Biased signalling and proteinase-activated receptors (PARs): targeting inflammatory disease
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Title
Biased signalling and proteinase-activated receptors (PARs): targeting inflammatory disease
Authors
Keywords
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Journal
BRITISH JOURNAL OF PHARMACOLOGY
Volume 171, Issue 5, Pages 1180-1194
Publisher
Wiley
Online
2013-12-21
DOI
10.1111/bph.12544
References
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Related references
Note: Only part of the references are listed.- The Concise Guide to PHARMACOLOGY 2013/14: G Protein-Coupled Receptors
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- Neutrophil Elastase and Proteinase-3 Trigger G Protein-biased Signaling through Proteinase-activated Receptor-1 (PAR1)
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- An antagonist of human protease activated receptor-2 attenuates PAR2 signaling, macrophage activation, mast cell degranulation, and collagen-induced arthritis in rats
- (2012) Rink-Jan Lohman et al. FASEB JOURNAL
- Protease-activated receptor-1 cleaved at R46 mediates cytoprotective effects
- (2012) R. A. SCHUEPBACH et al. JOURNAL OF THROMBOSIS AND HAEMOSTASIS
- Targeting proteinase-activated receptors: therapeutic potential and challenges
- (2012) Rithwik Ramachandran et al. NATURE REVIEWS DRUG DISCOVERY
- -Arrestin-2 mediates the proinflammatory effects of proteinase-activated receptor-2 in the airway
- (2012) H. L. Nichols et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Modulating human proteinase activated receptor 2 with a novel antagonist (GB88) and agonist (GB110)
- (2011) JY Suen et al. BRITISH JOURNAL OF PHARMACOLOGY
- Neutrophil Elastase Acts as a Biased Agonist for Proteinase-activated Receptor-2 (PAR2)
- (2011) Rithwik Ramachandran et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Mucosal Allergic Sensitization to Cockroach Allergens Is Dependent on Proteinase Activity and Proteinase-Activated Receptor-2 Activation
- (2011) N. G. Arizmendi et al. JOURNAL OF IMMUNOLOGY
- Structure, function and pathophysiology of protease activated receptors
- (2011) Mark N. Adams et al. PHARMACOLOGY & THERAPEUTICS
- Interdicting protease-activated receptor-2-driven inflammation with cell-penetrating pepducins
- (2011) L. M. Sevigny et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Functional Selectivity and Biased Receptor Signaling
- (2010) T. Kenakin JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
- Seven Transmembrane Receptors as Shapeshifting Proteins: The Impact of Allosteric Modulation and Functional Selectivity on New Drug Discovery
- (2010) T. Kenakin et al. PHARMACOLOGICAL REVIEWS
- Platelet Matrix Metalloprotease-1 Mediates Thrombogenesis by Activating PAR1 at a Cryptic Ligand Site
- (2009) Vishal Trivedi et al. CELL
- Agonist-Biased Signaling via Proteinase Activated Receptor-2: Differential Activation of Calcium and Mitogen-Activated Protein Kinase Pathways
- (2009) R. Ramachandran et al. MOLECULAR PHARMACOLOGY
- Caveolae are required for protease-selective signaling by protease-activated receptor-1
- (2009) A. Russo et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The protease-activated receptor-3 (PAR-3) can signal autonomously to induce interleukin-8 release
- (2008) E. Ostrowska et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- Discovery of a Novel, Orally Active Himbacine-Based Thrombin Receptor Antagonist (SCH 530348) with Potent Antiplatelet Activity
- (2008) Samuel Chackalamannil et al. JOURNAL OF MEDICINAL CHEMISTRY
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