals through carboxy terminal and linker region phosphorylation of Smad transcription factors

(2018) Parisa Dayati et al.   LIFE SCIENCES

Targeting sphingosine-1-phosphate lyase as an anabolic therapy for bone loss

(2018) Sarah Weske et al.   NATURE MEDICINE

Release of Platelet-Derived Sphingosine-1-Phosphate Involves Multidrug Resistance Protein 4 (MRP4/ABCC4) and Is Inhibited by Statins

(2018) Katja Vogt et al.   THROMBOSIS AND HAEMOSTASIS

Proteinase-activated receptor 2 promotes tumor cell proliferation and metastasis by inducing epithelial-mesenchymal transition and predicts poor prognosis in hepatocellular carcinoma

(2018) Liang Sun et al.   WORLD JOURNAL OF GASTROENTEROLOGY

TGF-β induced PAR-1 expression promotes tumor progression and osteoclast differentiation in giant cell tumor of bone

(2017) Ting Wang et al.   INTERNATIONAL JOURNAL OF CANCER

The Role of PAR2 in TGF-β1-Induced ERK Activation and Cell Motility

(2017) Hendrik Ungefroren et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Targeting coagulation factor receptors - protease-activated receptors in idiopathic pulmonary fibrosis

(2017) C. Lin et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Transforming Growth Factor- β 1/Activin Receptor-like Kinase 5-Mediated Cell Migration is Dependent on the Protein Proteinase-Activated Receptor 2 but not on Proteinase-Activated Receptor 2-Stimulated G q -Calcium Signaling

(2017) Hendrik Ungefroren et al.   MOLECULAR PHARMACOLOGY

Targeting PAR1: Now What?

(2017) Robert Flaumenhaft et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Protease-activated receptor-1 (PAR-1): a promising molecular target for cancer

(2017) Xuan Liu et al.   Oncotarget

Membrane-anchored Serine Protease Matriptase Is a Trigger of Pulmonary Fibrogenesis

(2016) Olivier Bardou et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Protease-activated receptor 1 and 2 contribute to angiotensin II-induced activation of adventitial fibroblasts from rat aorta

(2016) Rui-Qing He et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Extracellular vesicles from malignant effusions induce tumor cell migration: inhibitory effect of LMWH tinzaparin

(2016) Hans Gamperl et al.   CELL BIOLOGY INTERNATIONAL

Targeting Liver Fibrosis with a Cell-penetrating Protease-activated Receptor-2 (PAR2) Pepducin

(2016) Andrew M. Shearer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Proteinase-activated receptor 2 (PAR2) in hepatic stellate cells – evidence for a role in hepatocellular carcinoma growth in vivo

(2016) Franziska Mußbach et al.   Molecular Cancer

TGF-β: the master regulator of fibrosis

(2016) Xiao-ming Meng et al.   Nature Reviews Nephrology

Platelet phenotype changes associated with breast cancer and its treatment

(2016) Chris E. Holmes et al.   PLATELETS

TGFβ upregulates PAR-1 expression and signalling responses in A549 lung adenocarcinoma cells

(2016) Natalia Smoktunowicz et al.   Oncotarget

Proteinase-activated receptor 2 promotes TGF-β-dependent cell motility in pancreatic cancer cells by sustaining expression of the TGF-β type I receptor ALK5

(2016) Franziska Zeeh et al.   Oncotarget

PAR1 Scaffolds TGFβRII to Downregulate TGF-β Signaling and Activate ESC Differentiation to Endothelial Cells

(2016) Haixia Gong et al.   Stem Cell Reports

Intracellular Sphingosine 1-Phosphate Contributes to Collagen Expression of Hepatic Myofibroblasts in Human Liver Fibrosis Independent of Its Receptors

(2015) Lei Xiu et al.   AMERICAN JOURNAL OF PATHOLOGY

Protease-activated receptors (PARs)—biology and role in cancer invasion and metastasis

(2015) Marek Z. Wojtukiewicz et al.   CANCER AND METASTASIS REVIEWS

Protease-activated receptor (PAR)-2 is required for PAR-1 signalling in pulmonary fibrosis

(2015) Cong Lin et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Sphingosine-1-Phosphate and Its Receptors: A Mutual Link between Blood Coagulation and Inflammation

(2015) Shailaja Mahajan-Thakur et al.   MEDIATORS OF INFLAMMATION

Unknown

(2015) Cong Lin et al.   MOLECULAR MEDICINE

Activation of platelet protease-activated receptor-1 induces epithelial-mesenchymal transition and chemotaxis of colon cancer cell line SW620

(2015) YITAO JIA et al.   ONCOLOGY REPORTS

Protease activated receptor-1 regulates macrophage-mediated cellular senescence: a risk for idiopathic pulmonary fibrosis

(2015) Cong Lin et al.   Oncotarget

Daidzein exhibits anti-fibrotic effect by reducing the expressions of Proteinase activated receptor 2 and TGFβ1/smad mediated inflammation and apoptosis in Bleomycin-induced experimental pulmonary fibrosis

(2014) Syamala Soumyakrishnan et al.   BIOCHIMIE

Interleukin-8 and Interleukin-17 for Cancer

(2014) Paul Zarogoulidis et al.   CANCER INVESTIGATION

Sphingosine 1-Phosphate as a Link between Blood Coagulation and Inflammation

(2014) Bernhard Hermann Rauch   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

TGF-beta Signaling in Cancer Treatment

(2014) Isabel Fabregat et al.   CURRENT PHARMACEUTICAL DESIGN

Factor Xa in Mouse Fibroblasts May Induce Fibrosis More Than Thrombin

(2014) Lisa Kitasato et al.   International Heart Journal

Sphingosine-1-phosphate induces thrombin receptor PAR-4 expression to enhance cell migration and COX-2 formation in human monocytes

(2014) Shailaja Mahajan-Thakur et al.   JOURNAL OF LEUKOCYTE BIOLOGY

An update on the biology of sphingosine 1-phosphate receptors

(2014) Victoria A. Blaho et al.   JOURNAL OF LIPID RESEARCH

Protease-activated receptor 2 suppresses lymphangiogenesis and subsequent lymph node metastasis in a murine pancreatic cancer model

(2014) Kun Shi et al.   JOURNAL OF PATHOLOGY

Unknown

(2014) JanWillem Duitman et al.   MOLECULAR MEDICINE

The regulation of TGF-β/SMAD signaling by protein deubiquitination

(2014) Juan Zhang et al.   Protein & Cell

Proteinase-Activated Receptor-1, CCL2 and CCL7 Regulate Acute Neutrophilic Lung Inflammation

(2013) Paul F Mercer et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Pathogenesis of Idiopathic Pulmonary Fibrosis

(2013) Paul J. Wolters et al.   Annual Review of Pathology-Mechanisms of Disease

Biased signalling and proteinase-activated receptors (PARs): targeting inflammatory disease

(2013) M D Hollenberg et al.   BRITISH JOURNAL OF PHARMACOLOGY

Factor-Xa-induced mitogenesis and migration require sphingosine kinase activity and S1P formation in human vascular smooth muscle cells

(2013) Andreas Böhm et al.   CARDIOVASCULAR RESEARCH

Proteinase-activated receptors (PARs) – focus on receptor-receptor-interactions and their physiological and pathophysiological impact

(2013) Frank Gieseler et al.   Cell Communication and Signaling

Protease-activated-receptor-2 affects protease-activated-receptor-1-driven breast cancer

(2013) Mohammad Jaber et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Unchaining the beast; insights from structural and evolutionary studies on TGFβ secretion, sequestration, and activation

(2013) Ian B. Robertson et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Targeting sphingosine kinase 1 attenuates bleomycin-induced pulmonary fibrosis

(2013) Long Shuang Huang et al.   FASEB JOURNAL

Thrombin promotes airway remodeling via protease-activated receptor-1 and transforming growth factor-β1 in ovalbumin-allergic rats

(2013) Weiwei Zhu et al.   INHALATION TOXICOLOGY

Aspirin inhibits release of platelet-derived sphingosine-1-phosphate in acute myocardial infarction

(2013) Amin Polzin et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Proteinase-activated Receptor-2 Transactivation of Epidermal Growth Factor Receptor and Transforming Growth Factor-β Receptor Signaling Pathways Contributes to Renal Fibrosis

(2013) Hyunjae Chung et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protease-Activated Receptor 1 Inhibition by SCH79797 Attenuates Left Ventricular Remodeling and Profibrotic Activities of Cardiac Fibroblasts

(2013) Dmitry L. Sonin et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY AND THERAPEUTICS

Proteinase-Activated Receptors Differentially Modulate In Vitro Invasion of Human Pancreatic Adenocarcinoma PANC-1 Cells in Correlation With Changes in the Expression of CDC42 Protein

(2013) Liora Segal et al.   PANCREAS

MicroRNA-34a Mediates the Autocrine Signaling of PAR2-Activating Proteinase and Its Role in Colonic Cancer Cell Proliferation

(2013) Yiming Ma et al.   PLoS One

Smad4-mediated TGF-β signaling in tumorigenesis

(2012) Guan Yang et al.   International Journal of Biological Sciences

Novel Role for Proteinase-activated Receptor 2 (PAR2) in Membrane Trafficking of Proteinase-activated Receptor 4 (PAR4)

(2012) Margaret R. Cunningham et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Targeting proteinase-activated receptors: therapeutic potential and challenges

(2012) Rithwik Ramachandran et al.   NATURE REVIEWS DRUG DISCOVERY

Biological Significance of Local TGF-β Activation in Liver Diseases

(2012) Hiromitsu Hayashi et al.   Frontiers in Physiology

Role of Protease-activated Receptor-2 in Idiopathic Pulmonary Fibrosis

(2011) Malgorzata Wygrecka et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

TGF-β in progression of liver disease

(2011) Steven Dooley et al.   CELL AND TISSUE RESEARCH

Protease profiling of liver fibrosis reveals the ADAM metallopeptidase with thrombospondin type 1 motif, 1 as a central activator of transforming growth factor beta

(2011) Katia Bourd-Boittin et al.   HEPATOLOGY

Protease-activated receptor 2 promotes experimental liver fibrosis in mice and activates human hepatic stellate cells

(2011) Virginia Knight et al.   HEPATOLOGY

TGF- 1 induces proteinase-activated receptor 2 (PAR2) expression in endometriotic stromal cells and stimulates PAR2 activation-induced secretion of IL-6

(2011) A. Saito et al.   HUMAN REPRODUCTION

PAR1 plays a role in epithelial malignancies: Transcriptional regulation and novel signaling pathway

(2011) Rachel Bar-Shavit et al.   IUBMB LIFE

Release of sphingosine-1-phosphate from human platelets is dependent on thromboxane formation

(2011) T. ULRYCH et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

The Paradigm of G Protein Receptor Transactivation: A Mechanistic Definition and Novel Example

(2011) Peter J. Little et al.   TheScientificWorldJOURNAL

Tumor-promoting functions of transforming growth factor-β in progression of cancer

(2011) Kohei Miyazono et al.   UPSALA JOURNAL OF MEDICAL SCIENCES

Cross Talk among TGF-  Signaling Pathways, Integrins, and the Extracellular Matrix

(2011) J. S. Munger et al.   Cold Spring Harbor Perspectives in Biology

Thrombin Stimulation of Proteoglycan Synthesis in Vascular Smooth Muscle Is Mediated by Protease-activated Receptor-1 Transactivation of the Transforming Growth Factor β Type I Receptor

(2010) Micah L. Burch et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Thrombin down-regulates the TGF-β-mediated synthesis of collagen and fibronectin by human proximal tubule epithelial cells through the EPCR-dependent activation of PAR-1

(2010) Jong-Sup Bae et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Novel Agonists and Antagonists for Human Protease Activated Receptor 2

(2010) Grant D. Barry et al.   JOURNAL OF MEDICINAL CHEMISTRY

The miR-17-92 MicroRNA Cluster Regulates Multiple Components of the TGF-β Pathway in Neuroblastoma

(2010) Pieter Mestdagh et al.   MOLECULAR CELL

Profiling Gene Expression Induced by Protease-Activated Receptor 2 (PAR2) Activation in Human Kidney Cells

(2010) Jacky Y. Suen et al.   PLoS One

Overexpression of Transforming Growth Factor β1 in Malignant Prostate Cells is Partly Caused by a Runaway of TGF-β1 Auto-induction Mediated Through a Defective Recruitment of Protein Phosphatase 2A by TGF-β Type I Receptor

(2010) Nengwang Yu et al.   UROLOGY

The pathogenesis of idiopathic pulmonary fibrosis

(2010) William R. Coward et al.   Therapeutic Advances in Respiratory Disease

Thrombin-stimulated growth factor and cytokine expression in osteoblasts is mediated by protease-activated receptor-1 and prostanoids

(2009) Charles N. Pagel et al.   BONE

Characteristic response of astrocytes to plasminogen/plasmin to upregulate transforming growth factor beta 3 (TGFβ3) production/secretion through proteinase-activated receptor-1 (PAR-1) and the downstream phosphatidylinositol 3-kinase (PI3K)-Akt/PKB signaling cascade

(2009) Shyuichi Maeda et al.   BRAIN RESEARCH

Dual effect of the novel peptide antagonist K-14585 on proteinase-activated receptor-2-mediated signalling

(2009) Fui Goon Goh et al.   BRITISH JOURNAL OF PHARMACOLOGY

Met receptor tyrosine kinase transactivation is involved in proteinase-activated receptor-2-mediated hepatocellular carcinoma cell invasion

(2009) R. Kaufmann et al.   CARCINOGENESIS

Sphingosine-1-phosphate and sphingosine kinase are critical for transforming growth factor- -stimulated collagen production by cardiac fibroblasts

(2009) N. Gellings Lowe et al.   CARDIOVASCULAR RESEARCH

Essential Role of TGF-β Signaling in Glucose-Induced Cell Hypertrophy

(2009) Liyu Wu et al.   DEVELOPMENTAL CELL

Sphingosine kinase 1 is essential for proteinase-activated receptor-1 signalling in epithelial and endothelial cells

(2009) Andreas Billich et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Role of Matriptase and Proteinase-Activated Receptor-2 in Nonmelanoma Skin Cancer

(2009) Georgeta Bocheva et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Transforming growth factor-β2 upregulates sphingosine kinase-1 activity, which in turn attenuates the fibrotic response to TGF-β2 by impeding CTGF expression

(2009) Shuyu Ren et al.   KIDNEY INTERNATIONAL

TACE-Mediated Ectodomain Shedding of the Type I TGF-β Receptor Downregulates TGF-β Signaling

(2009) Cheng Liu et al.   MOLECULAR CELL

The in-vitro effects of E5555, a protease-activated receptor (PAR)-1 antagonist, on platelet biomarkers in healthy volunteers and patients with coronary artery disease

(2009) Victor L. Serebruany et al.   THROMBOSIS AND HAEMOSTASIS

Factor Xa Stimulates Proinflammatory and Profibrotic Responses in Fibroblasts via Protease-Activated Receptor-2 Activation

(2008) Keren Borensztajn et al.   AMERICAN JOURNAL OF PATHOLOGY

Procoagulant signalling mechanisms in lung inflammation and fibrosis: novel opportunities for pharmacological intervention?

(2008) R C Chambers   BRITISH JOURNAL OF PHARMACOLOGY

Protease-Activated Receptor (PAR) 2, but not PAR1, Signaling Promotes the Development of Mammary Adenocarcinoma in Polyoma Middle T Mice

(2008) H. H. Versteeg et al.   CANCER RESEARCH

TGFβ in Cancer

(2008) Joan Massagué   CELL

Sphingosine Kinases and Sphingosine-1-Phosphate Are Critical for Transforming Growth Factor  -Induced Extracellular Signal-Regulated Kinase 1 and 2 Activation and Promotion of Migration and Invasion of Esophageal Cancer Cells

(2008) A. V. Miller et al.   MOLECULAR AND CELLULAR BIOLOGY